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Clinical Cancer Research
Clinical Cancer Research
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About the Cover

Cover image

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U87MG glioma cells expressing the de2-7 EGFR (or EGFRvIII) were transiently transfected with the lysosomal marker lgp-120 tagged with GFP (green staining). After transfection, cells were incubated with mAb 806-cy3 at 4°C (red staining), before induction of internalization by incubating at 37°C for 0 (top left), 30 (top right), 60 (bottom left) and 120 (bottom right) minutes. Colocalization of mAb 806-Cy3 and lgp-120-GFP in the lysosomes can be clearly observed at 60 and 120 minutes (yellow staining). For further details, please see Johns et al. on page 1911 in this issue.

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Clinical Cancer Research: 13 (6)
March 2007
Volume 13, Issue 6
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Issue Highlights

  • The Efficacy of Epidermal Growth Factor Receptor–Specific Antibodies against Glioma Xenografts Is Influenced by Receptor Levels, Activation Status, and Heterodimerization
  • A Phase I/II Study of Arsenic Trioxide/Bortezomib/Ascorbic Acid Combination Therapy for the Treatment of Relapsed or Refractory Multiple Myeloma
  • Soluble PD-1 Facilitates 4-1BBL–Triggered Antitumor Immunity against Murine H22 Hepatocarcinoma In vivo
  • Monoclonal Antibody 4C5 Immunostains Human Melanomas and Inhibits Melanoma Cell Invasion and Metastasis
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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