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Clinical Cancer Research
Clinical Cancer Research
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About the Cover

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In this first preclinical study, synthetic polymeric vectors based on pseudodendritic oligoamines were used for tumor-specific delivery of the sodium iodide symporter (NIS) gene after systemic delivery, resulting in a significant therapeutic effect of radioiodine in a neuroblastoma mouse model. The figure shows immunofluorescence analysis using a Ki67-specific antibody (green) and an antibody against CD31 (red, labeling blood vessels) revealing high proliferation and blood vessel density in control tumors in contrast to NIS-transduced tumors after radioiodine treatment. For further details, please see Klutz and coworkers 6079 in this issue.

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Clinical Cancer Research: 15 (19)
October 2009
Volume 15, Issue 19
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Issue Highlights

  • A Comparison of Phase II Study Strategies
  • On Trk—The TrkB Signal Transduction Pathway Is an Increasingly Important Target in Cancer Biology
  • A Phase II Study of SGN-30 in Cutaneous Anaplastic Large Cell Lymphoma and Related Lymphoproliferative Disorders
  • Targeted Radioiodine Therapy of Neuroblastoma Tumors following Systemic Nonviral Delivery of the Sodium Iodide Symporter Gene
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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