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Cancer Therapy: Preclinical

Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer

Takeshi Shimamura, Samanthi A. Perera, Kevin P. Foley, Jim Sang, Scott J. Rodig, Takayo Inoue, Liang Chen, Danan Li, Julian Carretero, Yu-Chen Li, Papiya Sinha, Christopher D. Carey, Christa L. Borgman, John-Paul Jimenez, Matthew Meyerson, Weiwen Ying, James Barsoum, Kwok-Kin Wong and Geoffrey I. Shapiro
Takeshi Shimamura
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Samanthi A. Perera
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Kevin P. Foley
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Jim Sang
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Scott J. Rodig
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Takayo Inoue
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Liang Chen
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Danan Li
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Julian Carretero
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Yu-Chen Li
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Papiya Sinha
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Christopher D. Carey
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Christa L. Borgman
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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John-Paul Jimenez
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Matthew Meyerson
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Weiwen Ying
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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James Barsoum
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Kwok-Kin Wong
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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Geoffrey I. Shapiro
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
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DOI: 10.1158/1078-0432.CCR-11-2967 Published September 2012
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Article Information

Volume 18, Issue 18, pp. 4973-4985

DOI 
https://doi.org/10.1158/1078-0432.CCR-11-2967
PubMed 
22806877

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received November 23, 2011
  • Revision received July 3, 2012
  • Accepted July 3, 2012
  • Published first July 17, 2012.

Article Versions

  • Previous version (July 17, 2012 - 07:02).
  • Previous version (August 30, 2012 - 09:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2012 American Association for Cancer Research.

Author Information

  1. Takeshi Shimamura1,2,
  2. Samanthi A. Perera1,2,4,
  3. Kevin P. Foley4,
  4. Jim Sang4,
  5. Scott J. Rodig3,5,
  6. Takayo Inoue6,
  7. Liang Chen1,2,4,
  8. Danan Li1,2,4,
  9. Julian Carretero1,2,
  10. Yu-Chen Li1,
  11. Papiya Sinha3,
  12. Christopher D. Carey3,
  13. Christa L. Borgman1,
  14. John-Paul Jimenez6,
  15. Matthew Meyerson1,5,7,
  16. Weiwen Ying6,
  17. James Barsoum6,
  18. Kwok-Kin Wong1,2,4, and
  19. Geoffrey I. Shapiro1,2
  1. Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of 2Medicine, 3Pathology, Brigham and Women's Hospital and Harvard Medical School; 4Ludwig Center at Dana-Farber/Harvard Cancer Center; 5Department of Pathology, Harvard Medical School, Boston; 6Synta Pharmaceuticals Corp., Lexington; and 7The Broad Institute of MIT and Harvard, Cambridge, Massachusetts
  1. Corresponding Authors:
    Geoffrey I. Shapiro, Early Drug Development Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Mayer 446, 450 Brookline Ave., Boston, MA 02215. Phone: 617-632-4942; Fax: 617-632-1977; E-mail: geoffrey_shapiro{at}dfci.harvard.edu; and Kwok-Kin Wong, E-mail: kwong1{at}partners.org
  • Current address for T. Shimamura: Department of Molecular Pharmacology and Therapeutics, Oncology Institute, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois; for S.A. Perera: Merck & Co., Boston, Massachusetts; for K.P. Foley: GlaxoSmithKline, Collegeville, Pennsylvania; for L. Chen: National Institute of Biologic Sciences, Beijing, China; for D. Li: Pfizer Pharmaceuticals, La Jolla, California; for J. Carretero: Department of Physiology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain; for C.L. Borgman: University of Massachusetts School of Medicine, Worcester, Massachusetts; and current address for J. Barsoum: Theracrine, Inc., Cambridge, Massachusetts.

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Clinical Cancer Research: 18 (18)
September 2012
Volume 18, Issue 18
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Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer
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Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer
Takeshi Shimamura, Samanthi A. Perera, Kevin P. Foley, Jim Sang, Scott J. Rodig, Takayo Inoue, Liang Chen, Danan Li, Julian Carretero, Yu-Chen Li, Papiya Sinha, Christopher D. Carey, Christa L. Borgman, John-Paul Jimenez, Matthew Meyerson, Weiwen Ying, James Barsoum, Kwok-Kin Wong and Geoffrey I. Shapiro
Clin Cancer Res September 15 2012 (18) (18) 4973-4985; DOI: 10.1158/1078-0432.CCR-11-2967

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Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer
Takeshi Shimamura, Samanthi A. Perera, Kevin P. Foley, Jim Sang, Scott J. Rodig, Takayo Inoue, Liang Chen, Danan Li, Julian Carretero, Yu-Chen Li, Papiya Sinha, Christopher D. Carey, Christa L. Borgman, John-Paul Jimenez, Matthew Meyerson, Weiwen Ying, James Barsoum, Kwok-Kin Wong and Geoffrey I. Shapiro
Clin Cancer Res September 15 2012 (18) (18) 4973-4985; DOI: 10.1158/1078-0432.CCR-11-2967
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