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Predictive Biomarkers and Personalized Medicine

Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Response

Sahar A. Saddoughi, Elizabeth Garrett-Mayer, Uzair Chaudhary, Paul E. O'Brien, Larry B. Afrin, Terry A. Day, M. Boyd Gillespie, Anand K. Sharma, Christina S. Wilhoit, Robin Bostick, Can E. Senkal, Yusuf A. Hannun, Jacek Bielawski, George R. Simon, Keisuke Shirai and Besim Ogretmen
Sahar A. Saddoughi
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Elizabeth Garrett-Mayer
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Uzair Chaudhary
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Terry A. Day
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Can E. Senkal
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George R. Simon
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Keisuke Shirai
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DOI: 10.1158/1078-0432.CCR-11-0930 Published September 2011
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ARTICLE USAGE: July 2011 to January 2021

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Article Information

Volume 17, Issue 18, pp. 6097-6105

DOI 
https://doi.org/10.1158/1078-0432.CCR-11-0930
PubMed 
21791630

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received April 11, 2011
  • Revision received June 27, 2011
  • Accepted July 15, 2011
  • Published first July 26, 2011.

Article Versions

  • Previous version (July 26, 2011 - 12:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2011 American Association for Cancer Research.

Author Information

  1. Sahar A. Saddoughi1,2,
  2. Elizabeth Garrett-Mayer2,5,
  3. Uzair Chaudhary2,6,
  4. Paul E. O'Brien2,
  5. Larry B. Afrin2,
  6. Terry A. Day2,3,
  7. M. Boyd Gillespie2,3,
  8. Anand K. Sharma2,4,
  9. Christina S. Wilhoit2,
  10. Robin Bostick2,
  11. Can E. Senkal1,2,
  12. Yusuf A. Hannun1,2,
  13. Jacek Bielawski1,2,
  14. George R. Simon2,6,
  15. Keisuke Shirai2,6, and
  16. Besim Ogretmen1,2
  1. Authors' Affiliations: 1Department of Biochemistry and Molecular Biology; 2Hollings Cancer Center; 3Department of Otolaryngology and Head and Neck Surgery; 4Department of Radiation Oncology; 5Department of Medicine, Division of Biostatistics and Epidemiology; and 6Department of Medicine, Division of Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina
  1. Corresponding Author:
    Besim Ogretmen or Keisuke Shirai, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425. Phone: 843-792-0940; Fax: 832-792-2556; E-mail: ogretmen{at}musc.edu or shirai{at}musc.edu
  • Current address for U. Chaudhary: Department of Hematology & Oncology, University of California, San Francisco, UCSF/Fresno Medical Education Program, 2823 N. Fresno Street, Fresno, CA 93721.

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Clinical Cancer Research: 17 (18)
September 2011
Volume 17, Issue 18
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Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Response
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Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Response
Sahar A. Saddoughi, Elizabeth Garrett-Mayer, Uzair Chaudhary, Paul E. O'Brien, Larry B. Afrin, Terry A. Day, M. Boyd Gillespie, Anand K. Sharma, Christina S. Wilhoit, Robin Bostick, Can E. Senkal, Yusuf A. Hannun, Jacek Bielawski, George R. Simon, Keisuke Shirai and Besim Ogretmen
Clin Cancer Res September 15 2011 (17) (18) 6097-6105; DOI: 10.1158/1078-0432.CCR-11-0930

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Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Response
Sahar A. Saddoughi, Elizabeth Garrett-Mayer, Uzair Chaudhary, Paul E. O'Brien, Larry B. Afrin, Terry A. Day, M. Boyd Gillespie, Anand K. Sharma, Christina S. Wilhoit, Robin Bostick, Can E. Senkal, Yusuf A. Hannun, Jacek Bielawski, George R. Simon, Keisuke Shirai and Besim Ogretmen
Clin Cancer Res September 15 2011 (17) (18) 6097-6105; DOI: 10.1158/1078-0432.CCR-11-0930
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