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Cancer Therapy: Clinical

The Association Between Measures of Progression and Survival in Castrate-Metastatic Prostate Cancer

Howard I. Scher, Mary Warren and Glenn Heller
Howard I. Scher
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Mary Warren
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Glenn Heller
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DOI: 10.1158/1078-0432.CCR-06-1885 Published March 2007
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    Fig. 1.

    Kaplan-Meier estimate of survival among all 95 patients in the study.

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    Fig. 2.

    Time of radiographic progression-free survival plotted against the time to death, among patients for whom both radiographic progression and death were recorded.

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    Fig. 3.

    Time of PSA progression-free survival plotted against the time to death, among patients for whom both PSA progression and death were recorded.

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    Fig. 4.

    Association between radiographic progression-free survival and survival as a function of the time of the progression-free survival event (radiographic progression, death, or censoring). Solid line, local Kendall's τ estimates; dotted lines, the corresponding 95% pointwise confidence intervals.

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    Fig. 5.

    Association between PSA progression-free survival and survival as a function of the time of the progression-free survival event. Solid line, local Kendall's τ estimates; dotted lines, the corresponding 95% pointwise confidence intervals.

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  • Table 1.

    Distribution of disease in patients with castrate-metastatic prostate cancer

    CategoryOverallMemorial Sloan-Kettering Cancer Center
    Total no. of patients reviewed171116
    TEC (1997-1999)4940
    Hi-TEC (1999-2000)3024
    Epothilone (2001-2003)9852
    Median PSA at baseline (all studies)97.9 (range, 0.52-2,282.2)91.4 (range, 0.52-2,282.15)
    Number of patients with
        bone only51 (29.8%)35 (30.2%)
        bone and soft tissue95 (55.6%)63 (54.3%)
        soft tissue only25 (14.6%)18 (15.5%)
    • *Thirty-nine percent to 40% had “measurable disease” (including visceral disease).

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Clinical Cancer Research: 13 (5)
March 2007
Volume 13, Issue 5
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The Association Between Measures of Progression and Survival in Castrate-Metastatic Prostate Cancer
Howard I. Scher, Mary Warren and Glenn Heller
Clin Cancer Res March 1 2007 (13) (5) 1488-1492; DOI: 10.1158/1078-0432.CCR-06-1885

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The Association Between Measures of Progression and Survival in Castrate-Metastatic Prostate Cancer
Howard I. Scher, Mary Warren and Glenn Heller
Clin Cancer Res March 1 2007 (13) (5) 1488-1492; DOI: 10.1158/1078-0432.CCR-06-1885
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Clinical Cancer Research
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