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Clinical Cancer Research
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Cancer Therapy: Preclinical

Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells

Teun Guichelaar, Maarten E. Emmelot, Henk Rozemuller, Bianka Martini, Richard W.J. Groen, Gert Storm, Henk M. Lokhorst, Anton C. Martens and Tuna Mutis
Teun Guichelaar
Departments of 1Clinical Chemistry and Hematology, 2Immunology, and 3Hematology, University Medical Center Utrecht; and 4Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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Maarten E. Emmelot
Departments of 1Clinical Chemistry and Hematology, 2Immunology, and 3Hematology, University Medical Center Utrecht; and 4Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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Henk Rozemuller
Departments of 1Clinical Chemistry and Hematology, 2Immunology, and 3Hematology, University Medical Center Utrecht; and 4Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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Bianka Martini
Departments of 1Clinical Chemistry and Hematology, 2Immunology, and 3Hematology, University Medical Center Utrecht; and 4Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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Richard W.J. Groen
Departments of 1Clinical Chemistry and Hematology, 2Immunology, and 3Hematology, University Medical Center Utrecht; and 4Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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Gert Storm
Departments of 1Clinical Chemistry and Hematology, 2Immunology, and 3Hematology, University Medical Center Utrecht; and 4Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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Henk M. Lokhorst
Departments of 1Clinical Chemistry and Hematology, 2Immunology, and 3Hematology, University Medical Center Utrecht; and 4Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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Anton C. Martens
Departments of 1Clinical Chemistry and Hematology, 2Immunology, and 3Hematology, University Medical Center Utrecht; and 4Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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Tuna Mutis
Departments of 1Clinical Chemistry and Hematology, 2Immunology, and 3Hematology, University Medical Center Utrecht; and 4Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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DOI: 10.1158/1078-0432.CCR-12-2177 Published March 2013
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Cited By

Article Information

Volume 19, Issue 6, pp. 1467-1475

DOI 
https://doi.org/10.1158/1078-0432.CCR-12-2177
PubMed 
23382115

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received July 4, 2012
  • Revision received November 26, 2012
  • Accepted December 29, 2012
  • Published first February 4, 2013.

Article Versions

  • Previous version (February 4, 2013 - 06:48).
  • Previous version (March 6, 2013 - 09:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2012 American Association for Cancer Research.

Author Information

  1. Teun Guichelaar1,
  2. Maarten E. Emmelot1,
  3. Henk Rozemuller2,
  4. Bianka Martini1,
  5. Richard W.J. Groen2,
  6. Gert Storm4,
  7. Henk M. Lokhorst3,
  8. Anton C. Martens2, and
  9. Tuna Mutis1
  1. Authors' Affiliations: Departments of 1Clinical Chemistry and Hematology, 2Immunology, and 3Hematology, University Medical Center Utrecht; and 4Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
  1. Corresponding Author:
    Tuna Mutis, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands. Phone: 31-887556504; Fax: 31-887555418; E-mail: t.mutis{at}umcutrecht.nl
  • Current address for T. Guichelaar: Department of Vaccinology, Netherlands Institute for Health and the Environment, Bilthoven, the Netherlands.

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Clinical Cancer Research: 19 (6)
March 2013
Volume 19, Issue 6
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Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Teun Guichelaar, Maarten E. Emmelot, Henk Rozemuller, Bianka Martini, Richard W.J. Groen, Gert Storm, Henk M. Lokhorst, Anton C. Martens and Tuna Mutis
Clin Cancer Res March 15 2013 (19) (6) 1467-1475; DOI: 10.1158/1078-0432.CCR-12-2177

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Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Teun Guichelaar, Maarten E. Emmelot, Henk Rozemuller, Bianka Martini, Richard W.J. Groen, Gert Storm, Henk M. Lokhorst, Anton C. Martens and Tuna Mutis
Clin Cancer Res March 15 2013 (19) (6) 1467-1475; DOI: 10.1158/1078-0432.CCR-12-2177
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