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Table of Contents

CCR Translations

  • CCR Translations
    Genetic Screening for Oral Human Papillomavirus Infections and Cancers of the Head and Neck
    John C. Sok and Jennifer R. Grandis
    Clin Cancer Res November 1 2008 14 (21) 6723-6724; DOI:10.1158/1078-0432.CCR-08-1915

CCR Drug Updates

  • CCR Drug Updates
    Ixabepilone in Metastatic Breast Cancer: Complement or Alternative to Taxanes?
    Antoinette R. Tan and Deborah L. Toppmeyer
    Clin Cancer Res November 1 2008 14 (21) 6725-6729; DOI:10.1158/1078-0432.CCR-07-4704

Molecular Pathways

  • Molecular Pathways
    Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors
    Franklin L. Chen, Wenle Xia and Neil L. Spector
    Clin Cancer Res November 1 2008 14 (21) 6730-6734; DOI:10.1158/1078-0432.CCR-08-0581

  • Molecular Pathways
    The Interleukin-8 Pathway in Cancer
    David J.J. Waugh and Catherine Wilson
    Clin Cancer Res November 1 2008 14 (21) 6735-6741; DOI:10.1158/1078-0432.CCR-07-4843

Perspective

  • Perspective
    Smoking Out the Cholinergic Component in Lung Cancer
    Laura Paleari, Patrizia Russo, Luca Roz, Alfredo Cesario and Ugo Pastorino
    Clin Cancer Res November 1 2008 14 (21) 6742-6743; DOI:10.1158/1078-0432.CCR-08-1465

Review

  • Review
    Improving Gemcitabine-Mediated Radiosensitization Using Molecularly Targeted Therapy: A Review
    Meredith A. Morgan, Leslie A. Parsels, Jonathan Maybaum and Theodore S. Lawrence
    Clin Cancer Res November 1 2008 14 (21) 6744-6750; DOI:10.1158/1078-0432.CCR-08-1032

Human Cancer Biology

  • Human Cancer Biology
    CD44 is of Functional Importance for Colorectal Cancer Stem Cells
    Lei Du, Hongyi Wang, Leya He, Jingyu Zhang, Biyun Ni, Xiaohui Wang, Haijing Jin, Nathalie Cahuzac, Maryam Mehrpour, Youyong Lu and Quan Chen
    Clin Cancer Res November 1 2008 14 (21) 6751-6760; DOI:10.1158/1078-0432.CCR-08-1034

  • Human Cancer Biology
    Targeting the PI3K p110α Isoform Inhibits Medulloblastoma Proliferation, Chemoresistance, and Migration
    Ana S. Guerreiro, Sarah Fattet, Barbara Fischer, Tarek Shalaby, Shaun P. Jackson, Simone M. Schoenwaelder, Michael A. Grotzer, Olivier Delattre and Alexandre Arcaro
    Clin Cancer Res November 1 2008 14 (21) 6761-6769; DOI:10.1158/1078-0432.CCR-08-0385

  • Human Cancer Biology
    Reciprocal CD4+ T-Cell Balance of Effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ Regulatory T Cells in Small Cell Lung Cancer Reflects Disease Stage
    Kenichi Koyama, Hiroshi Kagamu, Satoru Miura, Toru Hiura, Takahiro Miyabayashi, Ryo Itoh, Hideyuki Kuriyama, Hiroshi Tanaka, Junta Tanaka, Hirohisa Yoshizawa, Koh Nakata and Fumitake Gejyo
    Clin Cancer Res November 1 2008 14 (21) 6770-6779; DOI:10.1158/1078-0432.CCR-08-1156

  • Human Cancer Biology
    SCCRO (DCUN1D1) Induces Extracellular Matrix Invasion by Activating Matrix Metalloproteinase 2
    Pornchai O-charoenrat, Inderpal Sarkaria, Simon G. Talbot, Pabbathi Reddy, Su Dao, Ivan Ngai, Ashok Shaha, Dennis Kraus, Jatin Shah, Valerie Rusch, Y. Ramanathan and Bhuvanesh Singh
    Clin Cancer Res November 1 2008 14 (21) 6780-6789; DOI:10.1158/1078-0432.CCR-08-0719

  • Human Cancer Biology
    Regulation of Pancreatic Tumor Cell Proliferation and Chemoresistance by the Histone Methyltransferase Enhancer of Zeste Homologue 2
    Andrei V. Ougolkov, Vladimir N. Bilim and Daniel D. Billadeau
    Clin Cancer Res November 1 2008 14 (21) 6790-6796; DOI:10.1158/1078-0432.CCR-08-1013

  • Human Cancer Biology
    BRCA1 5083del19 Mutant Allele Selectively Up-Regulates Periostin Expression In vitro and In vivo
    Barbara Quaresima, Francesco Romeo, Maria C. Faniello, Maddalena Di Sanzo, Chang-Gong Liu, Annamaria Lavecchia, Cristian Taccioli, Eugenio Gaudio, Francesco Baudi, Francesco Trapasso, Carlo M. Croce, Giovanni Cuda and Francesco Costanzo
    Clin Cancer Res November 1 2008 14 (21) 6797-6803; DOI:10.1158/1078-0432.CCR-07-5208

  • Human Cancer Biology
    Inhibition of Invasion and Metastasis of Hepatocellular Carcinoma Cells via Targeting RhoC In vitro and In vivo
    Wei Wang, Fan Wu, Feng Fang, Yiming Tao and Lianyue Yang
    Clin Cancer Res November 1 2008 14 (21) 6804-6812; DOI:10.1158/1078-0432.CCR-07-4820

  • Human Cancer Biology
    Aberrant Polo-Like Kinase 1-Cdc25A Pathway in Metastatic Hepatocellular Carcinoma
    Xiao Qi Wang, Yong Qiang Zhu, Karen S. Lui, Qi Cai, Ping Lu and Ronnie T. Poon
    Clin Cancer Res November 1 2008 14 (21) 6813-6820; DOI:10.1158/1078-0432.CCR-08-0626

  • Human Cancer Biology
    KIT Gene Mutations and Copy Number in Melanoma Subtypes
    Carol Beadling, Erick Jacobson-Dunlop, F. Stephen Hodi, Claudia Le, Andrea Warrick, Janice Patterson, Ajia Town, Amy Harlow, Frank Cruz III, Sharl Azar, Brian P. Rubin, Susan Muller, Rob West, Michael C. Heinrich and Christopher L. Corless
    Clin Cancer Res November 1 2008 14 (21) 6821-6828; DOI:10.1158/1078-0432.CCR-08-0575

  • Human Cancer Biology
    Recurrence of Urothelial Carcinoma of the Bladder: A Role for Insulin-Like Growth Factor-II Loss of Imprinting and Cytoplasmic E-Cadherin Immunolocalization
    Emma M. Gallagher, Deirdre M. O'Shea, Patricia Fitzpatrick, Michèle Harrison, Breege Gilmartin, Jenny A. Watson, Trevor Clarke, Martin O. Leonard, Aloysius McGoldrick, Maria Meehan, Chanel Watson, Fiona Furlong, Patrick O'Kelly, John M. Fitzpatrick, Peter A. Dervan, Anthony O'Grady, Elaine W. Kay and Amanda McCann
    Clin Cancer Res November 1 2008 14 (21) 6829-6838; DOI:10.1158/1078-0432.CCR-08-0577

  • Human Cancer Biology
    Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma
    Susan K. Lutgendorf, Donald M. Lamkin, Nicholas B. Jennings, Jesusa M.G. Arevalo, Frank Penedo, Koen DeGeest, Robert R. Langley, Joseph A. Lucci III, Steve W. Cole, David M. Lubaroff and Anil K. Sood
    Clin Cancer Res November 1 2008 14 (21) 6839-6846; DOI:10.1158/1078-0432.CCR-08-0230

  • Human Cancer Biology
    Systematic Review and Meta-analysis of Ovarian Cancers: Estimation of Microsatellite-High Frequency and Characterization of Mismatch Repair Deficient Tumor Histology
    Tuya Pal, Jenny Permuth-Wey, Ambuj Kumar and Thomas A. Sellers
    Clin Cancer Res November 1 2008 14 (21) 6847-6854; DOI:10.1158/1078-0432.CCR-08-1387

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Sulforaphane Enhances the Therapeutic Potential of TRAIL in Prostate Cancer Orthotopic Model through Regulation of Apoptosis, Metastasis, and Angiogenesis
    Sharmila Shankar, Suthakar Ganapathy and Rakesh K. Srivastava
    Clin Cancer Res November 1 2008 14 (21) 6855-6866; DOI:10.1158/1078-0432.CCR-08-0903

  • Cancer Therapy: Preclinical
    Reduced Erlotinib Sensitivity of Epidermal Growth Factor Receptor-Mutant Non–Small Cell Lung Cancer following Cisplatin Exposure: A Cell Culture Model of Second-line Erlotinib Treatment
    Tan Min Chin, Margaret P. Quinlan, Anurag Singh, Lecia V. Sequist, Thomas J. Lynch, Daniel A. Haber, Sreenath V. Sharma and Jeffrey Settleman
    Clin Cancer Res November 1 2008 14 (21) 6867-6876; DOI:10.1158/1078-0432.CCR-08-0093

  • Cancer Therapy: Preclinical
    Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts
    Robert J. Kinders, Melinda Hollingshead, Sonny Khin, Larry Rubinstein, Joseph E. Tomaszewski, James H. Doroshow, Ralph E. Parchment and the National Cancer Institute Phase 0 Clinical Trials Team
    Clin Cancer Res November 1 2008 14 (21) 6877-6885; DOI:10.1158/1078-0432.CCR-08-0214

  • Cancer Therapy: Preclinical
    A Multiple-Loop, Double-Cube Microarray Design Applied to Prostate Cancer Cell Lines with Variable Sensitivity to Histone Deacetylase Inhibitors
    Madeleine S.Q. Kortenhorst, Marianna Zahurak, Shabana Shabbeer, Sushant Kachhap, Nathan Galloway, Giovanni Parmigiani, Henk M.W. Verheul and Michael A. Carducci
    Clin Cancer Res November 1 2008 14 (21) 6886-6894; DOI:10.1158/1078-0432.CCR-08-0119

  • Cancer Therapy: Preclinical
    Therapeutic Antitumor Efficacy of Anti-CD137 Agonistic Monoclonal Antibody in Mouse Models of Myeloma
    Oihana Murillo, Ainhoa Arina, Sandra Hervas-Stubbs, Anjana Gupta, Brandon McCluskey, Juan Dubrot, Asís Palazón, Arantza Azpilikueta, Maria C. Ochoa, Carlos Alfaro, Sarai Solano, José L. Pérez-Gracia, Babatunde O. Oyajobi and Ignacio Melero
    Clin Cancer Res November 1 2008 14 (21) 6895-6906; DOI:10.1158/1078-0432.CCR-08-0285

  • Cancer Therapy: Preclinical
    Bendamustine Is Effective in p53-Deficient B-Cell Neoplasms and Requires Oxidative Stress and Caspase-Independent Signaling
    Gaël Roué, Mónica López-Guerra, Pierre Milpied, Patricia Pérez-Galán, Neus Villamor, Emili Montserrat, Elias Campo and Dolors Colomer
    Clin Cancer Res November 1 2008 14 (21) 6907-6915; DOI:10.1158/1078-0432.CCR-08-0388

  • Cancer Therapy: Preclinical
    Identification of an Immunogenic CTL Epitope of HIFPH3 for Immunotherapy of Renal Cell Carcinoma
    Eiji Sato, Toshihiko Torigoe, Yoshihiko Hirohashi, Hiroshi Kitamura, Toshiaki Tanaka, Ichiya Honma, Hiroko Asanuma, Kenji Harada, Hideo Takasu, Naoya Masumori, Naoki Ito, Tadashi Hasegawa, Taiji Tsukamoto and Noriyuki Sato
    Clin Cancer Res November 1 2008 14 (21) 6916-6923; DOI:10.1158/1078-0432.CCR-08-0466

  • Cancer Therapy: Preclinical
    Ankyrin Repeat Domain 1, ANKRD1, a Novel Determinant of Cisplatin Sensitivity Expressed in Ovarian Cancer
    Lyndee L. Scurr, Alexander D. Guminski, Yoke-Eng Chiew, Rosemary L. Balleine, Raghwa Sharma, Ying Lei, Kylie Pryor, Gerard V. Wain, Alison Brand, Karen Byth, Catherine Kennedy, Helen Rizos, Paul R. Harnett and Anna deFazio
    Clin Cancer Res November 1 2008 14 (21) 6924-6932; DOI:10.1158/1078-0432.CCR-07-5189

  • Cancer Therapy: Preclinical
    DNA Vaccines Targeting Tumor Antigens to B7 Molecules on Antigen-Presenting Cells Induce Protective Antitumor Immunity and Delay Onset of HER-2/Neu-Driven Mammary Carcinoma
    Arjen Sloots, Cristina Mastini, Florian Rohrbach, Robert Weth, Claudia Curcio, Ute Burkhardt, Elke Jäger, Guido Forni, Federica Cavallo and Winfried S. Wels
    Clin Cancer Res November 1 2008 14 (21) 6933-6943; DOI:10.1158/1078-0432.CCR-08-1257

  • Cancer Therapy: Preclinical
    Insulin-Like Growth Factor Binding Protein-2 Is a Novel Therapeutic Target Associated with Breast Cancer
    Alan I. So, Randy J. Levitt, Bernhard Eigl, Ladan Fazli, Motosugu Muramaki, Sam Leung, Maggie C.U. Cheang, Torsten O. Nielsen, Martin Gleave and Michael Pollak
    Clin Cancer Res November 1 2008 14 (21) 6944-6954; DOI:10.1158/1078-0432.CCR-08-0408

  • Cancer Therapy: Preclinical
    Generation of Antitumor Invariant Natural Killer T Cell Lines in Multiple Myeloma and Promotion of Their Functions via Lenalidomide: A Strategy for Immunotherapy
    Weihua Song, Hans J.J. van der Vliet, Yu-Tzu Tai, Rao Prabhala, Ruojie Wang, Klaus Podar, Laurence Catley, Masood A. Shammas, Kenneth C. Anderson, Steven P. Balk, Mark A. Exley and Nikhil C. Munshi
    Clin Cancer Res November 1 2008 14 (21) 6955-6962; DOI:10.1158/1078-0432.CCR-07-5290

  • Cancer Therapy: Preclinical
    Autocrine Production of Amphiregulin Predicts Sensitivity to Both Gefitinib and Cetuximab in EGFR Wild-type Cancers
    Kimio Yonesaka, Kreshnik Zejnullahu, Neal Lindeman, Alison J. Homes, David M. Jackman, Feng Zhao, Andrew M. Rogers, Bruce E. Johnson and Pasi A. Jänne
    Clin Cancer Res November 1 2008 14 (21) 6963-6973; DOI:10.1158/1078-0432.CCR-08-0957

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Serum YKL-40 and Interleukin 6 Levels in Hodgkin Lymphoma
    Robert J. Biggar, Julia S. Johansen, Karin Ekström Smedby, Klaus Rostgaard, Ellen T. Chang, Hans-Olov Adami, Bengt Glimelius, Daniel Molin, Stephen Hamilton-Dutoit, Mads Melbye and Henrik Hjalgrim
    Clin Cancer Res November 1 2008 14 (21) 6974-6978; DOI:10.1158/1078-0432.CCR-08-1026

  • Imaging, Diagnosis, Prognosis
    Macrophage Inflammatory Protein-3α Is a Novel Serum Marker for Nasopharyngeal Carcinoma Detection and Prediction of Treatment Outcomes
    Kai-Ping Chang, Sheng-Po Hao, Jui-Hung Chang, Chih-Ching Wu, Ngan-Ming Tsang, Yun-Shien Lee, Chen-Lung Hsu, Shir-Hwa Ueng, Shiau-Chin Liu, Yu-Lun Liu, Pei-Cih Wei, Yin Liang, Yu-Sun Chang and Jau-Song Yu
    Clin Cancer Res November 1 2008 14 (21) 6979-6987; DOI:10.1158/1078-0432.CCR-08-0090

  • Imaging, Diagnosis, Prognosis
    Cell Proliferation, Cell Cycle Abnormalities, and Cancer Outcome in Patients with Barrett's Esophagus: A Long-term Prospective Study
    Dennis L. Chao, Carissa A. Sanchez, Patricia C. Galipeau, Patricia L. Blount, Thomas G. Paulson, David S. Cowan, Kamran Ayub, Robert D. Odze, Peter S. Rabinovitch and Brian J. Reid
    Clin Cancer Res November 1 2008 14 (21) 6988-6995; DOI:10.1158/1078-0432.CCR-07-5063

  • Imaging, Diagnosis, Prognosis
    Clinical Significance of Sphingosine Kinase-1 Expression in Human Astrocytomas Progression and Overall Patient Survival
    Jun Li, Hong-Yu Guan, Li-Yun Gong, Li-Bing Song, Nu Zhang, Jueheng Wu, Jie Yuan, Yi-Jie Zheng, Zheng-Song Huang and Mengfeng Li
    Clin Cancer Res November 1 2008 14 (21) 6996-7003; DOI:10.1158/1078-0432.CCR-08-0754

  • Imaging, Diagnosis, Prognosis
    Circulating Tumor Cell Detection Predicts Early Metastatic Relapse After Neoadjuvant Chemotherapy in Large Operable and Locally Advanced Breast Cancer in a Phase II Randomized Trial
    Jean-Yves Pierga, François-Clément Bidard, Claire Mathiot, Etienne Brain, Suzette Delaloge, Sylvie Giachetti, Patricia de Cremoux, Rémy Salmon, Anne Vincent-Salomon and Michel Marty
    Clin Cancer Res November 1 2008 14 (21) 7004-7010; DOI:10.1158/1078-0432.CCR-08-0030

  • Imaging, Diagnosis, Prognosis
    Circulating Methylated-DCR2 Gene in Serum as an Indicator of Prognosis and Therapeutic Efficacy in Patients with MYCN Nonamplified Neuroblastoma
    Shigeki Yagyu, Takahiro Gotoh, Tomoko Iehara, Mitsuru Miyachi, Yoshiki Katsumi, Satoko Tsubai-Shimizu, Ken Kikuchi, Shinichi Tamura, Kunihiko Tsuchiya, Toshihiko Imamura, Akiko Misawa-Furihata, Tohru Sugimoto, Tadashi Sawada and Hajime Hosoi
    Clin Cancer Res November 1 2008 14 (21) 7011-7019; DOI:10.1158/1078-0432.CCR-08-1249

  • Imaging, Diagnosis, Prognosis
    Exploiting Gene Expression Profiling to Identify Novel Minimal Residual Disease Markers of Neuroblastoma
    Irene Y. Cheung, Yi Feng, William Gerald and Nai-Kong V. Cheung
    Clin Cancer Res November 1 2008 14 (21) 7020-7027; DOI:10.1158/1078-0432.CCR-08-0541

  • Imaging, Diagnosis, Prognosis
    Interleukin-6 and Soluble Interleukin-6 Receptor Levels as Markers of Disease Extent and Prognosis in Neuroblastoma
    Rachel A. Egler, Susan M. Burlingame, Jed G. Nuchtern and Heidi V. Russell
    Clin Cancer Res November 1 2008 14 (21) 7028-7034; DOI:10.1158/1078-0432.CCR-07-5017

  • Imaging, Diagnosis, Prognosis
    Claudin-1 Protein Expression is a Prognostic Marker of Patient Survival in Renal Cell Carcinomas
    Florian R. Fritzsche, Beibei Oelrich, Manfred Johannsen, Ilka Kristiansen, Holger Moch, Klaus Jung and Glen Kristiansen
    Clin Cancer Res November 1 2008 14 (21) 7035-7042; DOI:10.1158/1078-0432.CCR-08-0855

  • Imaging, Diagnosis, Prognosis
    Expression of MAP4K4 Is Associated with Worse Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma
    John J. Liang, Hua Wang, Asif Rashid, Tse-Hua Tan, Rosa F. Hwang, Stanley R. Hamilton, James L. Abbruzzese, Douglas B. Evans and Huamin Wang
    Clin Cancer Res November 1 2008 14 (21) 7043-7049; DOI:10.1158/1078-0432.CCR-08-0381

  • Imaging, Diagnosis, Prognosis
    Identification of Metastasis-Related Proteins and Their Clinical Relevance to Triple-Negative Human Breast Cancer
    Baocun Sun, Shiwu Zhang, Danfang Zhang, Yan Li, Xiulan Zhao, Ye Luo and Yuhong Guo
    Clin Cancer Res November 1 2008 14 (21) 7050-7059; DOI:10.1158/1078-0432.CCR-08-0520

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Effects of Erlotinib in EGFR Mutated Non-Small Cell Lung Cancers with Resistance to Gefitinib
    Daniel B. Costa, Kim-Son H. Nguyen, Byoung C. Cho, Lecia V. Sequist, David M. Jackman, Gregory J. Riely, Beow Y. Yeap, Balázs Halmos, Joo H. Kim, Pasi A. Jänne, Mark S. Huberman, William Pao, Daniel G. Tenen and Susumu Kobayashi
    Clin Cancer Res November 1 2008 14 (21) 7060-7067; DOI:10.1158/1078-0432.CCR-08-1455

  • Cancer Therapy: Clinical
    Bevacizumab Plus Irinotecan in Recurrent WHO Grade 3 Malignant Gliomas
    Annick Desjardins, David A. Reardon, James E. Herndon II, Jennifer Marcello, Jennifer A. Quinn, Jeremy N. Rich, Sith Sathornsumetee, Sridharan Gururangan, John Sampson, Leighann Bailey, Darell D. Bigner, Allan H. Friedman, Henry S. Friedman and James J. Vredenburgh
    Clin Cancer Res November 1 2008 14 (21) 7068-7073; DOI:10.1158/1078-0432.CCR-08-0260

  • Cancer Therapy: Clinical
    A Phase II Study of Gefitinib, 5-Fluorouracil, Leucovorin, and Oxaliplatin in Previously Untreated Patients with Metastatic Colorectal Cancer
    George A. Fisher, Timothy Kuo, Meghan Ramsey, Erich Schwartz, Robert V. Rouse, Cheryl D. Cho, Joanne Halsey and Branimir I. Sikic
    Clin Cancer Res November 1 2008 14 (21) 7074-7079; DOI:10.1158/1078-0432.CCR-08-1014

  • Cancer Therapy: Clinical
    Plasma Osteopontin, Hypoxia, and Response to Radiotherapy in Nasopharyngeal Cancer
    Edwin P. Hui, Fion L. Sung, Brian K.H. Yu, Cesar S.C. Wong, Brigette B.Y. Ma, Xiaorong Lin, Andrew Chan, Wai-lap Wong and Anthony T.C. Chan
    Clin Cancer Res November 1 2008 14 (21) 7080-7087; DOI:10.1158/1078-0432.CCR-08-0364

  • Cancer Therapy: Clinical
    Phase II Trial of Short-Course CHOP-R Followed by 90Y-ibritumomab Tiuxetan and Extended Rituximab in Previously Untreated Follicular Lymphoma
    Samuel A. Jacobs, Steven H. Swerdlow, Jeffrey Kant, Kenneth A. Foon, Rachel Jankowitz, Stephanie R. Land, Nicholas DeMonaco, Judith Joyce, Jennifer L. Osborn, Terry L. Evans, Patricia M. Schaefer and The Minh Luong
    Clin Cancer Res November 1 2008 14 (21) 7088-7094; DOI:10.1158/1078-0432.CCR-08-0529

  • Cancer Therapy: Clinical
    Histone Deacetylase Inhibitor Romidepsin Has Differential Activity in Core Binding Factor Acute Myeloid Leukemia
    Olatoyosi M. Odenike, Serhan Alkan, Dorie Sher, John E. Godwin, Dezheng Huo, Stephen J. Brandt, Margaret Green, Jingping Xie, Yanming Zhang, David H. Vesole, Patrick Stiff, John Wright, Richard A. Larson and Wendy Stock
    Clin Cancer Res November 1 2008 14 (21) 7095-7101; DOI:10.1158/1078-0432.CCR-08-1007

  • Cancer Therapy: Clinical
    Population Pharmacokinetics and Pharmacogenetics of Imatinib in Children and Adults
    Aurélie Petain, Darouna Kattygnarath, Julie Azard, Etienne Chatelut, Catherine Delbaldo, Birgit Geoerger, Michel Barrois, Sophie Séronie-Vivien, Axel LeCesne and Gilles Vassal
    Clin Cancer Res November 1 2008 14 (21) 7102-7109; DOI:10.1158/1078-0432.CCR-08-0950

  • Cancer Therapy: Clinical
    A Phase 1 Open-Label, Accelerated Dose-Escalation Study of the Hypoxia-Activated Prodrug AQ4N in Patients with Advanced Malignancies
    Kyriakos P. Papadopoulos, Sanjay Goel, Murali Beeram, Alvin Wong, Kavita Desai, Missak Haigentz, María L. Milián, Sridhar Mani, Anthony Tolcher, Alshad S. Lalani and John Sarantopoulos
    Clin Cancer Res November 1 2008 14 (21) 7110-7115; DOI:10.1158/1078-0432.CCR-08-0483

  • Cancer Therapy: Clinical
    PXR Pharmacogenetics: Association of Haplotypes with Hepatic CYP3A4 and ABCB1 Messenger RNA Expression and Doxorubicin Clearance in Asian Breast Cancer Patients
    Edwin Sandanaraj, Suman Lal, Viknesvaran Selvarajan, London Lucien Ooi, Zee Wan Wong, Nan Soon Wong, Peter Cher Siang Ang, Edmund J.D. Lee and Balram Chowbay
    Clin Cancer Res November 1 2008 14 (21) 7116-7126; DOI:10.1158/1078-0432.CCR-08-0411

  • Cancer Therapy: Clinical
    A Phase I Study of Intravenous Oncolytic Reovirus Type 3 Dearing in Patients with Advanced Cancer
    Laura Vidal, Hardev S. Pandha, Timothy A. Yap, Christine L. White, Katie Twigger, Richard G. Vile, Alan Melcher, Matt Coffey, Kevin J. Harrington and Johann S. DeBono
    Clin Cancer Res November 1 2008 14 (21) 7127-7137; DOI:10.1158/1078-0432.CCR-08-0524

  • Cancer Therapy: Clinical
    A Phase II Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) in Metastatic Breast Cancer: A California Cancer Consortium Study
    Thehang H. Luu, Robert J. Morgan, Lucille Leong, Dean Lim, Mark McNamara, Jana Portnow, Paul Frankel, David D. Smith, James H. Doroshow, David R. Gandara, Ana Aparicio, George Somlo and Carol Wong
    Clin Cancer Res November 1 2008 14 (21) 7138-7142; DOI:10.1158/1078-0432.CCR-08-0122

Cancer Prevention and Susceptibility

  • Cancer Prevention and Susceptibility
    Oral Human Papillomavirus Infection Before and After Treatment for Human Papillomavirus 16–Positive and Human Papillomavirus 16–Negative Head and Neck Squamous Cell Carcinoma
    Yuri Agrawal, Wayne M. Koch, Weihong Xiao, William H. Westra, Anna L. Trivett, David E. Symer and Maura L. Gillison
    Clin Cancer Res November 1 2008 14 (21) 7143-7150; DOI:10.1158/1078-0432.CCR-08-0498

  • Cancer Prevention and Susceptibility
    Increased Risk of Cancer Other Than Melanoma in CDKN2A Founder Mutation (p16-Leiden)-Positive Melanoma Families
    Femke A. de Snoo, D. Timothy Bishop, Wilma Bergman, Inge van Leeuwen, Clasine van der Drift, Frans A. van Nieuwpoort, Coby J. Out-Luiting, Hans F. Vasen, Jeanet A.C. ter Huurne, Rune R. Frants, Rein Willemze, Martijn H. Breuning and Nelleke A. Gruis
    Clin Cancer Res November 1 2008 14 (21) 7151-7157; DOI:10.1158/1078-0432.CCR-08-0403

Correction

  • Correction
    Correction: Article on Diagnostic Markers for Early Detection of Ovarian Cancer
    Clin Cancer Res November 1 2008 14 (21) 7158-7158; DOI:10.1158/1078-0432.CCR-14-22-COR

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Clinical Cancer Research: 14 (21)
November 2008
Volume 14, Issue 21
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Issue Highlights

  • Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors
  • Sulforaphane Enhances the Therapeutic Potential of TRAIL in Prostate Cancer Orthotopic Model through Regulation of Apoptosis, Metastasis, and Angiogenesis
  • Bevacizumab Plus Irinotecan in Recurrent WHO Grade 3 Malignant Gliomas
  • Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma

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  • Immune Checkpoint Blockade Requires Macrophage CXCL9/CXCL10
  • PDAC and GATA6 Expression
  • Characterization of Glioblastoma Patient-Derived Xenografts
  • Guadecitabine and Carboplatin in Ovarian Cancer
  • Toxicity Management Affects Checkpoint Inhibitor Efficacy
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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