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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res June 1 2013 19 (11) 2789-2789;

CCR Translations

  • CCR Translations
    Microenvironmental Induced Essentiality of Autophagy
    Dean C. Singleton and Adrian L. Harris
    Clin Cancer Res June 1 2013 19 (11) 2791-2793; DOI:10.1158/1078-0432.CCR-13-0634

  • CCR Translations
    Mouse Models of Kras-Mutant Colorectal Cancer: Valuable GEMMs for Drug Testing?
    Federica Di Nicolantonio and Alberto Bardelli
    Clin Cancer Res June 1 2013 19 (11) 2794-2796; DOI:10.1158/1078-0432.CCR-13-0339

CCR New Strategies

  • CCR New Strategies
    New Strategies in Hodgkin Lymphoma: Better Risk Profiling and Novel Treatments
    Catherine Diefenbach and Christian Steidl
    Clin Cancer Res June 1 2013 19 (11) 2797-2803; DOI:10.1158/1078-0432.CCR-12-3064

CCR Perspectives in Drug Approval

  • CCR Perspectives in Drug Approval
    Reevaluating the Accelerated Approval Process for Oncology Drugs
    Wyndham H. Wilson, David P. Schenkein, Cheryl L. Jernigan, Janet Woodcock and Richard L. Schilsky
    Clin Cancer Res June 1 2013 19 (11) 2804-2809; DOI:10.1158/1078-0432.CCR-13-0315

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: The Complex Roles of Inflammation Pathways in the Development and Treatment of Liver Cancer
    Kostas Nikolaou, Michalis Sarris and Iannis Talianidis
    Clin Cancer Res June 1 2013 19 (11) 2810-2816; DOI:10.1158/1078-0432.CCR-12-1961

Perspective

  • Perspective
    Developing Safety Criteria for Introducing New Agents into Neoadjuvant Trials
    Angela DeMichele, Donald A. Berry, JoAnne Zujewski, Sally Hunsberger, Larry Rubinstein, Joseph E. Tomaszewski, Gary Kelloff, Jane Perlmutter, Meredith Buxton, Julia Lyandres, Kathy S. Albain, Chris Benz, A. Jo Chien, Paul Haluska, Brian Leyland-Jones, Minetta C. Liu, Pamela Munster, Olufunmilayo Olopade, John W. Park, Barbara A. Parker, Lajos Pusztai, Debu Tripathy, Hope Rugo, Douglas Yee and Laura Esserman
    Clin Cancer Res June 1 2013 19 (11) 2817-2823; DOI:10.1158/1078-0432.CCR-12-2620

  • Perspective
    Predictive Biomarkers for Bevacizumab: Are We There Yet?
    Dipen Maru, Alan P. Venook and Lee M. Ellis
    Clin Cancer Res June 1 2013 19 (11) 2824-2827; DOI:10.1158/1078-0432.CCR-12-3409

  • Perspective
    A Proposal Regarding Reporting of In Vitro Testing Results
    Malcolm A. Smith and Peter Houghton
    Clin Cancer Res June 1 2013 19 (11) 2828-2833; DOI:10.1158/1078-0432.CCR-13-0043

Reviews

  • Reviews
    Infection and Cancer: Revaluation of the Hygiene Hypothesis
    Katerina Oikonomopoulou, Davor Brinc, Kyriacos Kyriacou and Eleftherios P. Diamandis
    Clin Cancer Res June 1 2013 19 (11) 2834-2841; DOI:10.1158/1078-0432.CCR-12-3661

  • Reviews
    Molecular Pathogenesis of Neuroendocrine Tumors: Implications for Current and Future Therapeutic Approaches
    Kjell Oberg, Oriol Casanovas, Justo P. Castaño, Daniel Chung, Gianfranco Delle Fave, Patrice Denèfle, Philip Harris, Mohid S. Khan, Matthew H. Kulke, Aldo Scarpa, Laura H. Tang and Bertram Wiedenmann
    Clin Cancer Res June 1 2013 19 (11) 2842-2849; DOI:10.1158/1078-0432.CCR-12-3458

Human Cancer Biology

  • Human Cancer Biology
    Translation Initiation Factor eIF3b Expression in Human Cancer and Its Role in Tumor Growth and Lung Colonization
    Hong Wang, Yuanbin Ru, Marta Sanchez-Carbayo, Xuejiao Wang, Jeffrey S. Kieft and Dan Theodorescu
    Clin Cancer Res June 1 2013 19 (11) 2850-2860; DOI:10.1158/1078-0432.CCR-12-3084

  • Human Cancer Biology
    ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance
    Hsuan-Ying Huang, Wen-Ren Wu, Yu-Hui Wang, Jun-Wen Wang, Fu-Min Fang, Jen-Wei Tsai, Shau-Hsuan Li, Hsiao-Chin Hung, Shih-Chen Yu, Jui Lan, Yow-Ling Shiue, Chung-His Hsing, Li-Tzong Chen and Chien-Feng Li
    Clin Cancer Res June 1 2013 19 (11) 2861-2872; DOI:10.1158/1078-0432.CCR-12-2641

  • Human Cancer Biology
    Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions
    Gautier Chene, Andrei Tchirkov, Eleonore Pierre-Eymard, Jacques Dauplat, Ines Raoelfils, Anne Cayre, Emmanuel Watkin, Philippe Vago and Frederique Penault-Llorca
    Clin Cancer Res June 1 2013 19 (11) 2873-2882; DOI:10.1158/1078-0432.CCR-12-3947

  • Human Cancer Biology
    The Tumor-Suppressive Function of UNC5D and Its Repressed Expression in Renal Cell Carcinoma
    Dan Lu, Dong Dong, Yu Zhou, Min Lu, Xue-Wen Pang, Yan Li, Xiao-Jun Tian, Yu Zhang and Jun Zhang
    Clin Cancer Res June 1 2013 19 (11) 2883-2892; DOI:10.1158/1078-0432.CCR-12-2978

  • Human Cancer Biology
    Clonal Evolution, Genomic Drivers, and Effects of Therapy in Chronic Lymphocytic Leukemia
    Peter Ouillette, Kamlai Saiya-Cork, Erlene Seymour, Cheng Li, Kerby Shedden and Sami N. Malek
    Clin Cancer Res June 1 2013 19 (11) 2893-2904; DOI:10.1158/1078-0432.CCR-13-0138

  • Human Cancer Biology | AuthorChoice
    Myeloid Differentiation Factor 88 Promotes Growth and Metastasis of Human Hepatocellular Carcinoma
    Beibei Liang, Rui Chen, Tao Wang, Lei Cao, Yingying Liu, Fan Yin, Minhui Zhu, Xiaoyu Fan, Yingchao Liang, Lu Zhang, Yajun Guo and Jian Zhao
    Clin Cancer Res June 1 2013 19 (11) 2905-2916; DOI:10.1158/1078-0432.CCR-12-1245

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Japonicone A Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF-κB
    Xiaoguang Li, Xinying Yang, Yanling Liu, Nuoxi Gong, Wenbo Yao, Peizhan Chen, Jiangjiang Qin, Huizi Jin, Jingquan Li, Ruiai Chu, Lei Shan, Ruiwen Zhang, Weidong Zhang and Hui Wang
    Clin Cancer Res June 1 2013 19 (11) 2917-2928; DOI:10.1158/1078-0432.CCR-12-3258

  • Cancer Therapy: Preclinical
    Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation
    Eric S. Martin, Peter J. Belmont, Mark J. Sinnamon, Larissa Georgeon Richard, Jing Yuan, Erin M. Coffee, Jatin Roper, Lydia Lee, Pedram Heidari, Sophia Y. Lunt, Gautam Goel, Xiadong Ji, Zhi Xie, Tao Xie, John Lamb, Scott L. Weinrich, Todd VanArsdale, Roderick T. Bronson, Ramnik J. Xavier, Matthew G. Vander Heiden, Julie L. C. Kan, Umar Mahmood and Kenneth E. Hung
    Clin Cancer Res June 1 2013 19 (11) 2929-2940; DOI:10.1158/1078-0432.CCR-12-2307

  • Cancer Therapy: Preclinical
    EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors
    Friedhelm Bladt, Bettina Faden, Manja Friese-Hamim, Christine Knuehl, Claudia Wilm, Claus Fittschen, Ulrich Grädler, Michael Meyring, Dieter Dorsch, Frank Jaehrling, Ulrich Pehl, Frank Stieber, Oliver Schadt and Andree Blaukat
    Clin Cancer Res June 1 2013 19 (11) 2941-2951; DOI:10.1158/1078-0432.CCR-12-3247

  • Cancer Therapy: Preclinical
    Colon Cancer–Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins
    Sandra Travica, Klaus Pors, Paul M. Loadman, Steven D. Shnyder, Inger Johansson, Mohammed N. Alandas, Helen M. Sheldrake, Souren Mkrtchian, Laurence H. Patterson and Magnus Ingelman-Sundberg
    Clin Cancer Res June 1 2013 19 (11) 2952-2961; DOI:10.1158/1078-0432.CCR-13-0238

  • Cancer Therapy: Preclinical
    Sequential Inhibitor Therapy in CML: In Vitro Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment
    Robert C. Bauer, Jana Sänger, Christian Peschel, Justus Duyster and Nikolas von Bubnoff
    Clin Cancer Res June 1 2013 19 (11) 2962-2972; DOI:10.1158/1078-0432.CCR-13-0052

  • Cancer Therapy: Preclinical | Free Article
    Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
    Patricia Vrignaud, Dorothée Sémiond, Pascale Lejeune, Hervé Bouchard, Loreley Calvet, Cecile Combeau, Jean-François Riou, Alain Commerçon, François Lavelle and Marie-Christine Bissery
    Clin Cancer Res June 1 2013 19 (11) 2973-2983; DOI:10.1158/1078-0432.CCR-12-3146

  • Cancer Therapy: Preclinical
    Dual Targeting of the Type 1 Insulin-like Growth Factor Receptor and Its Ligands as an Effective Antiangiogenic Strategy
    Hemant K. Bid, Cheryl A. London, Jin Gao, Haihong Zhong, Robert E. Hollingsworth, Soledad Fernandez, Xiaokui Mo and Peter J. Houghton
    Clin Cancer Res June 1 2013 19 (11) 2984-2994; DOI:10.1158/1078-0432.CCR-12-2008

  • Cancer Therapy: Preclinical
    Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy
    Muthu Selvakumaran, Ravi K. Amaravadi, Irina A. Vasilevskaya and Peter J. O'Dwyer
    Clin Cancer Res June 1 2013 19 (11) 2995-3007; DOI:10.1158/1078-0432.CCR-12-1542

  • Cancer Therapy: Preclinical
    Effects of Early Chemotherapeutic Treatment on Learning in Adolescent Mice: Implications for Cognitive Impairment and Remediation in Childhood Cancer Survivors
    Emily B. Bisen-Hersh, Philip N. Hineline and Ellen A. Walker
    Clin Cancer Res June 1 2013 19 (11) 3008-3018; DOI:10.1158/1078-0432.CCR-12-3764

  • Cancer Therapy: Preclinical | AuthorChoice
    In Vitro and In Vivo Antitumor Activity of a Novel Alkylating Agent, Melphalan-Flufenamide, against Multiple Myeloma Cells
    Dharminder Chauhan, Arghya Ray, Kristina Viktorsson, Jack Spira, Claudia Paba-Prada, Nikhil Munshi, Paul Richardson, Rolf Lewensohn and Kenneth C. Anderson
    Clin Cancer Res June 1 2013 19 (11) 3019-3031; DOI:10.1158/1078-0432.CCR-12-3752

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Discovery and Prevalidation of Salivary Extracellular microRNA Biomarkers Panel for the Noninvasive Detection of Benign and Malignant Parotid Gland Tumors
    Johannes H. Matse, Janice Yoshizawa, Xiaoyan Wang, David Elashoff, Jan G.M. Bolscher, Enno C.I. Veerman, Elisabeth Bloemena and David T.W. Wong
    Clin Cancer Res June 1 2013 19 (11) 3032-3038; DOI:10.1158/1078-0432.CCR-12-3505

  • Imaging, Diagnosis, Prognosis
    Identification and Validation of a Blood-Based 18-Gene Expression Signature in Colorectal Cancer
    Ye Xu, Qinghua Xu, Li Yang, Xun Ye, Fang Liu, Fei Wu, Shujuan Ni, Cong Tan, Guoxiang Cai, Xia Meng, Sanjun Cai and Xiang Du
    Clin Cancer Res June 1 2013 19 (11) 3039-3049; DOI:10.1158/1078-0432.CCR-12-3851

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma
    Alberto Broniscer, Sharyn D. Baker, Cynthia Wetmore, Atmaram S. Pai Panandiker, Jie Huang, Andrew M. Davidoff, Arzu Onar-Thomas, John C. Panetta, Thomas K. Chin, Thomas E. Merchant, Justin N. Baker, Sue C. Kaste, Amar Gajjar and Clinton F. Stewart
    Clin Cancer Res June 1 2013 19 (11) 3050-3058; DOI:10.1158/1078-0432.CCR-13-0306

  • Cancer Therapy: Clinical
    Evaluation of Food Effect on Pharmacokinetics of Vismodegib in Advanced Solid Tumor Patients
    Manish R. Sharma, Theodore G. Karrison, Bethany Kell, Kehua Wu, Michelle Turcich, David Geary, Soonmo P. Kang, Naoko Takebe, Richard A. Graham, Michael L. Maitland, Richard L. Schilsky, Mark J. Ratain and Ezra E.W. Cohen
    Clin Cancer Res June 1 2013 19 (11) 3059-3067; DOI:10.1158/1078-0432.CCR-12-3829

  • Cancer Therapy: Clinical
    A Multicenter Phase II Study of Ganetespib Monotherapy in Patients with Genotypically Defined Advanced Non–Small Cell Lung Cancer
    Mark A. Socinski, Jonathan Goldman, Iman El-Hariry, Marianna Koczywas, Vojo Vukovic, Leora Horn, Eugene Paschold, Ravi Salgia, Howard West, Lecia V. Sequist, Philip Bonomi, Julie Brahmer, Lin-Chi Chen, Alan Sandler, Chandra P. Belani, Timothy Webb, Harry Harper, Mark Huberman, Suresh Ramalingam, Kwok-Kin Wong, Florentina Teofilovici, Wei Guo and Geoffrey I. Shapiro
    Clin Cancer Res June 1 2013 19 (11) 3068-3077; DOI:10.1158/1078-0432.CCR-12-3381

  • Cancer Therapy: Clinical
    Phase I Study of U3-1287, a Fully Human Anti-HER3 Monoclonal Antibody, in Patients with Advanced Solid Tumors
    Patricia LoRusso, Pasi A. Jänne, Moacyr Oliveira, Naiyer Rizvi, Lisa Malburg, Vicki Keedy, Lorrin Yee, Catherine Copigneaux, Thore Hettmann, Chi-Yuan Wu, Agnes Ang, Abdel-Baset Halim, Robert A. Beckman, Darrin Beaupre and Jordan Berlin
    Clin Cancer Res June 1 2013 19 (11) 3078-3087; DOI:10.1158/1078-0432.CCR-12-3051

  • Cancer Therapy: Clinical
    A Dose-Ranging Study of Cabozantinib in Men with Castration-Resistant Prostate Cancer and Bone Metastases
    Richard J. Lee, Philip J. Saylor, M. Dror Michaelson, S. Michael Rothenberg, Malgorzata E. Smas, David T. Miyamoto, Carol A. Gurski, Wanling Xie, Shyamala Maheswaran, Daniel A. Haber, Jonathan G. Goldin and Matthew R. Smith
    Clin Cancer Res June 1 2013 19 (11) 3088-3094; DOI:10.1158/1078-0432.CCR-13-0319

  • Cancer Therapy: Clinical
    Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel
    Anne M. Noonan, Robin A. Eisch, David J. Liewehr, Tristan M. Sissung, David J. Venzon, Thomas P. Flagg, Mark C. Haigney, Seth M. Steinberg, William D. Figg, Richard L. Piekarz and Susan E. Bates
    Clin Cancer Res June 1 2013 19 (11) 3095-3104; DOI:10.1158/1078-0432.CCR-13-0109

Letters to the Editor

  • Letters to the Editor
    Gender, Cytidine Deaminase, and 5-Aza/Decitabine—Letter
    Joseph Ciccolini, Godefridus J. Peters and Elisa Giovannetti
    Clin Cancer Res June 1 2013 19 (11) 3105-3105; DOI:10.1158/1078-0432.CCR-13-0483

  • Letters to the Editor
    Gender, Cytidine Deaminase, and 5-Aza/Decitabine—Response
    Reda Z. Mahfouz, Lip Seng Koh, Marissa Teo, Chit Lai Chee, Han Chong Toh and Yogen Saunthararajah
    Clin Cancer Res June 1 2013 19 (11) 3106-3107; DOI:10.1158/1078-0432.CCR-13-0872

Correction

  • Correction
    Correction: The Anti-CD19 Antibody–Drug Conjugate SAR3419 Prevents Hematolymphoid Relapse Postinduction Therapy in Preclinical Models of Pediatric Acute Lymphoblastic Leukemia
    Clin Cancer Res June 1 2013 19 (11) 3108-3108; DOI:10.1158/1078-0432.CCR-13-1060

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Clinical Cancer Research: 19 (11)
June 2013
Volume 19, Issue 11
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Clinical Cancer Research
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