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Cancer Therapy: Clinical

Metformin Use Is Associated with Better Survival of Diabetic Patients with Pancreatic Cancer

Navid Sadeghi, James L. Abbruzzese, Sai-Ching J. Yeung, Manal Hassan and Donghui Li
Navid Sadeghi
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James L. Abbruzzese
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Sai-Ching J. Yeung
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Manal Hassan
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Donghui Li
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DOI: 10.1158/1078-0432.CCR-11-2994 Published May 2012
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Abstract

Purpose: Accumulating evidence suggests that metformin has antitumor activity. The aim of this study was to determine whether metformin use has a survival benefit in patients with pancreatic cancer.

Experimental Design: We conducted a retrospective study of patients with diabetes and pancreatic cancer treated at The University of Texas MD Anderson Cancer Center (Houston, TX). Information on diabetes history, including treatment modalities and clinical outcome of pancreatic cancer, was collected using personal interviews and medical record review. Survival analysis was carried out using a Kaplan–Meier plot, log-rank test, and Cox proportional hazards regression models.

Results: Among the 302 patients identified, there were no significant differences in demographic or major clinical characteristics between the patients who had received metformin (n = 117) and those who had not (n = 185). The 2-year survival rate was 30.1% for the metformin group and 15.4% for the non-metformin group (P = 0.004; χ2 test). The median overall survival time was 15.2 months for the metformin group, and 11.1 months for the non-metformin group (P = 0.004, log-rank test). Metformin users had a 32% lower risk of death; the HR (95% confidence interval) was 0.68 (0.52–0.89) in a univariate model (P = 0.004), 0.64 (0.48–0.86) after adjusting for other clinical predictors (P = 0.003), and 0.62 (0.44–0.87) after excluding insulin users (P = 0.006). Metformin use was significantly associated with longer survival in patients with nonmetastatic disease only.

Conclusions: Our finding that metformin use was associated with improved outcome of patients with diabetes and pancreatic cancer should be confirmed in independent studies. Future research should prospectively evaluate metformin as a supplemental therapy in this population. Clin Cancer Res; 18(10); 2905–12. ©2012 AACR.

Commentary by Pollak, p. 2723

This article is featured in Highlights of This Issue, p. 2721

  • Received November 22, 2011.
  • Revision received February 16, 2012.
  • Accepted February 18, 2012.
  • ©2012 American Association for Cancer Research.
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Clinical Cancer Research: 18 (10)
May 2012
Volume 18, Issue 10
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Metformin Use Is Associated with Better Survival of Diabetic Patients with Pancreatic Cancer
Navid Sadeghi, James L. Abbruzzese, Sai-Ching J. Yeung, Manal Hassan and Donghui Li
Clin Cancer Res May 15 2012 (18) (10) 2905-2912; DOI: 10.1158/1078-0432.CCR-11-2994

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Metformin Use Is Associated with Better Survival of Diabetic Patients with Pancreatic Cancer
Navid Sadeghi, James L. Abbruzzese, Sai-Ching J. Yeung, Manal Hassan and Donghui Li
Clin Cancer Res May 15 2012 (18) (10) 2905-2912; DOI: 10.1158/1078-0432.CCR-11-2994
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Clinical Cancer Research
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