Article Figures & Data
Figures
- Fig. 1.
Blue immunostaining of MCSP-positive tumor cells in peripheral blood of patients with primary uveal melanoma (A-C). Surrounding lymphocytes (B) and granulocytes enriched from peripheral blood of a healthy volunteer (D) do not express the antigen (5-bromo-4-chloro-3-indoyl phosphate and nitroblue tetrazolium, alkaline phosphatase–anti-alkaline phosphatase; original magnification, ×400).
Tables
- Table 1.
Association of established clinical prognostic markers with the presence of circulating tumor cells
Variable Positive for CTC (n = 10) Negative for CTC (n = 42) All patients (N = 52) P OR (95% Wald confidence limits) Age (y) Median 72 64 65 0.8368 1.0 (1.0, 1.1) Min, max 18, 81 26, 82 18, 82 Sex Female 6 21 27 0.5710 1.5 (0.4, 6.1) Male 4 21 25 LBD (mm)* Median 16.15 11.51 12.2 0.0030† NA Min, max 10.12, 19.27 4.22, 23.0 4.22, 23, 0 >14 6 10 16 0.0065 1.4 (1.1, 1.8) <14 4 31 35 Tumor height (mm) Median 8.84 6.87 7.76 0.0249† NA Min, max 4.65, 13.0 1.3, 18.0 1.3, 18, 0 Ciliary body infiltration Yes 5 2 7 0.0018 20.0 (3.0, 131.7) No 5 40 45 Localization Anterior 4 1 5 0.0206 4.0 (1.2, 12.7) Peripheral 3 20 23 Posterior 3 21 24 NOTE: All tests are based on fitting a univariate logistic regression model (Wald χ2 test) except for median tumor height and LBD, which were analyzed using the Wilcoxon rank sum test.
Abbreviations: CTC, circulating tumor cells; n, number; min, minimum; max, maximum; mm, millimeter; LBD, largest basal diameter; NA, not applicable.
↵* Missing data: n = 1.
↵† Analyzed using the Wilcoxon rank sum test.
- Table 2.
Association between tumor stage according to TNM 6th edition (A) and modified Augsburger classification no. 1 (B) with the presence of circulating tumor cells
A TNM 6th edition* No. pts examined No. pts positive Positivity rate, % (95% CI) T1N0M0 LBD ≤ 10 mm and height ≤ 2.5 mm regardless of extraocular extension 15 0 0.0 (0.0-18.0) T2N0M0 10 < LBD ≤ 16 mm and/or 2.5 < height ≤ 10 mm regardless of extraocular extension 30 5 17.0 (6.0-35.0) T3N0M0 LBD > 16mm and/or height >10 mm without extraocular extension 5 4 80.0 (28.0-99.0) T4N0M0 LDB > 16 mm and/or height > 10 mm with extraocular extension 2 1 50.0 (1.0-99.0) B Modified Augsburger alternative classification no. 1, ciliary body and choroid* No. pts examined No. pts positive Positivity rate, % (95% CI) T1N0M0 LBD ≤ 10 mm and height ≤ 5 mm regardless of extraocular extension 13 0 0.0 (0.0-21.0) T2N0M0 10 < LBD ≤ 15 mm and/or 5 < height ≤ 8 mm regardless of extraocular extension 20 1 5.0 (0.0-25.0) T3N0M0 LBD > 15 mm and/or height > 8 mm without extraocular extension 17 8 47.0 (23.0-72.0) T4N0M0 LBD > 15 mm and/or height > 8 mm with extraocular extension 2 1 50.0 (1.0-99.0)
Volume 14, Issue 14
