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Cancer Therapy: Preclinical

Insulin-like Growth Factor-I Receptor Signaling Pathway Induces Resistance to the Apoptotic Activities of SCH66336 (Lonafarnib) through Akt/Mammalian Target of Rapamycin–Mediated Increases in Survivin Expression

Seung Hyun Oh, Quanri Jin, Edward S. Kim, Fadlo R. Khuri and Ho-Young Lee
Seung Hyun Oh
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Quanri Jin
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Edward S. Kim
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Fadlo R. Khuri
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Ho-Young Lee
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DOI: 10.1158/1078-0432.CCR-07-0952 Published March 2008
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Article Information

Volume 14, Issue 5, pp. 1581-1589

DOI 
https://doi.org/10.1158/1078-0432.CCR-07-0952
PubMed 
18316583

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Accepted November 6, 2007
  • Received April 20, 2007
  • Revision received August 17, 2007
  • Published first March 3, 2008.

Copyright & Usage 
American Association for Cancer Research

Author Information

  1. Seung Hyun Oh1,
  2. Quanri Jin1,
  3. Edward S. Kim1,
  4. Fadlo R. Khuri2 and
  5. Ho-Young Lee1
  1. Authors' Affiliations:1Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas and 2Emory University School of Medicine, Atlanta, Georgia
  1. Requests for reprints:
    Ho-Young Lee, Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Unit 432, 1515 Holcombe Boulevard, Houston, TX 77030. Phone: 713-745-0769; Fax: 713-796-8655; E-mail: hlee{at}mdanderson.org.
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Clinical Cancer Research: 14 (5)
March 2008
Volume 14, Issue 5
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Insulin-like Growth Factor-I Receptor Signaling Pathway Induces Resistance to the Apoptotic Activities of SCH66336 (Lonafarnib) through Akt/Mammalian Target of Rapamycin–Mediated Increases in Survivin Expression
Seung Hyun Oh, Quanri Jin, Edward S. Kim, Fadlo R. Khuri and Ho-Young Lee
Clin Cancer Res March 1 2008 (14) (5) 1581-1589; DOI: 10.1158/1078-0432.CCR-07-0952

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Insulin-like Growth Factor-I Receptor Signaling Pathway Induces Resistance to the Apoptotic Activities of SCH66336 (Lonafarnib) through Akt/Mammalian Target of Rapamycin–Mediated Increases in Survivin Expression
Seung Hyun Oh, Quanri Jin, Edward S. Kim, Fadlo R. Khuri and Ho-Young Lee
Clin Cancer Res March 1 2008 (14) (5) 1581-1589; DOI: 10.1158/1078-0432.CCR-07-0952
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Clinical Cancer Research
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