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Molecular Pathways

New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network

Yun Dai and Steven Grant
Yun Dai
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Steven Grant
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DOI: 10.1158/1078-0432.CCR-09-1029 Published January 2010
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Volume 16, Issue 2, pp. 376-383

DOI 
https://doi.org/10.1158/1078-0432.CCR-09-1029
PubMed 
20068082

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received October 13, 2009
  • Accepted October 15, 2009
  • Published first January 12, 2010.

Article Versions

  • Previous version (January 12, 2010 - 08:38).
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©2010 American Association for Cancer Research.

Author Information

  1. Yun Dai1 and
  2. Steven Grant2
  1. Authors' Affiliations: 1Department of Medicine, 2Institute for Molecular Medicine, and Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia
  1. Corresponding Author:
    Steven Grant, Division of Hematology/Oncology, Virginia Commonwealth University/Medical College of Virginia, MCV Station Box 230, Richmond, VA 23298. Phone: 804-828-5211; Fax: 804-828-2174; E-mail: stgrant{at}vcu.edu.
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Clinical Cancer Research: 16 (2)
January 2010
Volume 16, Issue 2
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New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network
Yun Dai and Steven Grant
Clin Cancer Res January 15 2010 (16) (2) 376-383; DOI: 10.1158/1078-0432.CCR-09-1029

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New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network
Yun Dai and Steven Grant
Clin Cancer Res January 15 2010 (16) (2) 376-383; DOI: 10.1158/1078-0432.CCR-09-1029
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  • Article
    • Abstract
    • Checkpoint Signaling Cascades
    • Chk1 Activation Upstream Signals
    • Current Models for Chk1 Activation Mechanisms
    • Chk1 in DNA Damage Checkpoints
    • Other Chk1 Functions
    • Clinical-Translational Advances
    • Alternative Strategies: An Example Emphasizing the Link between Chk1 Inhibitors and the Ras/MEK/ERK Survival Pathway
    • Disclosure of Potential Conflicts of Interest
    • Acknowledgments
    • Footnotes
    • References
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Clinical Cancer Research
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