Clinical Implications of Fibroblast Activation Protein in Patients with Colon Cancer

DOI: 10.1158/1078-0432.CCR-06-1746 Published March 2007

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Fig. 1.
Representative examples of FAP expression by immunohistochemistry. Semiquantitative analysis of stromal expression of FAP was graded as 0, 1+ (1-10% stromal staining), 2+ (11-50% stromal staining), and 3+ (51-100% stromal staining). Representative examples of the various categories of FAP staining.
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Fig. 2.
FAP expression in representative HT29 xenografted tumor tissues. A to C, immunohistochemical analysis of FAP expression of different tumor sizes (A, 0.047 g; B, 0.32 g; C, 0.98 g). Arrows, stromal area in the tumor. D, measurement of area and intensity of FAP expression by ACIS. Histogram shows the average percent of FAP expression [% = brown area / brown (FAP staining) + blue (nuclear staining) × 100].
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Fig. 3.
Kaplan-Meier curve of patients with known metastases. Survival was estimated using Kaplan-Meier methods, which showed greater FAP intensity resulted in worse survival.

Table 1.

Patient and tumor characteristics

↵* Twelve patients had chemotherapy in both the adjuvant and metastatic setting.

Table 2.

FAP expression in relation to cancer stage

FAP expression	No. of specimens (N = 138)	FAP semiquantitatively high, n (%)	FAP semiquantitatively low, n (%)	P	FAP intensity high, n (%)	FAP intensity low, n (%)	P
Stage
I	6	5 (83)	1 (17)	0.01	4 (67)	2 (33)	0.009
II	52	45 (87)	7 (13)		37 (71)	15 (29)
III	43	30 (70)	13 (30)		29 (67)	14 (33)
IV	37	21 (57)	16 (43)		14 (38)	23 (62)
Grade
Well differentiated	7	5 (71)	2 (29)	0.75	4 (57)	3 (43)	0.94
Moderately differentiated	110	79 (72)	31 (28)		66 (60)	44 (40)
Poorly differentiated	20	16 (80)	4 (20)		13 (65)	7 (35)
Unknown	1	1 (100)			1 (100)