Clinical Cancer Research: 18 (18)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res September 15 2012 18 (18) 4863-4863;

CCR Translations

CCR Translations

Hidden Dangers: A Cryptic Exon Disrupts BRCA2 mRNA

James D. Fackenthal, Younghee Lee and Olufunmilayo I. Olopade

Clin Cancer Res September 15 2012 18 (18) 4865-4867; DOI:10.1158/1078-0432.CCR-12-2090
CCR Translations

Aflibercept in Pediatric Solid Tumors: Moving Beyond the Trap

Cindy H. Chau and William D. Figg

Clin Cancer Res September 15 2012 18 (18) 4868-4871; DOI:10.1158/1078-0432.CCR-12-2212

Statistics in Clinical Cancer Research

Statistics in Clinical Cancer Research

Overestimation of the Effect Size in Group Sequential Trials

Jenny J. Zhang, Gideon M. Blumenthal, Kun He, Shenghui Tang, Patricia Cortazar and Rajeshwari Sridhara

Clin Cancer Res September 15 2012 18 (18) 4872-4876; DOI:10.1158/1078-0432.CCR-11-3118

Molecular Pathways

Molecular Pathways

Molecular Pathways: Tumor-Infiltrating Myeloid Cells and Reactive Oxygen Species in Regulation of Tumor Microenvironment

Tangying Lu and Dmitry I. Gabrilovich

Clin Cancer Res September 15 2012 18 (18) 4877-4882; DOI:10.1158/1078-0432.CCR-11-2939
Molecular Pathways

Molecular Pathways: The Hedgehog Signaling Pathway in Cancer

Ross McMillan and William Matsui

Clin Cancer Res September 15 2012 18 (18) 4883-4888; DOI:10.1158/1078-0432.CCR-11-2509

Perspective

Perspective

Personalized Nanomedicine

Twan Lammers, Larissa Y. Rizzo, Gert Storm and Fabian Kiessling

Clin Cancer Res September 15 2012 18 (18) 4889-4894; DOI:10.1158/1078-0432.CCR-12-1414

Review

Review

A New Approach to Reducing Postsurgical Cancer Recurrence: Perioperative Targeting of Catecholamines and Prostaglandins

Elad Neeman, Oded Zmora and Shamgar Ben-Eliyahu

Clin Cancer Res September 15 2012 18 (18) 4895-4902; DOI:10.1158/1078-0432.CCR-12-1087

Human Cancer Biology

Human Cancer Biology

BRCA2 Deep Intronic Mutation Causing Activation of a Cryptic Exon: Opening toward a New Preventive Therapeutic Strategy

Olga Anczuków, Monique Buisson, Mélanie Léoné, Christine Coutanson, Christine Lasset, Alain Calender, Olga M. Sinilnikova and Sylvie Mazoyer

Clin Cancer Res September 15 2012 18 (18) 4903-4909; DOI:10.1158/1078-0432.CCR-12-1100
Human Cancer Biology

Prevalence, Clinicopathologic Associations, and Molecular Spectrum of ERBB2 (HER2) Tyrosine Kinase Mutations in Lung Adenocarcinomas

Maria E. Arcila, Jamie E. Chaft, Khedoudja Nafa, Sinchita Roy-Chowdhuri, Christopher Lau, Michael Zaidinski, Paul K. Paik, Maureen F. Zakowski, Mark G. Kris and Marc Ladanyi

Clin Cancer Res September 15 2012 18 (18) 4910-4918; DOI:10.1158/1078-0432.CCR-12-0912
Human Cancer Biology

The Rectal Cancer microRNAome – microRNA Expression in Rectal Cancer and Matched Normal Mucosa

Jochen Gaedcke, Marian Grade, Jordi Camps, Rolf Søkilde, Bogumil Kaczkowski, Aaron J. Schetter, Michael J. Difilippantonio, Curtis C. Harris, B. Michael Ghadimi, Søren Møller, Tim Beissbarth, Thomas Ried and Thomas Litman

Clin Cancer Res September 15 2012 18 (18) 4919-4930; DOI:10.1158/1078-0432.CCR-12-0016

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV

Ji Young Yoo, Jason Pradarelli, Amy Haseley, Jeffrey Wojton, Azeem Kaka, Anna Bratasz, Christopher A. Alvarez-Breckenridge, Jun-Ge Yu, Kimerly Powell, Andrew P. Mazar, Theodoros N. Teknos, E. Antonio Chiocca, Joseph C. Glorioso, Matthew Old and Balveen Kaur

Clin Cancer Res September 15 2012 18 (18) 4931-4941; DOI:10.1158/1078-0432.CCR-12-0697
Cancer Therapy: Preclinical

Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine

Sahdeo Prasad, Vivek R. Yadav, Bokyung Sung, Simone Reuter, Ramaswamy Kannappan, Amit Deorukhkar, Parmeswaran Diagaradjane, Caimiao Wei, Veerabhadran Baladandayuthapani, Sunil Krishnan, Sushovan Guha and Bharat B. Aggarwal

Clin Cancer Res September 15 2012 18 (18) 4942-4953; DOI:10.1158/1078-0432.CCR-11-2805
Cancer Therapy: Preclinical

Vitamin E Protects against Lipid Peroxidation and Rescues Tumorigenic Phenotypes in Cowden/Cowden-like Patient-Derived Lymphoblast Cells with Germline SDHx Variants

Ying Ni and Charis Eng

Clin Cancer Res September 15 2012 18 (18) 4954-4961; DOI:10.1158/1078-0432.CCR-12-1055
Cancer Therapy: Preclinical

Reovirus as a Viable Therapeutic Option for the Treatment of Multiple Myeloma

Chandini M. Thirukkumaran, Zhong Qiao Shi, Joanne Luider, Karen Kopciuk, He Gao, Nizar Bahlis, Paola Neri, Mark Pho, Douglas Stewart, Adnan Mansoor and Don G. Morris

Clin Cancer Res September 15 2012 18 (18) 4962-4972; DOI:10.1158/1078-0432.CCR-11-3085
Cancer Therapy: Preclinical

Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer

Takeshi Shimamura, Samanthi A. Perera, Kevin P. Foley, Jim Sang, Scott J. Rodig, Takayo Inoue, Liang Chen, Danan Li, Julian Carretero, Yu-Chen Li, Papiya Sinha, Christopher D. Carey, Christa L. Borgman, John-Paul Jimenez, Matthew Meyerson, Weiwen Ying, James Barsoum, Kwok-Kin Wong and Geoffrey I. Shapiro

Clin Cancer Res September 15 2012 18 (18) 4973-4985; DOI:10.1158/1078-0432.CCR-11-2967
Cancer Therapy: Preclinical

Targeting Stat3 Abrogates EGFR Inhibitor Resistance in Cancer

Malabika Sen, Sonali Joyce, Mary Panahandeh, Changyou Li, Sufi M. Thomas, Jessica Maxwell, Lin Wang, William E. Gooding, Daniel E. Johnson and Jennifer R. Grandis

Clin Cancer Res September 15 2012 18 (18) 4986-4996; DOI:10.1158/1078-0432.CCR-12-0792
Cancer Therapy: Preclinical

Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib

Anja Lachenmayer, Clara Alsinet, Radoslav Savic, Laia Cabellos, Sara Toffanin, Yujin Hoshida, Augusto Villanueva, Beatriz Minguez, Philippa Newell, Hung-Wen Tsai, Jordi Barretina, Swan Thung, Stephen C. Ward, Jordi Bruix, Vincenzo Mazzaferro, Myron Schwartz, Scott L. Friedman and Josep M. Llovet

Clin Cancer Res September 15 2012 18 (18) 4997-5007; DOI:10.1158/1078-0432.CCR-11-2322
Cancer Therapy: Preclinical

Biomarker and Pharmacologic Evaluation of the γ-Secretase Inhibitor PF-03084014 in Breast Cancer Models

Cathy C. Zhang, Adam Pavlicek, Qin Zhang, Maruja E. Lira, Cory L. Painter, Zhengming Yan, Xianxian Zheng, Nathan V. Lee, Mark Ozeck, Ming Qiu, Qing Zong, Patrick B. Lappin, Anthony Wong, Paul A. Rejto, Tod Smeal and James G. Christensen

Clin Cancer Res September 15 2012 18 (18) 5008-5019; DOI:10.1158/1078-0432.CCR-12-1379
Cancer Therapy: Preclinical | Free Article

Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target

Ami V. Patel, David Eaves, Walter J. Jessen, Tilat A. Rizvi, Jeffrey A. Ecsedy, Mark G. Qian, Bruce J. Aronow, John P. Perentesis, Eduard Serra, Timothy P. Cripe, Shyra J. Miller and Nancy Ratner

Clin Cancer Res September 15 2012 18 (18) 5020-5030; DOI:10.1158/1078-0432.CCR-12-1072
Cancer Therapy: Preclinical

Apricoxib, a Novel Inhibitor of COX-2, Markedly Improves Standard Therapy Response in Molecularly Defined Models of Pancreatic Cancer

Amanda Kirane, Jason E. Toombs, Katherine Ostapoff, Juliet G. Carbon, Sara Zaknoen, Jordan Braunfeld, Roderich E. Schwarz, Francis J. Burrows and Rolf A. Brekken

Clin Cancer Res September 15 2012 18 (18) 5031-5042; DOI:10.1158/1078-0432.CCR-12-0453

Cancer Therapy: Clinical

Cancer Therapy: Clinical

A Multicenter Phase II Study of Single-Agent Enzastaurin in Previously Treated Waldenström Macroglobulinemia

Irene M. Ghobrial, Philippe Moreau, Brianna Harris, Tiffany Poon, Eric Jourdan, Hervé Maisonneuve, Karim A. Benhadji, Anwar M. Hossain, Tuan S. Nguyen, James E. Wooldridge and Veronique Leblond

Clin Cancer Res September 15 2012 18 (18) 5043-5050; DOI:10.1158/1078-0432.CCR-12-0181
Cancer Therapy: Clinical

Long-term Outcomes of 1,263 Patients with Mycosis Fungoides and Sézary Syndrome from 1982 to 2009

Rakhshandra Talpur, Lotika Singh, Seema Daulat, Ping Liu, Sarah Seyfer, Tanya Trynosky, Wei Wei and Madeleine Duvic

Clin Cancer Res September 15 2012 18 (18) 5051-5060; DOI:10.1158/1078-0432.CCR-12-0604
Cancer Therapy: Clinical

Cytolytic Virus Activation Therapy for Epstein-Barr Virus–Driven Tumors

Maarten A. Wildeman, Zlata Novalić, Sandra A.W.M. Verkuijlen, Hedy Juwana, Alwin D.R. Huitema, I. Bing Tan, Jaap M. Middeldorp, Jan Paul de Boer and Astrid E. Greijer

Clin Cancer Res September 15 2012 18 (18) 5061-5070; DOI:10.1158/1078-0432.CCR-12-0574
Cancer Therapy: Clinical

A Tumor Growth Inhibition Model for Low-Grade Glioma Treated with Chemotherapy or Radiotherapy

Benjamin Ribba, Gentian Kaloshi, Mathieu Peyre, Damien Ricard, Vincent Calvez, Michel Tod, Branka Čajavec-Bernard, Ahmed Idbaih, Dimitri Psimaras, Linda Dainese, Johan Pallud, Stéphanie Cartalat-Carel, Jean-Yves Delattre, Jérôme Honnorat, Emmanuel Grenier and François Ducray

Clin Cancer Res September 15 2012 18 (18) 5071-5080; DOI:10.1158/1078-0432.CCR-12-0084
Cancer Therapy: Clinical

A Phase I Trial and Pharmacokinetic Study of Aflibercept (VEGF Trap) in Children with Refractory Solid Tumors: A Children's Oncology Group Phase I Consortium Report

Julia Glade Bender, Susan M. Blaney, Scott Borinstein, Joel M. Reid, Sylvain Baruchel, Charlotte Ahern, Ashish M. Ingle, Darrell J. Yamashiro, Alice Chen, Brenda Weigel, Peter C. Adamson and Julie R. Park

Clin Cancer Res September 15 2012 18 (18) 5081-5089; DOI:10.1158/1078-0432.CCR-12-0078
Cancer Therapy: Clinical

A Phase I Dose-Escalation Trial of Trastuzumab and Alvespimycin Hydrochloride (KOS-1022; 17 DMAG) in the Treatment of Advanced Solid Tumors

Komal Jhaveri, Kathy Miller, Lee Rosen, Bryan Schneider, Linnea Chap, Alison Hannah, Ziyang Zhong, Weining Ma, Clifford Hudis and Shanu Modi

Clin Cancer Res September 15 2012 18 (18) 5090-5098; DOI:10.1158/1078-0432.CCR-11-3200

Predictive Biomarkers and Personalized Medicine

Predictive Biomarkers and Personalized Medicine

A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101

R. Michael Baldwin, Kouros Owzar, Hitoshi Zembutsu, Aparna Chhibber, Michiaki Kubo, Chen Jiang, Dorothy Watson, Rachel J. Eclov, Joel Mefford, Howard L. McLeod, Paula N. Friedman, Clifford A. Hudis, Eric P. Winer, Eric M. Jorgenson, John S. Witte, Lawrence N. Shulman, Yusuke Nakamura, Mark J. Ratain and Deanna L. Kroetz

Clin Cancer Res September 15 2012 18 (18) 5099-5109; DOI:10.1158/1078-0432.CCR-12-1590
Predictive Biomarkers and Personalized Medicine

RB-Pathway Disruption Is Associated with Improved Response to Neoadjuvant Chemotherapy in Breast Cancer

Agnieszka K. Witkiewicz, Adam Ertel, Jeanne McFalls, Matias E. Valsecchi, Gordon Schwartz and Erik S. Knudsen

Clin Cancer Res September 15 2012 18 (18) 5110-5122; DOI:10.1158/1078-0432.CCR-12-0903
Predictive Biomarkers and Personalized Medicine

Contrasted Outcomes to Gefitinib on Tumoral IGF1R Expression in Head and Neck Cancer Patients Receiving Postoperative Chemoradiation (GORTEC Trial 2004-02)

Juliette Thariat, René-Jean Bensadoun, Marie-Christine Etienne-Grimaldi, Dominique Grall, Frédérique Penault-Llorca, Olivier Dassonville, Francois Bertucci, Anne Cayre, Dominique De Raucourt, Lionnel Geoffrois, Pascal Finetti, Philippe Giraud, Séverine Racadot, Sylvain Morinière, Anne Sudaka, Ellen Van Obberghen-Schilling and Gérard Milano

Clin Cancer Res September 15 2012 18 (18) 5123-5133; DOI:10.1158/1078-0432.CCR-12-1518
Predictive Biomarkers and Personalized Medicine

Validation of a Radiosensitivity Molecular Signature in Breast Cancer

Steven A. Eschrich, William J. Fulp, Yudi Pawitan, John A. Foekens, Marcel Smid, John W.M. Martens, Michelle Echevarria, Vidya Kamath, Ji-Hyun Lee, Eleanor E. Harris, Jonas Bergh and Javier F. Torres-Roca

Clin Cancer Res September 15 2012 18 (18) 5134-5143; DOI:10.1158/1078-0432.CCR-12-0891
Predictive Biomarkers and Personalized Medicine

Let-7 Expression Is a Significant Determinant of Response to Chemotherapy through the Regulation of IL-6/STAT3 Pathway in Esophageal Squamous Cell Carcinoma

Keijiro Sugimura, Hiroshi Miyata, Koji Tanaka, Rie Hamano, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori and Yuichiro Doki

Clin Cancer Res September 15 2012 18 (18) 5144-5153; DOI:10.1158/1078-0432.CCR-12-0701

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Highlights

CCR Translations

Statistics in Clinical Cancer Research

Molecular Pathways

Perspective

Review

Human Cancer Biology

Cancer Therapy: Preclinical

Cancer Therapy: Clinical

Predictive Biomarkers and Personalized Medicine

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