Table of Contents

Cancer Therapy: Preclinical

• Cancer Therapy: Preclinical

  Src Tyrosine Kinase Regulates Adhesion and Chemotaxis in Waldenstrom Macroglobulinemia

  Hai T. Ngo, Abdel Kareem Azab, Mena Farag, Xiaoying Jia, Molly M. Melhem, Judith Runnels, Aldo M. Roccaro, Feda Azab, Antonio Sacco, Xavier Leleu, Kenneth C. Anderson and Irene M. Ghobrial

  Clin Cancer Res October 1 2009 15 (19) 6035-6041; DOI:10.1158/1078-0432.CCR-09-0718

  
  
• Cancer Therapy: Preclinical

  Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis

  Roberta E. Burden, Julie A. Gormley, Thomas J. Jaquin, Donna M. Small, Derek J. Quinn, Shauna M. Hegarty, Claire Ward, Brian Walker, James A. Johnston, Shane A. Olwill and Christopher J. Scott

  Clin Cancer Res October 1 2009 15 (19) 6042-6051; DOI:10.1158/1078-0432.CCR-09-1262

  
  
• Cancer Therapy: Preclinical

  CEACAM5-Targeted Therapy of Human Colonic and Pancreatic Cancer Xenografts with Potent Labetuzumab-SN-38 Immunoconjugates

  Serengulam V. Govindan, Thomas M. Cardillo, Sung-Ju Moon, Hans J. Hansen and David M. Goldenberg

  Clin Cancer Res October 1 2009 15 (19) 6052-6061; DOI:10.1158/1078-0432.CCR-09-0586

  
  
• Cancer Therapy: Preclinical

  Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters

  Shuiying Hu, Zhaoyuan Chen, Ryan Franke, Shelley Orwick, Ming Zhao, Michelle A. Rudek, Alex Sparreboom and Sharyn D. Baker

  Clin Cancer Res October 1 2009 15 (19) 6062-6069; DOI:10.1158/1078-0432.CCR-09-0048

  
  
• Cancer Therapy: Preclinical

  High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth

  Kristiina Iljin, Kirsi Ketola, Paula Vainio, Pasi Halonen, Pekka Kohonen, Vidal Fey, Roland C. Grafström, Merja Perälä and Olli Kallioniemi

  Clin Cancer Res October 1 2009 15 (19) 6070-6078; DOI:10.1158/1078-0432.CCR-09-1035

  
  
• Cancer Therapy: Preclinical

  Targeted Radioiodine Therapy of Neuroblastoma Tumors following Systemic Nonviral Delivery of the Sodium Iodide Symporter Gene

  Kathrin Klutz, Verena Russ, Michael J. Willhauck, Nathalie Wunderlich, Christian Zach, Franz Josef Gildehaus, Burkhard Göke, Ernst Wagner, Manfred Ogris and Christine Spitzweg

  Clin Cancer Res October 1 2009 15 (19) 6079-6086; DOI:10.1158/1078-0432.CCR-09-0851

  
  
• Cancer Therapy: Preclinical

  Blockade of MGMT Expression by O⁶ Benzyl Guanine Leads to Inhibition of Pancreatic Cancer Growth and Induction of Apoptosis

  Santhi D. Konduri, Jonathan Ticku, George C. Bobustuc, Robert M. Sutphin, Jimmie Colon, Beth Isley, Kishor K. Bhakat, Srivenugopal S. Kalkunte and Cheryl H. Baker

  Clin Cancer Res October 1 2009 15 (19) 6087-6095; DOI:10.1158/1078-0432.CCR-09-0887

  
  
• Cancer Therapy: Preclinical

  Combined Bcl-2/Mammalian Target of Rapamycin Inhibition Leads to Enhanced Radiosensitization via Induction of Apoptosis and Autophagy in Non–Small Cell Lung Tumor Xenograft Model

  Kwang Woon Kim, Luigi Moretti, Lauren Rhea Mitchell, Dae Kwang Jung and Bo Lu

  Clin Cancer Res October 1 2009 15 (19) 6096-6105; DOI:10.1158/1078-0432.CCR-09-0589

  
  
• Cancer Therapy: Preclinical

  Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo?

  Majid Ali, Brian A. Telfer, Cian McCrudden, Martin O'Rourke, Huw D. Thomas, Marzieh Kamjoo, Suzanne Kyle, Tracy Robson, Chris Shaw, David G. Hirst, Nicola J. Curtin and Kaye J. Williams

  Clin Cancer Res October 1 2009 15 (19) 6106-6112; DOI:10.1158/1078-0432.CCR-09-0398

  
  
• Cancer Therapy: Preclinical

  Antiglioma Immunological Memory in Response to Conditional Cytotoxic/Immune-Stimulatory Gene Therapy: Humoral and Cellular Immunity Lead to Tumor Regression

  A.K.M. Ghulam Muhammad, Marianela Candolfi, Gwendalyn D. King, Kader Yagiz, David Foulad, Yohei Mineharu, Kurt M. Kroeger, Katherine A. Treuer, W. Stephen Nichols, Nicholas S. Sanderson, Jieping Yang, Maksim Khayznikov, Nico Van Rooijen, Pedro R. Lowenstein and Maria G. Castro

  Clin Cancer Res October 1 2009 15 (19) 6113-6127; DOI:10.1158/1078-0432.CCR-09-1087

  
  
• Cancer Therapy: Preclinical

  Identification of a Novel Small Molecule HIF-1α Translation Inhibitor

  Takuhito Narita, Shaoman Yin, Christine F. Gelin, Carlos S. Moreno, Manuel Yepes, K.C. Nicolaou and Erwin G. Van Meir

  Clin Cancer Res October 1 2009 15 (19) 6128-6136; DOI:10.1158/1078-0432.CCR-08-3180

  
  
• Cancer Therapy: Preclinical

  A Novel Reduced Immunogenicity Bispecific Targeted Toxin Simultaneously Recognizing Human Epidermal Growth Factor and Interleukin-4 Receptors in a Mouse Model of Metastatic Breast Carcinoma

  Seunguk Oh, Brad J. Stish, Deepali Sachdev, Hua Chen, Arkadiusz Z. Dudek and Daniel A. Vallera

  Clin Cancer Res October 1 2009 15 (19) 6137-6147; DOI:10.1158/1078-0432.CCR-09-0696

  
  
• Cancer Therapy: Preclinical

  Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks

  Diane Palmieri, Paul R. Lockman, Fancy C. Thomas, Emily Hua, Jeanne Herring, Elizabeth Hargrave, Matthew Johnson, Natasha Flores, Yongzhen Qian, Eleazar Vega-Valle, Kunal S. Taskar, Vinay Rudraraju, Rajendar K. Mittapalli, Julie A. Gaasch, Kaci A. Bohn, Helen R. Thorsheim, David J. Liewehr, Sean Davis, John F. Reilly, Robert Walker, Julie L. Bronder, Lionel Feigenbaum, Seth M. Steinberg, Kevin Camphausen, Paul S. Meltzer, Victoria M. Richon, Quentin R. Smith and Patricia S. Steeg

  Clin Cancer Res October 1 2009 15 (19) 6148-6157; DOI:10.1158/1078-0432.CCR-09-1039

  
  
• Cancer Therapy: Preclinical

  Synergistic Effects of Oncolytic Reovirus and Cisplatin Chemotherapy in Murine Malignant Melanoma

  Hardev S. Pandha, Lucy Heinemann, Guy R. Simpson, Alan Melcher, Robin Prestwich, Fiona Errington, Matt Coffey, Kevin J. Harrington and Richard Morgan

  Clin Cancer Res October 1 2009 15 (19) 6158-6166; DOI:10.1158/1078-0432.CCR-09-0796

  
  
• Cancer Therapy: Preclinical

  Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors

  Kent A. Smith, Brenna L. Meisenburg, Victor L. Tam, Robb R. Pagarigan, Raymond Wong, Diljeet K. Joea, Liz Lantzy, Mayra A. Carrillo, Todd M. Gross, Uriel M. Malyankar, Chih-Sheng Chiang, Diane M. Da Silva, Thomas M. Kündig, W. Martin Kast, Zhiyong Qiu and Adrian Bot

  Clin Cancer Res October 1 2009 15 (19) 6167-6176; DOI:10.1158/1078-0432.CCR-09-0645

  
  
• Cancer Therapy: Preclinical

  Translocator Protein Blockade Reduces Prostate Tumor Growth

  Arlee Fafalios, Ardavan Akhavan, Anil V. Parwani, Robert R. Bies, Kevin J. McHugh and Beth R. Pflug

  Clin Cancer Res October 1 2009 15 (19) 6177-6184; DOI:10.1158/1078-0432.CCR-09-0844