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OtherImaging, Diagnosis, Prognosis

Topoisomerase IIα Expression as an Independent Prognostic Factor in Hodgkin's Lymphoma

Ipatia A. Doussis-Anagnostopoulou, Theodoros P. Vassilakopoulos, Irini Thymara, Penelope Korkolopoulou, Maria K. Angelopoulou, Marina P. Siakantaris, Styliani I. Kokoris, Evangelia M. Dimitriadou, Christina Kalpadakis, Marina Matzouranis, Loukas Kaklamanis, Panayiotis Panayiotidis, Marie-Christine Kyrtsonis, Athina Androulaki, Efstratios Patsouris, Christos Kittas, Gerassimos A. Pangalis
DOI: 10.1158/1078-0432.CCR-07-1395 Published 15 March 2008
Ipatia A. Doussis-Anagnostopoulou
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Theodoros P. Vassilakopoulos
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Irini Thymara
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Penelope Korkolopoulou
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Maria K. Angelopoulou
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Marina P. Siakantaris
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Styliani I. Kokoris
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Evangelia M. Dimitriadou
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Christina Kalpadakis
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Marina Matzouranis
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Loukas Kaklamanis
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Panayiotis Panayiotidis
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Marie-Christine Kyrtsonis
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Athina Androulaki
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Efstratios Patsouris
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Christos Kittas
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Gerassimos A. Pangalis
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Fig. 1.

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Fig. 1.

A, topoisomerase IIα expression was seen in all cases and was mainly present in the neoplastic HRS cells and variants, as a diffuse nuclear staining. B, C, D, effect of topoisomerase IIα expression on the outcome of patients with Hodgkin's lymphoma treated with ABVD or equivalent regimens with or without radiotherapy: (B) Failure Free Survival (FFS) in all patients; (C) FFS in early clinical stages (IA and IIA); (D) FFS in advanced clinical stages (IB, IIB, III and IV).

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Clinical Cancer Research: 27 (8)
April 2021
Volume 27, Issue 8
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Clinical Cancer Research
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