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Cancer Therapy: Clinical

Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study

Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Greve, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-May Chen, Michael L. Friedlander, Bella Kaufman, Amit M. Oza, Ursula Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James Campbell, Lina Chen, Johann S. de Bono, Martin E. Gore, Christopher J. Lord, Alan Ashworth and Stan B. Kaye
Joo Ern Ang
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Charlie Gourley
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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C. Bethan Powell
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Hilda High
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Ronnie Shapira-Frommer
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Vincent Castonguay
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Jacques De Greve
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Tina Atkinson
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Timothy A. Yap
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Shahneen Sandhu
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Susana Banerjee
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Lee-May Chen
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Michael L. Friedlander
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Bella Kaufman
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Amit M. Oza
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Ursula Matulonis
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Louise J. Barber
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Iwanka Kozarewa
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Kerry Fenwick
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Ioannis Assiotis
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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James Campbell
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Lina Chen
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Johann S. de Bono
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Martin E. Gore
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Christopher J. Lord
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Alan Ashworth
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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Stan B. Kaye
1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
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DOI: 10.1158/1078-0432.CCR-13-1262 Published October 2013
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Article Information

Volume 19, Issue 19, pp. 5485-5493

DOI 
https://doi.org/10.1158/1078-0432.CCR-13-1262
PubMed 
23922302

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received May 8, 2013
  • Revision received June 17, 2013
  • Accepted June 30, 2013
  • Published first August 6, 2013.

Article Versions

  • Previous version (August 6, 2013 - 05:51).
  • Previous version (September 23, 2013 - 09:15).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2013 American Association for Cancer Research.

Author Information

  1. Joo Ern Ang1,
  2. Charlie Gourley2,
  3. C. Bethan Powell6,
  4. Hilda High7,
  5. Ronnie Shapira-Frommer8,
  6. Vincent Castonguay9,
  7. Jacques De Greve10,
  8. Tina Atkinson11,
  9. Timothy A. Yap1,
  10. Shahneen Sandhu1,
  11. Susana Banerjee1,
  12. Lee-May Chen6,
  13. Michael L. Friedlander7,
  14. Bella Kaufman8,
  15. Amit M. Oza9,
  16. Ursula Matulonis11,
  17. Louise J. Barber3,4,
  18. Iwanka Kozarewa5,
  19. Kerry Fenwick5,
  20. Ioannis Assiotis5,
  21. James Campbell3,4,5,
  22. Lina Chen5,
  23. Johann S. de Bono1,
  24. Martin E. Gore1,
  25. Christopher J. Lord3,4,
  26. Alan Ashworth3,4, and
  27. Stan B. Kaye1
  1. Authors' Affiliations: 1The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton; 2Edinburgh Cancer Research UK Center, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh; 3The Cancer Research UK Gene Function Laboratory; 4Breakthrough Breast Cancer Research Center; 5Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom; 6University of California San Francisco, San Francisco, California; 7Department of Medical Oncology, Prince of Wales Clinical School, Prince of Wales Hospital, Sydney, Australia; 8The Chaim Sheba Medical Center, Tel Hashomer, Israel; 9Princess Margaret Hospital, Toronto, Canada; 10Oncologisch Centrum Vrije Universiteit Brussel, Brussels, Belgium; and 11Dana Farber Cancer Center, Boston, Massachusetts
  1. Corresponding Author:
    Stan B. Kaye, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Downs Road, 15 Cotswold Road, Sutton, Surrey SM2 5PT, United Kingdom. Phone: 44-20-8661-3539; Fax: 44-20-8661-3541; E-mail: stan.kaye{at}rmh.nhs.uk
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Clinical Cancer Research: 19 (19)
October 2013
Volume 19, Issue 19
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Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study
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Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study
Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Greve, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-May Chen, Michael L. Friedlander, Bella Kaufman, Amit M. Oza, Ursula Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James Campbell, Lina Chen, Johann S. de Bono, Martin E. Gore, Christopher J. Lord, Alan Ashworth and Stan B. Kaye
Clin Cancer Res October 1 2013 (19) (19) 5485-5493; DOI: 10.1158/1078-0432.CCR-13-1262

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Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study
Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Greve, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-May Chen, Michael L. Friedlander, Bella Kaufman, Amit M. Oza, Ursula Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James Campbell, Lina Chen, Johann S. de Bono, Martin E. Gore, Christopher J. Lord, Alan Ashworth and Stan B. Kaye
Clin Cancer Res October 1 2013 (19) (19) 5485-5493; DOI: 10.1158/1078-0432.CCR-13-1262
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Clinical Cancer Research
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