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Clinical Cancer Research
Clinical Cancer Research
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About the Cover

Cover image

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A CNPase promoter directed expression of Ha-RasV12 to peripheral nerve Schwann cells. Staining of teased fibers from adult sciatic nerve detects Ras (anti-HA, red) at the membrane of thick myelinated fibers; Schwann cell cytoplasm is counterstained with anti-S100 (green). Thinner unmyelinated fibers containing small axons and Schwann cells also express Ha-RasV12 (red). Nerves from these mice enabled identification of Ras-driven gene expression, which was used to define therapeutic targets in Schwann cell tumors. Photograph was taken by Tilat A. Rizvi. For details, see the article by Patel and colleagues on page 5020 of this issue.

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Clinical Cancer Research: 18 (18)
September 2012
Volume 18, Issue 18
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Issue Highlights

  • Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target
  • Reovirus as a Viable Therapeutic Option for the Treatment of Multiple Myeloma
  • Biomarker and Pharmacologic Evaluation of the γ-Secretase Inhibitor PF-03084014 in Breast Cancer Models
  • A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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