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The B7 Family and Cancer Therapy: Costimulation and Coinhibition

Xingxing Zang and James P. Allison
Xingxing Zang
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James P. Allison
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DOI: 10.1158/1078-0432.CCR-07-1030 Published September 2007
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Article Information

Volume 13, Issue 18, pp. 5271-5279

DOI 
https://doi.org/10.1158/1078-0432.CCR-07-1030
PubMed 
17875755

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received April 30, 2007
  • Revision received June 11, 2007
  • Accepted June 27, 2007
  • Published first September 17, 2007.

Copyright & Usage 
American Association for Cancer Research

Author Information

  1. Xingxing Zang and
  2. James P. Allison
  1. Authors' Affiliation: Howard Hughes Medical Institute, Immunology Program, Ludwig Center of Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center, New York, New York
  1. Requests for reprints:
    James P. Allison, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, 415 East 68th Street, Box 470, New York, NY 10021. Phone: 646-888-2332; Fax: 646-422-0470; E-mail: allisonj{at}mskcc.org.
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Clinical Cancer Research: 13 (18)
September 2007
Volume 13, Issue 18
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The B7 Family and Cancer Therapy: Costimulation and Coinhibition
Xingxing Zang and James P. Allison
Clin Cancer Res September 15 2007 (13) (18) 5271-5279; DOI: 10.1158/1078-0432.CCR-07-1030

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The B7 Family and Cancer Therapy: Costimulation and Coinhibition
Xingxing Zang and James P. Allison
Clin Cancer Res September 15 2007 (13) (18) 5271-5279; DOI: 10.1158/1078-0432.CCR-07-1030
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  • Article
    • Abstract
    • Extended B7 Family and CD28 Family
    • Enhancement of Costimulation: B7-1, B7-2, B7h–Transfected Tumor Cell Vaccines
    • Blockade of Coinhibition: Anti–CTLA-4 Therapy
    • PD-L1/PD-1: Tumor Evasion Pathway
    • Tumor-Associated B7-H3 and B7x: Last-ditch Mechanism
    • Conclusion
    • Acknowledgments
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Clinical Cancer Research
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