EWSR1-CREB1 and EWSR1-ATF1 Fusion Genes in Angiomatoid Fibrous Histiocytoma

Morphologic features of AFH. A, a case of AFH showing typical pushing borders and peripheral stromal fibrosis with a lymphoid aggregate (case 7; magnification, ×10). B, a high-power view of the same case in (A), showing the typical spindle and ovoid palely eosinophilic cells (case 7; magnification, ×40). C, another case of AFH characterized by the typical pseudovascular spaces with RBCs (case 10; magnification, ×20). D, the same case in (C) with diffuse nuclear pleomorphism (case 10; magnification, ×20).