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Cancer Therapy: Clinical

Evaluation of Lapatinib and Topotecan Combination Therapy: Tissue Culture, Murine Xenograft, and Phase I Clinical Trial Data

Julian R. Molina, Scott H. Kaufmann, Joel M. Reid, Stephen D. Rubin, Marina Gálvez-Peralta, Robert Friedman, Karen S. Flatten, Kevin M. Koch, Tona M. Gilmer, Robert J. Mullin, Roxanne C. Jewell, Sara J. Felten, Sumithra Mandrekar, Alex A. Adjei and Charles Erlichman
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Joel M. Reid
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Stephen D. Rubin
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Marina Gálvez-Peralta
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Robert Friedman
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Kevin M. Koch
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Tona M. Gilmer
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Robert J. Mullin
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Roxanne C. Jewell
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Sara J. Felten
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Sumithra Mandrekar
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Alex A. Adjei
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Charles Erlichman
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DOI: 10.1158/1078-0432.CCR-08-0415 Published December 2008
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Article Information

Volume 14, Issue 23, pp. 7900-7908

DOI 
https://doi.org/10.1158/1078-0432.CCR-08-0415
PubMed 
19047120

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Accepted July 7, 2008
  • Received February 15, 2008
  • Revision received June 9, 2008
  • Published first December 1, 2008.

Copyright & Usage 
American Association for Cancer Research

Author Information

  1. Julian R. Molina1,
  2. Scott H. Kaufmann1,2,
  3. Joel M. Reid1,
  4. Stephen D. Rubin4,
  5. Marina Gálvez-Peralta1,
  6. Robert Friedman4,
  7. Karen S. Flatten1,
  8. Kevin M. Koch5,
  9. Tona M. Gilmer5,
  10. Robert J. Mullin5,
  11. Roxanne C. Jewell5,
  12. Sara J. Felten3,
  13. Sumithra Mandrekar3,
  14. Alex A. Adjei1 and
  15. Charles Erlichman1
  1. Authors' Affiliations: Departments of 1Oncology, 2Molecular Pharmacology and Experimental Therapeutics, and 3Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota; 4GlaxoSmithKline, Collegeville, Pennsylvania; and 5GlaxoSmithKline, Research Triangle Park, North Carolina
  1. Requests for reprints:
    Julian R. Molina, Department of Oncology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905. Phone: 507-284-8318; Fax: 507-284-1803; E-mail: molina.julian{at}mayo.edu.
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Clinical Cancer Research: 14 (23)
December 2008
Volume 14, Issue 23
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Evaluation of Lapatinib and Topotecan Combination Therapy: Tissue Culture, Murine Xenograft, and Phase I Clinical Trial Data
Julian R. Molina, Scott H. Kaufmann, Joel M. Reid, Stephen D. Rubin, Marina Gálvez-Peralta, Robert Friedman, Karen S. Flatten, Kevin M. Koch, Tona M. Gilmer, Robert J. Mullin, Roxanne C. Jewell, Sara J. Felten, Sumithra Mandrekar, Alex A. Adjei and Charles Erlichman
Clin Cancer Res December 1 2008 (14) (23) 7900-7908; DOI: 10.1158/1078-0432.CCR-08-0415

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Evaluation of Lapatinib and Topotecan Combination Therapy: Tissue Culture, Murine Xenograft, and Phase I Clinical Trial Data
Julian R. Molina, Scott H. Kaufmann, Joel M. Reid, Stephen D. Rubin, Marina Gálvez-Peralta, Robert Friedman, Karen S. Flatten, Kevin M. Koch, Tona M. Gilmer, Robert J. Mullin, Roxanne C. Jewell, Sara J. Felten, Sumithra Mandrekar, Alex A. Adjei and Charles Erlichman
Clin Cancer Res December 1 2008 (14) (23) 7900-7908; DOI: 10.1158/1078-0432.CCR-08-0415
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