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Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res October 15 2012 18 (20) 5515-5515;

CCR Translations

  • CCR Translations
    Therapeutic Drug Monitoring of Imatinib—New Data Strengthen the Case
    Ian Judson
    Clin Cancer Res October 15 2012 18 (20) 5517-5519; DOI:10.1158/1078-0432.CCR-12-2570

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: VCAM-1 as a Potential Therapeutic Target in Metastasis
    Qing Chen and Joan Massagué
    Clin Cancer Res October 15 2012 18 (20) 5520-5525; DOI:10.1158/1078-0432.CCR-11-2904

  • Molecular Pathways
    Molecular Pathways: The Complexity of the Epigenome in Cancer and Recent Clinical Advances
    Mariarosaria Conte and Lucia Altucci
    Clin Cancer Res October 15 2012 18 (20) 5526-5534; DOI:10.1158/1078-0432.CCR-12-2037

CCR Focus

  • CCR Focus
    Reinventing Cancer Cell Metabolism
    Susan E. Bates
    Clin Cancer Res October 15 2012 18 (20) 5536-5536; DOI:10.1158/1078-0432.CCR-12-2884

  • CCR Focus
    Targeting Cancer Metabolism
    Beverly A. Teicher, W. Marston Linehan and Lee J. Helman
    Clin Cancer Res October 15 2012 18 (20) 5537-5545; DOI:10.1158/1078-0432.CCR-12-2587

  • CCR Focus
    c-Myc and Cancer Metabolism
    Donald M. Miller, Shelia D. Thomas, Ashraful Islam, David Muench and Kara Sedoris
    Clin Cancer Res October 15 2012 18 (20) 5546-5553; DOI:10.1158/1078-0432.CCR-12-0977

  • CCR Focus
    Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells
    Mayumi Tamada, Makoto Suematsu and Hideyuki Saya
    Clin Cancer Res October 15 2012 18 (20) 5554-5561; DOI:10.1158/1078-0432.CCR-12-0859

  • CCR Focus
    IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives
    Hui Yang, Dan Ye, Kun-Liang Guan and Yue Xiong
    Clin Cancer Res October 15 2012 18 (20) 5562-5571; DOI:10.1158/1078-0432.CCR-12-1773

  • CCR Focus
    Predicting Drug Targets and Biomarkers of Cancer via Genome-Scale Metabolic Modeling
    Livnat Jerby and Eytan Ruppin
    Clin Cancer Res October 15 2012 18 (20) 5572-5584; DOI:10.1158/1078-0432.CCR-12-1856

  • CCR Focus
    Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy
    Tineke W.H. Meijer, Johannes H.A.M. Kaanders, Paul N. Span and Johan Bussink
    Clin Cancer Res October 15 2012 18 (20) 5585-5594; DOI:10.1158/1078-0432.CCR-12-0858

Human Cancer Biology

  • Human Cancer Biology | Free Article
    Genomic Estimates of Aneuploid Content in Glioblastoma Multiforme and Improved Classification
    Bo Li, Yasin Senbabaoglu, Weiping Peng, Min-Lee Yang, Jishu Xu and Jun Z. Li
    Clin Cancer Res October 15 2012 18 (20) 5595-5605; DOI:10.1158/1078-0432.CCR-12-1427

  • Human Cancer Biology
    A Comparative and Integrative Approach Identifies ATPase Family, AAA Domain Containing 2 as a Likely Driver of Cell Proliferation in Lung Adenocarcinoma
    Robert Fouret, Julien Laffaire, Paul Hofman, Michèle Beau-Faller, Julien Mazieres, Pierre Validire, Philippe Girard, Sophie Camilleri-Bröet, Fabien Vaylet, François Leroy-Ladurie, Jean-Charles Soria and Pierre Fouret
    Clin Cancer Res October 15 2012 18 (20) 5606-5616; DOI:10.1158/1078-0432.CCR-12-0505

  • Human Cancer Biology
    14-3-3ζ, a Novel Androgen-Responsive Gene, Is Upregulated in Prostate Cancer and Promotes Prostate Cancer Cell Proliferation and Survival
    Taro Murata, Ken-ichi Takayama, Tomohiko Urano, Tetsuya Fujimura, Daisaku Ashikari, Daisuke Obinata, Kuniko Horie-Inoue, Satoru Takahashi, Yasuyoshi Ouchi, Yukio Homma and Satoshi Inoue
    Clin Cancer Res October 15 2012 18 (20) 5617-5627; DOI:10.1158/1078-0432.CCR-12-0281

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Intracerebral CpG Immunotherapy with Carbon Nanotubes Abrogates Growth of Subcutaneous Melanomas in Mice
    Haitao Fan, Ian Zhang, Xuebo Chen, Leying Zhang, Huaqing Wang, Anna Da Fonseca, Edwin R. Manuel, Don J. Diamond, Andrew Raubitschek and Behnam Badie
    Clin Cancer Res October 15 2012 18 (20) 5628-5638; DOI:10.1158/1078-0432.CCR-12-1911

  • Cancer Therapy: Preclinical
    Carfilzomib and ONX 0912 Inhibit Cell Survival and Tumor Growth of Head and Neck Cancer and Their Activities Are Enhanced by Suppression of Mcl-1 or Autophagy
    Yan Zang, Sufi M. Thomas, Elena T. Chan, Christopher J. Kirk, Maria L. Freilino, Hannah M. DeLancey, Jennifer R. Grandis, Changyou Li and Daniel E. Johnson
    Clin Cancer Res October 15 2012 18 (20) 5639-5649; DOI:10.1158/1078-0432.CCR-12-1213

  • Cancer Therapy: Preclinical
    CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs
    Mike I. Walton, Paul D. Eve, Angela Hayes, Melanie R. Valenti, Alexis K. De Haven Brandon, Gary Box, Albert Hallsworth, Elizabeth L. Smith, Kathy J. Boxall, Michael Lainchbury, Thomas P. Matthews, Yann Jamin, Simon P. Robinson, G. Wynne Aherne, John C. Reader, Louis Chesler, Florence I. Raynaud, Suzanne A. Eccles, Ian Collins and Michelle D. Garrett
    Clin Cancer Res October 15 2012 18 (20) 5650-5661; DOI:10.1158/1078-0432.CCR-12-1322

  • Cancer Therapy: Preclinical
    Sorafenib Inhibits Hypoxia-Inducible Factor-1α Synthesis: Implications for Antiangiogenic Activity in Hepatocellular Carcinoma
    Li-ping Liu, Rocky L. K. Ho, George G. Chen and Paul B. S. Lai
    Clin Cancer Res October 15 2012 18 (20) 5662-5671; DOI:10.1158/1078-0432.CCR-12-0552

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Gene Expression Signature–Based Prognostic Risk Score in Patients with Primary Central Nervous System Lymphoma
    Atsushi Kawaguchi, Yasuo Iwadate, Yoshihiro Komohara, Masakazu Sano, Koji Kajiwara, Naoki Yajima, Naoto Tsuchiya, Jumpei Homma, Hiroshi Aoki, Tsutomu Kobayashi, Yuko Sakai, Hiroaki Hondoh, Yukihiko Fujii, Tatsuyuki Kakuma and Ryuya Yamanaka
    Clin Cancer Res October 15 2012 18 (20) 5672-5681; DOI:10.1158/1078-0432.CCR-12-0596

  • Imaging, Diagnosis, Prognosis
    A Prospective PCR-Based Screening for the EML4-ALK Oncogene in Non–Small Cell Lung Cancer
    Manabu Soda, Kazutoshi Isobe, Akira Inoue, Makoto Maemondo, Satoshi Oizumi, Yuka Fujita, Akihiko Gemma, Yoshihiro Yamashita, Toshihide Ueno, Kengo Takeuchi, Young Lim Choi, Hitoshi Miyazawa, Tomoaki Tanaka, Koichi Hagiwara, Hiroyuki Mano and for the North-East Japan Study Group and the ALK Lung Cancer Study Group
    Clin Cancer Res October 15 2012 18 (20) 5682-5689; DOI:10.1158/1078-0432.CCR-11-2947

  • Imaging, Diagnosis, Prognosis
    Prognostic Significance of Promoter DNA Methylation in Patients with Childhood Neuroblastoma
    Diana T. Lau, Luke B. Hesson, Murray D. Norris, Glenn M. Marshall, Michelle Haber and Lesley J. Ashton
    Clin Cancer Res October 15 2012 18 (20) 5690-5700; DOI:10.1158/1078-0432.CCR-12-0294

  • Imaging, Diagnosis, Prognosis
    Meta-Analysis of the Prognostic Value of Circulating Tumor Cells in Breast Cancer
    Liling Zhang, Sabine Riethdorf, Gang Wu, Tao Wang, Kunyu Yang, Gang Peng, Junli Liu and Klaus Pantel
    Clin Cancer Res October 15 2012 18 (20) 5701-5710; DOI:10.1158/1078-0432.CCR-12-1587

  • Imaging, Diagnosis, Prognosis
    Challenges in the Enumeration and Phenotyping of CTC
    Frank A.W. Coumans, Sjoerd T. Ligthart, Jonathan W. Uhr and Leon W.M.M. Terstappen
    Clin Cancer Res October 15 2012 18 (20) 5711-5718; DOI:10.1158/1078-0432.CCR-12-1585

  • Imaging, Diagnosis, Prognosis
    Loss of Heterozygosity at Tumor Suppressor Genes Detectable on Fractionated Circulating Cell-Free Tumor DNA as Indicator of Breast Cancer Progression
    Heidi Schwarzenbach, Corinna Eichelser, Jolanthe Kropidlowski, Wolfgang Janni, Brigitte Rack and Klaus Pantel
    Clin Cancer Res October 15 2012 18 (20) 5719-5730; DOI:10.1158/1078-0432.CCR-12-0142

  • Imaging, Diagnosis, Prognosis
    Integrin αvβ3-Targeted IRDye 800CW Near-Infrared Imaging of Glioblastoma
    Ruimin Huang, Jelena Vider, Joy L. Kovar, D. Michael Olive, Ingo K. Mellinghoff, Philipp Mayer-Kuckuk, Moritz F. Kircher and Ronald G. Blasberg
    Clin Cancer Res October 15 2012 18 (20) 5731-5740; DOI:10.1158/1078-0432.CCR-12-0374

  • Imaging, Diagnosis, Prognosis
    Intraoperative Near-Infrared Imaging of Surgical Wounds after Tumor Resections Can Detect Residual Disease
    Brian Madajewski, Brendan F. Judy, Anas Mouchli, Veena Kapoor, David Holt, May D. Wang, Shuming Nie and Sunil Singhal
    Clin Cancer Res October 15 2012 18 (20) 5741-5751; DOI:10.1158/1078-0432.CCR-12-1188

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    A Phase I Dose-Finding Trial of Recombinant Interleukin-21 and Rituximab in Relapsed and Refractory Low Grade B-cell Lymphoproliferative Disorders
    John M. Timmerman, John C. Byrd, David J. Andorsky, Reiko E. Yamada, Janet Kramer, Natarajan Muthusamy, Naomi Hunder and John M. Pagel
    Clin Cancer Res October 15 2012 18 (20) 5752-5760; DOI:10.1158/1078-0432.CCR-12-0456

  • Cancer Therapy: Clinical
    Mutated BCR-ABL Generates Immunogenic T-cell Epitopes in CML Patients
    Ann Cai, Derin B. Keskin, David S. DeLuca, Anselmo Alonso, Wandi Zhang, Guang Lan Zhang, Naa Norkor Hammond, Valentina Nardi, Richard M. Stone, Donna Neuberg, John Sidney, Vladimir Brusic and Catherine J. Wu
    Clin Cancer Res October 15 2012 18 (20) 5761-5772; DOI:10.1158/1078-0432.CCR-12-1182

  • Cancer Therapy: Clinical
    Clinicopathologic Features and Long-term Outcomes of NUT Midline Carcinoma
    Daniel E. Bauer, Chelsey M. Mitchell, Kelly M. Strait, Christopher S. Lathan, Edward B. Stelow, Sonja C. Lüer, Somala Muhammed, Andrew G. Evans, Lynette M. Sholl, Juan Rosai, Eugenia Giraldi, Richard P. Oakley, Carlos Rodriguez-Galindo, Wendy B. London, Stephen E. Sallan, James E. Bradner and Christopher A. French
    Clin Cancer Res October 15 2012 18 (20) 5773-5779; DOI:10.1158/1078-0432.CCR-12-1153

  • Cancer Therapy: Clinical
    A Long-term Prospective Population Pharmacokinetic Study on Imatinib Plasma Concentrations in GIST Patients
    Karel Eechoute, Martin N. Fransson, An K. Reyners, Floris A. de Jong, Alex Sparreboom, Winette T.A. van der Graaf, Lena E. Friberg, Gaia Schiavon, Erik A.C. Wiemer, Jaap Verweij, Walter J. Loos, Ron H.J. Mathijssen and Ugo De Giorgi
    Clin Cancer Res October 15 2012 18 (20) 5780-5787; DOI:10.1158/1078-0432.CCR-12-0490

  • Cancer Therapy: Clinical
    Ontogeny and Sorafenib Metabolism
    Eric I. Zimmerman, Justin L. Roberts, Lie Li, David Finkelstein, Alice Gibson, Amarjit S. Chaudhry, Erin G. Schuetz, Jeffrey E. Rubnitz, Hiroto Inaba and Sharyn D. Baker
    Clin Cancer Res October 15 2012 18 (20) 5788-5795; DOI:10.1158/1078-0432.CCR-12-1967

  • Cancer Therapy: Clinical
    Phase I Study of the Antiangiogenic Antibody Bevacizumab and the mTOR/Hypoxia-Inducible Factor Inhibitor Temsirolimus Combined with Liposomal Doxorubicin: Tolerance and Biological Activity
    John Moroney, Siqing Fu, Stacy Moulder, Gerald Falchook, Thorunn Helgason, Charles Levenback, David Hong, Aung Naing, Jennifer Wheler and Razelle Kurzrock
    Clin Cancer Res October 15 2012 18 (20) 5796-5805; DOI:10.1158/1078-0432.CCR-12-1158

Predictive Biomarkers and Personalized Medicine

  • Predictive Biomarkers and Personalized Medicine
    Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome
    Zhigang C. Wang, Nicolai Juul Birkbak, Aedín C. Culhane, Ronny Drapkin, Aquila Fatima, Ruiyang Tian, Matthew Schwede, Kathryn Alsop, Kathryn E. Daniels, Huiying Piao, Joyce Liu, Dariush Etemadmoghadam, Alexander Miron, Helga B. Salvesen, Gillian Mitchell, Anna DeFazio, John Quackenbush, Ross S. Berkowitz, J. Dirk Iglehart, David D.L. Bowtell, for the Australian Ovarian Cancer Study Group and Ursula A. Matulonis
    Clin Cancer Res October 15 2012 18 (20) 5806-5815; DOI:10.1158/1078-0432.CCR-12-0857

  • Predictive Biomarkers and Personalized Medicine
    Biomarkers of Response to Akt Inhibitor MK-2206 in Breast Cancer
    Takafumi Sangai, Argun Akcakanat, Huiqin Chen, Emily Tarco, Yun Wu, Kim-Anh Do, Todd W. Miller, Carlos L. Arteaga, Gordon B. Mills, Ana Maria Gonzalez-Angulo and Funda Meric-Bernstam
    Clin Cancer Res October 15 2012 18 (20) 5816-5828; DOI:10.1158/1078-0432.CCR-12-1141

Correction

  • Correction
    Correction: Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma
    Clin Cancer Res October 15 2012 18 (20) 5829-5829; DOI:10.1158/1078-0432.CCR-12-2786

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Clinical Cancer Research: 18 (20)
October 2012
Volume 18, Issue 20
  • Table of Contents
  • Table of Contents (PDF)
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Issue Highlights

  • Intraoperative Near-Infrared Imaging of Surgical Wounds after Tumor Resections Can Detect Residual Disease
  • Genomic Estimates of Aneuploid Content in Glioblastoma Multiforme and Improved Classification
  • A Comparative and Integrative Approach Identifies ATPase Family, AAA Domain Containing 2 as a Likely Driver of Cell Proliferation in Lung Adenocarcinoma
  • Carfilzomib and ONX 0912 Inhibit Cell Survival and Tumor Growth of Head and Neck Cancer and Their Activities Are Enhanced by Suppression of Mcl-1 or Autophagy
  • A Long-term Prospective Population Pharmacokinetic Study on Imatinib Plasma Concentrations in GIST Patients

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  • Immune Checkpoint Blockade Requires Macrophage CXCL9/CXCL10
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Clinical Cancer Research
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