Clinical Cancer Research: 19 (8)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res April 15 2013 19 (8) 1915-1915;

CCR Translations

CCR Translations

Zoom Zoom: Racing CARs for Multiple Myeloma

Marcela V. Maus and Carl H. June

Clin Cancer Res April 15 2013 19 (8) 1917-1919; DOI:10.1158/1078-0432.CCR-13-0168

CCR Drug Updates

CCR Drug Updates

Aflibercept

Kristen K. Ciombor, Jordan Berlin and Emily Chan

Clin Cancer Res April 15 2013 19 (8) 1920-1925; DOI:10.1158/1078-0432.CCR-12-2911

Molecular Pathways

Molecular Pathways

Molecular Pathways: Adiponectin and Leptin Signaling in Cancer

Michael N. VanSaun

Clin Cancer Res April 15 2013 19 (8) 1926-1932; DOI:10.1158/1078-0432.CCR-12-0930
Molecular Pathways

Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance

Alfonso Quintás-Cardama and Srdan Verstovsek

Clin Cancer Res April 15 2013 19 (8) 1933-1940; DOI:10.1158/1078-0432.CCR-12-0284

Tobacco Statement

Tobacco Statement | Free Article

Assessing Tobacco Use by Cancer Patients and Facilitating Cessation: An American Association for Cancer Research Policy Statement

Benjamin A. Toll, Thomas H. Brandon, Ellen R. Gritz, Graham W. Warren and Roy S. Herbst; Writing Committee for the AACR Subcommittee on Tobacco and Cancer

Clin Cancer Res April 15 2013 19 (8) 1941-1948; DOI:10.1158/1078-0432.CCR-13-0666

Human Cancer Biology

Human Cancer Biology

C-Reactive Protein Downregulates TRAIL Expression in Human Peripheral Monocytes via an Egr-1–Dependent Pathway

Paola Secchiero, Erika Rimondi, Maria Grazia di Iasio, Chiara Agnoletto, Elisabetta Melloni, Ilaria Volpi and Giorgio Zauli

Clin Cancer Res April 15 2013 19 (8) 1949-1959; DOI:10.1158/1078-0432.CCR-12-3027
Human Cancer Biology

Copy Number Aberrations of Genes Regulating Normal Thymus Development in Thymic Epithelial Tumors

Iacopo Petrini, Yisong Wang, Paolo A. Zucali, Hye Seung Lee, Trung Pham, Donna Voeller, Paul S. Meltzer and Giuseppe Giaccone

Clin Cancer Res April 15 2013 19 (8) 1960-1971; DOI:10.1158/1078-0432.CCR-12-3260
Human Cancer Biology

Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma

Khaled A. Hassan, Luo Wang, Hasan Korkaya, Guoan Chen, Ivan Maillard, David G. Beer, Gregory P. Kalemkerian and Max S. Wicha

Clin Cancer Res April 15 2013 19 (8) 1972-1980; DOI:10.1158/1078-0432.CCR-12-0370
Human Cancer Biology

Aberrant Expression of Mucin Core Proteins and O-Linked Glycans Associated with Progression of Pancreatic Cancer

Neeley Remmers, Judy M. Anderson, Erin M. Linde, Dominick J. DiMaio, Audrey J. Lazenby, Hans H. Wandall, Ulla Mandel, Henrik Clausen, Fang Yu and Michael A. Hollingsworth

Clin Cancer Res April 15 2013 19 (8) 1981-1993; DOI:10.1158/1078-0432.CCR-12-2662
Human Cancer Biology

Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer

Sanne R. Martens-de Kemp, Remco Nagel, Marijke Stigter-van Walsum, Ida H. van der Meulen, Victor W. van Beusechem, Boudewijn J.M. Braakhuis and Ruud H. Brakenhoff

Clin Cancer Res April 15 2013 19 (8) 1994-2003; DOI:10.1158/1078-0432.CCR-12-2539
Human Cancer Biology

Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88)

Hidetoshi Nitta, Yoshihiro Wada, Yoshiaki Kawano, Yoji Murakami, Atsushi Irie, Keisuke Taniguchi, Ken Kikuchi, Gen Yamada, Kentaro Suzuki, Jiro Honda, Masayo Wilson-Morifuji, Norie Araki, Masatoshi Eto, Hideo Baba and Takahisa Imamura

Clin Cancer Res April 15 2013 19 (8) 2004-2013; DOI:10.1158/1078-0432.CCR-12-1204
Human Cancer Biology

The Prognostic Significance and Therapeutic Potential of Hedgehog Signaling in Intrahepatic Cholangiocellular Carcinoma

Liang Tang, Ye-Xiong Tan, Bei-Ge Jiang, Yu-Fei Pan, Shuang-Xi Li, Guang-Zhen Yang, Min Wang, Qing Wang, Jian Zhang, Wei-Ping Zhou, Li-Wei Dong and Hong-Yang Wang

Clin Cancer Res April 15 2013 19 (8) 2014-2024; DOI:10.1158/1078-0432.CCR-12-0349

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Targeting the NF-κB and mTOR Pathways with a Quinoxaline Urea Analog That Inhibits IKKβ for Pancreas Cancer Therapy

Prakash Radhakrishnan, Vashti C. Bryant, Elizabeth C. Blowers, Rajkumar N. Rajule, Nagsen Gautam, Muhammad M. Anwar, Ashley M. Mohr, Paul M. Grandgenett, Stephanie K. Bunt, Jamie L. Arnst, Subodh M. Lele, Yazen Alnouti, Michael A. Hollingsworth and Amarnath Natarajan

Clin Cancer Res April 15 2013 19 (8) 2025-2035; DOI:10.1158/1078-0432.CCR-12-2909
Cancer Therapy: Preclinical | AuthorChoice

hTERT Inhibition Triggers Epstein–Barr Virus Lytic Cycle and Apoptosis in Immortalized and Transformed B Cells: A Basis for New Therapies

Silvia Giunco, Riccardo Dolcetti, Sonia Keppel, Andrea Celeghin, Stefano Indraccolo, Jessica Dal Col, Katy Mastorci and Anita De Rossi

Clin Cancer Res April 15 2013 19 (8) 2036-2047; DOI:10.1158/1078-0432.CCR-12-2537
Cancer Therapy: Preclinical

B-cell Maturation Antigen Is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma

Robert O. Carpenter, Moses O. Evbuomwan, Stefania Pittaluga, Jeremy J. Rose, Mark Raffeld, Shicheng Yang, Ronald E. Gress, Frances T. Hakim and James N. Kochenderfer

Clin Cancer Res April 15 2013 19 (8) 2048-2060; DOI:10.1158/1078-0432.CCR-12-2422
Cancer Therapy: Preclinical | Free Article

A Targeted RNAi Screen of the Breast Cancer Genome Identifies KIF14 and TLN1 as Genes That Modulate Docetaxel Chemosensitivity in Triple-Negative Breast Cancer

Stina Mui Singel, Crystal Cornelius, Kimberly Batten, Gail Fasciani, Woodring E. Wright, Lawrence Lum and Jerry W. Shay

Clin Cancer Res April 15 2013 19 (8) 2061-2070; DOI:10.1158/1078-0432.CCR-13-0082
Cancer Therapy: Preclinical

Extracellular Signal–Regulated Kinase 5: A Potential Therapeutic Target for Malignant Mesotheliomas

Arti Shukla, Jill M. Miller, Christopher Cason, Mutlay Sayan, Maximilian B. MacPherson, Stacie L. Beuschel, Jedd Hillegass, Pamela M. Vacek, Harvey I. Pass and Brooke T. Mossman

Clin Cancer Res April 15 2013 19 (8) 2071-2083; DOI:10.1158/1078-0432.CCR-12-3202
Cancer Therapy: Preclinical

Abcc4 Together with Abcb1 and Abcg2 Form a Robust Cooperative Drug Efflux System That Restricts the Brain Entry of Camptothecin Analogues

Fan Lin, Serena Marchetti, Dick Pluim, Dilek Iusuf, Roberto Mazzanti, Jan H.M. Schellens, Jos H. Beijnen and Olaf van Tellingen

Clin Cancer Res April 15 2013 19 (8) 2084-2095; DOI:10.1158/1078-0432.CCR-12-3105
Cancer Therapy: Preclinical

Targeting miR-21 Inhibits In Vitro and In Vivo Multiple Myeloma Cell Growth

Emanuela Leone, Eugenio Morelli, Maria T. Di Martino, Nicola Amodio, Umberto Foresta, Annamaria Gullà, Marco Rossi, Antonino Neri, Antonio Giordano, Nikhil C. Munshi, Kenneth C. Anderson, Pierosandro Tagliaferri and Pierfrancesco Tassone

Clin Cancer Res April 15 2013 19 (8) 2096-2106; DOI:10.1158/1078-0432.CCR-12-3325
Cancer Therapy: Preclinical

Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78

Yu Rebecca Miao, Bedrich L. Eckhardt, Yuan Cao, Renata Pasqualini, Pedram Argani, Wadih Arap, Robert G. Ramsay and Robin L. Anderson

Clin Cancer Res April 15 2013 19 (8) 2107-2116; DOI:10.1158/1078-0432.CCR-12-2991
Cancer Therapy: Preclinical

The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 Upregulation in Osteosarcoma Preclinical Models

Ymera Pignochino, Carmine Dell'Aglio, Marco Basiricò, Federica Capozzi, Marco Soster, Serena Marchiò, Stefania Bruno, Loretta Gammaitoni, Dario Sangiolo, Erica Torchiaro, Lorenzo D'Ambrosio, Franca Fagioli, Stefano Ferrari, Marco Alberghini, Piero Picci, Massimo Aglietta and Giovanni Grignani

Clin Cancer Res April 15 2013 19 (8) 2117-2131; DOI:10.1158/1078-0432.CCR-12-2293
Cancer Therapy: Preclinical | AuthorChoice

Growth and Activation of Natural Killer Cells Ex Vivo from Children with Neuroblastoma for Adoptive Cell Therapy

Yin Liu, Hong-Wei Wu, Michael A. Sheard, Richard Sposto, Srinivas S. Somanchi, Laurence J.N. Cooper, Dean A. Lee and Robert C. Seeger

Clin Cancer Res April 15 2013 19 (8) 2132-2143; DOI:10.1158/1078-0432.CCR-12-1243

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

Mammographic Breast Density Response to Aromatase Inhibition

Celine M. Vachon, Vera J. Suman, Kathleen R. Brandt, Matthew L. Kosel, Aman U. Buzdar, Janet E. Olson, Fang-Fang Wu, Lynn M. Flickinger, Giske Ursin, Catherine R. Elliott, Lois Shepherd, Richard M. Weinshilboum, Paul E. Goss and James N. Ingle

Clin Cancer Res April 15 2013 19 (8) 2144-2153; DOI:10.1158/1078-0432.CCR-12-2789
Imaging, Diagnosis, Prognosis

Potentially Prognostic miRNAs in HPV-Associated Oropharyngeal Carcinoma

Angela B.Y. Hui, Alice Lin, Wei Xu, Levi Waldron, Bayardo Perez-Ordonez, Ilan Weinreb, Wei Shi, Jeff Bruce, Shao Hui Huang, Brian O'Sullivan, John Waldron, Patrick Gullane, Jonathan C. Irish, Kelvin Chan and Fei-Fei Liu

Clin Cancer Res April 15 2013 19 (8) 2154-2162; DOI:10.1158/1078-0432.CCR-12-3572
Imaging, Diagnosis, Prognosis

Quantitative Ultrasound Evaluation of Tumor Cell Death Response in Locally Advanced Breast Cancer Patients Receiving Chemotherapy

Ali Sadeghi-Naini, Naum Papanicolau, Omar Falou, Judit Zubovits, Rebecca Dent, Sunil Verma, Maureen Trudeau, Jean Francois Boileau, Jacqueline Spayne, Sara Iradji, Ervis Sofroni, Justin Lee, Sharon Lemon-Wong, Martin Yaffe, Michael C. Kolios and Gregory J. Czarnota

Clin Cancer Res April 15 2013 19 (8) 2163-2174; DOI:10.1158/1078-0432.CCR-12-2965
Imaging, Diagnosis, Prognosis

Epstein-Barr Virus DNA Load in Nasopharyngeal Brushings and Whole Blood in Nasopharyngeal Carcinoma Patients before and after Treatment

Marlinda Adham, Astrid E. Greijer, Sandra A.W.M. Verkuijlen, Hedy Juwana, Sabine Fleig, Lisnawati Rachmadi, Octavia Malik, A.N. Kurniawan, Averdi Roezin, Soehartati Gondhowiardjo, Djumhana Atmakusumah, Servi J.C. Stevens, Bambang Hermani, I. Bing Tan and Jaap M. Middeldorp

Clin Cancer Res April 15 2013 19 (8) 2175-2186; DOI:10.1158/1078-0432.CCR-12-2897
Imaging, Diagnosis, Prognosis

MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia

David C. de Leeuw, Willemijn van den Ancker, Fedor Denkers, Renée X. de Menezes, Theresia M. Westers, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht and Linda Smit

Clin Cancer Res April 15 2013 19 (8) 2187-2196; DOI:10.1158/1078-0432.CCR-12-3657
Imaging, Diagnosis, Prognosis

CD44 and OTP Are Strong Prognostic Markers for Pulmonary Carcinoids

Dorian R.A. Swarts, Mieke E.R. Henfling, Leander Van Neste, Robert-Jan van Suylen, Anne-Marie C. Dingemans, Winand N.M. Dinjens, Annick Haesevoets, Martina Rudelius, Erik Thunnissen, Marco Volante, Wim Van Criekinge, Manon van Engeland, Frans C.S. Ramaekers and Ernst-Jan M. Speel

Clin Cancer Res April 15 2013 19 (8) 2197-2207; DOI:10.1158/1078-0432.CCR-12-3078
Imaging, Diagnosis, Prognosis

An International Collaboration to Harmonize the Quantitative Plasma Epstein-Barr Virus DNA Assay for Future Biomarker-Guided Trials in Nasopharyngeal Carcinoma

Quynh-Thu Le, Qiang Zhang, Hongbin Cao, Ann-Joy Cheng, Benjamin A. Pinsky, Ruey-Long Hong, Joseph T. Chang, Chun-Wei Wang, Kuo-Chien Tsao, YM Dennis Lo, Nancy Lee, K. Kian Ang, Anthony T.C. Chan and K.C. Allen Chan

Clin Cancer Res April 15 2013 19 (8) 2208-2215; DOI:10.1158/1078-0432.CCR-12-3702
Imaging, Diagnosis, Prognosis

Methylation of the hTERT Promoter: A Novel Cancer Biomarker for Leptomeningeal Metastasis Detection in Cerebrospinal Fluids

Stéphanie Bougel, Benoit Lhermitte, Gabrielle Gallagher, Jeanne-Chantal de Flaugergues, Robert C. Janzer and Jean Benhattar

Clin Cancer Res April 15 2013 19 (8) 2216-2223; DOI:10.1158/1078-0432.CCR-12-1246

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Long-term Vaccination with Multiple Peptides Derived from Cancer-Testis Antigens Can Maintain a Specific T-cell Response and Achieve Disease Stability in Advanced Biliary Tract Cancer

Atsushi Aruga, Nobuhiro Takeshita, Yoshihito Kotera, Ryuji Okuyama, Norimasa Matsushita, Takehiro Ohta, Kazuyoshi Takeda and Masakazu Yamamoto

Clin Cancer Res April 15 2013 19 (8) 2224-2231; DOI:10.1158/1078-0432.CCR-12-3592
Cancer Therapy: Clinical

Efficacy and Safety of Retreatment with Ipilimumab in Patients with Pretreated Advanced Melanoma Who Progressed after Initially Achieving Disease Control

Caroline Robert, Dirk Schadendorf, Marianne Messina, F. Stephen Hodi and Steven O'Day; for the MDX010-20 investigators

Clin Cancer Res April 15 2013 19 (8) 2232-2239; DOI:10.1158/1078-0432.CCR-12-3080
Cancer Therapy: Clinical

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers

Helena A. Yu, Maria E. Arcila, Natasha Rekhtman, Camelia S. Sima, Maureen F. Zakowski, William Pao, Mark G. Kris, Vincent A. Miller, Marc Ladanyi and Gregory J. Riely

Clin Cancer Res April 15 2013 19 (8) 2240-2247; DOI:10.1158/1078-0432.CCR-12-2246
Cancer Therapy: Clinical

Phase Ib Dose-Escalation Study (PX-171-006) of Carfilzomib, Lenalidomide, and Low-Dose Dexamethasone in Relapsed or Progressive Multiple Myeloma

Ruben Niesvizky, Thomas G. Martin III, William I. Bensinger, Melissa Alsina, David S. Siegel, Lori A. Kunkel, Alvin F. Wong, Susan Lee, Robert Z. Orlowski and Michael Wang

Clin Cancer Res April 15 2013 19 (8) 2248-2256; DOI:10.1158/1078-0432.CCR-12-3352

Predictive Biomarkers and Personalized Medicine

Predictive Biomarkers and Personalized Medicine

Phase II Trial of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with BRAF^V600E/K-Mutated Melanoma

Federica Catalanotti, David B. Solit, Melissa P. Pulitzer, Michael F. Berger, Sasinya N. Scott, Tunc Iyriboz, Mario E. Lacouture, Katherine S. Panageas, Jedd D. Wolchok, Richard D. Carvajal, Gary K. Schwartz, Neal Rosen and Paul B. Chapman

Clin Cancer Res April 15 2013 19 (8) 2257-2264; DOI:10.1158/1078-0432.CCR-12-3476
Predictive Biomarkers and Personalized Medicine

Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer

Alessio Amatu, Andrea Sartore-Bianchi, Catia Moutinho, Alessandro Belotti, Katia Bencardino, Giuseppe Chirico, Andrea Cassingena, Francesca Rusconi, Anna Esposito, Michele Nichelatti, Manel Esteller and Salvatore Siena

Clin Cancer Res April 15 2013 19 (8) 2265-2272; DOI:10.1158/1078-0432.CCR-12-3518

Correction

Correction

Correction: Polyphenon E Enhances the Antitumor Immune Response in Neuroblastoma by Inactivating Myeloid Suppressor Cells

Clin Cancer Res April 15 2013 19 (8) 2273-2273; DOI:10.1158/1078-0432.CCR-13-0727

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Table of Contents

Highlights

CCR Translations

CCR Drug Updates

Molecular Pathways

Tobacco Statement

Human Cancer Biology

Cancer Therapy: Preclinical

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Predictive Biomarkers and Personalized Medicine

Correction

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