Cancer Therapy: Clinical
Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study
Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Greve, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-May Chen, Michael L. Friedlander, Bella Kaufman, Amit M. Oza, Ursula Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James Campbell, Lina Chen, Johann S. de Bono, Martin E. Gore, Christopher J. Lord, Alan Ashworth and Stan B. Kaye
Joo Ern Ang
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Charlie Gourley
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
C. Bethan Powell
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Hilda High
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Ronnie Shapira-Frommer
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Vincent Castonguay
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Jacques De Greve
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Tina Atkinson
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Timothy A. Yap
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Shahneen Sandhu
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Susana Banerjee
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Lee-May Chen
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Michael L. Friedlander
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Bella Kaufman
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Amit M. Oza
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Ursula Matulonis
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Louise J. Barber
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Iwanka Kozarewa
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Kerry Fenwick
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Ioannis Assiotis
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
James Campbell
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Lina Chen
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Johann S. de Bono
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Martin E. Gore
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Christopher J. Lord
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Alan Ashworth
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
Stan B. Kaye
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
DOI: 10.1158/1078-0432.CCR-13-1262 Published October 2013

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Volume 19, Issue 19, pp. 5485-5493
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History
- Received May 8, 2013
- Revision received June 17, 2013
- Accepted June 30, 2013
- Published first August 6, 2013.
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- Previous version (August 6, 2013 - 05:51).
- Previous version (September 23, 2013 - 09:15).
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©2013 American Association for Cancer Research.
Author Information
- Joo Ern Ang1,
- Charlie Gourley2,
- C. Bethan Powell6,
- Hilda High7,
- Ronnie Shapira-Frommer8,
- Vincent Castonguay9,
- Jacques De Greve10,
- Tina Atkinson11,
- Timothy A. Yap1,
- Shahneen Sandhu1,
- Susana Banerjee1,
- Lee-May Chen6,
- Michael L. Friedlander7,
- Bella Kaufman8,
- Amit M. Oza9,
- Ursula Matulonis11,
- Louise J. Barber3,4,
- Iwanka Kozarewa5,
- Kerry Fenwick5,
- Ioannis Assiotis5,
- James Campbell3,4,5,
- Lina Chen5,
- Johann S. de Bono1,
- Martin E. Gore1,
- Christopher J. Lord3,4,
- Alan Ashworth3,4, and
- Stan B. Kaye1
- Authors' Affiliations: 1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
- Corresponding Author:
Stan B. Kaye, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Downs Road, 15 Cotswold Road, Sutton, Surrey SM2 5PT, United Kingdom. Phone: 44-20-8661-3539; Fax: 44-20-8661-3541; E-mail: stan.kaye{at}rmh.nhs.uk
October 2013
Volume 19, Issue 19
Volume 19, Issue 19
Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study
Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Greve, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-May Chen, Michael L. Friedlander, Bella Kaufman, Amit M. Oza, Ursula Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James Campbell, Lina Chen, Johann S. de Bono, Martin E. Gore, Christopher J. Lord, Alan Ashworth and Stan B. Kaye
Clin Cancer Res October 1 2013 (19) (19) 5485-5493; DOI: 10.1158/1078-0432.CCR-13-1262
Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study
Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Greve, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-May Chen, Michael L. Friedlander, Bella Kaufman, Amit M. Oza, Ursula Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James Campbell, Lina Chen, Johann S. de Bono, Martin E. Gore, Christopher J. Lord, Alan Ashworth and Stan B. Kaye
Clin Cancer Res October 1 2013 (19) (19) 5485-5493; DOI: 10.1158/1078-0432.CCR-13-1262
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