Tumor Metabolism and Blood Flow as Assessed by Positron Emission Tomography Varies by Tumor Subtype in Locally Advanced Breast Cancer

DOI: 10.1158/1078-0432.CCR-10-0026 Published May 2010

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Fig. 1.
MRFDG (μmol/min/100 g) by subtype using box and whisker plots. □, data points.
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Fig. 2.
BF (mL/min/g) by subtype using box and whisker plots. □, data points.
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Fig. 3.
MRFDG/BF ratio by subtype using box and whisker plots. □, data points.
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Fig. 4.
MRFDG (μmol/min/100 g) and BF (mL/min/g) for each subtype. Light shaded symbols, nonresponders; dark shaded symbols, patients who achieved pCR. •, pCR in TN tumors; ▪, pCR in HER2 tumors; ▴, pCR in luminal tumors.

Table 1.

Selected characteristics among patients with LABC

Characteristics	No. of patients (n = 71)	%
Age, y
<40	19	27
40-49	25	35
50-59	19	27
≥60	8	11
Race
Non-Hispanic white	56	79
African-American	9	13
Asian/Pacific Islander	6	8
Histology
Ductal	65	92
Lobular	6	8
Clinical tumor classification
T1	3	4
T2	14	20
T3	41	58
T4	13	18
Clinical lymph node classification
N0	15	21
N1	43	61
N2	11	15
N3	2	3
Tumor size, cm
0-1.9	5	7
2.0-5	35	49
>5	31	44
Ki-67 proliferative index^*
Low or intermediate (≤20%)	16	26
High (>20%)	45	74
Menopausal status
Pre	47	66
Post	24	34
Tumor grade
1	5	7
2	22	31
3	44	62
Breast cancer subtype (by IHC)
TN	25	35
HER2	6	8
Luminal	40	56

Table 2.

Tumor characteristics and PET parameters by subtype

Characteristics	TN (n = 25)	HER2 (n = 6)	Luminal n = 40	P global difference by subtype^*	Odds ratio, P TN vs luminal^†
Tumor grade
3 (vs 1 or 2)^‡	22 (88%)	4 (67%)	18 (45%)		8.7
95% CI^§	(70%, 96%)	(30%, 90%)	(31%, 60%)	0.001	<0.001
Ki-67 proliferative index^∥
High (vs low or intermediate)	20 (95%)	3 (60%)	22 (63%)	0.01	11.4
95% CI^§	(77%, 100%)	(23%, 88%)	(46%, 77%)		0.009
PCR
pCR (vs no or partial response)	7 (28%)	4 (67%)	5 (13%)	0.014	2.7
95% CI^§	(14%, 48%)	(30%, 90%)	(5%, 26%)		0.188
MRFDG, μmol/min/100 g
Mean	15.9	7.58	9.72	0.009	0.019
SD	10.4	5.31	7.8
BF, mL/min/g
Mean	0.354	0.315	0.352	0.731	0.773
SD	0.148	0.129	0.214
MRFDG: BF ratio
Mean	44.3	24.1	28.7	0.004	0.011
SD	23	14.6	14.6

↵*Fisher's exact test for grade, Ki-67, pCR; likelihood ratio test for PET.
↵^†Odds ratio and Fisher's exact test P value for grade, Ki-67, and pCR; Tukey-Kramer test for PET (difference not given for log-transformed variables).
↵^‡Five luminal tumors were grade 1; others were grade 2.
↵^§CIs computed using Wilson (score) method.
↵^∥Missing values, n = 4 (TN), n = 1 (Her2), and n = 5 (luminal).