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Clinical Cancer Research
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Table of Contents

Editor's Note

  • Editor's Note
    Introducing Statistics in Clinical Cancer Research
    Steven Piantadosi
    Clin Cancer Res July 15 2008 14 (14) 4357-4357; DOI:10.1158/1078-0432.CCR-14-14-ED

Statistics in Clinical Cancer Research

  • Statistics in Clinical Cancer Research
    Randomized Phase III Clinical Trial Designs for Targeted Agents
    Antje Hoering, Mike LeBlanc and John J. Crowley
    Clin Cancer Res July 15 2008 14 (14) 4358-4367; DOI:10.1158/1078-0432.CCR-08-0288

  • Statistics in Clinical Cancer Research
    Multi-Arm Clinical Trials of New Agents: Some Design Considerations
    Boris Freidlin, Edward L. Korn, Robert Gray and Alison Martin
    Clin Cancer Res July 15 2008 14 (14) 4368-4371; DOI:10.1158/1078-0432.CCR-08-0325

Molecular Pathways

  • Molecular Pathways
    RLIP76 and Cancer
    Sanjay Awasthi, Sharad S. Singhal, Yogesh C. Awasthi, Bryan Martin, Jung-Hee Woo, C. Casey Cunningham and Arthur E. Frankel
    Clin Cancer Res July 15 2008 14 (14) 4372-4377; DOI:10.1158/1078-0432.CCR-08-0145

Report from the FDA

  • Report from the FDA
    Ixabepilone in Combination with Capecitabine and as Monotherapy for Treatment of Advanced Breast Cancer Refractory to Previous Chemotherapies
    Robert J. Lechleider, Edvardas Kaminskas, Xiaoping Jiang, Robeena Aziz, Julie Bullock, Ravindra Kasliwal, Ravi Harapanhalli, Sarah Pope, Rajeshwari Sridhara, John Leighton, Brian Booth, Ramzi Dagher, Robert Justice and Richard Pazdur
    Clin Cancer Res July 15 2008 14 (14) 4378-4384; DOI:10.1158/1078-0432.CCR-08-0015

Perspective

  • Perspective
    Targeted Therapies to Improve Tumor Immunotherapy
    Jonathan Begley and Antoni Ribas
    Clin Cancer Res July 15 2008 14 (14) 4385-4391; DOI:10.1158/1078-0432.CCR-07-4804

Reviews

  • Reviews
    Therapeutic Options Against BCR-ABL1 T315I-Positive Chronic Myelogenous Leukemia
    Alfonso Quintás-Cardama and Jorge Cortes
    Clin Cancer Res July 15 2008 14 (14) 4392-4399; DOI:10.1158/1078-0432.CCR-08-0117

  • Reviews
    Comparison of Nomograms With Other Methods for Predicting Outcomes in Prostate Cancer: A Critical Analysis of the Literature
    Shahrokh F. Shariat, Pierre I. Karakiewicz, Nazareno Suardi and Michael W. Kattan
    Clin Cancer Res July 15 2008 14 (14) 4400-4407; DOI:10.1158/1078-0432.CCR-07-4713

Human Cancer Biology

  • Human Cancer Biology
    Function of JunB in Transient Amplifying Cell Senescence and Progression of Human Prostate Cancer
    Noboru Konishi, Keiji Shimada, Mitsutoshi Nakamura, Eiwa Ishida, Ichiro Ota, Nobumichi Tanaka and Kiyohide Fujimoto
    Clin Cancer Res July 15 2008 14 (14) 4408-4416; DOI:10.1158/1078-0432.CCR-07-4120

  • Human Cancer Biology
    Intratumoral Estrogens and Estrogen Receptors in Human Non–Small Cell Lung Carcinoma
    Hiromichi Niikawa, Takashi Suzuki, Yasuhiro Miki, Satoshi Suzuki, Shuji Nagasaki, Junichi Akahira, Seijiro Honma, Dean B. Evans, Shin-ichi Hayashi, Takashi Kondo and Hironobu Sasano
    Clin Cancer Res July 15 2008 14 (14) 4417-4426; DOI:10.1158/1078-0432.CCR-07-1950

  • Human Cancer Biology
    Anti-invasive and Antimetastatic Activities of Ribosomal Protein S6 Kinase 4 in Breast Cancer Cells
    Archana Thakur, Yuan Sun, Aliccia Bollig, Jack Wu, Hector Biliran, Sanjeev Banerjee, Fazlul H. Sarkar and D. Joshua Liao
    Clin Cancer Res July 15 2008 14 (14) 4427-4436; DOI:10.1158/1078-0432.CCR-08-0458

  • Human Cancer Biology
    Transformation by Oncogenic Mutants and Ligand-Dependent Activation of FLT3 Wild-type Requires the Tyrosine Residues 589 and 591
    Sridhar Vempati, Carola Reindl, Ulla Wolf, Ruth Kern, Konstantin Petropoulos, Vegi M. Naidu, Christian Buske, Wolfgang Hiddemann, Tobias M. Kohl and Karsten Spiekermann
    Clin Cancer Res July 15 2008 14 (14) 4437-4445; DOI:10.1158/1078-0432.CCR-07-1873

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Genomic Differences Between Pure Ductal Carcinoma In Situ of the Breast and that Associated with Invasive Disease: a Calibrated aCGH Study
    Vladimir V. Iakovlev, Nona C.R. Arneson, Vietty Wong, Chunjie Wang, Stephanie Leung, Gaiane Iakovleva, Keisha Warren, Melania Pintilie and Susan J. Done
    Clin Cancer Res July 15 2008 14 (14) 4446-4454; DOI:10.1158/1078-0432.CCR-07-4960

  • Imaging, Diagnosis, Prognosis
    Expression of Aurora A (but Not Aurora B) Is Predictive of Survival in Breast Cancer
    Yasmine Nadler, Robert L. Camp, Candice Schwartz, David L. Rimm, Harriet M. Kluger and Yuval Kluger
    Clin Cancer Res July 15 2008 14 (14) 4455-4462; DOI:10.1158/1078-0432.CCR-07-5268

  • Imaging, Diagnosis, Prognosis
    Analysis and Reproducibility of 3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography Imaging in Patients with Non–Small Cell Lung Cancer
    Anthony F. Shields, Jawana M. Lawhorn-Crews, David A. Briston, Sajad Zalzala, Shirish Gadgeel, Kirk A. Douglas, Thomas J. Mangner, Lance K. Heilbrun and Otto Muzik
    Clin Cancer Res July 15 2008 14 (14) 4463-4468; DOI:10.1158/1078-0432.CCR-07-5243

  • Imaging, Diagnosis, Prognosis
    Visualization of Circulating Melanoma Cells in Peripheral Blood of Patients with Primary Uveal Melanoma
    Anja Ulmer, Julia Beutel, Daniela Süsskind, Ralf-Dieter Hilgers, Focke Ziemssen, Matthias Lüke, Martin Röcken, Martin Rohrbach, Gerhard Fierlbeck, Karl-Ulrich Bartz-Schmidt and Salvatore Grisanti
    Clin Cancer Res July 15 2008 14 (14) 4469-4474; DOI:10.1158/1078-0432.CCR-08-0012

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Irradiance-Dependent Photobleaching and Pain in δ-Aminolevulinic Acid-Photodynamic Therapy of Superficial Basal Cell Carcinomas
    William J. Cottrell, Anne D. Paquette, Kenneth R. Keymel, Thomas H. Foster and Allan R. Oseroff
    Clin Cancer Res July 15 2008 14 (14) 4475-4483; DOI:10.1158/1078-0432.CCR-07-5199

  • Cancer Therapy: Clinical
    A Phase I and Pharmacokinetic Study of Lapatinib in Combination with Letrozole in Patients with Advanced Cancer
    Quincy S.C. Chu, Mary E. Cianfrocca, Lori J. Goldstein, Meg Gale, Nicholas Murray, Jill Loftiss, Nikita Arya, Kevin M. Koch, Lini Pandite, Ronald A. Fleming, Elaine Paul and Eric K. Rowinsky
    Clin Cancer Res July 15 2008 14 (14) 4484-4490; DOI:10.1158/1078-0432.CCR-07-4417

  • Cancer Therapy: Clinical
    Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
    Navneet Dhillon, Bharat B. Aggarwal, Robert A. Newman, Robert A. Wolff, Ajaikumar B. Kunnumakkara, James L. Abbruzzese, Chaan S. Ng, Vladimir Badmaev and Razelle Kurzrock
    Clin Cancer Res July 15 2008 14 (14) 4491-4499; DOI:10.1158/1078-0432.CCR-08-0024

  • Cancer Therapy: Clinical
    Histone Deacetylase Inhibitor Panobinostat Induces Clinical Responses with Associated Alterations in Gene Expression Profiles in Cutaneous T-Cell Lymphoma
    Leigh Ellis, Yan Pan, Gordon K. Smyth, Daniel J. George, Chris McCormack, Roxanne Williams-Truax, Monica Mita, Joachim Beck, Howard Burris, Gail Ryan, Peter Atadja, Dale Butterfoss, Margaret Dugan, Kenneth Culver, Ricky W. Johnstone and H. Miles Prince
    Clin Cancer Res July 15 2008 14 (14) 4500-4510; DOI:10.1158/1078-0432.CCR-07-4262

  • Cancer Therapy: Clinical
    Class III β-Tubulin Isotype Predicts Response in Advanced Breast Cancer Patients Randomly Treated Either with Single-Agent Doxorubicin or Docetaxel
    Carlos M. Galmarini, Isabelle Treilleux, Fatima Cardoso, Chantal Bernard-Marty, Virginie Durbecq, David Gancberg, Marie-Christine Bissery, Marianne Paesmans, Denis Larsimont, Martine J. Piccart, Angelo Di Leo and Charles Dumontet
    Clin Cancer Res July 15 2008 14 (14) 4511-4516; DOI:10.1158/1078-0432.CCR-07-4741

  • Cancer Therapy: Clinical
    A Phase I and Pharmacokinetic Study of the Oral Histone Deacetylase Inhibitor, MS-275, in Patients with Refractory Solid Tumors and Lymphomas
    Lia Gore, Mace L. Rothenberg, Cindy L. O'Bryant, Mary Kay Schultz, Alan B. Sandler, Denise Coffin, Candice McCoy, Astrid Schott, Catherine Scholz and S. Gail Eckhardt
    Clin Cancer Res July 15 2008 14 (14) 4517-4525; DOI:10.1158/1078-0432.CCR-07-1461

  • Cancer Therapy: Clinical
    Analysis of Overall Survival in Patients with Nonmetastatic Castration-Resistant Prostate Cancer Treated with Vaccine, Nilutamide, and Combination Therapy
    Ravi A. Madan, James L. Gulley, Jeffrey Schlom, Seth M. Steinberg, David J. Liewehr, William L. Dahut and Philip M. Arlen
    Clin Cancer Res July 15 2008 14 (14) 4526-4531; DOI:10.1158/1078-0432.CCR-07-5048

  • Cancer Therapy: Clinical
    Local Administration of PF-3512676 CpG-B Instigates Tumor-Specific CD8+ T-Cell Reactivity in Melanoma Patients
    Barbara G. Molenkamp, Berbel J.R. Sluijter, Paul A.M. van Leeuwen, Saskia J.A.M. Santegoets, Sybren Meijer, Pepijn G.J.T.B. Wijnands, John B.A.G. Haanen, Alfons J.M. van den Eertwegh, Rik J. Scheper and Tanja D. de Gruijl
    Clin Cancer Res July 15 2008 14 (14) 4532-4542; DOI:10.1158/1078-0432.CCR-07-4711

  • Cancer Therapy: Clinical
    ABCB1 Genetic Variation Influences the Toxicity and Clinical Outcome of Patients with Androgen-Independent Prostate Cancer Treated with Docetaxel
    Tristan M. Sissung, Caitlin E. Baum, John Deeken, Douglas K. Price, Jeanny Aragon-Ching, Seth M. Steinberg, William Dahut, Alex Sparreboom and William D. Figg
    Clin Cancer Res July 15 2008 14 (14) 4543-4549; DOI:10.1158/1078-0432.CCR-07-4230

  • Cancer Therapy: Clinical
    Therapeutic Consequences from Molecular Biology for Gastrointestinal Stromal Tumor Patients Affected by Neurofibromatosis Type 1
    Chiara Mussi, Hans-Ulrich Schildhaus, Alessandro Gronchi, Eva Wardelmann and Peter Hohenberger
    Clin Cancer Res July 15 2008 14 (14) 4550-4555; DOI:10.1158/1078-0432.CCR-08-0086

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Prevention and Treatment of Experimental Estrogen Receptor–Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268
    Karen Liby, Renee Risingsong, Darlene B. Royce, Charlotte R. Williams, Mark M. Yore, Tadashi Honda, Gordon W. Gribble, William W. Lamph, Nicola Vannini, Ilaria Sogno, Adriana Albini and Michael B. Sporn
    Clin Cancer Res July 15 2008 14 (14) 4556-4563; DOI:10.1158/1078-0432.CCR-08-0040

  • Cancer Therapy: Preclinical
    Expression of t-DARPP Mediates Trastuzumab Resistance in Breast Cancer Cells
    Abbes Belkhiri, Altaf A. Dar, Dun Fa Peng, Mohammad H. Razvi, Cammie Rinehart, Carlos L. Arteaga and Wael El-Rifai
    Clin Cancer Res July 15 2008 14 (14) 4564-4571; DOI:10.1158/1078-0432.CCR-08-0121

  • Cancer Therapy: Preclinical
    Molecular Characterization of the Pediatric Preclinical Testing Panel
    Geoffrey Neale, Xiaoping Su, Christopher L. Morton, Doris Phelps, Richard Gorlick, Richard B. Lock, C. Patrick Reynolds, John M. Maris, Henry S. Friedman, Jeffrey Dome, Joseph Khoury, Timothy J. Triche, Robert C. Seeger, Richard Gilbertson, Javed Khan, Malcolm A. Smith and Peter J. Houghton
    Clin Cancer Res July 15 2008 14 (14) 4572-4583; DOI:10.1158/1078-0432.CCR-07-5090

  • Cancer Therapy: Preclinical
    Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts
    Elinborg Ostermann, Pilar Garin-Chesa, Karl Heinz Heider, Milena Kalat, Herbert Lamche, Christina Puri, Dontscho Kerjaschki, Wolfgang J. Rettig and Guenther R. Adolf
    Clin Cancer Res July 15 2008 14 (14) 4584-4592; DOI:10.1158/1078-0432.CCR-07-5211

  • Cancer Therapy: Preclinical
    KML001 Cytotoxic Activity Is Associated with Its Binding to Telomeric Sequences and Telomere Erosion in Prostate Cancer Cells
    Pornima Phatak, Fangping Dai, Melody Butler, M.P. Nandakumar, Peter L. Gutierrez, Martin J. Edelman, Hans Hendriks and Angelika M. Burger
    Clin Cancer Res July 15 2008 14 (14) 4593-4602; DOI:10.1158/1078-0432.CCR-07-4572

  • Cancer Therapy: Preclinical
    Paclitaxel Encapsulated in Cationic Liposomes Increases Tumor Microvessel Leakiness and Improves Therapeutic Efficacy in Combination with Cisplatin
    Sebastian Strieth, Martin E. Eichhorn, Alexander Werner, Birgitta Sauer, Michael Teifel, Uwe Michaelis, Alexander Berghaus and Marc Dellian
    Clin Cancer Res July 15 2008 14 (14) 4603-4611; DOI:10.1158/1078-0432.CCR-07-4738

  • Cancer Therapy: Preclinical
    A Novel Recombinant Soluble Splice Variant of Met Is a Potent Antagonist of the Hepatocyte Growth Factor/Scatter Factor-Met Pathway
    Zohar Tiran, Anat Oren, Chen Hermesh, Galit Rotman, Zurit Levine, Hagit Amitai, Tal Handelsman, Merav Beiman, Aviva Chen, Dalit Landesman-Milo, Liat Dassa, Yair Peres, Cynthia Koifman, Sarit Glezer, Rinat Vidal-Finkelstein, Kobi Bahat, Tania Pergam, Cylia Israel, Judith Horev, Ilan Tsarfaty and Michal Ayalon-Soffer
    Clin Cancer Res July 15 2008 14 (14) 4612-4621; DOI:10.1158/1078-0432.CCR-08-0108

  • Cancer Therapy: Preclinical
    Slug (SNAI2) Down-Regulation by RNA Interference Facilitates Apoptosis and Inhibits Invasive Growth in Neuroblastoma Preclinical Models
    Roberta Vitali, Camillo Mancini, Vincenzo Cesi, Barbara Tanno, Mariateresa Mancuso, Gianluca Bossi, Ying Zhang, Robert V. Martinez, Bruno Calabretta, Carlo Dominici and Giuseppe Raschellà
    Clin Cancer Res July 15 2008 14 (14) 4622-4630; DOI:10.1158/1078-0432.CCR-07-5210

  • Cancer Therapy: Preclinical
    Dual Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect in Esophageal Adenocarcinoma In vitro and In vivo
    Nobuyuki Watanabe, Munenori Takaoka, Kazufumi Sakurama, Yasuko Tomono, Shinji Hatakeyama, Osamu Ohmori, Takayuki Motoki, Yasuhiro Shirakawa, Tomoki Yamatsuji, Minoru Haisa, Junji Matsuoka, David G. Beer, Hitoshi Nagatsuka, Noriaki Tanaka and Yoshio Naomoto
    Clin Cancer Res July 15 2008 14 (14) 4631-4639; DOI:10.1158/1078-0432.CCR-07-4755

  • Cancer Therapy: Preclinical
    Statin-Dependent Suppression of the Akt/Mammalian Target of Rapamycin Signaling Cascade and Programmed Cell Death 4 Up-Regulation in Renal Cell Carcinoma
    Jennifer Woodard, Antonella Sassano, Nissim Hay and Leonidas C. Platanias
    Clin Cancer Res July 15 2008 14 (14) 4640-4649; DOI:10.1158/1078-0432.CCR-07-5232

  • Cancer Therapy: Preclinical
    Lenalidomide Enhances Natural Killer Cell and Monocyte-Mediated Antibody-Dependent Cellular Cytotoxicity of Rituximab-Treated CD20+ Tumor Cells
    Lei Wu, Mary Adams, Troy Carter, Roger Chen, George Muller, David Stirling, Peter Schafer and J. Blake Bartlett
    Clin Cancer Res July 15 2008 14 (14) 4650-4657; DOI:10.1158/1078-0432.CCR-07-4405

  • Cancer Therapy: Preclinical
    Differential Effect of Doxorubicin and Zoledronic Acid on Intraosseous versus Extraosseous Breast Tumor Growth In vivo
    Penelope D. Ottewell, Blandine Deux, Hannu Mönkkönen, Simon Cross, Robert E. Coleman, Philippe Clezardin and Ingunn Holen
    Clin Cancer Res July 15 2008 14 (14) 4658-4666; DOI:10.1158/1078-0432.CCR-07-1545

Cancer Prevention and Susceptibility

  • Cancer Prevention and Susceptibility
    Penetrance Analysis of the PALB2 c.1592delT Founder Mutation
    Hannele Erkko, James G. Dowty, Jenni Nikkilä, Kirsi Syrjäkoski, Arto Mannermaa, Katri Pylkäs, Melissa C. Southey, Kaija Holli, Anne Kallioniemi, Arja Jukkola-Vuorinen, Vesa Kataja, Veli-Matti Kosma, Bing Xia, David M. Livingston, Robert Winqvist and John L. Hopper
    Clin Cancer Res July 15 2008 14 (14) 4667-4671; DOI:10.1158/1078-0432.CCR-08-0210

  • Cancer Prevention and Susceptibility
    A Novel Breast Cancer–Associated BRIP1 (FANCJ/BACH1) Germ-line Mutation Impairs Protein Stability and Function
    Arcangela De Nicolo, Mariella Tancredi, Grazia Lombardi, Cristina Chantal Flemma, Serena Barbuti, Claudio Di Cristofano, Bijan Sobhian, Generoso Bevilacqua, Ronny Drapkin and Maria Adelaide Caligo
    Clin Cancer Res July 15 2008 14 (14) 4672-4680; DOI:10.1158/1078-0432.CCR-08-0087

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Clinical Cancer Research: 14 (14)
July 2008
Volume 14, Issue 14
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Issue Highlights

  • Randomized Phase III Clinical Trial Designs for Targeted Agents
  • Histone Deacetylase Inhibitor Panobinostat Induces Clinical Responses with Associated Alterations in Gene Expression Profiles in Cutaneous T-Cell Lymphoma
  • Prevention and Treatment of Experimental Estrogen Receptor–Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268
  • Function of JunB in Transient Amplifying Cell Senescence and Progression of Human Prostate Cancer

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  • Statistics in Clinical Cancer Research
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  • Report from the FDA
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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