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Clinical Cancer Research
Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res September 15 2012 18 (18) 4863-4863;

CCR Translations

  • CCR Translations
    Hidden Dangers: A Cryptic Exon Disrupts BRCA2 mRNA
    James D. Fackenthal, Younghee Lee and Olufunmilayo I. Olopade
    Clin Cancer Res September 15 2012 18 (18) 4865-4867; DOI:10.1158/1078-0432.CCR-12-2090

  • CCR Translations
    Aflibercept in Pediatric Solid Tumors: Moving Beyond the Trap
    Cindy H. Chau and William D. Figg
    Clin Cancer Res September 15 2012 18 (18) 4868-4871; DOI:10.1158/1078-0432.CCR-12-2212

Statistics in Clinical Cancer Research

  • Statistics in Clinical Cancer Research
    Overestimation of the Effect Size in Group Sequential Trials
    Jenny J. Zhang, Gideon M. Blumenthal, Kun He, Shenghui Tang, Patricia Cortazar and Rajeshwari Sridhara
    Clin Cancer Res September 15 2012 18 (18) 4872-4876; DOI:10.1158/1078-0432.CCR-11-3118

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: Tumor-Infiltrating Myeloid Cells and Reactive Oxygen Species in Regulation of Tumor Microenvironment
    Tangying Lu and Dmitry I. Gabrilovich
    Clin Cancer Res September 15 2012 18 (18) 4877-4882; DOI:10.1158/1078-0432.CCR-11-2939

  • Molecular Pathways
    Molecular Pathways: The Hedgehog Signaling Pathway in Cancer
    Ross McMillan and William Matsui
    Clin Cancer Res September 15 2012 18 (18) 4883-4888; DOI:10.1158/1078-0432.CCR-11-2509

Perspective

  • Perspective
    Personalized Nanomedicine
    Twan Lammers, Larissa Y. Rizzo, Gert Storm and Fabian Kiessling
    Clin Cancer Res September 15 2012 18 (18) 4889-4894; DOI:10.1158/1078-0432.CCR-12-1414

Review

  • Review
    A New Approach to Reducing Postsurgical Cancer Recurrence: Perioperative Targeting of Catecholamines and Prostaglandins
    Elad Neeman, Oded Zmora and Shamgar Ben-Eliyahu
    Clin Cancer Res September 15 2012 18 (18) 4895-4902; DOI:10.1158/1078-0432.CCR-12-1087

Human Cancer Biology

  • Human Cancer Biology
    BRCA2 Deep Intronic Mutation Causing Activation of a Cryptic Exon: Opening toward a New Preventive Therapeutic Strategy
    Olga Anczuków, Monique Buisson, Mélanie Léoné, Christine Coutanson, Christine Lasset, Alain Calender, Olga M. Sinilnikova and Sylvie Mazoyer
    Clin Cancer Res September 15 2012 18 (18) 4903-4909; DOI:10.1158/1078-0432.CCR-12-1100

  • Human Cancer Biology
    Prevalence, Clinicopathologic Associations, and Molecular Spectrum of ERBB2 (HER2) Tyrosine Kinase Mutations in Lung Adenocarcinomas
    Maria E. Arcila, Jamie E. Chaft, Khedoudja Nafa, Sinchita Roy-Chowdhuri, Christopher Lau, Michael Zaidinski, Paul K. Paik, Maureen F. Zakowski, Mark G. Kris and Marc Ladanyi
    Clin Cancer Res September 15 2012 18 (18) 4910-4918; DOI:10.1158/1078-0432.CCR-12-0912

  • Human Cancer Biology
    The Rectal Cancer microRNAome – microRNA Expression in Rectal Cancer and Matched Normal Mucosa
    Jochen Gaedcke, Marian Grade, Jordi Camps, Rolf Søkilde, Bogumil Kaczkowski, Aaron J. Schetter, Michael J. Difilippantonio, Curtis C. Harris, B. Michael Ghadimi, Søren Møller, Tim Beissbarth, Thomas Ried and Thomas Litman
    Clin Cancer Res September 15 2012 18 (18) 4919-4930; DOI:10.1158/1078-0432.CCR-12-0016

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV
    Ji Young Yoo, Jason Pradarelli, Amy Haseley, Jeffrey Wojton, Azeem Kaka, Anna Bratasz, Christopher A. Alvarez-Breckenridge, Jun-Ge Yu, Kimerly Powell, Andrew P. Mazar, Theodoros N. Teknos, E. Antonio Chiocca, Joseph C. Glorioso, Matthew Old and Balveen Kaur
    Clin Cancer Res September 15 2012 18 (18) 4931-4941; DOI:10.1158/1078-0432.CCR-12-0697

  • Cancer Therapy: Preclinical
    Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine
    Sahdeo Prasad, Vivek R. Yadav, Bokyung Sung, Simone Reuter, Ramaswamy Kannappan, Amit Deorukhkar, Parmeswaran Diagaradjane, Caimiao Wei, Veerabhadran Baladandayuthapani, Sunil Krishnan, Sushovan Guha and Bharat B. Aggarwal
    Clin Cancer Res September 15 2012 18 (18) 4942-4953; DOI:10.1158/1078-0432.CCR-11-2805

  • Cancer Therapy: Preclinical
    Vitamin E Protects against Lipid Peroxidation and Rescues Tumorigenic Phenotypes in Cowden/Cowden-like Patient-Derived Lymphoblast Cells with Germline SDHx Variants
    Ying Ni and Charis Eng
    Clin Cancer Res September 15 2012 18 (18) 4954-4961; DOI:10.1158/1078-0432.CCR-12-1055

  • Cancer Therapy: Preclinical
    Reovirus as a Viable Therapeutic Option for the Treatment of Multiple Myeloma
    Chandini M. Thirukkumaran, Zhong Qiao Shi, Joanne Luider, Karen Kopciuk, He Gao, Nizar Bahlis, Paola Neri, Mark Pho, Douglas Stewart, Adnan Mansoor and Don G. Morris
    Clin Cancer Res September 15 2012 18 (18) 4962-4972; DOI:10.1158/1078-0432.CCR-11-3085

  • Cancer Therapy: Preclinical
    Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer
    Takeshi Shimamura, Samanthi A. Perera, Kevin P. Foley, Jim Sang, Scott J. Rodig, Takayo Inoue, Liang Chen, Danan Li, Julian Carretero, Yu-Chen Li, Papiya Sinha, Christopher D. Carey, Christa L. Borgman, John-Paul Jimenez, Matthew Meyerson, Weiwen Ying, James Barsoum, Kwok-Kin Wong and Geoffrey I. Shapiro
    Clin Cancer Res September 15 2012 18 (18) 4973-4985; DOI:10.1158/1078-0432.CCR-11-2967

  • Cancer Therapy: Preclinical
    Targeting Stat3 Abrogates EGFR Inhibitor Resistance in Cancer
    Malabika Sen, Sonali Joyce, Mary Panahandeh, Changyou Li, Sufi M. Thomas, Jessica Maxwell, Lin Wang, William E. Gooding, Daniel E. Johnson and Jennifer R. Grandis
    Clin Cancer Res September 15 2012 18 (18) 4986-4996; DOI:10.1158/1078-0432.CCR-12-0792

  • Cancer Therapy: Preclinical
    Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib
    Anja Lachenmayer, Clara Alsinet, Radoslav Savic, Laia Cabellos, Sara Toffanin, Yujin Hoshida, Augusto Villanueva, Beatriz Minguez, Philippa Newell, Hung-Wen Tsai, Jordi Barretina, Swan Thung, Stephen C. Ward, Jordi Bruix, Vincenzo Mazzaferro, Myron Schwartz, Scott L. Friedman and Josep M. Llovet
    Clin Cancer Res September 15 2012 18 (18) 4997-5007; DOI:10.1158/1078-0432.CCR-11-2322

  • Cancer Therapy: Preclinical
    Biomarker and Pharmacologic Evaluation of the γ-Secretase Inhibitor PF-03084014 in Breast Cancer Models
    Cathy C. Zhang, Adam Pavlicek, Qin Zhang, Maruja E. Lira, Cory L. Painter, Zhengming Yan, Xianxian Zheng, Nathan V. Lee, Mark Ozeck, Ming Qiu, Qing Zong, Patrick B. Lappin, Anthony Wong, Paul A. Rejto, Tod Smeal and James G. Christensen
    Clin Cancer Res September 15 2012 18 (18) 5008-5019; DOI:10.1158/1078-0432.CCR-12-1379

  • Cancer Therapy: Preclinical | Free Article
    Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target
    Ami V. Patel, David Eaves, Walter J. Jessen, Tilat A. Rizvi, Jeffrey A. Ecsedy, Mark G. Qian, Bruce J. Aronow, John P. Perentesis, Eduard Serra, Timothy P. Cripe, Shyra J. Miller and Nancy Ratner
    Clin Cancer Res September 15 2012 18 (18) 5020-5030; DOI:10.1158/1078-0432.CCR-12-1072

  • Cancer Therapy: Preclinical
    Apricoxib, a Novel Inhibitor of COX-2, Markedly Improves Standard Therapy Response in Molecularly Defined Models of Pancreatic Cancer
    Amanda Kirane, Jason E. Toombs, Katherine Ostapoff, Juliet G. Carbon, Sara Zaknoen, Jordan Braunfeld, Roderich E. Schwarz, Francis J. Burrows and Rolf A. Brekken
    Clin Cancer Res September 15 2012 18 (18) 5031-5042; DOI:10.1158/1078-0432.CCR-12-0453

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    A Multicenter Phase II Study of Single-Agent Enzastaurin in Previously Treated Waldenström Macroglobulinemia
    Irene M. Ghobrial, Philippe Moreau, Brianna Harris, Tiffany Poon, Eric Jourdan, Hervé Maisonneuve, Karim A. Benhadji, Anwar M. Hossain, Tuan S. Nguyen, James E. Wooldridge and Veronique Leblond
    Clin Cancer Res September 15 2012 18 (18) 5043-5050; DOI:10.1158/1078-0432.CCR-12-0181

  • Cancer Therapy: Clinical
    Long-term Outcomes of 1,263 Patients with Mycosis Fungoides and Sézary Syndrome from 1982 to 2009
    Rakhshandra Talpur, Lotika Singh, Seema Daulat, Ping Liu, Sarah Seyfer, Tanya Trynosky, Wei Wei and Madeleine Duvic
    Clin Cancer Res September 15 2012 18 (18) 5051-5060; DOI:10.1158/1078-0432.CCR-12-0604

  • Cancer Therapy: Clinical
    Cytolytic Virus Activation Therapy for Epstein-Barr Virus–Driven Tumors
    Maarten A. Wildeman, Zlata Novalić, Sandra A.W.M. Verkuijlen, Hedy Juwana, Alwin D.R. Huitema, I. Bing Tan, Jaap M. Middeldorp, Jan Paul de Boer and Astrid E. Greijer
    Clin Cancer Res September 15 2012 18 (18) 5061-5070; DOI:10.1158/1078-0432.CCR-12-0574

  • Cancer Therapy: Clinical
    A Tumor Growth Inhibition Model for Low-Grade Glioma Treated with Chemotherapy or Radiotherapy
    Benjamin Ribba, Gentian Kaloshi, Mathieu Peyre, Damien Ricard, Vincent Calvez, Michel Tod, Branka Čajavec-Bernard, Ahmed Idbaih, Dimitri Psimaras, Linda Dainese, Johan Pallud, Stéphanie Cartalat-Carel, Jean-Yves Delattre, Jérôme Honnorat, Emmanuel Grenier and François Ducray
    Clin Cancer Res September 15 2012 18 (18) 5071-5080; DOI:10.1158/1078-0432.CCR-12-0084

  • Cancer Therapy: Clinical
    A Phase I Trial and Pharmacokinetic Study of Aflibercept (VEGF Trap) in Children with Refractory Solid Tumors: A Children's Oncology Group Phase I Consortium Report
    Julia Glade Bender, Susan M. Blaney, Scott Borinstein, Joel M. Reid, Sylvain Baruchel, Charlotte Ahern, Ashish M. Ingle, Darrell J. Yamashiro, Alice Chen, Brenda Weigel, Peter C. Adamson and Julie R. Park
    Clin Cancer Res September 15 2012 18 (18) 5081-5089; DOI:10.1158/1078-0432.CCR-12-0078

  • Cancer Therapy: Clinical
    A Phase I Dose-Escalation Trial of Trastuzumab and Alvespimycin Hydrochloride (KOS-1022; 17 DMAG) in the Treatment of Advanced Solid Tumors
    Komal Jhaveri, Kathy Miller, Lee Rosen, Bryan Schneider, Linnea Chap, Alison Hannah, Ziyang Zhong, Weining Ma, Clifford Hudis and Shanu Modi
    Clin Cancer Res September 15 2012 18 (18) 5090-5098; DOI:10.1158/1078-0432.CCR-11-3200

Predictive Biomarkers and Personalized Medicine

  • Predictive Biomarkers and Personalized Medicine
    A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101
    R. Michael Baldwin, Kouros Owzar, Hitoshi Zembutsu, Aparna Chhibber, Michiaki Kubo, Chen Jiang, Dorothy Watson, Rachel J. Eclov, Joel Mefford, Howard L. McLeod, Paula N. Friedman, Clifford A. Hudis, Eric P. Winer, Eric M. Jorgenson, John S. Witte, Lawrence N. Shulman, Yusuke Nakamura, Mark J. Ratain and Deanna L. Kroetz
    Clin Cancer Res September 15 2012 18 (18) 5099-5109; DOI:10.1158/1078-0432.CCR-12-1590

  • Predictive Biomarkers and Personalized Medicine
    RB-Pathway Disruption Is Associated with Improved Response to Neoadjuvant Chemotherapy in Breast Cancer
    Agnieszka K. Witkiewicz, Adam Ertel, Jeanne McFalls, Matias E. Valsecchi, Gordon Schwartz and Erik S. Knudsen
    Clin Cancer Res September 15 2012 18 (18) 5110-5122; DOI:10.1158/1078-0432.CCR-12-0903

  • Predictive Biomarkers and Personalized Medicine
    Contrasted Outcomes to Gefitinib on Tumoral IGF1R Expression in Head and Neck Cancer Patients Receiving Postoperative Chemoradiation (GORTEC Trial 2004-02)
    Juliette Thariat, René-Jean Bensadoun, Marie-Christine Etienne-Grimaldi, Dominique Grall, Frédérique Penault-Llorca, Olivier Dassonville, Francois Bertucci, Anne Cayre, Dominique De Raucourt, Lionnel Geoffrois, Pascal Finetti, Philippe Giraud, Séverine Racadot, Sylvain Morinière, Anne Sudaka, Ellen Van Obberghen-Schilling and Gérard Milano
    Clin Cancer Res September 15 2012 18 (18) 5123-5133; DOI:10.1158/1078-0432.CCR-12-1518

  • Predictive Biomarkers and Personalized Medicine
    Validation of a Radiosensitivity Molecular Signature in Breast Cancer
    Steven A. Eschrich, William J. Fulp, Yudi Pawitan, John A. Foekens, Marcel Smid, John W.M. Martens, Michelle Echevarria, Vidya Kamath, Ji-Hyun Lee, Eleanor E. Harris, Jonas Bergh and Javier F. Torres-Roca
    Clin Cancer Res September 15 2012 18 (18) 5134-5143; DOI:10.1158/1078-0432.CCR-12-0891

  • Predictive Biomarkers and Personalized Medicine
    Let-7 Expression Is a Significant Determinant of Response to Chemotherapy through the Regulation of IL-6/STAT3 Pathway in Esophageal Squamous Cell Carcinoma
    Keijiro Sugimura, Hiroshi Miyata, Koji Tanaka, Rie Hamano, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori and Yuichiro Doki
    Clin Cancer Res September 15 2012 18 (18) 5144-5153; DOI:10.1158/1078-0432.CCR-12-0701

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Clinical Cancer Research: 18 (18)
September 2012
Volume 18, Issue 18
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  • Table of Contents (PDF)
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Issue Highlights

  • Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target
  • Reovirus as a Viable Therapeutic Option for the Treatment of Multiple Myeloma
  • Biomarker and Pharmacologic Evaluation of the γ-Secretase Inhibitor PF-03084014 in Breast Cancer Models
  • A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101

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Clinical Cancer Research
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