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Cancer Therapy: Clinical

Clinicopathologic Features and Long-term Outcomes of NUT Midline Carcinoma

Daniel E. Bauer, Chelsey M. Mitchell, Kelly M. Strait, Christopher S. Lathan, Edward B. Stelow, Sonja C. Lüer, Somala Muhammed, Andrew G. Evans, Lynette M. Sholl, Juan Rosai, Eugenia Giraldi, Richard P. Oakley, Carlos Rodriguez-Galindo, Wendy B. London, Stephen E. Sallan, James E. Bradner and Christopher A. French
Daniel E. Bauer
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Chelsey M. Mitchell
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Kelly M. Strait
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Christopher S. Lathan
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Edward B. Stelow
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Sonja C. Lüer
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Somala Muhammed
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Andrew G. Evans
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Lynette M. Sholl
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Juan Rosai
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Eugenia Giraldi
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Richard P. Oakley
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Carlos Rodriguez-Galindo
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Wendy B. London
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Stephen E. Sallan
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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James E. Bradner
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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Christopher A. French
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
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DOI: 10.1158/1078-0432.CCR-12-1153 Published October 2012
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Article Information

Volume 18, Issue 20, pp. 5773-5779

DOI 
https://doi.org/10.1158/1078-0432.CCR-12-1153
PubMed 
22896655

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received April 9, 2012
  • Revision received July 20, 2012
  • Accepted July 31, 2012
  • Published first August 15, 2012.

Article Versions

  • Previous version (August 15, 2012 - 08:51).
  • Previous version (September 17, 2012 - 13:23).
  • Previous version (October 5, 2012 - 09:30).
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©2012 American Association for Cancer Research.

Author Information

  1. Daniel E. Bauer1,
  2. Chelsey M. Mitchell3,
  3. Kelly M. Strait1,
  4. Christopher S. Lathan2,
  5. Edward B. Stelow4,
  6. Sonja C. Lüer5,
  7. Somala Muhammed1,
  8. Andrew G. Evans3,
  9. Lynette M. Sholl3,
  10. Juan Rosai6,
  11. Eugenia Giraldi7,
  12. Richard P. Oakley2,
  13. Carlos Rodriguez-Galindo1,
  14. Wendy B. London1,
  15. Stephen E. Sallan1,
  16. James E. Bradner2, and
  17. Christopher A. French3
  1. Authors' Affiliations: 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 3Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; 4Department of Pathology, University of Virginia, Charlottesville, Virginia; 5Department of Pediatric Hematology/Oncology, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; 6Centro Diagnostico Italiano International Center for Oncologic Pathology Consultations, Milan; and 7Department of Pediatrics, Ospedali Riuniti, Bergamo, Italy
  1. Corresponding Authors:
    Christopher A. French, Department of Pathology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115. Phone: 617-525-4415; Fax: 617-525-4422; and James E. Bradner, Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, D510D, Boston, MA 02115. Phone: 617-632-6629; Fax: 617-582-7370; E-mail: james_bradner{at}dfci.harvard.edu
  1. D.E. Bauer and C.M. Mitchell contributed equally to this work.

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Clinical Cancer Research: 18 (20)
October 2012
Volume 18, Issue 20
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Clinicopathologic Features and Long-term Outcomes of NUT Midline Carcinoma
Daniel E. Bauer, Chelsey M. Mitchell, Kelly M. Strait, Christopher S. Lathan, Edward B. Stelow, Sonja C. Lüer, Somala Muhammed, Andrew G. Evans, Lynette M. Sholl, Juan Rosai, Eugenia Giraldi, Richard P. Oakley, Carlos Rodriguez-Galindo, Wendy B. London, Stephen E. Sallan, James E. Bradner and Christopher A. French
Clin Cancer Res October 15 2012 (18) (20) 5773-5779; DOI: 10.1158/1078-0432.CCR-12-1153

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Clinicopathologic Features and Long-term Outcomes of NUT Midline Carcinoma
Daniel E. Bauer, Chelsey M. Mitchell, Kelly M. Strait, Christopher S. Lathan, Edward B. Stelow, Sonja C. Lüer, Somala Muhammed, Andrew G. Evans, Lynette M. Sholl, Juan Rosai, Eugenia Giraldi, Richard P. Oakley, Carlos Rodriguez-Galindo, Wendy B. London, Stephen E. Sallan, James E. Bradner and Christopher A. French
Clin Cancer Res October 15 2012 (18) (20) 5773-5779; DOI: 10.1158/1078-0432.CCR-12-1153
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