Clinical Cancer Research: 17 (22)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res November 15 2011 17 (22) 6953-6953;

CCR Translations

CCR Translations

MAGE: The Spell Is Broken

Katayoun Rezvani

Clin Cancer Res November 15 2011 17 (22) 6955-6957; DOI:10.1158/1078-0432.CCR-11-2302

CCR Drug Updates

CCR Drug Updates

Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma

Evan J. Lipson and Charles G. Drake

Clin Cancer Res November 15 2011 17 (22) 6958-6962; DOI:10.1158/1078-0432.CCR-11-1595

Molecular Pathways

Molecular Pathways

Novel Insights into the Role of Interleukin-27 and Interleukin-23 in Human Malignant and Normal Plasma Cells

Nicola Giuliani and Irma Airoldi

Clin Cancer Res November 15 2011 17 (22) 6963-6970; DOI:10.1158/1078-0432.CCR-11-1724

Perspective

Perspective

DNA Cytometry Testing for Cervical Cancer Screening: Approaches and Reporting Standards for New Technologies

Graham A. Colditz and John Crowley

Clin Cancer Res November 15 2011 17 (22) 6971-6972; DOI:10.1158/1078-0432.CCR-11-1862

Reviews

Reviews

DNA Repair: From Genome Maintenance to Biomarker and Therapeutic Target

Shadia Jalal, Jennifer N. Earley and John J. Turchi

Clin Cancer Res November 15 2011 17 (22) 6973-6984; DOI:10.1158/1078-0432.CCR-11-0761
Reviews

Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives

Jessica Godin-Ethier, Laïla-Aïcha Hanafi, Ciriaco A. Piccirillo and Réjean Lapointe

Clin Cancer Res November 15 2011 17 (22) 6985-6991; DOI:10.1158/1078-0432.CCR-11-1331

Human Cancer Biology

Human Cancer Biology | Free Article

Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

Trisha R. Sippel, Jason White, Kamalika Nag, Vadim Tsvankin, Marci Klaassen, B.K. Kleinschmidt-DeMasters and Allen Waziri

Clin Cancer Res November 15 2011 17 (22) 6992-7002; DOI:10.1158/1078-0432.CCR-11-1107
Human Cancer Biology

Novel Chromosomal Rearrangements and Break Points at the t(6;9) in Salivary Adenoid Cystic Carcinoma: Association with MYB–NFIB Chimeric Fusion, MYB Expression, and Clinical Outcome

Yoshitsugu Mitani, Pulivarthi H. Rao, P. Andrew Futreal, Dianna B. Roberts, Philip J. Stephens, Yi-Jue Zhao, Li Zhang, Mutsumi Mitani, Randal S. Weber, Scott M. Lippman, Carlos Caulin and Adel K. El-Naggar

Clin Cancer Res November 15 2011 17 (22) 7003-7014; DOI:10.1158/1078-0432.CCR-11-1870
Human Cancer Biology

Mast Cells in Tumor Microenvironment Promotes the In Vivo Growth of Pancreatic Ductal Adenocarcinoma

David Z. Chang, Ying Ma, Baoan Ji, Huamin Wang, Defeng Deng, Yan Liu, James L. Abbruzzese, Yong-jun Liu, Craig D. Logsdon and Patrick Hwu

Clin Cancer Res November 15 2011 17 (22) 7015-7023; DOI:10.1158/1078-0432.CCR-11-0607
Human Cancer Biology

Two Distinct Routes to Oral Cancer Differing in Genome Instability and Risk for Cervical Node Metastasis

Aditi Bhattacharya, Ritu Roy, Antoine M. Snijders, Gregory Hamilton, Jesse Paquette, Taku Tokuyasu, Henrik Bengtsson, Richard C. K. Jordan, Adam B. Olshen, Daniel Pinkel, Brian L. Schmidt and Donna G. Albertson

Clin Cancer Res November 15 2011 17 (22) 7024-7034; DOI:10.1158/1078-0432.CCR-11-1944
Human Cancer Biology

Serum Galectin-2, -4, and -8 Are Greatly Increased in Colon and Breast Cancer Patients and Promote Cancer Cell Adhesion to Blood Vascular Endothelium

Hannah Barrow, Xiuli Guo, Hans H. Wandall, Johannes W. Pedersen, Bo Fu, Qicheng Zhao, Chen Chen, Jonathan M. Rhodes and Lu-Gang Yu

Clin Cancer Res November 15 2011 17 (22) 7035-7046; DOI:10.1158/1078-0432.CCR-11-1462

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Tumor-Derived Autophagosome Vaccine: Mechanism of Cross-Presentation and Therapeutic Efficacy

Yuhuan Li, Li-Xin Wang, Puiyi Pang, Zhihua Cui, Sandra Aung, Daniel Haley, Bernard A. Fox, Walter J. Urba and Hong-Ming Hu

Clin Cancer Res November 15 2011 17 (22) 7047-7057; DOI:10.1158/1078-0432.CCR-11-0951
Cancer Therapy: Preclinical

Improving T-cell Therapy for Relapsed EBV-Negative Hodgkin Lymphoma by Targeting Upregulated MAGE-A4

Conrad R. Cruz, Ulrike Gerdemann, Ann M. Leen, Jessica A. Shafer, Stephanie Ku, Benjamin Tzou, Terzah M. Horton, Andrea Sheehan, Amanda Copeland, Anas Younes, Cliona M. Rooney, Helen E. Heslop and Catherine M. Bollard

Clin Cancer Res November 15 2011 17 (22) 7058-7066; DOI:10.1158/1078-0432.CCR-11-1873
Cancer Therapy: Preclinical

Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells

Andreas Höglund, Lisa M. Nilsson, Somsundar Veppil Muralidharan, Lisa A. Hasvold, Philip Merta, Martina Rudelius, Viktoriya Nikolova, Ulrich Keller and Jonas A. Nilsson

Clin Cancer Res November 15 2011 17 (22) 7067-7079; DOI:10.1158/1078-0432.CCR-11-1198
Cancer Therapy: Preclinical

Glutamatergic Pathway Targeting in Melanoma: Single-Agent and Combinatorial Therapies

Hwa Jin Lee, Brian A. Wall, Janet Wangari-Talbot, Seung-Shick Shin, Stephen Rosenberg, Joseph L-K. Chan, Jin Namkoong, James S. Goydos and Suzie Chen

Clin Cancer Res November 15 2011 17 (22) 7080-7092; DOI:10.1158/1078-0432.CCR-11-0098
Cancer Therapy: Preclinical

Synergistic Activity of Fenretinide and the Bcl-2 Family Protein Inhibitor ABT-737 against Human Neuroblastoma

Hua Fang, Theresa M. Harned, Ondrej Kalous, Vanessa Maldonado, Yves A. DeClerck and C. Patrick Reynolds

Clin Cancer Res November 15 2011 17 (22) 7093-7104; DOI:10.1158/1078-0432.CCR-11-0578
Cancer Therapy: Preclinical

Reduced miR-128 in Breast Tumor–Initiating Cells Induces Chemotherapeutic Resistance via Bmi-1 and ABCC5

Yinghua Zhu, Fengyan Yu, Yu Jiao, Juan Feng, Wei Tang, Herui Yao, Chang Gong, Jianing Chen, Fengxi Su, Yan Zhang and Erwei Song

Clin Cancer Res November 15 2011 17 (22) 7105-7115; DOI:10.1158/1078-0432.CCR-11-0071
Cancer Therapy: Preclinical

Novel Phosphoinositide 3-Kinase/mTOR Dual Inhibitor, NVP-BGT226, Displays Potent Growth-Inhibitory Activity against Human Head and Neck Cancer Cells In Vitro and In Vivo

Kwang-Yu Chang, Shan-Yin Tsai, Ching-Ming Wu, Chia-Jui Yen, Bin-Fay Chuang and Jang-Yang Chang

Clin Cancer Res November 15 2011 17 (22) 7116-7126; DOI:10.1158/1078-0432.CCR-11-0796
Cancer Therapy: Preclinical

A Novel Kinase Inhibitor, INCB28060, Blocks c-MET–Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3

Xiangdong Liu, Qian Wang, Gengjie Yang, Cindy Marando, Holly K. Koblish, Leslie M. Hall, Jordan S. Fridman, Elham Behshad, Richard Wynn, Yu Li, Jason Boer, Sharon Diamond, Chunhong He, Meizhong Xu, Jincong Zhuo, Wenqing Yao, Robert C. Newton and Peggy A. Scherle

Clin Cancer Res November 15 2011 17 (22) 7127-7138; DOI:10.1158/1078-0432.CCR-11-1157

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

Genetic Variation in Inflammatory Pathways Is Related to Colorectal Cancer Survival

Anna E. Coghill, Polly A. Newcomb, Elizabeth M. Poole, Carolyn M. Hutter, Karen W. Makar, Dave Duggan, John D. Potter and Cornelia M. Ulrich

Clin Cancer Res November 15 2011 17 (22) 7139-7147; DOI:10.1158/1078-0432.CCR-11-1134
Imaging, Diagnosis, Prognosis

A Hypermethylated Phenotype Is a Better Predictor of Survival than MGMT Methylation in Anaplastic Oligodendroglial Brain Tumors: A Report from EORTC Study 26951

Martin J. van den Bent, Lonneke A. Gravendeel, Thierry Gorlia, Johan M. Kros, Lariesa Lapre, Pieter Wesseling, Johannes L. Teepen, Ahmed Idbaih, Marc Sanson, Peter A.E. Sillevis Smitt and Pim J. French

Clin Cancer Res November 15 2011 17 (22) 7148-7155; DOI:10.1158/1078-0432.CCR-11-1274

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Biologic and Clinical Activity of Tivozanib (AV-951, KRN-951), a Selective Inhibitor of VEGF Receptor-1, -2, and -3 Tyrosine Kinases, in a 4-Week-On, 2-Week-Off Schedule in Patients with Advanced Solid Tumors

Ferry A.L.M. Eskens, Maja J.A. de Jonge, Pankaj Bhargava, Toshiyuki Isoe, Monette M. Cotreau, Brooke Esteves, Kunihiko Hayashi, Herman Burger, Maarten Thomeer, Leni van Doorn and Jaap Verweij

Clin Cancer Res November 15 2011 17 (22) 7156-7163; DOI:10.1158/1078-0432.CCR-11-0411
Cancer Therapy: Clinical

A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer

Mahsa Mohebtash, Kwong-Yok Tsang, Ravi A. Madan, Ngar-Yee Huen, Diane J. Poole, Caroline Jochems, Jacquin Jones, Theresa Ferrara, Christopher R. Heery, Philip M. Arlen, Seth M. Steinberg, Mary Pazdur, Myrna Rauckhorst, Elizabeth C. Jones, William L. Dahut, Jeffrey Schlom and James L. Gulley

Clin Cancer Res November 15 2011 17 (22) 7164-7173; DOI:10.1158/1078-0432.CCR-11-0649
Cancer Therapy: Clinical

GLIPR1 Tumor Suppressor Gene Expressed by Adenoviral Vector as Neoadjuvant Intraprostatic Injection for Localized Intermediate or High-Risk Prostate Cancer Preceding Radical Prostatectomy

Guru Sonpavde, Timothy C. Thompson, Rajul K. Jain, Gustavo E. Ayala, Shinji Kurosaka, Kohei Edamura, Ken-ichi Tabata, Chengzhen Ren, Alexei A. Goltsov, Martha P. Mims, Teresa G. Hayes, Michael M. Ittmann, Thomas M. Wheeler, Adrian Gee, Brian J. Miles and Dov Kadmon

Clin Cancer Res November 15 2011 17 (22) 7174-7182; DOI:10.1158/1078-0432.CCR-11-1899

Predictive Biomarkers and Personalized Medicine

Predictive Biomarkers and Personalized Medicine

Cytokeratin-19 and Mammaglobin Gene Expression in Circulating Tumor Cells from Metastatic Breast Cancer Patients Enrolled in North Central Cancer Treatment Group Trials, N0234/336/436/437

Monica M. Reinholz, Kathleen A. Kitzmann, Kathleen Tenner, David Hillman, Amylou C. Dueck, Timothy J. Hobday, Donald W. Northfelt, Alvaro Moreno-Aspitia, Vivek Roy, Betsy LaPlant, Jake B. Allred, Philip J. Stella, Wilma L. Lingle and Edith A. Perez

Clin Cancer Res November 15 2011 17 (22) 7183-7193; DOI:10.1158/1078-0432.CCR-11-0981
Predictive Biomarkers and Personalized Medicine

Relationship between Quantitative GRB7 RNA Expression and Recurrence after Adjuvant Anthracycline Chemotherapy in Triple-Negative Breast Cancer

Joseph A. Sparano, Lori J. Goldstein, Barrett H. Childs, Steven Shak, Diana Brassard, Sunil Badve, Frederick L. Baehner, Roberto Bugarini, Steve Rowley, Edith A. Perez, Lawrence N. Shulman, Silvana Martino, Nancy E. Davidson, Paraic A. Kenny, George W. Sledge Jr and Robert Gray

Clin Cancer Res November 15 2011 17 (22) 7194-7203; DOI:10.1158/1078-0432.CCR-10-3357

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Table of Contents

Highlights

CCR Translations

CCR Drug Updates

Molecular Pathways

Perspective

Reviews

Human Cancer Biology

Cancer Therapy: Preclinical

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Predictive Biomarkers and Personalized Medicine

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