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The Biology Behind

Targeting the Molecular Chaperone Heat Shock Protein 90 Provides a Multifaceted Effect on Diverse Cell Signaling Pathways of Cancer Cells

Wanping Xu and Len Neckers
Wanping Xu
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Len Neckers
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DOI: 10.1158/1078-0432.CCR-06-2966 Published March 2007
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Article Information

Volume 13, Issue 6, pp. 1625-1629

DOI 
https://doi.org/10.1158/1078-0432.CCR-06-2966
PubMed 
17363512

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received December 14, 2006
  • Accepted December 28, 2006
  • Published first March 15, 2007.

Copyright & Usage 
American Association for Cancer Research

Author Information

  1. Wanping Xu and
  2. Len Neckers
  1. Authors' Affiliation: Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland
  1. Requests for reprints:
    Len Neckers, Urologic Oncology Branch, National Cancer Institute, Building 10/CRC, Room 1-5940, 9000 Rockville Pike, Bethesda, MD 20892-1107. Phone: 301-496-5899; Fax: 301-402-0922; E-mail: len{at}helix.nih.gov.
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Clinical Cancer Research: 13 (6)
March 2007
Volume 13, Issue 6
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Targeting the Molecular Chaperone Heat Shock Protein 90 Provides a Multifaceted Effect on Diverse Cell Signaling Pathways of Cancer Cells
Wanping Xu and Len Neckers
Clin Cancer Res March 15 2007 (13) (6) 1625-1629; DOI: 10.1158/1078-0432.CCR-06-2966

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Targeting the Molecular Chaperone Heat Shock Protein 90 Provides a Multifaceted Effect on Diverse Cell Signaling Pathways of Cancer Cells
Wanping Xu and Len Neckers
Clin Cancer Res March 15 2007 (13) (6) 1625-1629; DOI: 10.1158/1078-0432.CCR-06-2966
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    • Targeting Hsp90 to Deprive Cancer Cells of Self-sufficiency in Growth Signals
    • Targeting Hsp90 to Combat Insensitivity of Cancer Cells to Antigrowth Signals
    • Targeting Hsp90 to Induce Apoptosis
    • Targeting Hsp90 to Ablate Limitless Replicative Potential
    • Targeting Hsp90 to Combat Sustained Angiogenesis
    • Targeting Hsp90 to Inhibit Tissue Invasion and Metastasis
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Clinical Cancer Research
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