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Cancer Therapy: Preclinical

Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

Alan McIntyre, Shalini Patiar, Simon Wigfield, Ji-liang Li, Ioanna Ledaki, Helen Turley, Russell Leek, Cameron Snell, Kevin Gatter, William S. Sly, Richard D. Vaughan-Jones, Pawel Swietach and Adrian L. Harris
Alan McIntyre
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Shalini Patiar
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Simon Wigfield
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Ji-liang Li
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Ioanna Ledaki
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Helen Turley
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Russell Leek
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Cameron Snell
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Kevin Gatter
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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William S. Sly
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Richard D. Vaughan-Jones
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Pawel Swietach
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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Adrian L. Harris
1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
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DOI: 10.1158/1078-0432.CCR-11-1877 Published June 2012
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AbstractFull-text HTMLPDF
Total520140956338

Cited By

Article Information

Volume 18, Issue 11, pp. 3100-3111

DOI 
https://doi.org/10.1158/1078-0432.CCR-11-1877
PubMed 
22498007

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received July 20, 2011
  • Revision received March 20, 2012
  • Accepted March 29, 2012
  • Published first April 12, 2012.

Article Versions

  • Previous version (April 12, 2012 - 11:45).
  • Previous version (May 9, 2012 - 11:34).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2012 American Association for Cancer Research.

Author Information

  1. Alan McIntyre1,
  2. Shalini Patiar1,
  3. Simon Wigfield1,
  4. Ji-liang Li1,
  5. Ioanna Ledaki1,
  6. Helen Turley1,3,
  7. Russell Leek1,3,
  8. Cameron Snell1,3,
  9. Kevin Gatter3,
  10. William S. Sly4,
  11. Richard D. Vaughan-Jones2,
  12. Pawel Swietach2, and
  13. Adrian L. Harris1
  1. Authors' Affiliations: 1Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, 2Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, 3Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4St. Louis University School of Medicine, St. Louis, Missouri
  1. Corresponding Author:
    Adrian L. Harris, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom. Phone: 44-01865-222457; Fax: 44-01865-222431; E-mail: aharris.lab{at}oncology.ox.ac.uk
  1. A. McIntyre and S. Patiar contributed equally to this work.

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Clinical Cancer Research: 18 (11)
June 2012
Volume 18, Issue 11
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Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy
Alan McIntyre, Shalini Patiar, Simon Wigfield, Ji-liang Li, Ioanna Ledaki, Helen Turley, Russell Leek, Cameron Snell, Kevin Gatter, William S. Sly, Richard D. Vaughan-Jones, Pawel Swietach and Adrian L. Harris
Clin Cancer Res June 1 2012 (18) (11) 3100-3111; DOI: 10.1158/1078-0432.CCR-11-1877

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Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy
Alan McIntyre, Shalini Patiar, Simon Wigfield, Ji-liang Li, Ioanna Ledaki, Helen Turley, Russell Leek, Cameron Snell, Kevin Gatter, William S. Sly, Richard D. Vaughan-Jones, Pawel Swietach and Adrian L. Harris
Clin Cancer Res June 1 2012 (18) (11) 3100-3111; DOI: 10.1158/1078-0432.CCR-11-1877
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