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Cancer Therapy: Clinical

Cetuximab-Activated Natural Killer and Dendritic Cells Collaborate to Trigger Tumor Antigen–Specific T-cell Immunity in Head and Neck Cancer Patients

Raghvendra M. Srivastava, Steve C. Lee, Pedro A. Andrade Filho, Christopher A. Lord, Hyun-Bae Jie, H. Carter Davidson, Andrés López-Albaitero, Sandra P. Gibson, William E. Gooding, Soldano Ferrone and Robert L. Ferris
Raghvendra M. Srivastava
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Steve C. Lee
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Pedro A. Andrade Filho
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Christopher A. Lord
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Hyun-Bae Jie
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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H. Carter Davidson
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Andrés López-Albaitero
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Sandra P. Gibson
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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William E. Gooding
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Soldano Ferrone
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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Robert L. Ferris
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
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DOI: 10.1158/1078-0432.CCR-12-2426 Published April 2013
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Article Information

Volume 19, Issue 7, pp. 1858-1872

DOI 
https://doi.org/10.1158/1078-0432.CCR-12-2426
PubMed 
23444227

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received July 19, 2012
  • Revision received December 30, 2012
  • Accepted January 25, 2013
  • Published first February 26, 2013.

Article Versions

  • Previous version (February 26, 2013 - 08:23).
  • Previous version (March 20, 2013 - 09:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2013 American Association for Cancer Research.

Author Information

  1. Raghvendra M. Srivastava1,
  2. Steve C. Lee1,
  3. Pedro A. Andrade Filho1,
  4. Christopher A. Lord1,
  5. Hyun-Bae Jie1,
  6. H. Carter Davidson1,
  7. Andrés López-Albaitero1,
  8. Sandra P. Gibson1,
  9. William E. Gooding5,
  10. Soldano Ferrone2,3,4,6, and
  11. Robert L. Ferris1,4,6
  1. Authors' Affiliations: Departments of 1Otolaryngology, 2Surgery, 3Pathology, and 4Immunology, University of Pittsburgh; 5Biostatistics Facility and 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
  1. Corresponding Author:
    Robert L. Ferris, The Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Room 2.26b, Pittsburgh, PA 15213. Phone: 412-623-0327; Fax: 412-623-4840; E-mail: ferrisrl{at}upmc.edu
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Clinical Cancer Research: 19 (7)
April 2013
Volume 19, Issue 7
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Cetuximab-Activated Natural Killer and Dendritic Cells Collaborate to Trigger Tumor Antigen–Specific T-cell Immunity in Head and Neck Cancer Patients
Raghvendra M. Srivastava, Steve C. Lee, Pedro A. Andrade Filho, Christopher A. Lord, Hyun-Bae Jie, H. Carter Davidson, Andrés López-Albaitero, Sandra P. Gibson, William E. Gooding, Soldano Ferrone and Robert L. Ferris
Clin Cancer Res April 1 2013 (19) (7) 1858-1872; DOI: 10.1158/1078-0432.CCR-12-2426

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Cetuximab-Activated Natural Killer and Dendritic Cells Collaborate to Trigger Tumor Antigen–Specific T-cell Immunity in Head and Neck Cancer Patients
Raghvendra M. Srivastava, Steve C. Lee, Pedro A. Andrade Filho, Christopher A. Lord, Hyun-Bae Jie, H. Carter Davidson, Andrés López-Albaitero, Sandra P. Gibson, William E. Gooding, Soldano Ferrone and Robert L. Ferris
Clin Cancer Res April 1 2013 (19) (7) 1858-1872; DOI: 10.1158/1078-0432.CCR-12-2426
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