Topoisomerase IIα Expression as an Independent Prognostic Factor in Hodgkin's Lymphoma

A, topoisomerase IIα expression was seen in all cases and was mainly present in the neoplastic HRS cells and variants, as a diffuse nuclear staining. B, C, D, effect of topoisomerase IIα expression on the outcome of patients with Hodgkin's lymphoma treated with ABVD or equivalent regimens with or without radiotherapy: (B) Failure Free Survival (FFS) in all patients; (C) FFS in early clinical stages (IA and IIA); (D) FFS in advanced clinical stages (IB, IIB, III and IV).