Imaging, Diagnosis, Prognosis
EDNRB and DCC Salivary Rinse Hypermethylation Has a Similar Performance as Expert Clinical Examination in Discrimination of Oral Cancer/Dysplasia versus Benign Lesions
Juliana Schussel, Xian Chong Zhou, Zhe Zhang, Kavita Pattani, Francisco Bermudez, Germain Jean-Charles, Thomas McCaffrey, Tapan Padhya, Joan Phelan, Silvia Spivakovsky, Mariana Brait, Ryan Li, Helen Yoo Bowne, Judith D. Goldberg, Linda Rolnitzky, Miriam Robbins, A. Ross Kerr, David Sirois and Joseph A. Califano
Juliana Schussel
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Xian Chong Zhou
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Zhe Zhang
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Kavita Pattani
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Francisco Bermudez
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Germain Jean-Charles
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Thomas McCaffrey
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Tapan Padhya
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Joan Phelan
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Silvia Spivakovsky
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Mariana Brait
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Ryan Li
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Helen Yoo Bowne
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Judith D. Goldberg
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Linda Rolnitzky
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Miriam Robbins
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
A. Ross Kerr
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
David Sirois
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
Joseph A. Califano
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
DOI: 10.1158/1078-0432.CCR-12-3496 Published June 2013
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Volume 19, Issue 12, pp. 3268-3275
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History
- Received November 11, 2012
- Revision received April 12, 2013
- Accepted April 15, 2013
- Published first May 1, 2013.
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©2013 American Association for Cancer Research.
Author Information
- Juliana Schussel1,
- Xian Chong Zhou2,
- Zhe Zhang2,
- Kavita Pattani1,
- Francisco Bermudez10,
- Germain Jean-Charles9,
- Thomas McCaffrey11,
- Tapan Padhya12,
- Joan Phelan4,5,6,
- Silvia Spivakovsky4,5,6,
- Mariana Brait1,13,
- Ryan Li1,
- Helen Yoo Bowne7,
- Judith D. Goldberg8,
- Linda Rolnitzky8,
- Miriam Robbins4,5,6,
- A. Ross Kerr4,5,6,
- David Sirois4,5,6, and
- Joseph A. Califano1,3
- Authors' Affiliations: 1Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions; 2Division of Oncology Biostatistics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; 3Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland; Departments of 4Oral Maxillofacial Pathology, 5Radiology, and 6Medicine, New York University; 7Department of Otolaryngology Head and Neck Surgery, St. Vincent's Medical Center; 8Division of Biostatistics, New York University School of Medicine, New York; 9Department of Oral Maxillofacial Pathology, SUNY at Buffalo School of Dental Medicine, Buffalo, New York; 10University of Puerto Rico School of Dental Medicine, San Juan, Puerto Rico; 11Department of Otolaryngology Head and Neck Surgery, 12Division of Head and Neck Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; and 13Clinical Research Coordination, Instituto Nacional de Câncer (INCA) - Brazilian National Cancer Institute, Rio de Janeiro, Rio de Janeiro, Brazil
- Corresponding Authors:
Joseph Califano, Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions, 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287. Phone: 410-955-6420; Fax: 410-614-1411; E-mail: jcalifa{at}jhmi.edu; and David Sirois, Department of Oral and Maxillofacial Pathology, Radiology and Medicine, NYU College of Dentistry, 345 East 24th Street, Floor 10W, New York, New York 10010. Phone: 212-998-9549; Fax: 212-998-9629; E-mail: ds6{at}nyu.edu
June 2013
Volume 19, Issue 12
Volume 19, Issue 12
EDNRB and DCC Salivary Rinse Hypermethylation Has a Similar Performance as Expert Clinical Examination in Discrimination of Oral Cancer/Dysplasia versus Benign Lesions
Juliana Schussel, Xian Chong Zhou, Zhe Zhang, Kavita Pattani, Francisco Bermudez, Germain Jean-Charles, Thomas McCaffrey, Tapan Padhya, Joan Phelan, Silvia Spivakovsky, Mariana Brait, Ryan Li, Helen Yoo Bowne, Judith D. Goldberg, Linda Rolnitzky, Miriam Robbins, A. Ross Kerr, David Sirois and Joseph A. Califano
Clin Cancer Res June 15 2013 (19) (12) 3268-3275; DOI: 10.1158/1078-0432.CCR-12-3496
EDNRB and DCC Salivary Rinse Hypermethylation Has a Similar Performance as Expert Clinical Examination in Discrimination of Oral Cancer/Dysplasia versus Benign Lesions
Juliana Schussel, Xian Chong Zhou, Zhe Zhang, Kavita Pattani, Francisco Bermudez, Germain Jean-Charles, Thomas McCaffrey, Tapan Padhya, Joan Phelan, Silvia Spivakovsky, Mariana Brait, Ryan Li, Helen Yoo Bowne, Judith D. Goldberg, Linda Rolnitzky, Miriam Robbins, A. Ross Kerr, David Sirois and Joseph A. Califano
Clin Cancer Res June 15 2013 (19) (12) 3268-3275; DOI: 10.1158/1078-0432.CCR-12-3496
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