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Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res May 15 2012 18 (10) 2721-2721;

CCR Translations

  • CCR Translations
    Metformin and Pancreatic Cancer: A Clue Requiring Investigation
    Michael Pollak
    Clin Cancer Res May 15 2012 18 (10) 2723-2725; DOI:10.1158/1078-0432.CCR-12-0694

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: Vasculogenic Mimicry in Tumor Cells: Diagnostic and Therapeutic Implications
    Dawn A. Kirschmann, Elisabeth A. Seftor, Katharine M. Hardy, Richard E.B. Seftor and Mary J.C. Hendrix
    Clin Cancer Res May 15 2012 18 (10) 2726-2732; DOI:10.1158/1078-0432.CCR-11-3237

From the Editor

  • From the Editor
    Progress in Pediatric Cancer
    Susan E. Bates
    Clin Cancer Res May 15 2012 18 (10) 2734-2734; DOI:10.1158/1078-0432.CCR-12-1014

CCR Focus

  • CCR Focus
    Genetically InFormed Therapies—A “GIFT” for Children with Cancer
    Carol J. Thiele and Susan L. Cohn
    Clin Cancer Res May 15 2012 18 (10) 2735-2739; DOI:10.1158/1078-0432.CCR-11-1940

  • CCR Focus
    Promising Therapeutic Targets in Neuroblastoma
    Katherine K. Matthay, Rani E. George and Alice L. Yu
    Clin Cancer Res May 15 2012 18 (10) 2740-2753; DOI:10.1158/1078-0432.CCR-11-1939

  • CCR Focus
    Advances in the Genetics of High-Risk Childhood B-Progenitor Acute Lymphoblastic Leukemia and Juvenile Myelomonocytic Leukemia: Implications for Therapy
    Mignon L. Loh and Charles G. Mullighan
    Clin Cancer Res May 15 2012 18 (10) 2754-2767; DOI:10.1158/1078-0432.CCR-11-1936

  • CCR Focus | Free Article
    Epigenetic Changes in Pediatric Solid Tumors: Promising New Targets
    Elizabeth R. Lawlor and Carol J. Thiele
    Clin Cancer Res May 15 2012 18 (10) 2768-2779; DOI:10.1158/1078-0432.CCR-11-1921

  • CCR Focus
    The Future Is Now: Chimeric Antigen Receptors as New Targeted Therapies for Childhood Cancer
    Daniel W. Lee, David M. Barrett, Crystal Mackall, Rimas Orentas and Stephan A. Grupp
    Clin Cancer Res May 15 2012 18 (10) 2780-2790; DOI:10.1158/1078-0432.CCR-11-1920

  • CCR Focus
    Using Germline Genomics to Individualize Pediatric Cancer Treatments
    Navin Pinto, Susan L. Cohn and M. Eileen Dolan
    Clin Cancer Res May 15 2012 18 (10) 2791-2800; DOI:10.1158/1078-0432.CCR-11-1938

Perspective

  • Perspective
    Disrupting the Networks of Cancer
    Daniel F. Camacho and Kenneth J. Pienta
    Clin Cancer Res May 15 2012 18 (10) 2801-2808; DOI:10.1158/1078-0432.CCR-12-0366

Review

  • Review
    Pharmacogenomics in Early-Phase Oncology Clinical Trials: Is There a Sweet Spot in Phase II?
    Peter H. O'Donnell and Walter M. Stadler
    Clin Cancer Res May 15 2012 18 (10) 2809-2816; DOI:10.1158/1078-0432.CCR-11-2445

Human Cancer Biology

  • Human Cancer Biology
    Suppression of Skeletal Muscle Turnover in Cancer Cachexia: Evidence from the Transcriptome in Sequential Human Muscle Biopsies
    Iain J. Gallagher, Nathan A. Stephens, Alisdair J. MacDonald, Richard J.E. Skipworth, Holger Husi, Carolyn A. Greig, James A. Ross, James A. Timmons and Kenneth C.H. Fearon
    Clin Cancer Res May 15 2012 18 (10) 2817-2827; DOI:10.1158/1078-0432.CCR-11-2133

  • Human Cancer Biology
    MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma
    Nelly Burnichon, Alberto Cascón, Francesca Schiavi, Nicole Paes Morales, Iñaki Comino-Méndez, Nasséra Abermil, Lucía Inglada-Pérez, Aguirre A. de Cubas, Laurence Amar, Marta Barontini, Sandra Bernaldo de Quirós, Jérôme Bertherat, Yves-Jean Bignon, Marinus J. Blok, Sara Bobisse, Salud Borrego, Maurizio Castellano, Philippe Chanson, María-Dolores Chiara, Eleonora P.M. Corssmit, Mara Giacchè, Ronald R. de Krijger, Tonino Ercolino, Xavier Girerd, Encarna B. Gómez-García, Álvaro Gómez-Graña, Isabelle Guilhem, Frederik J. Hes, Emiliano Honrado, Esther Korpershoek, Jacques W.M. Lenders, Rocío Letón, Arjen R. Mensenkamp, Anna Merlo, Luigi Mori, Arnaud Murat, Peggy Pierre, Pierre-François Plouin, Tamara Prodanov, Miguel Quesada-Charneco, Nan Qin, Elena Rapizzi, Victoria Raymond, Nicole Reisch, Giovanna Roncador, Macarena Ruiz-Ferrer, Frank Schillo, Alexander P.A. Stegmann, Carlos Suarez, Elisa Taschin, Henri J.L.M. Timmers, Carli M.J. Tops, Miguel Urioste, Felix Beuschlein, Karel Pacak, Massimo Mannelli, Patricia L. M. Dahia, Giuseppe Opocher, Graeme Eisenhofer, Anne-Paule Gimenez-Roqueplo and Mercedes Robledo
    Clin Cancer Res May 15 2012 18 (10) 2828-2837; DOI:10.1158/1078-0432.CCR-12-0160

  • Human Cancer Biology
    Molecular Profiling of Pancreatic Neuroendocrine Tumors in Sporadic and Von Hippel-Lindau Patients
    Daniela Speisky, Aurélie Duces, Ivan Bièche, Vinciane Rebours, Pascal Hammel, Alain Sauvanet, Stéphane Richard, Pierre Bedossa, Michel Vidaud, Arnaud Murat, Patricia Niccoli, Jean-Yves Scoazec, Philippe Ruszniewski and Anne Couvelard
    Clin Cancer Res May 15 2012 18 (10) 2838-2849; DOI:10.1158/1078-0432.CCR-11-2759

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Lyn Kinase Mediates Cell Motility and Tumor Growth in EGFRvIII-Expressing Head and Neck Cancer
    Sarah E. Wheeler, Elena M. Morariu, Joseph S. Bednash, Charlton G. Otte, Raja R. Seethala, Simion I. Chiosea and Jennifer R. Grandis
    Clin Cancer Res May 15 2012 18 (10) 2850-2860; DOI:10.1158/1078-0432.CCR-11-2486

  • Cancer Therapy: Preclinical | Free Article
    L-BLP25 Vaccine plus Letrozole Induces a TH1 Immune Response and Has Additive Antitumor Activity in MUC1-Expressing Mammary Tumors in Mice
    Neelima R. Mehta, Gregory T. Wurz, Rebekah A. Burich, Brittany E. Greenberg, Stephen Griffey, Audrey Gutierrez, Katie E. Bell, Jamie L. McCall, Michael Wolf and Michael DeGregorio
    Clin Cancer Res May 15 2012 18 (10) 2861-2871; DOI:10.1158/1078-0432.CCR-12-0168

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Tumor Infiltrating Immune Cells and Outcome of Merkel Cell Carcinoma: A Population-Based Study
    Harri Sihto, Tom Böhling, Heli Kavola, Virve Koljonen, Marko Salmi, Sirpa Jalkanen and Heikki Joensuu
    Clin Cancer Res May 15 2012 18 (10) 2872-2881; DOI:10.1158/1078-0432.CCR-11-3020

  • Imaging, Diagnosis, Prognosis
    Global Methylation Profiling for Risk Prediction of Prostate Cancer
    Saswati Mahapatra, Eric W. Klee, Charles Y.F. Young, Zhifu Sun, Rafael E. Jimenez, George G. Klee, Donald J. Tindall and Krishna Vanaja Donkena
    Clin Cancer Res May 15 2012 18 (10) 2882-2895; DOI:10.1158/1078-0432.CCR-11-2090

  • Imaging, Diagnosis, Prognosis
    Correlation of ERG Expression and DNA Methylation Biomarkers with Adverse Clinicopathologic Features of Prostate Cancer
    Ken Kron, Liyang Liu, Dominique Trudel, Vaijayanti Pethe, John Trachtenberg, Neil Fleshner, Bharati Bapat and Theodorus van der Kwast
    Clin Cancer Res May 15 2012 18 (10) 2896-2904; DOI:10.1158/1078-0432.CCR-11-2901

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Metformin Use Is Associated with Better Survival of Diabetic Patients with Pancreatic Cancer
    Navid Sadeghi, James L. Abbruzzese, Sai-Ching J. Yeung, Manal Hassan and Donghui Li
    Clin Cancer Res May 15 2012 18 (10) 2905-2912; DOI:10.1158/1078-0432.CCR-11-2994

  • Cancer Therapy: Clinical
    Pharmacokinetics and Repolarization Effects of Intravenous and Transdermal Granisetron
    Jay W. Mason, Daniel S. Selness, Thomas E. Moon, Bridget O'Mahony, Peter Donachie and Julian Howell
    Clin Cancer Res May 15 2012 18 (10) 2913-2921; DOI:10.1158/1078-0432.CCR-11-2785

  • Cancer Therapy: Clinical
    Survival of 1,181 Patients in a Phase I Clinic: The MD Anderson Clinical Center for Targeted Therapy Experience
    Jennifer Wheler, Apostolia M. Tsimberidou, David Hong, Aung Naing, Gerald Falchook, Sarina Piha-Paul, Siqing Fu, Stacy Moulder, Bettzy Stephen, Sijin Wen and Razelle Kurzrock
    Clin Cancer Res May 15 2012 18 (10) 2922-2929; DOI:10.1158/1078-0432.CCR-11-2217

  • Cancer Therapy: Clinical
    Microarray Analysis Verifies Two Distinct Phenotypes of Glioblastomas Resistant to Antiangiogenic Therapy
    Michael DeLay, Arman Jahangiri, W. Shawn Carbonell, Yu-Long Hu, Sean Tsao, Maxwell Wing Tom, Jesse Paquette, Taku A. Tokuyasu and Manish K. Aghi
    Clin Cancer Res May 15 2012 18 (10) 2930-2942; DOI:10.1158/1078-0432.CCR-11-2390

  • Cancer Therapy: Clinical
    Analysis of Spontaneous Tumor-Specific CD4 T-cell Immunity in Lung Cancer Using Promiscuous HLA-DR Telomerase-Derived Epitopes: Potential Synergistic Effect with Chemotherapy Response
    Yann Godet, Elizabeth Fabre, Magalie Dosset, Michele Lamuraglia, Emeline Levionnois, Patrice Ravel, Nadine Benhamouda, Aurélie Cazes, Françoise Le Pimpec-Barthes, Beatrice Gaugler, Pierre Langlade-Demoyen, Xavier Pivot, Philippe Saas, Bernard Maillère, Eric Tartour, Christophe Borg and Olivier Adotévi
    Clin Cancer Res May 15 2012 18 (10) 2943-2953; DOI:10.1158/1078-0432.CCR-11-3185

  • Cancer Therapy: Clinical
    Pharmacokinetics and Safety of Bortezomib in Patients with Advanced Malignancies and Varying Degrees of Liver Dysfunction: Phase I NCI Organ Dysfunction Working Group Study NCI-6432
    Patricia M. LoRusso, Karthik Venkatakrishnan, Ramesh K. Ramanathan, John Sarantopoulos, Daniel Mulkerin, Stephen I. Shibata, Anne Hamilton, Afshin Dowlati, Sridhar Mani, Michelle A. Rudek, Chris H. Takimoto, Rachel Neuwirth, Dixie-Lee Esseltine and Percy Ivy
    Clin Cancer Res May 15 2012 18 (10) 2954-2963; DOI:10.1158/1078-0432.CCR-11-2873

Predictive Biomarkers and Personalized Medicine

  • Predictive Biomarkers and Personalized Medicine
    Gender Influences the Class III and V β-Tubulin Ability to Predict Poor Outcome in Colorectal Cancer
    Marisa Mariani, Gian Franco Zannoni, Stefano Sioletic, Steven Sieber, Candice Martino, Enrica Martinelli, Claudio Coco, Giovanni Scambia, Shohreh Shahabi and Cristiano Ferlini
    Clin Cancer Res May 15 2012 18 (10) 2964-2975; DOI:10.1158/1078-0432.CCR-11-2318

  • Predictive Biomarkers and Personalized Medicine
    An Apoptosis Methylation Prognostic Signature for Early Lung Cancer in the IFCT-0002 Trial
    Florence de Fraipont, Guénaëlle Levallet, Christian Creveuil, Emmanuel Bergot, Michèle Beau-Faller, Mounia Mounawar, Nicolas Richard, Martine Antoine, Isabelle Rouquette, Marie-Christine Favrot, Didier Debieuvre, Denis Braun, Virginie Westeel, Elisabeth Quoix, Elisabeth Brambilla, Pierre Hainaut, Denis Moro-Sibilot, Franck Morin, Bernard Milleron and Gérard Zalcman
    Clin Cancer Res May 15 2012 18 (10) 2976-2986; DOI:10.1158/1078-0432.CCR-11-2797

  • Predictive Biomarkers and Personalized Medicine
    Prognostic and Predictive Role of JWA and XRCC1 Expressions in Gastric Cancer
    Shouyu Wang, Xuming Wu, Yansu Chen, Jianbing Zhang, Jingjing Ding, Yan Zhou, Song He, Yongfei Tan, Fulin Qiang, Jin Bai, Jinyan Zeng, Zhenghua Gong, Aiping Li, Gang Li, Oluf Dimitri Røe and Jianwei Zhou
    Clin Cancer Res May 15 2012 18 (10) 2987-2996; DOI:10.1158/1078-0432.CCR-11-2863

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Clinical Cancer Research: 18 (10)
May 2012
Volume 18, Issue 10
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Issue Highlights

  • An Apoptosis Methylation Prognostic Signature for Early Lung Cancer in the IFCT-0002 Trial
  • L-BLP25 Vaccine plus Letrozole Induces a TH1 Immune Response and Has Additive Antitumor Activity in MUC1-Expressing Mammary Tumors in Mice
  • Tumor Infiltrating Immune Cells and Outcome of Merkel Cell Carcinoma: A Population-Based Study
  • Global Methylation Profiling for Risk Prediction of Prostate Cancer
  • Metformin Use Is Associated with Better Survival of Diabetic Patients with Pancreatic Cancer

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  • From the Editor
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  • Predictive Biomarkers and Personalized Medicine
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Clinical Cancer Research
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