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Predictive Biomarkers and Personalized Medicine

Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome

Zhigang C. Wang, Nicolai Juul Birkbak, Aedín C. Culhane, Ronny Drapkin, Aquila Fatima, Ruiyang Tian, Matthew Schwede, Kathryn Alsop, Kathryn E. Daniels, Huiying Piao, Joyce Liu, Dariush Etemadmoghadam, Alexander Miron, Helga B. Salvesen, Gillian Mitchell, Anna DeFazio, John Quackenbush, Ross S. Berkowitz, J. Dirk Iglehart, David D.L. Bowtell, for the Australian Ovarian Cancer Study Group and Ursula A. Matulonis
Zhigang C. Wang
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Nicolai Juul Birkbak
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Aedín C. Culhane
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Ronny Drapkin
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Aquila Fatima
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Ruiyang Tian
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Matthew Schwede
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Kathryn Alsop
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Kathryn E. Daniels
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Huiying Piao
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Joyce Liu
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Dariush Etemadmoghadam
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Alexander Miron
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Helga B. Salvesen
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Gillian Mitchell
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Anna DeFazio
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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John Quackenbush
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Ross S. Berkowitz
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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J. Dirk Iglehart
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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David D.L. Bowtell
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
Ursula A. Matulonis
Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
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DOI: 10.1158/1078-0432.CCR-12-0857 Published October 2012
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Volume 18, Issue 20, pp. 5806-5815

DOI 
https://doi.org/10.1158/1078-0432.CCR-12-0857
PubMed 
22912389

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received March 20, 2012
  • Revision received July 25, 2012
  • Accepted August 13, 2012
  • Published first August 21, 2012.

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  • Previous version (August 21, 2012 - 06:59).
  • Previous version (September 28, 2012 - 07:15).
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©2012 American Association for Cancer Research.

Author Information

  1. Zhigang C. Wang1,
  2. Nicolai Juul Birkbak1,6,
  3. Aedín C. Culhane2,
  4. Ronny Drapkin3,4,
  5. Aquila Fatima1,
  6. Ruiyang Tian1,
  7. Matthew Schwede2,
  8. Kathryn Alsop10,
  9. Kathryn E. Daniels3,
  10. Huiying Piao3,4,
  11. Joyce Liu3,
  12. Dariush Etemadmoghadam7,8,9,
  13. Alexander Miron1,
  14. Helga B. Salvesen12,13,
  15. Gillian Mitchell10,
  16. Anna DeFazio11,
  17. John Quackenbush2,
  18. Ross S. Berkowitz5,
  19. J. Dirk Iglehart1,
  20. David D.L. Bowtell7,8,9,
  21. for the Australian Ovarian Cancer Study Group, and
  22. Ursula A. Matulonis3
  1. Authors' Affiliations: Departments of 1Cancer Biology, 2Biostatistics and Computational Biology, and 3Medical Oncology, Dana-Farber Cancer Institute; 4Department of Pathology and 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts; 6Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; 7Cancer Genomics Program, Departments of 8Biochemistry and 9Pathology, and 10Familial Cancer Centre, Peter MacCallum Cancer Centre and the University of Melbourne, Parkville, Melbourne, Victoria; 11Department of Gynaecological Oncology and Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia; 12Department of Obstetrics and Gynecology, Haukeland University Hospital; and 13Department of Clinical Medicine, University of Bergen, Bergen, Norway
  1. Corresponding Authors:
    J. Dirk Iglehart, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215. Phone: 617-632-5178; Fax: 617-632-3709; E-mail: jiglehart{at}partners.org; and Ursula A. Matulonis, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215. Phone: 617-632-2334; Fax: 617-632-3479; E-mail: umatulonis{at}partners.org
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Clinical Cancer Research: 18 (20)
October 2012
Volume 18, Issue 20
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Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome
Zhigang C. Wang, Nicolai Juul Birkbak, Aedín C. Culhane, Ronny Drapkin, Aquila Fatima, Ruiyang Tian, Matthew Schwede, Kathryn Alsop, Kathryn E. Daniels, Huiying Piao, Joyce Liu, Dariush Etemadmoghadam, Alexander Miron, Helga B. Salvesen, Gillian Mitchell, Anna DeFazio, John Quackenbush, Ross S. Berkowitz, J. Dirk Iglehart, David D.L. Bowtell, for the Australian Ovarian Cancer Study Group and Ursula A. Matulonis
Clin Cancer Res October 15 2012 (18) (20) 5806-5815; DOI: 10.1158/1078-0432.CCR-12-0857

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Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome
Zhigang C. Wang, Nicolai Juul Birkbak, Aedín C. Culhane, Ronny Drapkin, Aquila Fatima, Ruiyang Tian, Matthew Schwede, Kathryn Alsop, Kathryn E. Daniels, Huiying Piao, Joyce Liu, Dariush Etemadmoghadam, Alexander Miron, Helga B. Salvesen, Gillian Mitchell, Anna DeFazio, John Quackenbush, Ross S. Berkowitz, J. Dirk Iglehart, David D.L. Bowtell, for the Australian Ovarian Cancer Study Group and Ursula A. Matulonis
Clin Cancer Res October 15 2012 (18) (20) 5806-5815; DOI: 10.1158/1078-0432.CCR-12-0857
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