Clinical Cancer Research: 18 (14)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res July 15 2012 18 (14) 3717-3717;

CCR Translations

CCR Translations

Mind the Gap: Potential for Rebounds during Antiangiogenic Treatment Breaks

John M.L. Ebos and Roberto Pili

Clin Cancer Res July 15 2012 18 (14) 3719-3721; DOI:10.1158/1078-0432.CCR-12-1459

CCR Perspectives in Drug Approval

CCR Perspectives in Drug Approval

Vandetanib for the Treatment of Symptomatic or Progressive Medullary Thyroid Cancer in Patients with Unresectable Locally Advanced or Metastatic Disease: U.S. Food and Drug Administration Drug Approval Summary

Katherine Thornton, Geoffrey Kim, V. Ellen Maher, Somesh Chattopadhyay, Shenghui Tang, Young Jin Moon, Pengfei Song, Anshu Marathe, Suchitra Balakrishnan, Hao Zhu, Christine Garnett, Qi Liu, Brian Booth, Brenda Gehrke, Robert Dorsam, Leigh Verbois, Debasis Ghosh, Wendy Wilson, John Duan, Haripada Sarker, Sarah Pope Miksinski, Lisa Skarupa, Amna Ibrahim, Robert Justice, Anthony Murgo and Richard Pazdur

Clin Cancer Res July 15 2012 18 (14) 3722-3730; DOI:10.1158/1078-0432.CCR-12-0411

Statistics in Clinical Cancer Research

Statistics in Clinical Cancer Research

Cure Models as a Useful Statistical Tool for Analyzing Survival

Megan Othus, Bart Barlogie, Michael L. LeBlanc and John J. Crowley

Clin Cancer Res July 15 2012 18 (14) 3731-3736; DOI:10.1158/1078-0432.CCR-11-2859

CCR Drug Updates

CCR Drug Updates

Crizotinib for ALK-Rearranged Non–Small Cell Lung Cancer: A New Targeted Therapy for a New Target

Leena Gandhi and Pasi A. Jänne

Clin Cancer Res July 15 2012 18 (14) 3737-3742; DOI:10.1158/1078-0432.CCR-11-2393

Molecular Pathways

Molecular Pathways

Molecular Pathways: Targeting P21-Activated Kinase 1 Signaling in Cancer—Opportunities, Challenges, and Limitations

Jeyanthy Eswaran, Da-Qiang Li, Anil Shah and Rakesh Kumar

Clin Cancer Res July 15 2012 18 (14) 3743-3749; DOI:10.1158/1078-0432.CCR-11-1952

Review

Review

Combining Antiangiogenics to Overcome Resistance: Rationale and Clinical Experience

Victor Moreno Garcia, Bristi Basu, L. Rhoda Molife and Stan B. Kaye

Clin Cancer Res July 15 2012 18 (14) 3750-3761; DOI:10.1158/1078-0432.CCR-11-1275

Human Cancer Biology

Human Cancer Biology

Tumor-Associated Macrophages in Pediatric Classical Hodgkin Lymphoma: Association with Epstein-Barr Virus, Lymphocyte Subsets, and Prognostic Impact

Mário Henrique M. Barros, Rocio Hassan and Gerald Niedobitek

Clin Cancer Res July 15 2012 18 (14) 3762-3771; DOI:10.1158/1078-0432.CCR-12-0129
Human Cancer Biology

Defective Epidermal Innate Immunity and Resultant Superficial Dermatophytosis in Adult T-cell Leukemia/Lymphoma

Yu Sawada, Motonobu Nakamura, Rieko Kabashima-Kubo, Takatoshi Shimauchi, Miwa Kobayashi and Yoshiki Tokura

Clin Cancer Res July 15 2012 18 (14) 3772-3779; DOI:10.1158/1078-0432.CCR-12-0292
Human Cancer Biology

FGFR4 Blockade Exerts Distinct Antitumorigenic Effects in Human Embryonal versus Alveolar Rhabdomyosarcoma

Lisa E.S. Crose, Katherine T. Etheridge, Candy Chen, Brian Belyea, Lindsay J. Talbot, Rex C. Bentley and Corinne M. Linardic

Clin Cancer Res July 15 2012 18 (14) 3780-3790; DOI:10.1158/1078-0432.CCR-10-3063
Human Cancer Biology

Integrative Genomic Analysis Implicates Gain of PIK3CA at 3q26 and MYC at 8q24 in Chronic Lymphocytic Leukemia

Jennifer R. Brown, Megan Hanna, Bethany Tesar, Lillian Werner, Nathalie Pochet, John M. Asara, Yaoyu E. Wang, Paola dal Cin, Stacey M. Fernandes, Christina Thompson, Laura MacConaill, Catherine J. Wu, Yves Van de Peer, Mick Correll, Aviv Regev, Donna Neuberg and Arnold S. Freedman

Clin Cancer Res July 15 2012 18 (14) 3791-3802; DOI:10.1158/1078-0432.CCR-11-2342

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Development and Characterization of a Novel CD19CherryLuciferase (CD19CL) Transgenic Mouse for the Preclinical Study of B-Cell Lymphomas

Luigi Scotto, Marianna Kruithof-de Julio, Luca Paoluzzi, Matko Kalac, Enrica Marchi, Jairo Baquero Buitrago, Jennifer Amengual, Michael M. Shen and Owen A. O'Connor

Clin Cancer Res July 15 2012 18 (14) 3803-3811; DOI:10.1158/1078-0432.CCR-11-2588
Cancer Therapy: Preclinical

Development of a Human Monoclonal Antibody for Potential Therapy of CD27-Expressing Lymphoma and Leukemia

Laura A. Vitale, Li-Zhen He, Lawrence J. Thomas, Jennifer Widger, Jeffrey Weidlick, Andrea Crocker, Thomas O'Neill, James Storey, Martin J. Glennie, Deanna M. Grote, Stephen M. Ansell, Henry Marsh and Tibor Keler

Clin Cancer Res July 15 2012 18 (14) 3812-3821; DOI:10.1158/1078-0432.CCR-11-3308
Cancer Therapy: Preclinical

Elevation of c-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor–Targeted Therapy

Clare McCourt, Pamela Maxwell, Roberta Mazzucchelli, Rodolfo Montironi, Marina Scarpelli, Manuel Salto-Tellez, Joe M. O'Sullivan, Daniel B. Longley and David J.J. Waugh

Clin Cancer Res July 15 2012 18 (14) 3822-3833; DOI:10.1158/1078-0432.CCR-11-3277
Cancer Therapy: Preclinical

Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity

Deryk Loo, Ralph F. Alderson, Francine Z. Chen, Ling Huang, Wenjun Zhang, Sergey Gorlatov, Steve Burke, Valentina Ciccarone, Hua Li, Yinhua Yang, Tom Son, Yan Chen, Ann N. Easton, Jonathan C. Li, Jill R. Rillema, Monica Licea, Claudia Fieger, Tony W. Liang, Jennie P. Mather, Scott Koenig, Stanford J. Stewart, Syd Johnson, Ezio Bonvini and Paul A. Moore

Clin Cancer Res July 15 2012 18 (14) 3834-3845; DOI:10.1158/1078-0432.CCR-12-0715
Cancer Therapy: Preclinical

Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response

Harvey Wong, Edna F. Choo, Bruno Alicke, Xiao Ding, Hank La, Erin McNamara, Frank-Peter Theil, Jay Tibbitts, Lori S. Friedman, Cornelis E.C.A. Hop and Stephen E. Gould

Clin Cancer Res July 15 2012 18 (14) 3846-3855; DOI:10.1158/1078-0432.CCR-12-0738
Cancer Therapy: Preclinical

Anti-Myeloma Effects of the Novel Anthracycline Derivative INNO-206

Eric Sanchez, Mingjie Li, Cathy Wang, Cydney M. Nichols, Jennifer Li, Haiming Chen and James R. Berenson

Clin Cancer Res July 15 2012 18 (14) 3856-3867; DOI:10.1158/1078-0432.CCR-11-3130
Cancer Therapy: Preclinical

Brachyury, a Driver of the Epithelial–Mesenchymal Transition, Is Overexpressed in Human Lung Tumors: An Opportunity for Novel Interventions against Lung Cancer

Mario Roselli, Romaine I. Fernando, Fiorella Guadagni, Antonella Spila, Jhessica Alessandroni, Raffaele Palmirotta, Leopoldo Costarelli, Mary Litzinger, Duane Hamilton, Bruce Huang, Joanne Tucker, Kwong-Yok Tsang, Jeffrey Schlom and Claudia Palena

Clin Cancer Res July 15 2012 18 (14) 3868-3879; DOI:10.1158/1078-0432.CCR-11-3211
Cancer Therapy: Preclinical

Targeting Fibroblast Growth Factor Receptor Signaling Inhibits Prostate Cancer Progression

Shu Feng, Longjiang Shao, Wendong Yu, Paul Gavine and Michael Ittmann

Clin Cancer Res July 15 2012 18 (14) 3880-3888; DOI:10.1158/1078-0432.CCR-11-3214
Cancer Therapy: Preclinical

Resistance to TRAIL Is Mediated by DARPP-32 in Gastric Cancer

Abbes Belkhiri, Shoumin Zhu, Zheng Chen, Mohammed Soutto and Wael El-Rifai

Clin Cancer Res July 15 2012 18 (14) 3889-3900; DOI:10.1158/1078-0432.CCR-11-3182
Cancer Therapy: Preclinical

GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death In Vitro and In Vivo

Jeffrey J. Wallin, Jane Guan, Wei Wei Prior, Leslie B. Lee, Leanne Berry, Lisa D. Belmont, Hartmut Koeppen, Marcia Belvin, Lori S. Friedman and Deepak Sampath

Clin Cancer Res July 15 2012 18 (14) 3901-3911; DOI:10.1158/1078-0432.CCR-11-2088
Cancer Therapy: Preclinical

AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Timothy A. Yap, Mike I. Walton, Kyla M. Grimshaw, Robert H. te Poele, Paul D. Eve, Melanie R. Valenti, Alexis K. de Haven Brandon, Vanessa Martins, Anna Zetterlund, Simon P. Heaton, Kathrin Heinzmann, Paul S. Jones, Ruth E. Feltell, Matthias Reule, Steven J. Woodhead, Thomas G. Davies, John F. Lyons, Florence I. Raynaud, Suzanne A. Eccles, Paul Workman, Neil T. Thompson and Michelle D. Garrett

Clin Cancer Res July 15 2012 18 (14) 3912-3923; DOI:10.1158/1078-0432.CCR-11-3313
Cancer Therapy: Preclinical

Vandetanib, an Inhibitor of VEGF Receptor-2 and EGF Receptor, Suppresses Tumor Development and Improves Prognosis of Liver Cancer in Mice

Kinya Inoue, Takuji Torimura, Toru Nakamura, Hideki Iwamoto, Hiroshi Masuda, Mitsuhiko Abe, Osamu Hashimoto, Hironori Koga, Takato Ueno, Hirohisa Yano and Michio Sata

Clin Cancer Res July 15 2012 18 (14) 3924-3933; DOI:10.1158/1078-0432.CCR-11-2041

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis | Free Article

Pyrophosphorolysis-Activated Polymerization Detects Circulating Tumor DNA in Metastatic Uveal Melanoma

Jordan Madic, Sophie Piperno-Neumann, Vincent Servois, Aurore Rampanou, Maud Milder, Bénédicte Trouiller, David Gentien, Stéphanie Saada, Franck Assayag, Aurélie Thuleau, Fariba Nemati, Didier Decaudin, François-Clément Bidard, Laurence Desjardins, Pascale Mariani, Olivier Lantz and Marc-Henri Stern

Clin Cancer Res July 15 2012 18 (14) 3934-3941; DOI:10.1158/1078-0432.CCR-12-0309
Imaging, Diagnosis, Prognosis

A Replication Study and Genome-Wide Scan of Single-Nucleotide Polymorphisms Associated with Pancreatic Cancer Risk and Overall Survival

Jason A. Willis, Sara H. Olson, Irene Orlow, Semanti Mukherjee, Robert R. McWilliams, Robert C. Kurtz and Robert J. Klein

Clin Cancer Res July 15 2012 18 (14) 3942-3951; DOI:10.1158/1078-0432.CCR-11-2856
Imaging, Diagnosis, Prognosis

Multisite Validation Study to Determine Performance Characteristics of a 92-Gene Molecular Cancer Classifier

Sarah E. Kerr, Catherine A. Schnabel, Peggy S. Sullivan, Yi Zhang, Veena Singh, Brittany Carey, Mark G. Erlander, W. Edward Highsmith, Sarah M. Dry and Elena F. Brachtel

Clin Cancer Res July 15 2012 18 (14) 3952-3960; DOI:10.1158/1078-0432.CCR-12-0920

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Rapid Angiogenesis Onset after Discontinuation of Sunitinib Treatment of Renal Cell Carcinoma Patients

Arjan W. Griffioen, Laurie A. Mans, Annemarie M.A. de Graaf, Patrycja Nowak-Sliwinska, Céline L.M.M. de Hoog, Trees A.M. de Jong, Florry A. Vyth-Dreese, Judy R. van Beijnum, Axel Bex and Eric Jonasch

Clin Cancer Res July 15 2012 18 (14) 3961-3971; DOI:10.1158/1078-0432.CCR-12-0002

Predictive Biomarkers and Personalized Medicine

Predictive Biomarkers and Personalized Medicine

Predictive Value of XRCC1 Gene Polymorphisms on Platinum-Based Chemotherapy in Advanced Non–Small Cell Lung Cancer Patients: A Systematic Review and Meta-analysis

Junjie Wu, Jie Liu, Yuhao Zhou, Jun Ying, Houdong Zou, Shicheng Guo, Lei Wang, Naiqing Zhao, Jianjun Hu, Daru Lu, Li Jin, Qiang Li and Jiu-Cun Wang

Clin Cancer Res July 15 2012 18 (14) 3972-3981; DOI:10.1158/1078-0432.CCR-11-1531
Predictive Biomarkers and Personalized Medicine

Genetic Polymorphisms in MicroRNA-Related Genes as Predictors of Clinical Outcomes in Colorectal Adenocarcinoma Patients

Moubin Lin, Jian Gu, Cathy Eng, Lee M. Ellis, Michelle A. Hildebrandt, Jie Lin, Maosheng Huang, George A. Calin, Dingzhi Wang, Raymond N. DuBois, Ernest T. Hawk and Xifeng Wu

Clin Cancer Res July 15 2012 18 (14) 3982-3991; DOI:10.1158/1078-0432.CCR-11-2951
Predictive Biomarkers and Personalized Medicine

Serum Insulin-Like Growth Factor-1 Levels Predict Outcomes of Patients with Advanced Hepatocellular Carcinoma Receiving Antiangiogenic Therapy

Yu-Yun Shao, Chien-Chung Huang, Shiou-Der Lin, Chih-Hung Hsu and Ann-Lii Cheng

Clin Cancer Res July 15 2012 18 (14) 3992-3997; DOI:10.1158/1078-0432.CCR-11-2853

Correction

Correction

Correction: A Phase I Trial of Erlotinib and Concurrent Chemoradiotherapy for Stage III and IV (M0) Squamous Cell Carcinoma of the Head and Neck

Clin Cancer Res July 15 2012 18 (14) 3998-3998; DOI:10.1158/1078-0432.CCR-12-1736

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Table of Contents

Highlights

CCR Translations

CCR Perspectives in Drug Approval

Statistics in Clinical Cancer Research

CCR Drug Updates

Molecular Pathways

Review

Human Cancer Biology

Cancer Therapy: Preclinical

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Predictive Biomarkers and Personalized Medicine

Correction

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