Clinical Cancer Research: 18 (20)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res October 15 2012 18 (20) 5515-5515;

CCR Translations

CCR Translations

Therapeutic Drug Monitoring of Imatinib—New Data Strengthen the Case

Ian Judson

Clin Cancer Res October 15 2012 18 (20) 5517-5519; DOI:10.1158/1078-0432.CCR-12-2570

Molecular Pathways

Molecular Pathways

Molecular Pathways: VCAM-1 as a Potential Therapeutic Target in Metastasis

Qing Chen and Joan Massagué

Clin Cancer Res October 15 2012 18 (20) 5520-5525; DOI:10.1158/1078-0432.CCR-11-2904
Molecular Pathways

Molecular Pathways: The Complexity of the Epigenome in Cancer and Recent Clinical Advances

Mariarosaria Conte and Lucia Altucci

Clin Cancer Res October 15 2012 18 (20) 5526-5534; DOI:10.1158/1078-0432.CCR-12-2037

CCR Focus

CCR Focus

Reinventing Cancer Cell Metabolism

Susan E. Bates

Clin Cancer Res October 15 2012 18 (20) 5536-5536; DOI:10.1158/1078-0432.CCR-12-2884
CCR Focus

Targeting Cancer Metabolism

Beverly A. Teicher, W. Marston Linehan and Lee J. Helman

Clin Cancer Res October 15 2012 18 (20) 5537-5545; DOI:10.1158/1078-0432.CCR-12-2587
CCR Focus

c-Myc and Cancer Metabolism

Donald M. Miller, Shelia D. Thomas, Ashraful Islam, David Muench and Kara Sedoris

Clin Cancer Res October 15 2012 18 (20) 5546-5553; DOI:10.1158/1078-0432.CCR-12-0977
CCR Focus

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells

Mayumi Tamada, Makoto Suematsu and Hideyuki Saya

Clin Cancer Res October 15 2012 18 (20) 5554-5561; DOI:10.1158/1078-0432.CCR-12-0859
CCR Focus

IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives

Hui Yang, Dan Ye, Kun-Liang Guan and Yue Xiong

Clin Cancer Res October 15 2012 18 (20) 5562-5571; DOI:10.1158/1078-0432.CCR-12-1773
CCR Focus

Predicting Drug Targets and Biomarkers of Cancer via Genome-Scale Metabolic Modeling

Livnat Jerby and Eytan Ruppin

Clin Cancer Res October 15 2012 18 (20) 5572-5584; DOI:10.1158/1078-0432.CCR-12-1856
CCR Focus

Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

Tineke W.H. Meijer, Johannes H.A.M. Kaanders, Paul N. Span and Johan Bussink

Clin Cancer Res October 15 2012 18 (20) 5585-5594; DOI:10.1158/1078-0432.CCR-12-0858

Human Cancer Biology

Human Cancer Biology | Free Article

Genomic Estimates of Aneuploid Content in Glioblastoma Multiforme and Improved Classification

Bo Li, Yasin Senbabaoglu, Weiping Peng, Min-Lee Yang, Jishu Xu and Jun Z. Li

Clin Cancer Res October 15 2012 18 (20) 5595-5605; DOI:10.1158/1078-0432.CCR-12-1427
Human Cancer Biology

A Comparative and Integrative Approach Identifies ATPase Family, AAA Domain Containing 2 as a Likely Driver of Cell Proliferation in Lung Adenocarcinoma

Robert Fouret, Julien Laffaire, Paul Hofman, Michèle Beau-Faller, Julien Mazieres, Pierre Validire, Philippe Girard, Sophie Camilleri-Bröet, Fabien Vaylet, François Leroy-Ladurie, Jean-Charles Soria and Pierre Fouret

Clin Cancer Res October 15 2012 18 (20) 5606-5616; DOI:10.1158/1078-0432.CCR-12-0505
Human Cancer Biology

14-3-3ζ, a Novel Androgen-Responsive Gene, Is Upregulated in Prostate Cancer and Promotes Prostate Cancer Cell Proliferation and Survival

Taro Murata, Ken-ichi Takayama, Tomohiko Urano, Tetsuya Fujimura, Daisaku Ashikari, Daisuke Obinata, Kuniko Horie-Inoue, Satoru Takahashi, Yasuyoshi Ouchi, Yukio Homma and Satoshi Inoue

Clin Cancer Res October 15 2012 18 (20) 5617-5627; DOI:10.1158/1078-0432.CCR-12-0281

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Intracerebral CpG Immunotherapy with Carbon Nanotubes Abrogates Growth of Subcutaneous Melanomas in Mice

Haitao Fan, Ian Zhang, Xuebo Chen, Leying Zhang, Huaqing Wang, Anna Da Fonseca, Edwin R. Manuel, Don J. Diamond, Andrew Raubitschek and Behnam Badie

Clin Cancer Res October 15 2012 18 (20) 5628-5638; DOI:10.1158/1078-0432.CCR-12-1911
Cancer Therapy: Preclinical

Carfilzomib and ONX 0912 Inhibit Cell Survival and Tumor Growth of Head and Neck Cancer and Their Activities Are Enhanced by Suppression of Mcl-1 or Autophagy

Yan Zang, Sufi M. Thomas, Elena T. Chan, Christopher J. Kirk, Maria L. Freilino, Hannah M. DeLancey, Jennifer R. Grandis, Changyou Li and Daniel E. Johnson

Clin Cancer Res October 15 2012 18 (20) 5639-5649; DOI:10.1158/1078-0432.CCR-12-1213
Cancer Therapy: Preclinical

CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs

Mike I. Walton, Paul D. Eve, Angela Hayes, Melanie R. Valenti, Alexis K. De Haven Brandon, Gary Box, Albert Hallsworth, Elizabeth L. Smith, Kathy J. Boxall, Michael Lainchbury, Thomas P. Matthews, Yann Jamin, Simon P. Robinson, G. Wynne Aherne, John C. Reader, Louis Chesler, Florence I. Raynaud, Suzanne A. Eccles, Ian Collins and Michelle D. Garrett

Clin Cancer Res October 15 2012 18 (20) 5650-5661; DOI:10.1158/1078-0432.CCR-12-1322
Cancer Therapy: Preclinical

Sorafenib Inhibits Hypoxia-Inducible Factor-1α Synthesis: Implications for Antiangiogenic Activity in Hepatocellular Carcinoma

Li-ping Liu, Rocky L. K. Ho, George G. Chen and Paul B. S. Lai

Clin Cancer Res October 15 2012 18 (20) 5662-5671; DOI:10.1158/1078-0432.CCR-12-0552

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

Gene Expression Signature–Based Prognostic Risk Score in Patients with Primary Central Nervous System Lymphoma

Atsushi Kawaguchi, Yasuo Iwadate, Yoshihiro Komohara, Masakazu Sano, Koji Kajiwara, Naoki Yajima, Naoto Tsuchiya, Jumpei Homma, Hiroshi Aoki, Tsutomu Kobayashi, Yuko Sakai, Hiroaki Hondoh, Yukihiko Fujii, Tatsuyuki Kakuma and Ryuya Yamanaka

Clin Cancer Res October 15 2012 18 (20) 5672-5681; DOI:10.1158/1078-0432.CCR-12-0596
Imaging, Diagnosis, Prognosis

A Prospective PCR-Based Screening for the EML4-ALK Oncogene in Non–Small Cell Lung Cancer

Manabu Soda, Kazutoshi Isobe, Akira Inoue, Makoto Maemondo, Satoshi Oizumi, Yuka Fujita, Akihiko Gemma, Yoshihiro Yamashita, Toshihide Ueno, Kengo Takeuchi, Young Lim Choi, Hitoshi Miyazawa, Tomoaki Tanaka, Koichi Hagiwara, Hiroyuki Mano and for the North-East Japan Study Group and the ALK Lung Cancer Study Group

Clin Cancer Res October 15 2012 18 (20) 5682-5689; DOI:10.1158/1078-0432.CCR-11-2947
Imaging, Diagnosis, Prognosis

Prognostic Significance of Promoter DNA Methylation in Patients with Childhood Neuroblastoma

Diana T. Lau, Luke B. Hesson, Murray D. Norris, Glenn M. Marshall, Michelle Haber and Lesley J. Ashton

Clin Cancer Res October 15 2012 18 (20) 5690-5700; DOI:10.1158/1078-0432.CCR-12-0294
Imaging, Diagnosis, Prognosis

Meta-Analysis of the Prognostic Value of Circulating Tumor Cells in Breast Cancer

Liling Zhang, Sabine Riethdorf, Gang Wu, Tao Wang, Kunyu Yang, Gang Peng, Junli Liu and Klaus Pantel

Clin Cancer Res October 15 2012 18 (20) 5701-5710; DOI:10.1158/1078-0432.CCR-12-1587
Imaging, Diagnosis, Prognosis

Challenges in the Enumeration and Phenotyping of CTC

Frank A.W. Coumans, Sjoerd T. Ligthart, Jonathan W. Uhr and Leon W.M.M. Terstappen

Clin Cancer Res October 15 2012 18 (20) 5711-5718; DOI:10.1158/1078-0432.CCR-12-1585
Imaging, Diagnosis, Prognosis

Loss of Heterozygosity at Tumor Suppressor Genes Detectable on Fractionated Circulating Cell-Free Tumor DNA as Indicator of Breast Cancer Progression

Heidi Schwarzenbach, Corinna Eichelser, Jolanthe Kropidlowski, Wolfgang Janni, Brigitte Rack and Klaus Pantel

Clin Cancer Res October 15 2012 18 (20) 5719-5730; DOI:10.1158/1078-0432.CCR-12-0142
Imaging, Diagnosis, Prognosis

Integrin α_vβ₃-Targeted IRDye 800CW Near-Infrared Imaging of Glioblastoma

Ruimin Huang, Jelena Vider, Joy L. Kovar, D. Michael Olive, Ingo K. Mellinghoff, Philipp Mayer-Kuckuk, Moritz F. Kircher and Ronald G. Blasberg

Clin Cancer Res October 15 2012 18 (20) 5731-5740; DOI:10.1158/1078-0432.CCR-12-0374
Imaging, Diagnosis, Prognosis

Intraoperative Near-Infrared Imaging of Surgical Wounds after Tumor Resections Can Detect Residual Disease

Brian Madajewski, Brendan F. Judy, Anas Mouchli, Veena Kapoor, David Holt, May D. Wang, Shuming Nie and Sunil Singhal

Clin Cancer Res October 15 2012 18 (20) 5741-5751; DOI:10.1158/1078-0432.CCR-12-1188

Cancer Therapy: Clinical

Cancer Therapy: Clinical

A Phase I Dose-Finding Trial of Recombinant Interleukin-21 and Rituximab in Relapsed and Refractory Low Grade B-cell Lymphoproliferative Disorders

John M. Timmerman, John C. Byrd, David J. Andorsky, Reiko E. Yamada, Janet Kramer, Natarajan Muthusamy, Naomi Hunder and John M. Pagel

Clin Cancer Res October 15 2012 18 (20) 5752-5760; DOI:10.1158/1078-0432.CCR-12-0456
Cancer Therapy: Clinical

Mutated BCR-ABL Generates Immunogenic T-cell Epitopes in CML Patients

Ann Cai, Derin B. Keskin, David S. DeLuca, Anselmo Alonso, Wandi Zhang, Guang Lan Zhang, Naa Norkor Hammond, Valentina Nardi, Richard M. Stone, Donna Neuberg, John Sidney, Vladimir Brusic and Catherine J. Wu

Clin Cancer Res October 15 2012 18 (20) 5761-5772; DOI:10.1158/1078-0432.CCR-12-1182
Cancer Therapy: Clinical

Clinicopathologic Features and Long-term Outcomes of NUT Midline Carcinoma

Daniel E. Bauer, Chelsey M. Mitchell, Kelly M. Strait, Christopher S. Lathan, Edward B. Stelow, Sonja C. Lüer, Somala Muhammed, Andrew G. Evans, Lynette M. Sholl, Juan Rosai, Eugenia Giraldi, Richard P. Oakley, Carlos Rodriguez-Galindo, Wendy B. London, Stephen E. Sallan, James E. Bradner and Christopher A. French

Clin Cancer Res October 15 2012 18 (20) 5773-5779; DOI:10.1158/1078-0432.CCR-12-1153
Cancer Therapy: Clinical

A Long-term Prospective Population Pharmacokinetic Study on Imatinib Plasma Concentrations in GIST Patients

Karel Eechoute, Martin N. Fransson, An K. Reyners, Floris A. de Jong, Alex Sparreboom, Winette T.A. van der Graaf, Lena E. Friberg, Gaia Schiavon, Erik A.C. Wiemer, Jaap Verweij, Walter J. Loos, Ron H.J. Mathijssen and Ugo De Giorgi

Clin Cancer Res October 15 2012 18 (20) 5780-5787; DOI:10.1158/1078-0432.CCR-12-0490
Cancer Therapy: Clinical

Ontogeny and Sorafenib Metabolism

Eric I. Zimmerman, Justin L. Roberts, Lie Li, David Finkelstein, Alice Gibson, Amarjit S. Chaudhry, Erin G. Schuetz, Jeffrey E. Rubnitz, Hiroto Inaba and Sharyn D. Baker

Clin Cancer Res October 15 2012 18 (20) 5788-5795; DOI:10.1158/1078-0432.CCR-12-1967
Cancer Therapy: Clinical

Phase I Study of the Antiangiogenic Antibody Bevacizumab and the mTOR/Hypoxia-Inducible Factor Inhibitor Temsirolimus Combined with Liposomal Doxorubicin: Tolerance and Biological Activity

John Moroney, Siqing Fu, Stacy Moulder, Gerald Falchook, Thorunn Helgason, Charles Levenback, David Hong, Aung Naing, Jennifer Wheler and Razelle Kurzrock

Clin Cancer Res October 15 2012 18 (20) 5796-5805; DOI:10.1158/1078-0432.CCR-12-1158

Predictive Biomarkers and Personalized Medicine

Predictive Biomarkers and Personalized Medicine

Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome

Zhigang C. Wang, Nicolai Juul Birkbak, Aedín C. Culhane, Ronny Drapkin, Aquila Fatima, Ruiyang Tian, Matthew Schwede, Kathryn Alsop, Kathryn E. Daniels, Huiying Piao, Joyce Liu, Dariush Etemadmoghadam, Alexander Miron, Helga B. Salvesen, Gillian Mitchell, Anna DeFazio, John Quackenbush, Ross S. Berkowitz, J. Dirk Iglehart, David D.L. Bowtell, for the Australian Ovarian Cancer Study Group and Ursula A. Matulonis

Clin Cancer Res October 15 2012 18 (20) 5806-5815; DOI:10.1158/1078-0432.CCR-12-0857
Predictive Biomarkers and Personalized Medicine

Biomarkers of Response to Akt Inhibitor MK-2206 in Breast Cancer

Takafumi Sangai, Argun Akcakanat, Huiqin Chen, Emily Tarco, Yun Wu, Kim-Anh Do, Todd W. Miller, Carlos L. Arteaga, Gordon B. Mills, Ana Maria Gonzalez-Angulo and Funda Meric-Bernstam

Clin Cancer Res October 15 2012 18 (20) 5816-5828; DOI:10.1158/1078-0432.CCR-12-1141

Correction

Correction

Correction: Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma

Clin Cancer Res October 15 2012 18 (20) 5829-5829; DOI:10.1158/1078-0432.CCR-12-2786

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Table of Contents

Highlights

CCR Translations

Molecular Pathways

CCR Focus

Human Cancer Biology

Cancer Therapy: Preclinical

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Predictive Biomarkers and Personalized Medicine

Correction

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