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Clinical Cancer Research
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Cancer Therapy: Preclinical

Targeting Stat3 Abrogates EGFR Inhibitor Resistance in Cancer

Malabika Sen, Sonali Joyce, Mary Panahandeh, Changyou Li, Sufi M. Thomas, Jessica Maxwell, Lin Wang, William E. Gooding, Daniel E. Johnson and Jennifer R. Grandis
Malabika Sen
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Sonali Joyce
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Mary Panahandeh
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Changyou Li
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Sufi M. Thomas
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Jessica Maxwell
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Lin Wang
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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William E. Gooding
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Daniel E. Johnson
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Jennifer R. Grandis
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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DOI: 10.1158/1078-0432.CCR-12-0792 Published September 2012
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Total523128233229

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Article Information

Volume 18, Issue 18, pp. 4986-4996

DOI 
https://doi.org/10.1158/1078-0432.CCR-12-0792
PubMed 
22825581

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received March 6, 2012
  • Revision received June 8, 2012
  • Accepted July 3, 2012
  • Published first July 23, 2012.

Article Versions

  • Previous version (July 23, 2012 - 12:09).
  • Previous version (August 13, 2012 - 09:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2012 American Association for Cancer Research.

Author Information

  1. Malabika Sen1,
  2. Sonali Joyce1,
  3. Mary Panahandeh1,
  4. Changyou Li2,
  5. Sufi M. Thomas1,
  6. Jessica Maxwell1,
  7. Lin Wang3,
  8. William E. Gooding4,
  9. Daniel E. Johnson2,5, and
  10. Jennifer R. Grandis1,5
  1. Authors' Affiliations: Departments of 1Otolaryngology, 2Medicine, 3Pathology, 4Biostatistics, and 5Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
  1. Corresponding Author:
    Jennifer R. Grandis, University of Pittsburgh School of Medicine, 200 Lothrop Street, Suite 500, Pittsburgh, PA 15213. Phone: 412-647-5979; Fax: 412-383-5409; E-mail: jgrandis{at}pitt.edu
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Clinical Cancer Research: 18 (18)
September 2012
Volume 18, Issue 18
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Targeting Stat3 Abrogates EGFR Inhibitor Resistance in Cancer
Malabika Sen, Sonali Joyce, Mary Panahandeh, Changyou Li, Sufi M. Thomas, Jessica Maxwell, Lin Wang, William E. Gooding, Daniel E. Johnson and Jennifer R. Grandis
Clin Cancer Res September 15 2012 (18) (18) 4986-4996; DOI: 10.1158/1078-0432.CCR-12-0792

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Targeting Stat3 Abrogates EGFR Inhibitor Resistance in Cancer
Malabika Sen, Sonali Joyce, Mary Panahandeh, Changyou Li, Sufi M. Thomas, Jessica Maxwell, Lin Wang, William E. Gooding, Daniel E. Johnson and Jennifer R. Grandis
Clin Cancer Res September 15 2012 (18) (18) 4986-4996; DOI: 10.1158/1078-0432.CCR-12-0792
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