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Serum levels of cytokines in patients with untreated primary lung cancer.

N Katsumata, K Eguchi, M Fukuda, N Yamamoto, Y Ohe, F Oshita, T Tamura, T Shinkai and N Saijo
N Katsumata
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K Eguchi
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M Fukuda
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N Yamamoto
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Y Ohe
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F Oshita
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T Tamura
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T Shinkai
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N Saijo
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DOI:  Published March 1996
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Abstract

To evaluate the relationships between serum endogenous cytokine levels and their clinical implications in cancer patients, we measured the serum levels of endogenous granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interleukin 6 (IL-6) in patients with untreated primary lung cancer. The serum G-CSF level was measured using a chemiluminescent ELISA, and the other cytokine levels were measured using ELISA. Fifty healthy adults and 183 patients with primary lung cancer were studied. The mean M-CSF level in the lung cancer patients (1106.4 units/ml) was significantly higher than that in the healthy adults (836 units/ml, P = 0.0001). In patients with large cell carcinoma, endogenous G-CSF, M-CSF, and IL-6 levels were significantly higher than those in patients with carcinomas of other cell types (P < 0.05). Univariate analysis showed that survival of 159 non-small cell lung cancer patients with high (more than cutoff level) G-CSF, M-CSF, and IL-6 levels was significantly poorer than that of patients with low levels (Wilcoxon's test, P = 0.018, P < 0. 0001, and P < 0.0001, respectively). Survival of patients with high levels of two or more cytokines was poorer than that of those with high levels of one cytokine or normal cytokine levels (P < 0.0001). Multivariate analysis using Cox's proportional hazards model showed that high M-CSF and C-reactive protein levels correlated significantly with poor survival (P = 0.037 and 0.037, respectively). Our preliminary data suggest that high M-CSF levels in non-small cell lung cancer may be of poor prognostic value.

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March 1996
Volume 2, Issue 3
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Serum levels of cytokines in patients with untreated primary lung cancer.
N Katsumata, K Eguchi, M Fukuda, N Yamamoto, Y Ohe, F Oshita, T Tamura, T Shinkai and N Saijo
Clin Cancer Res March 1 1996 (2) (3) 553-559;

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Serum levels of cytokines in patients with untreated primary lung cancer.
N Katsumata, K Eguchi, M Fukuda, N Yamamoto, Y Ohe, F Oshita, T Tamura, T Shinkai and N Saijo
Clin Cancer Res March 1 1996 (2) (3) 553-559;
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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