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Imaging, Diagnosis, Prognosis

Pentraxin-3 Is a Novel Biomarker of Lung Carcinoma

Eleftherios P. Diamandis, Lee Goodglick, Chris Planque and Mark D. Thornquist
Eleftherios P. Diamandis
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Lee Goodglick
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Chris Planque
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Mark D. Thornquist
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DOI: 10.1158/1078-0432.CCR-10-3024 Published April 2011
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    Figure 1.

    A, ROC curve for pentraxin-3 comparing all cases (N = 203) and all controls (N = 223). AUC = 0.66, 95% CI, 0.61 to 0.71. B, ROC curve for pentraxin-3 comparing all cases (N = 203) and high-risk controls (N = 180). AUC = 0.69, 95% CI, 0.64 to 0.75. C, ROC curve for pentraxin-3 comparing all cases (N = 203) and other cancer controls (N = 43). AUC = 0.54, 95% CI, 0.44 to 0.63.

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  • Table 1.

    Sensitivity and specificity of pentraxin-3 in lung cancer patients

    SpecificitySensitivity
    Versus high-risk controls aVersus all controls a
    Estimate95% CIEstimate95% CI
    0.990.054(0.000–0.158)0.054(0.000–0.133)
    0.950.192(0.094–0.296)0.177(0.118–0.281)
    0.900.374(0.212–0.478)0.251(0.163–0.399)
    0.800.478(0.394–0.557)0.448(0.365–0.542)
    0.700.611(0.493–0.734)0.512(0.419–0.611)
    0.600.719(0.621–0.783)0.655(0.542–0.734)
    0.500.744(0.670–0.798)0.739(0.680–0.808)
    • ↵aPlease see text for descriptions.

  • Table 2.

    Area under the ROC curve per lung cancer type

    Lung cancer typeN aAUC b95% CI
    All types1200.670.60–0.74
    NSCLC900.650.58–0.72
    SCLC130.670.47–0.83
    NSCLC
     Adenocarcinoma570.650.56–0.76
     Squamous300.630.52–0.75
    • ↵aNumber of lung cancer patients.

    • ↵bComparison to 119 high-risk controls; some patients do not have complete information. AUC, area under the curve.

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    Supplementary Figures S1-S3.

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    • Supplementary Figures S1-S3 - Supplementary Figures S1-S3.
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Clinical Cancer Research: 17 (8)
April 2011
Volume 17, Issue 8
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Pentraxin-3 Is a Novel Biomarker of Lung Carcinoma
Eleftherios P. Diamandis, Lee Goodglick, Chris Planque and Mark D. Thornquist
Clin Cancer Res April 15 2011 (17) (8) 2395-2399; DOI: 10.1158/1078-0432.CCR-10-3024

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Pentraxin-3 Is a Novel Biomarker of Lung Carcinoma
Eleftherios P. Diamandis, Lee Goodglick, Chris Planque and Mark D. Thornquist
Clin Cancer Res April 15 2011 (17) (8) 2395-2399; DOI: 10.1158/1078-0432.CCR-10-3024
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Clinical Cancer Research
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