Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer

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Volume 18, Issue 18, pp. 4973-4985
- Received November 23, 2011
- Revision received July 3, 2012
- Accepted July 3, 2012
- Published first July 17, 2012.
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Author Information
- Takeshi Shimamura1,2,
- Samanthi A. Perera1,2,4,
- Kevin P. Foley4,
- Jim Sang4,
- Scott J. Rodig3,5,
- Takayo Inoue6,
- Liang Chen1,2,4,
- Danan Li1,2,4,
- Julian Carretero1,2,
- Yu-Chen Li1,
- Papiya Sinha3,
- Christopher D. Carey3,
- Christa L. Borgman1,
- John-Paul Jimenez6,
- Matthew Meyerson1,5,7,
- Weiwen Ying6,
- James Barsoum6,
- Kwok-Kin Wong1,2,4, and
- Geoffrey I. Shapiro1,2
- Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
- Corresponding Authors:
Geoffrey I. Shapiro, Early Drug Development Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Mayer 446, 450 Brookline Ave., Boston, MA 02215. Phone: 617-632-4942; Fax: 617-632-1977; E-mail: geoffrey_shapiro{at}dfci.harvard.edu; and Kwok-Kin Wong, E-mail: kwong1{at}partners.org
Current address for T. Shimamura: Department of Molecular Pharmacology and Therapeutics, Oncology Institute, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois; for S.A. Perera: Merck & Co., Boston, Massachusetts; for K.P. Foley: GlaxoSmithKline, Collegeville, Pennsylvania; for L. Chen: National Institute of Biologic Sciences, Beijing, China; for D. Li: Pfizer Pharmaceuticals, La Jolla, California; for J. Carretero: Department of Physiology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain; for C.L. Borgman: University of Massachusetts School of Medicine, Worcester, Massachusetts; and current address for J. Barsoum: Theracrine, Inc., Cambridge, Massachusetts.
Volume 18, Issue 18