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Antibody-Radionuclide Conjugates for Cancer Therapy: Historical Considerations and New Trends

Martina Steiner and Dario Neri
Martina Steiner
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Dario Neri
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DOI: 10.1158/1078-0432.CCR-11-0483 Published October 2011
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Article Information

Volume 17, Issue 20, pp. 6406-6416

DOI 
https://doi.org/10.1158/1078-0432.CCR-11-0483
PubMed 
22003068

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received April 8, 2011
  • Revision received May 27, 2011
  • Accepted June 14, 2011
  • Published first October 14, 2011.

Copyright & Usage 
©2011 American Association for Cancer Research.

Author Information

  1. Martina Steiner and
  2. Dario Neri
  1. Authors' Affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
  1. Corresponding author:
    Dario Neri, Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, Zurich 8093, Switzerland. Phone: 41-44-6337401; E-mail: neri{at}pharma.ethz.ch
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Clinical Cancer Research: 17 (20)
October 2011
Volume 17, Issue 20
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Antibody-Radionuclide Conjugates for Cancer Therapy: Historical Considerations and New Trends
Martina Steiner and Dario Neri
Clin Cancer Res October 15 2011 (17) (20) 6406-6416; DOI: 10.1158/1078-0432.CCR-11-0483

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Antibody-Radionuclide Conjugates for Cancer Therapy: Historical Considerations and New Trends
Martina Steiner and Dario Neri
Clin Cancer Res October 15 2011 (17) (20) 6406-6416; DOI: 10.1158/1078-0432.CCR-11-0483
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  • Article
    • Abstract
    • Introduction
    • Role of the Antibody Format
    • Pretargeting
    • Considerations Regarding the Choice of the Radionuclide
    • Vascular Tumor Targeting
    • Locoregional Approaches
    • Combination Therapy
    • Conclusions
    • Disclosure of Potential Conflicts of Interest
    • References
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  • Limitations and Challenges in Immuno-oncology Trials
  • Developing Early-Phase Combination Immunotherapy Trials
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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