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Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res July 15 2012 18 (14) 3717-3717;

CCR Translations

  • CCR Translations
    Mind the Gap: Potential for Rebounds during Antiangiogenic Treatment Breaks
    John M.L. Ebos and Roberto Pili
    Clin Cancer Res July 15 2012 18 (14) 3719-3721; DOI:10.1158/1078-0432.CCR-12-1459

CCR Perspectives in Drug Approval

  • CCR Perspectives in Drug Approval
    Vandetanib for the Treatment of Symptomatic or Progressive Medullary Thyroid Cancer in Patients with Unresectable Locally Advanced or Metastatic Disease: U.S. Food and Drug Administration Drug Approval Summary
    Katherine Thornton, Geoffrey Kim, V. Ellen Maher, Somesh Chattopadhyay, Shenghui Tang, Young Jin Moon, Pengfei Song, Anshu Marathe, Suchitra Balakrishnan, Hao Zhu, Christine Garnett, Qi Liu, Brian Booth, Brenda Gehrke, Robert Dorsam, Leigh Verbois, Debasis Ghosh, Wendy Wilson, John Duan, Haripada Sarker, Sarah Pope Miksinski, Lisa Skarupa, Amna Ibrahim, Robert Justice, Anthony Murgo and Richard Pazdur
    Clin Cancer Res July 15 2012 18 (14) 3722-3730; DOI:10.1158/1078-0432.CCR-12-0411

Statistics in Clinical Cancer Research

  • Statistics in Clinical Cancer Research
    Cure Models as a Useful Statistical Tool for Analyzing Survival
    Megan Othus, Bart Barlogie, Michael L. LeBlanc and John J. Crowley
    Clin Cancer Res July 15 2012 18 (14) 3731-3736; DOI:10.1158/1078-0432.CCR-11-2859

CCR Drug Updates

  • CCR Drug Updates
    Crizotinib for ALK-Rearranged Non–Small Cell Lung Cancer: A New Targeted Therapy for a New Target
    Leena Gandhi and Pasi A. Jänne
    Clin Cancer Res July 15 2012 18 (14) 3737-3742; DOI:10.1158/1078-0432.CCR-11-2393

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: Targeting P21-Activated Kinase 1 Signaling in Cancer—Opportunities, Challenges, and Limitations
    Jeyanthy Eswaran, Da-Qiang Li, Anil Shah and Rakesh Kumar
    Clin Cancer Res July 15 2012 18 (14) 3743-3749; DOI:10.1158/1078-0432.CCR-11-1952

Review

  • Review
    Combining Antiangiogenics to Overcome Resistance: Rationale and Clinical Experience
    Victor Moreno Garcia, Bristi Basu, L. Rhoda Molife and Stan B. Kaye
    Clin Cancer Res July 15 2012 18 (14) 3750-3761; DOI:10.1158/1078-0432.CCR-11-1275

Human Cancer Biology

  • Human Cancer Biology
    Tumor-Associated Macrophages in Pediatric Classical Hodgkin Lymphoma: Association with Epstein-Barr Virus, Lymphocyte Subsets, and Prognostic Impact
    Mário Henrique M. Barros, Rocio Hassan and Gerald Niedobitek
    Clin Cancer Res July 15 2012 18 (14) 3762-3771; DOI:10.1158/1078-0432.CCR-12-0129

  • Human Cancer Biology
    Defective Epidermal Innate Immunity and Resultant Superficial Dermatophytosis in Adult T-cell Leukemia/Lymphoma
    Yu Sawada, Motonobu Nakamura, Rieko Kabashima-Kubo, Takatoshi Shimauchi, Miwa Kobayashi and Yoshiki Tokura
    Clin Cancer Res July 15 2012 18 (14) 3772-3779; DOI:10.1158/1078-0432.CCR-12-0292

  • Human Cancer Biology
    FGFR4 Blockade Exerts Distinct Antitumorigenic Effects in Human Embryonal versus Alveolar Rhabdomyosarcoma
    Lisa E.S. Crose, Katherine T. Etheridge, Candy Chen, Brian Belyea, Lindsay J. Talbot, Rex C. Bentley and Corinne M. Linardic
    Clin Cancer Res July 15 2012 18 (14) 3780-3790; DOI:10.1158/1078-0432.CCR-10-3063

  • Human Cancer Biology
    Integrative Genomic Analysis Implicates Gain of PIK3CA at 3q26 and MYC at 8q24 in Chronic Lymphocytic Leukemia
    Jennifer R. Brown, Megan Hanna, Bethany Tesar, Lillian Werner, Nathalie Pochet, John M. Asara, Yaoyu E. Wang, Paola dal Cin, Stacey M. Fernandes, Christina Thompson, Laura MacConaill, Catherine J. Wu, Yves Van de Peer, Mick Correll, Aviv Regev, Donna Neuberg and Arnold S. Freedman
    Clin Cancer Res July 15 2012 18 (14) 3791-3802; DOI:10.1158/1078-0432.CCR-11-2342

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Development and Characterization of a Novel CD19CherryLuciferase (CD19CL) Transgenic Mouse for the Preclinical Study of B-Cell Lymphomas
    Luigi Scotto, Marianna Kruithof-de Julio, Luca Paoluzzi, Matko Kalac, Enrica Marchi, Jairo Baquero Buitrago, Jennifer Amengual, Michael M. Shen and Owen A. O'Connor
    Clin Cancer Res July 15 2012 18 (14) 3803-3811; DOI:10.1158/1078-0432.CCR-11-2588

  • Cancer Therapy: Preclinical
    Development of a Human Monoclonal Antibody for Potential Therapy of CD27-Expressing Lymphoma and Leukemia
    Laura A. Vitale, Li-Zhen He, Lawrence J. Thomas, Jennifer Widger, Jeffrey Weidlick, Andrea Crocker, Thomas O'Neill, James Storey, Martin J. Glennie, Deanna M. Grote, Stephen M. Ansell, Henry Marsh and Tibor Keler
    Clin Cancer Res July 15 2012 18 (14) 3812-3821; DOI:10.1158/1078-0432.CCR-11-3308

  • Cancer Therapy: Preclinical
    Elevation of c-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor–Targeted Therapy
    Clare McCourt, Pamela Maxwell, Roberta Mazzucchelli, Rodolfo Montironi, Marina Scarpelli, Manuel Salto-Tellez, Joe M. O'Sullivan, Daniel B. Longley and David J.J. Waugh
    Clin Cancer Res July 15 2012 18 (14) 3822-3833; DOI:10.1158/1078-0432.CCR-11-3277

  • Cancer Therapy: Preclinical
    Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity
    Deryk Loo, Ralph F. Alderson, Francine Z. Chen, Ling Huang, Wenjun Zhang, Sergey Gorlatov, Steve Burke, Valentina Ciccarone, Hua Li, Yinhua Yang, Tom Son, Yan Chen, Ann N. Easton, Jonathan C. Li, Jill R. Rillema, Monica Licea, Claudia Fieger, Tony W. Liang, Jennie P. Mather, Scott Koenig, Stanford J. Stewart, Syd Johnson, Ezio Bonvini and Paul A. Moore
    Clin Cancer Res July 15 2012 18 (14) 3834-3845; DOI:10.1158/1078-0432.CCR-12-0715

  • Cancer Therapy: Preclinical
    Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response
    Harvey Wong, Edna F. Choo, Bruno Alicke, Xiao Ding, Hank La, Erin McNamara, Frank-Peter Theil, Jay Tibbitts, Lori S. Friedman, Cornelis E.C.A. Hop and Stephen E. Gould
    Clin Cancer Res July 15 2012 18 (14) 3846-3855; DOI:10.1158/1078-0432.CCR-12-0738

  • Cancer Therapy: Preclinical
    Anti-Myeloma Effects of the Novel Anthracycline Derivative INNO-206
    Eric Sanchez, Mingjie Li, Cathy Wang, Cydney M. Nichols, Jennifer Li, Haiming Chen and James R. Berenson
    Clin Cancer Res July 15 2012 18 (14) 3856-3867; DOI:10.1158/1078-0432.CCR-11-3130

  • Cancer Therapy: Preclinical
    Brachyury, a Driver of the Epithelial–Mesenchymal Transition, Is Overexpressed in Human Lung Tumors: An Opportunity for Novel Interventions against Lung Cancer
    Mario Roselli, Romaine I. Fernando, Fiorella Guadagni, Antonella Spila, Jhessica Alessandroni, Raffaele Palmirotta, Leopoldo Costarelli, Mary Litzinger, Duane Hamilton, Bruce Huang, Joanne Tucker, Kwong-Yok Tsang, Jeffrey Schlom and Claudia Palena
    Clin Cancer Res July 15 2012 18 (14) 3868-3879; DOI:10.1158/1078-0432.CCR-11-3211

  • Cancer Therapy: Preclinical
    Targeting Fibroblast Growth Factor Receptor Signaling Inhibits Prostate Cancer Progression
    Shu Feng, Longjiang Shao, Wendong Yu, Paul Gavine and Michael Ittmann
    Clin Cancer Res July 15 2012 18 (14) 3880-3888; DOI:10.1158/1078-0432.CCR-11-3214

  • Cancer Therapy: Preclinical
    Resistance to TRAIL Is Mediated by DARPP-32 in Gastric Cancer
    Abbes Belkhiri, Shoumin Zhu, Zheng Chen, Mohammed Soutto and Wael El-Rifai
    Clin Cancer Res July 15 2012 18 (14) 3889-3900; DOI:10.1158/1078-0432.CCR-11-3182

  • Cancer Therapy: Preclinical
    GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death In Vitro and In Vivo
    Jeffrey J. Wallin, Jane Guan, Wei Wei Prior, Leslie B. Lee, Leanne Berry, Lisa D. Belmont, Hartmut Koeppen, Marcia Belvin, Lori S. Friedman and Deepak Sampath
    Clin Cancer Res July 15 2012 18 (14) 3901-3911; DOI:10.1158/1078-0432.CCR-11-2088

  • Cancer Therapy: Preclinical
    AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
    Timothy A. Yap, Mike I. Walton, Kyla M. Grimshaw, Robert H. te Poele, Paul D. Eve, Melanie R. Valenti, Alexis K. de Haven Brandon, Vanessa Martins, Anna Zetterlund, Simon P. Heaton, Kathrin Heinzmann, Paul S. Jones, Ruth E. Feltell, Matthias Reule, Steven J. Woodhead, Thomas G. Davies, John F. Lyons, Florence I. Raynaud, Suzanne A. Eccles, Paul Workman, Neil T. Thompson and Michelle D. Garrett
    Clin Cancer Res July 15 2012 18 (14) 3912-3923; DOI:10.1158/1078-0432.CCR-11-3313

  • Cancer Therapy: Preclinical
    Vandetanib, an Inhibitor of VEGF Receptor-2 and EGF Receptor, Suppresses Tumor Development and Improves Prognosis of Liver Cancer in Mice
    Kinya Inoue, Takuji Torimura, Toru Nakamura, Hideki Iwamoto, Hiroshi Masuda, Mitsuhiko Abe, Osamu Hashimoto, Hironori Koga, Takato Ueno, Hirohisa Yano and Michio Sata
    Clin Cancer Res July 15 2012 18 (14) 3924-3933; DOI:10.1158/1078-0432.CCR-11-2041

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis | Free Article
    Pyrophosphorolysis-Activated Polymerization Detects Circulating Tumor DNA in Metastatic Uveal Melanoma
    Jordan Madic, Sophie Piperno-Neumann, Vincent Servois, Aurore Rampanou, Maud Milder, Bénédicte Trouiller, David Gentien, Stéphanie Saada, Franck Assayag, Aurélie Thuleau, Fariba Nemati, Didier Decaudin, François-Clément Bidard, Laurence Desjardins, Pascale Mariani, Olivier Lantz and Marc-Henri Stern
    Clin Cancer Res July 15 2012 18 (14) 3934-3941; DOI:10.1158/1078-0432.CCR-12-0309

  • Imaging, Diagnosis, Prognosis
    A Replication Study and Genome-Wide Scan of Single-Nucleotide Polymorphisms Associated with Pancreatic Cancer Risk and Overall Survival
    Jason A. Willis, Sara H. Olson, Irene Orlow, Semanti Mukherjee, Robert R. McWilliams, Robert C. Kurtz and Robert J. Klein
    Clin Cancer Res July 15 2012 18 (14) 3942-3951; DOI:10.1158/1078-0432.CCR-11-2856

  • Imaging, Diagnosis, Prognosis
    Multisite Validation Study to Determine Performance Characteristics of a 92-Gene Molecular Cancer Classifier
    Sarah E. Kerr, Catherine A. Schnabel, Peggy S. Sullivan, Yi Zhang, Veena Singh, Brittany Carey, Mark G. Erlander, W. Edward Highsmith, Sarah M. Dry and Elena F. Brachtel
    Clin Cancer Res July 15 2012 18 (14) 3952-3960; DOI:10.1158/1078-0432.CCR-12-0920

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Rapid Angiogenesis Onset after Discontinuation of Sunitinib Treatment of Renal Cell Carcinoma Patients
    Arjan W. Griffioen, Laurie A. Mans, Annemarie M.A. de Graaf, Patrycja Nowak-Sliwinska, Céline L.M.M. de Hoog, Trees A.M. de Jong, Florry A. Vyth-Dreese, Judy R. van Beijnum, Axel Bex and Eric Jonasch
    Clin Cancer Res July 15 2012 18 (14) 3961-3971; DOI:10.1158/1078-0432.CCR-12-0002

Predictive Biomarkers and Personalized Medicine

  • Predictive Biomarkers and Personalized Medicine
    Predictive Value of XRCC1 Gene Polymorphisms on Platinum-Based Chemotherapy in Advanced Non–Small Cell Lung Cancer Patients: A Systematic Review and Meta-analysis
    Junjie Wu, Jie Liu, Yuhao Zhou, Jun Ying, Houdong Zou, Shicheng Guo, Lei Wang, Naiqing Zhao, Jianjun Hu, Daru Lu, Li Jin, Qiang Li and Jiu-Cun Wang
    Clin Cancer Res July 15 2012 18 (14) 3972-3981; DOI:10.1158/1078-0432.CCR-11-1531

  • Predictive Biomarkers and Personalized Medicine
    Genetic Polymorphisms in MicroRNA-Related Genes as Predictors of Clinical Outcomes in Colorectal Adenocarcinoma Patients
    Moubin Lin, Jian Gu, Cathy Eng, Lee M. Ellis, Michelle A. Hildebrandt, Jie Lin, Maosheng Huang, George A. Calin, Dingzhi Wang, Raymond N. DuBois, Ernest T. Hawk and Xifeng Wu
    Clin Cancer Res July 15 2012 18 (14) 3982-3991; DOI:10.1158/1078-0432.CCR-11-2951

  • Predictive Biomarkers and Personalized Medicine
    Serum Insulin-Like Growth Factor-1 Levels Predict Outcomes of Patients with Advanced Hepatocellular Carcinoma Receiving Antiangiogenic Therapy
    Yu-Yun Shao, Chien-Chung Huang, Shiou-Der Lin, Chih-Hung Hsu and Ann-Lii Cheng
    Clin Cancer Res July 15 2012 18 (14) 3992-3997; DOI:10.1158/1078-0432.CCR-11-2853

Correction

  • Correction
    Correction: A Phase I Trial of Erlotinib and Concurrent Chemoradiotherapy for Stage III and IV (M0) Squamous Cell Carcinoma of the Head and Neck
    Clin Cancer Res July 15 2012 18 (14) 3998-3998; DOI:10.1158/1078-0432.CCR-12-1736

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Clinical Cancer Research: 18 (14)
July 2012
Volume 18, Issue 14
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  • Table of Contents (PDF)
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Issue Highlights

  • Elevation of c-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor–Targeted Therapy
  • Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity
  • Tumor-Associated Macrophages in Pediatric Classical Hodgkin Lymphoma: Association with Epstein-Barr Virus, Lymphocyte Subsets, and Prognostic Impact
  • Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response
  • Pyrophosphorolysis-Activated Polymerization Detects Circulating Tumor DNA in Metastatic Uveal Melanoma

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Clinical Cancer Research
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ISSN: 1078-0432

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