Clinical Cancer Research: 14 (2)

Editorial

Editorial

Hearsay Medicine Is Not Evidence-Based Medicine

Robert S. DiPaola and Michael A. Gallo

Clin Cancer Res January 15 2008 14 (2) 337-338; DOI:10.1158/1078-0432.CCR-07-2237

The Biology Behind

The Biology Behind

Is Breast Tumor Progression Really Linear?

Kornelia Polyak

Clin Cancer Res January 15 2008 14 (2) 339-341; DOI:10.1158/1078-0432.CCR-07-2188

Molecular Pathways

Molecular Pathways

Advances in Targeting the Ras/Raf/MEK/Erk Mitogen-Activated Protein Kinase Cascade with MEK Inhibitors for Cancer Therapy

Bret B. Friday and Alex A. Adjei

Clin Cancer Res January 15 2008 14 (2) 342-346; DOI:10.1158/1078-0432.CCR-07-4790
Molecular Pathways

Role of IG20 Splice Variants in TRAIL Resistance

Bellur S. Prabhakar, Nirupama Mulherkar and Kanteti V. Prasad

Clin Cancer Res January 15 2008 14 (2) 347-351; DOI:10.1158/1078-0432.CCR-07-0493

Report from the FDA

Report from the FDA

Sprycel for Chronic Myeloid Leukemia and Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia Resistant to or Intolerant of Imatinib Mesylate

Michael Brave, Vicki Goodman, Edvardas Kaminskas, Ann Farrell, William Timmer, Sarah Pope, Ravi Harapanhalli, Haleh Saber, David Morse, Julie Bullock, Angela Men, Carol Noory, Roshni Ramchandani, Leslie Kenna, Brian Booth, Joga Gobburu, Xiaoping Jiang, Rajeshwari Sridhara, Robert Justice and Richard Pazdur

Clin Cancer Res January 15 2008 14 (2) 352-359; DOI:10.1158/1078-0432.CCR-07-4175

Review

Review

MicroRNAs as Prognostic Indicators and Therapeutic Targets: Potential Effect on Breast Cancer Management

Aoife J. Lowery, Nicola Miller, Roisin E. McNeill and Michael J. Kerin

Clin Cancer Res January 15 2008 14 (2) 360-365; DOI:10.1158/1078-0432.CCR-07-0992

Human Cancer Biology

Human Cancer Biology

Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p53 Gene Mutations in Squamous Cell Carcinoma of the Head and Neck

William H. Westra, Janis M. Taube, M.L. Poeta, Shanaz Begum, David Sidransky and Wayne M. Koch

Clin Cancer Res January 15 2008 14 (2) 366-369; DOI:10.1158/1078-0432.CCR-07-1402
Human Cancer Biology

Ductal Carcinoma In situ and the Emergence of Diversity during Breast Cancer Evolution

D. Craig Allred, Yun Wu, Sufeng Mao, Iris D. Nagtegaal, Sangjun Lee, Charles M. Perou, Syed K. Mohsin, Peter O'Connell, Anna Tsimelzon and Dan Medina

Clin Cancer Res January 15 2008 14 (2) 370-378; DOI:10.1158/1078-0432.CCR-07-1127
Human Cancer Biology

Overexpression of Cellular Iron Import Proteins Is Associated with Malignant Progression of Esophageal Adenocarcinoma

Jessica Boult, Keith Roberts, Matthew J. Brookes, Sharon Hughes, Jonathan P. Bury, Simon S. Cross, Gregory J. Anderson, Robert Spychal, Tariq Iqbal and Chris Tselepis

Clin Cancer Res January 15 2008 14 (2) 379-387; DOI:10.1158/1078-0432.CCR-07-1054
Human Cancer Biology

Large Deletions of the PRKAR1A Gene in Carney Complex

Anelia Horvath, Ioannis Bossis, Christoforos Giatzakis, Elizabeth Levine, Frank Weinberg, Elise Meoli, Audrey Robinson-White, Jennifer Siegel, Payal Soni, Lionel Groussin, Ludmila Matyakhina, Somya Verma, Elaine Remmers, Maria Nesterova, J. Aidan Carney, Jérôme Bertherat and Constantine A. Stratakis

Clin Cancer Res January 15 2008 14 (2) 388-395; DOI:10.1158/1078-0432.CCR-07-1155
Human Cancer Biology

Unique Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Human B-Cell Chronic Lymphocytic Leukemia

Sivasubramanian Baskar, Ka Yin Kwong, Thomas Hofer, Jessica M. Levy, Michael G. Kennedy, Elinor Lee, Louis M. Staudt, Wyndham H. Wilson, Adrian Wiestner and Christoph Rader

Clin Cancer Res January 15 2008 14 (2) 396-404; DOI:10.1158/1078-0432.CCR-07-1823
Human Cancer Biology

Carcinoembryonic Antigen Cell Adhesion Molecule 6 Predicts Breast Cancer Recurrence following Adjuvant Tamoxifen

Loaie Maraqa, Michele Cummings, Mark B. Peter, Abeer M. Shaaban, Kieran Horgan, Andrew M. Hanby and Valerie Speirs

Clin Cancer Res January 15 2008 14 (2) 405-411; DOI:10.1158/1078-0432.CCR-07-1363
Human Cancer Biology

Absence of E-Cadherin Expression Distinguishes Noncohesive from Cohesive Pancreatic Cancer

Jordan M. Winter, Angela H. Ting, Felip Vilardell, Eike Gallmeier, Steve B. Baylin, Ralph H. Hruban, Scott E. Kern and Christine A. Iacobuzio-Donahue

Clin Cancer Res January 15 2008 14 (2) 412-418; DOI:10.1158/1078-0432.CCR-07-0487

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival

Jinmai Jiang, Yuriy Gusev, Ileana Aderca, Teresa A. Mettler, David M. Nagorney, Daniel J. Brackett, Lewis R. Roberts and Thomas D. Schmittgen

Clin Cancer Res January 15 2008 14 (2) 419-427; DOI:10.1158/1078-0432.CCR-07-0523
Imaging, Diagnosis, Prognosis

Serum Interleukin-6 Level but not Genotype Predicts Survival after Resection in Stages II and III Gastric Carcinoma

Wei-Chih Liao, Jaw-Town Lin, Chun-Ying Wu, Shih-Pei Huang, Ming-Tsan Lin, Ariel Sing-Huei Wu, Yu-Jie Huang and Ming-Shiang Wu

Clin Cancer Res January 15 2008 14 (2) 428-434; DOI:10.1158/1078-0432.CCR-07-1032
Imaging, Diagnosis, Prognosis

Identification of Novel Nasopharyngeal Carcinoma Biomarkers by Laser Capture Microdissection and Proteomic Analysis

Ai-Lan Cheng, Wei-Guo Huang, Zhu-Chu Chen, Fang Peng, Peng-Fei Zhang, Mao-Yu Li, Feng Li, Jian-Ling Li, Cui Li, Hong Yi, Bin Yi and Zhi-Qiang Xiao

Clin Cancer Res January 15 2008 14 (2) 435-445; DOI:10.1158/1078-0432.CCR-07-1215
Imaging, Diagnosis, Prognosis

Plasma Stromal Cell–Derived Factor-1: Host Derived Marker Predictive of Distant Metastasis in Breast Cancer

Saima Hassan, Andrea Baccarelli, Ombretta Salvucci and Mark Basik

Clin Cancer Res January 15 2008 14 (2) 446-454; DOI:10.1158/1078-0432.CCR-07-1189
Imaging, Diagnosis, Prognosis

Novel Blood-Based, Five-Gene Biomarker Set for the Detection of Colorectal Cancer

Mark Han, Choong Tsek Liew, Hong Wei Zhang, Samuel Chao, Run Zheng, Kok Thye Yip, Zhen-Ya Song, Hiu Ming Li, Xiao Ping Geng, Li Xin Zhu, Jian-Jiang Lin, K. Wayne Marshall and Choong Chin Liew

Clin Cancer Res January 15 2008 14 (2) 455-460; DOI:10.1158/1078-0432.CCR-07-1801
Imaging, Diagnosis, Prognosis

Clinical Validation of a Customized Multiple Signature Microarray for Breast Cancer

Benita K.T. Tan, Lay Keng Tan, Kun Yu, Puay Hoon Tan, Ming Lee, Lang Hiong Sii, Chow Yin Wong, Gay Hui Ho, Allen W.Y. Yeo, Pierce K.H. Chow, Heng Nung Koong, Wei Sean Yong, Dennis T.H. Lim, London L.P.J. Ooi, Khee Chee Soo and Patrick Tan

Clin Cancer Res January 15 2008 14 (2) 461-469; DOI:10.1158/1078-0432.CCR-07-0999
Imaging, Diagnosis, Prognosis

Serum Proteomics and Biomarkers in Hepatocellular Carcinoma and Chronic Liver Disease

Noah T. Zinkin, Franck Grall, Killimangalam Bhaskar, Hasan H. Otu, Dimitrios Spentzos, Brett Kalmowitz, Meghan Wells, Manuel Guerrero, John M. Asara, Towia A. Libermann and Nezam H. Afdhal

Clin Cancer Res January 15 2008 14 (2) 470-477; DOI:10.1158/1078-0432.CCR-07-0586
Imaging, Diagnosis, Prognosis

Predicting Outcome in Follicular Lymphoma by Using Interactive Gene Pairs

David LeBrun, Tara Baetz, Cheryl Foster, Patricia Farmer, Roger Sidhu, Hong Guo, Karen Harrison, Roland Somogyi, Larry D. Greller and Harriet Feilotter

Clin Cancer Res January 15 2008 14 (2) 478-487; DOI:10.1158/1078-0432.CCR-07-1720
Imaging, Diagnosis, Prognosis

Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples

Koji Yoshimoto, Julie Dang, Shaojun Zhu, David Nathanson, Tiffany Huang, Rebecca Dumont, David B. Seligson, William H. Yong, Zhenggang Xiong, Nagesh Rao, Henrik Winther, Arnab Chakravarti, Darell D. Bigner, Ingo K. Mellinghoff, Steve Horvath, Webster K. Cavenee, Timothy F. Cloughesy and Paul S. Mischel

Clin Cancer Res January 15 2008 14 (2) 488-493; DOI:10.1158/1078-0432.CCR-07-1966
Imaging, Diagnosis, Prognosis

EMMPRIN Expression as a Prognostic Factor in Radiotherapy of Cervical Cancer

Xing-Zhu Ju, Jin-Ming Yang, Xiao-Yan Zhou, Zi-Ting Li and Xiao-Hua Wu

Clin Cancer Res January 15 2008 14 (2) 494-501; DOI:10.1158/1078-0432.CCR-07-1072

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Dose and Schedule Study of Panitumumab Monotherapy in Patients with Advanced Solid Malignancies

Louis M. Weiner, Arie S. Belldegrun, Jeffrey Crawford, Anthony W. Tolcher, Pamela Lockbaum, Rosalin H. Arends, Lynn Navale, Rafael G. Amado, Gisela Schwab and Robert A. Figlin

Clin Cancer Res January 15 2008 14 (2) 502-508; DOI:10.1158/1078-0432.CCR-07-1509
Cancer Therapy: Clinical

Phase I Study of Alternate-Week Administration of Tipifarnib in Patients with Myelodysplastic Syndrome

Razelle Kurzrock, Hagop M. Kantarjian, Michelle A. Blascovich, Cindy Bucher, Srdan Verstovsek, John J. Wright, Susan R. Pilat, Jorge E. Cortes, Elihu H. Estey, Francis J. Giles, Miloslav Beran and Said M. Sebti

Clin Cancer Res January 15 2008 14 (2) 509-514; DOI:10.1158/1078-0432.CCR-07-1532

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Image-Guided Enzyme/Prodrug Cancer Therapy

Cong Li, Marie-France Penet, Paul Winnard Jr., Dmitri Artemov and Zaver M. Bhujwalla

Clin Cancer Res January 15 2008 14 (2) 515-522; DOI:10.1158/1078-0432.CCR-07-1837
Cancer Therapy: Preclinical

Rhabdoid Tumor Growth is Inhibited by Flavopiridol

Melissa E. Smith, Velasco Cimica, Srinivasa Chinni, Kavitha Challagulla, Sridhar Mani and Ganjam V. Kalpana

Clin Cancer Res January 15 2008 14 (2) 523-532; DOI:10.1158/1078-0432.CCR-07-1347
Cancer Therapy: Preclinical

Sodium Thiosulfate Administered Six Hours after Cisplatin Does Not Compromise Antineuroblastoma Activity

Theresa M. Harned, Ondrej Kalous, Alexander Neuwelt, Jason Loera, Lingyun Ji, Peter Iovine, Richard Sposto, Edward A. Neuwelt and C. Patrick Reynolds

Clin Cancer Res January 15 2008 14 (2) 533-540; DOI:10.1158/1078-0432.CCR-06-2289
Cancer Therapy: Preclinical

Imatinib Mesylate Enhances Therapeutic Effects of Gemcitabine in Human Malignant Mesothelioma Xenografts

Pietro Bertino, Federica Piccardi, Camillo Porta, Roberto Favoni, Michele Cilli, Luciano Mutti and Giovanni Gaudino

Clin Cancer Res January 15 2008 14 (2) 541-548; DOI:10.1158/1078-0432.CCR-07-1388
Cancer Therapy: Preclinical

Interactions between Bortezomib and Romidepsin and Belinostat in Chronic Lymphocytic Leukemia Cells

Yun Dai, Shuang Chen, Lora B. Kramer, Vanessa L. Funk, Paul Dent and Steven Grant

Clin Cancer Res January 15 2008 14 (2) 549-558; DOI:10.1158/1078-0432.CCR-07-1934
Cancer Therapy: Preclinical

Effects of Plasmid-Based Stat3-Specific Short Hairpin RNA and GRIM-19 on PC-3M Tumor Cell Growth

Ling Zhang, Lifang Gao, Yang Li, Guimiao Lin, Yueting Shao, Kun Ji, Hao Yu, Jiadi Hu, Dhananjaya V. Kalvakolanu, Dennis J. Kopecko, Xuejian Zhao and De-Qi Xu

Clin Cancer Res January 15 2008 14 (2) 559-568; DOI:10.1158/1078-0432.CCR-07-1176
Cancer Therapy: Preclinical

A Novel Raji-Burkitt's Lymphoma Model for Preclinical and Mechanistic Evaluation of CD52-Targeted Immunotherapeutic Agents

Rosa Lapalombella, Xiaobin Zhao, Georgia Triantafillou, Bo Yu, Yan Jin, Gerard Lozanski, Carolyn Cheney, Nyla Heerema, David Jarjoura, Amy Lehman, L. James Lee, Guido Marcucci, Robert J. Lee, Michael A. Caligiuri, Natarajan Muthusamy and John C. Byrd

Clin Cancer Res January 15 2008 14 (2) 569-578; DOI:10.1158/1078-0432.CCR-07-1006
Cancer Therapy: Preclinical

Construction and Preclinical Characterization of Fc-mGITRL for the Immunotherapy of Cancer

Peisheng Hu, Robyn S. Arias, Rebecca E. Sadun, Yu-Chih Nien, Nan Zhang, Helen Sabzevari, M.E. Christine Lutsiak, Leslie A. Khawli and Alan L. Epstein

Clin Cancer Res January 15 2008 14 (2) 579-588; DOI:10.1158/1078-0432.CCR-07-0940
Cancer Therapy: Preclinical

In vivo and Microarray Analysis of Rexinoid-Responsive Anaplastic Thyroid Carcinoma

Joshua P. Klopper, Andrew Berenz, William R. Hays, Vibha Sharma, Umarani Pugazhenthi, Jennifer Janssen, Meenakshi Singh, Reid P. Bissonnette and Bryan R. Haugen

Clin Cancer Res January 15 2008 14 (2) 589-596; DOI:10.1158/1078-0432.CCR-07-0269
Cancer Therapy: Preclinical

STX140 Is Efficacious In vitro and In vivo in Taxane-Resistant Breast Carcinoma Cells

Simon P. Newman, Paul A. Foster, Chloe Stengel, Joanna M. Day, Yaik T. Ho, Jean-Gabriel Judde, Myriam Lassalle, Gregoire Prevost, Mathew P. Leese, Barry V.L. Potter, Michael J. Reed and Atul Purohit

Clin Cancer Res January 15 2008 14 (2) 597-606; DOI:10.1158/1078-0432.CCR-07-1717

Cancer Susceptibility and Prevention

Cancer Susceptibility and Prevention

Herbal/Hormonal Dietary Supplement Possibly Associated with Prostate Cancer Progression

Shahrokh F. Shariat, Dolores J. Lamb, Radha G. Iyengar, Claus G. Roehrborn and Kevin M. Slawin

Clin Cancer Res January 15 2008 14 (2) 607-611; DOI:10.1158/1078-0432.CCR-07-1576
Cancer Susceptibility and Prevention

Vascular Endothelial Growth Factor Genotypes, Haplotypes, Gender, and the Risk of Non–Small Cell Lung Cancer

Rihong Zhai, Geoffrey Liu, Wei Zhou, Li Su, Rebecca Suk Heist, Thomas J. Lynch, John C. Wain, Kofi Asomaning, Xihong Lin and David C. Christiani

Clin Cancer Res January 15 2008 14 (2) 612-617; DOI:10.1158/1078-0432.CCR-07-1655

Letters to the Editor

Letters to the Editor

Are Triple-Negative and Basal-Like Breast Cancer Synonymous?

Emad Rakha, Ian Ellis and Jorge Reis-Filho

Clin Cancer Res January 15 2008 14 (2) 618-618; DOI:10.1158/1078-0432.CCR-07-1943
Letters to the Editor

Steven Narod, Rebecca Dent and Wedad Hanna

Clin Cancer Res January 15 2008 14 (2) 618-618; DOI:10.1158/1078-0432.CCR-07-2178

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Table of Contents

Editorial

The Biology Behind

Molecular Pathways

Report from the FDA

Review

Human Cancer Biology

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Cancer Therapy: Preclinical

Cancer Susceptibility and Prevention

Letters to the Editor

Issue Highlights

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