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Clinical Cancer Research
Clinical Cancer Research
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About the Cover

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APL is driven by a PML/RARA fusion that enhances self-renewal of clonogenic progenitors and blocks promyelocytes differentiation. PML/RARA binds RXR, Daxx and corepressors. Retinoic acid promotes differentiation through transcriptional activation and PML/RARA degradation by the proteasome. Arsenic primarily degrades PML/RARA, through sumoylation of its PML moiety and subsequent ubiquitination. Oncogene degradation affects self-renewal of the progenitors and tightly correlates with disease clearance and cure. For further details, please see Nasr and coworkers 6321 in this issue.

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Clinical Cancer Research: 15 (20)
October 2009
Volume 15, Issue 20
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Issue Highlights

  • Identification of Novel Kinase Targets for the Treatment of Estrogen Receptor–Negative Breast Cancer
  • Phase I Study of Ipilimumab, an Anti–CTLA-4 Monoclonal Antibody, in Patients with Relapsed and Refractory B-Cell Non–Hodgkin Lymphoma
  • Dose-Ranging Study of Metronomic Oral Vinorelbine in Patients with Advanced Refractory Cancer
  • Therapy-induced PML/RARA Proteolysis and Acute Promyelocytic Leukemia Cure
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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