Clinical Cancer Research: 14 (17)

CCR Translations

CCR Translations

Expanding the Use of Retinoids in Acute Myeloid Leukemia: Spotlight on Bexarotene

Suzan McNamara and Wilson H. Miller Jr.

Clin Cancer Res September 1 2008 14 (17) 5311-5313; DOI:10.1158/1078-0432.CCR-08-1081

Molecular Pathways

Molecular Pathways

Oncogenic NOTCH1 Control of MYC and PI3K: Challenges and Opportunities for Anti-NOTCH1 Therapy in T-Cell Acute Lymphoblastic Leukemias and Lymphomas

Teresa Palomero and Adolfo Ferrando

Clin Cancer Res September 1 2008 14 (17) 5314-5317; DOI:10.1158/1078-0432.CCR-07-4864
Molecular Pathways

Targeting the MDM2-p53 Interaction for Cancer Therapy

Sanjeev Shangary and Shaomeng Wang

Clin Cancer Res September 1 2008 14 (17) 5318-5324; DOI:10.1158/1078-0432.CCR-07-5136

Report from the FDA

Report from the FDA

Tasigna for Chronic and Accelerated Phase Philadelphia Chromosome–Positive Chronic Myelogenous Leukemia Resistant to or Intolerant of Imatinib

Maitreyee Hazarika, Xiaoping Jiang, Qi Liu, Shwu-Luan Lee, Roshni Ramchandani, Christine Garnett, Micheal S. Orr, Rajeshwari Sridhara, Brian Booth, John K. Leighton, William Timmer, Ravi Harapanhalli, Ramzi Dagher, Robert Justice and Richard Pazdur

Clin Cancer Res September 1 2008 14 (17) 5325-5331; DOI:10.1158/1078-0432.CCR-08-0308

Human Cancer Biology

Human Cancer Biology

Expanding the Roles for Pregnane X Receptor in Cancer: Proliferation and Drug Resistance in Ovarian Cancer

Divya Gupta, Madhukumar Venkatesh, Hongwei Wang, Sean Kim, Michael Sinz, Gary L. Goldberg, Kathleen Whitney, Clifford Longley and Sridhar Mani

Clin Cancer Res September 1 2008 14 (17) 5332-5340; DOI:10.1158/1078-0432.CCR-08-1033
Human Cancer Biology

β2-Microglobulin Signaling Blockade Inhibited Androgen Receptor Axis and Caused Apoptosis in Human Prostate Cancer Cells

Wen-Chin Huang, Jonathan J. Havel, Haiyen E. Zhau, Wei Ping Qian, Hui-Wen Lue, Chia-Yi Chu, Takeo Nomura and Leland W.K. Chung

Clin Cancer Res September 1 2008 14 (17) 5341-5347; DOI:10.1158/1078-0432.CCR-08-0793
Human Cancer Biology

Expression and Gene Amplification of Actinin-4 in Invasive Ductal Carcinoma of the Pancreas

Satoru Kikuchi, Kazufumi Honda, Hitoshi Tsuda, Nobuyoshi Hiraoka, Issei Imoto, Tomoo Kosuge, Tomoko Umaki, Kaoru Onozato, Miki Shitashige, Umio Yamaguchi, Masaya Ono, Akihiko Tsuchida, Tatsuya Aoki, Johji Inazawa, Setsuo Hirohashi and Tesshi Yamada

Clin Cancer Res September 1 2008 14 (17) 5348-5356; DOI:10.1158/1078-0432.CCR-08-0075
Human Cancer Biology

Epithelial and Stromal Cathepsin K and CXCL14 Expression in Breast Tumor Progression

Celina G. Kleer, Noga Bloushtain-Qimron, Yu-Hui Chen, Daniel Carrasco, Min Hu, Jun Yao, Stine-Kathrein Kraeft, Laura C. Collins, Michael S. Sabel, Pedram Argani, Rebecca Gelman, Stuart J. Schnitt, Ian E. Krop and Kornelia Polyak

Clin Cancer Res September 1 2008 14 (17) 5357-5367; DOI:10.1158/1078-0432.CCR-08-0732
Human Cancer Biology

Induction of Receptor for Advanced Glycation End Products by EBV Latent Membrane Protein 1 and Its Correlation with Angiogenesis and Cervical Lymph Node Metastasis in Nasopharyngeal Carcinoma

Akira Tsuji, Naohiro Wakisaka, Satoru Kondo, Shigeyuki Murono, Mitsuru Furukawa and Tomokazu Yoshizaki

Clin Cancer Res September 1 2008 14 (17) 5368-5375; DOI:10.1158/1078-0432.CCR-08-0198
Human Cancer Biology

Overexpression of the Zinc Uptake Transporter hZIP1 Inhibits Nuclear Factor-κB and Reduces the Malignant Potential of Prostate Cancer Cells In vitro and In vivo

Konstantin Golovine, Peter Makhov, Robert G. Uzzo, Tavis Shaw, David Kunkle and Vladimir M. Kolenko

Clin Cancer Res September 1 2008 14 (17) 5376-5384; DOI:10.1158/1078-0432.CCR-08-0455

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

Guo Zhang, Margaret A. Park, Clint Mitchell, Hossein Hamed, Mohamed Rahmani, Aditi Pandya Martin, David T. Curiel, Adly Yacoub, Martin Graf, Ray Lee, John D. Roberts, Paul B. Fisher, Steven Grant and Paul Dent

Clin Cancer Res September 1 2008 14 (17) 5385-5399; DOI:10.1158/1078-0432.CCR-08-0469
Cancer Therapy: Preclinical

Oncostatin M Induces Bone Loss and Sensitizes Rat Osteosarcoma to the Antitumor Effect of Midostaurin In vivo

Bénédicte Brounais, Céline Chipoy, Kanji Mori, Céline Charrier, Séverine Battaglia, Paul Pilet, Carl D. Richards, Dominique Heymann, Françoise Rédini and Frédéric Blanchard

Clin Cancer Res September 1 2008 14 (17) 5400-5409; DOI:10.1158/1078-0432.CCR-07-4781
Cancer Therapy: Preclinical

Postradiation Sensitization of the Histone Deacetylase Inhibitor Valproic Acid

Prakash Chinnaiyan, David Cerna, William E. Burgan, Katie Beam, Eli S. Williams, Kevin Camphausen and Philip J. Tofilon

Clin Cancer Res September 1 2008 14 (17) 5410-5415; DOI:10.1158/1078-0432.CCR-08-0643
Cancer Therapy: Preclinical

Inhibition of the p53 E3 Ligase HDM-2 Induces Apoptosis and DNA Damage–Independent p53 Phosphorylation in Mantle Cell Lymphoma

Richard J. Jones, Qing Chen, Peter M. Voorhees, Ken H. Young, Nathalie Bruey-Sedano, Dajun Yang and Robert Z. Orlowski

Clin Cancer Res September 1 2008 14 (17) 5416-5425; DOI:10.1158/1078-0432.CCR-08-0150
Cancer Therapy: Preclinical

Matuzumab Short-Term Therapy in Experimental Pancreatic Cancer: Prolonged Antitumor Activity in Combination with Gemcitabine

Axel Kleespies, Ivan Ischenko, Martin E. Eichhorn, Hendrik Seeliger, Christiane Amendt, Ole Mantell, Karl-Walter Jauch and Christiane J. Bruns

Clin Cancer Res September 1 2008 14 (17) 5426-5436; DOI:10.1158/1078-0432.CCR-07-5245
Cancer Therapy: Preclinical

Targeting Aurora Kinase with MK-0457 Inhibits Ovarian Cancer Growth

Yvonne G. Lin, Anand Immaneni, William M. Merritt, Lingegowda S. Mangala, Seung Wook Kim, Mian M.K. Shahzad, Yvonne T.M. Tsang, Guillermo N. Armaiz-Pena, Chunhua Lu, Aparna A. Kamat, Liz Y. Han, Whitney A. Spannuth, Alpa M. Nick, Charles N. Landen Jr., Kwong K. Wong, Michael J. Gray, Robert L. Coleman, Diane C. Bodurka, William R. Brinkley and Anil K. Sood

Clin Cancer Res September 1 2008 14 (17) 5437-5446; DOI:10.1158/1078-0432.CCR-07-4922
Cancer Therapy: Preclinical

Inhibition of Glioblastoma Growth in a Highly Invasive Nude Mouse Model Can Be Achieved by Targeting Epidermal Growth Factor Receptor but not Vascular Endothelial Growth Factor Receptor-2

Tobias Martens, Yvonne Laabs, Hauke S. Günther, Dirk Kemming, Zhenping Zhu, Larry Witte, Christian Hagel, Manfred Westphal and Katrin Lamszus

Clin Cancer Res September 1 2008 14 (17) 5447-5458; DOI:10.1158/1078-0432.CCR-08-0147
Cancer Therapy: Preclinical

Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase

Junji Matsui, Yasuhiro Funahashi, Toshimitsu Uenaka, Tatsuo Watanabe, Akihiko Tsuruoka and Makoto Asada

Clin Cancer Res September 1 2008 14 (17) 5459-5465; DOI:10.1158/1078-0432.CCR-07-5270
Cancer Therapy: Preclinical

Combined Vascular Endothelial Growth Factor Receptor/Epidermal Growth Factor Receptor Blockade with Chemotherapy for Treatment of Local, Uterine, and Metastatic Soft Tissue Sarcoma

Wenhong Ren, Borys Korchin, Guy Lahat, Caimiao Wei, Svetlana Bolshakov, Theresa Nguyen, William Merritt, Adam Dicker, Alexander Lazar, Anil Sood, Raphael E. Pollock and Dina Lev

Clin Cancer Res September 1 2008 14 (17) 5466-5475; DOI:10.1158/1078-0432.CCR-08-0562
Cancer Therapy: Preclinical

Thymidine Selectively Enhances Growth Suppressive Effects of Camptothecin/Irinotecan in MSI+ Cells and Tumors Containing a Mutation of MRE11

Rene Rodriguez, Lasse Tengbjerg Hansen, Geraldine Phear, Jennifer Scorah, Mogens Spang-Thomsen, Angela Cox, Thomas Helleday and Mark Meuth

Clin Cancer Res September 1 2008 14 (17) 5476-5483; DOI:10.1158/1078-0432.CCR-08-0274
Cancer Therapy: Preclinical

Effective CpG Immunotherapy of Breast Carcinoma Prevents but Fails to Eradicate Established Brain Metastasis

Zhengming Xiong, Soheila Gharagozlou, Isabelita Vengco, Wei Chen and John R. Ohlfest

Clin Cancer Res September 1 2008 14 (17) 5484-5493; DOI:10.1158/1078-0432.CCR-07-4139
Cancer Therapy: Preclinical

TMTP1, a Novel Tumor-Homing Peptide Specifically Targeting Metastasis

Wanhua Yang, Danfeng Luo, Shixuan Wang, Rui Wang, Rui Chen, Yan Liu, Tao Zhu, Xiangyi Ma, Ronghua Liu, Gang Xu, Li Meng, Yunping Lu, Jianfeng Zhou and Ding Ma

Clin Cancer Res September 1 2008 14 (17) 5494-5502; DOI:10.1158/1078-0432.CCR-08-0233
Cancer Therapy: Preclinical

Matrilysin (MMP-7) Is a Novel Broadly Expressed Tumor Antigen Recognized by Antigen-Specific T Cells

Yuko Yokoyama, Frank Grünebach, Susanne M. Schmidt, Annkristin Heine, Maik Häntschel, Stefan Stevanovic, Hans-Georg Rammensee and Peter Brossart

Clin Cancer Res September 1 2008 14 (17) 5503-5511; DOI:10.1158/1078-0432.CCR-07-4041
Cancer Therapy: Preclinical

Eradication of Ovarian Tumor Xenografts by Locoregional Administration of Targeted Immunotherapy

Michelandrea De Cesare, Claudia Calcaterra, Graziella Pratesi, Laura Gatti, Franco Zunino, Sylvie Mènard and Andrea Balsari

Clin Cancer Res September 1 2008 14 (17) 5512-5518; DOI:10.1158/1078-0432.CCR-08-0445
Cancer Therapy: Preclinical

Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

Junmei Hou, Disong Wang, Ruiwen Zhang and Hui Wang

Clin Cancer Res September 1 2008 14 (17) 5519-5530; DOI:10.1158/1078-0432.CCR-08-0197

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

Genetic Clustering of Clear Cell Renal Cell Carcinoma Based on Array-Comparative Genomic Hybridization: Its Association with DNA Methylation Alteration and Patient Outcome

Eri Arai, Saori Ushijima, Hitoshi Tsuda, Hiroyuki Fujimoto, Fumie Hosoda, Tatsuhiro Shibata, Tadashi Kondo, Issei Imoto, Johji Inazawa, Setsuo Hirohashi and Yae Kanai

Clin Cancer Res September 1 2008 14 (17) 5531-5539; DOI:10.1158/1078-0432.CCR-08-0443
Imaging, Diagnosis, Prognosis

Whole Chromosome Alterations Predict Survival in High-Risk Neuroblastoma without MYCN Amplification

Sven Bilke, Qing-Rong Chen, Jun S. Wei and Javed Khan

Clin Cancer Res September 1 2008 14 (17) 5540-5547; DOI:10.1158/1078-0432.CCR-07-4461
Imaging, Diagnosis, Prognosis

Magnetic Resonance Imaging–Measured Blood Flow Change after Antiangiogenic Therapy with PTK787/ZK 222584 Correlates with Clinical Outcome in Metastatic Renal Cell Carcinoma

Cedric de Bazelaire, David C. Alsop, Daniel George, Ivan Pedrosa, Yongyu Wang, M. Dror Michaelson and Neil M. Rofsky

Clin Cancer Res September 1 2008 14 (17) 5548-5554; DOI:10.1158/1078-0432.CCR-08-0417
Imaging, Diagnosis, Prognosis

Association of an Extracellular Matrix Gene Cluster with Breast Cancer Prognosis and Endocrine Therapy Response

Jozien Helleman, Maurice P.H.M. Jansen, Kirsten Ruigrok-Ritstier, Iris L. van Staveren, Maxime P. Look, Marion E. Meijer-van Gelder, Anieta M. Sieuwerts, Jan G.M. Klijn, Stefan Sleijfer, John A. Foekens and Els M.J.J. Berns

Clin Cancer Res September 1 2008 14 (17) 5555-5564; DOI:10.1158/1078-0432.CCR-08-0555
Imaging, Diagnosis, Prognosis

A Multigene Assay Is Prognostic of Survival in Patients with Early-Stage Lung Adenocarcinoma

Dan J. Raz, M. Roshni Ray, Jae Y. Kim, Biao He, Miquel Taron, Marcin Skrzypski, Mark Segal, David R. Gandara, Rafael Rosell and David M. Jablons

Clin Cancer Res September 1 2008 14 (17) 5565-5570; DOI:10.1158/1078-0432.CCR-08-0544
Imaging, Diagnosis, Prognosis

Molecular Diagnosis of Sentinel Lymph Node Metastases in Cervical Cancer Using Squamous Cell Carcinoma Antigen

Song-Hua Yuan, Xue-Fang Liang, Wei-Hua Jia, Jian-Ling Huang, Mei Wei, Ling Deng, Li-Zhi Liang, Xiao-Yun Wang and Yi-Xin Zeng

Clin Cancer Res September 1 2008 14 (17) 5571-5578; DOI:10.1158/1078-0432.CCR-08-0346
Imaging, Diagnosis, Prognosis

Combination of Quantitative IMP3 and Tumor Stage: A New System to Predict Metastasis for Patients with Localized Renal Cell Carcinomas

Zhong Jiang, Peigou G. Chu, Bruce A. Woda, Qin Liu, K.C. Balaji, Kenneth L. Rock and Chin-Lee Wu

Clin Cancer Res September 1 2008 14 (17) 5579-5584; DOI:10.1158/1078-0432.CCR-08-0504

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Gemtuzumab Ozogamicin as Part of Reduced-Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation in Patients with Relapsed Acute Myeloid Leukemia

Martin Bornhäuser, Thomas Illmer, Uta Oelschlaegel, Johannes Schetelig, Rainer Ordemann, Markus Schaich, Mathias Hänel, Ulrich Schuler, Christian Thiede, Alexander Kiani, Uwe Platzbecker and Gerhard Ehninger

Clin Cancer Res September 1 2008 14 (17) 5585-5593; DOI:10.1158/1078-0432.CCR-08-0894
Cancer Therapy: Clinical

ABCB1 (MDR 1) Polymorphisms and Progression-Free Survival among Women with Ovarian Cancer following Paclitaxel/Carboplatin Chemotherapy

Sharon E. Johnatty, Jonathan Beesley, Jim Paul, Sian Fereday, Amanda B. Spurdle, Penelope M. Webb, Karen Byth, Sharon Marsh, Howard McLeod, AOCS Study Group, Paul R. Harnett, Robert Brown, Anna deFazio and Georgia Chenevix-Trench

Clin Cancer Res September 1 2008 14 (17) 5594-5601; DOI:10.1158/1078-0432.CCR-08-0606
Cancer Therapy: Clinical

A Phase I Study of EKB-569 in Combination with Capecitabine in Patients with Advanced Colorectal Cancer

Dan Laheru, Gary Croghan, Ronald Bukowski, Michelle Rudek, Wells Messersmith, Charles Erlichman, Robert Pelley, Antonio Jimeno, Ross Donehower, Joseph Boni, Richat Abbas, Patricia Martins, Charles Zacharchuk and Manuel Hidalgo

Clin Cancer Res September 1 2008 14 (17) 5602-5609; DOI:10.1158/1078-0432.CCR-08-0433
Cancer Therapy: Clinical

Treatment of Metastatic Melanoma Using Interleukin-2 Alone or in Conjunction with Vaccines

Franz O. Smith, Stephanie G. Downey, Jacob A. Klapper, James C. Yang, Richard M. Sherry, Richard E. Royal, Udai S. Kammula, Marybeth S. Hughes, Nicholas P. Restifo, Catherine L. Levy, Donald E. White, Seth M. Steinberg and Steven A. Rosenberg

Clin Cancer Res September 1 2008 14 (17) 5610-5618; DOI:10.1158/1078-0432.CCR-08-0116
Cancer Therapy: Clinical

A Phase I Study of Bexarotene, a Retinoic X Receptor Agonist, in Non-M3 Acute Myeloid Leukemia

Donald E. Tsai, Selina M. Luger, Charalambos Andreadis, Dan T. Vogl, Allison Kemner, Melissa Potuzak, Ami Goradia, Alison W. Loren, Alexander E. Perl, Stephen J. Schuster, David L. Porter, Edward A. Stadtmauer, Steven C. Goldstein, James E. Thompson, Cezary Swider, Adam Bagg, Anthony R. Mato and Martin Carroll

Clin Cancer Res September 1 2008 14 (17) 5619-5625; DOI:10.1158/1078-0432.CCR-07-5185
Cancer Therapy: Clinical

CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans

W. Nicholas Haining, Jeffrey Davies, Holger Kanzler, Linda Drury, Thomas Brenn, John Evans, Jill Angelosanto, Steven Rivoli, Kate Russell, Suzanne George, Paul Sims, Donna Neuberg, Xiaochun Li, Jeffrey Kutok, Jeffrey Morgan, Patrick Wen, George Demetri, Robert L. Coffman and Lee M. Nadler

Clin Cancer Res September 1 2008 14 (17) 5626-5634; DOI:10.1158/1078-0432.CCR-08-0526

Cancer Prevention and Susceptibility

Cancer Prevention and Susceptibility

Effect of Genetic Variability within 8q24 on Aggressiveness Patterns at Diagnosis and Familial Status of Prostate Cancer

Olivier Cussenot, Abdel-Rahmène Azzouzi, Gladys Bantsimba-Malanda, Cecile Gaffory, Philippe Mangin, Luc Cormier, Georges Fournier, Antoine Valeri, Lionel Jouffe, Morgan Roupret, Gaelle Fromont, Mathilde Sibony, Eva Comperat and Géraldine Cancel-Tassin

Clin Cancer Res September 1 2008 14 (17) 5635-5639; DOI:10.1158/1078-0432.CCR-07-4999

Letters to the Editor

Letters to the Editor

IMP3: A New and Important Biomarker of Systemic Malignancies

Shailendra Kapoor

Clin Cancer Res September 1 2008 14 (17) 5640-5640; DOI:10.1158/1078-0432.CCR-08-0813
Letters to the Editor

Reply to the Letter to the Editor from S. Kapoor

Zhong Jiang

Clin Cancer Res September 1 2008 14 (17) 5640-5640; DOI:10.1158/1078-0432.CCR-08-1236

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Cancer Therapy: Preclinical

Imaging, Diagnosis, Prognosis

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