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Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res May 15 2014 20 (10) 2503-2503;

CCR Translations

  • CCR Translations
    Minimal Residual Disease in Breast Cancer: In Blood Veritas
    Giulia Siravegna and Alberto Bardelli
    Clin Cancer Res May 15 2014 20 (10) 2505-2507; DOI:10.1158/1078-0432.CCR-14-0370

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: Preclinical Models and Clinical Trials with Metformin in Breast Cancer
    Alastair M. Thompson
    Clin Cancer Res May 15 2014 20 (10) 2508-2515; DOI:10.1158/1078-0432.CCR-13-0354

  • Molecular Pathways
    Molecular Pathways: Adaptive Kinome Reprogramming in Response to Targeted Inhibition of the BRAF–MEK–ERK Pathway in Cancer
    Gary L. Johnson, Timothy J. Stuhlmiller, Steven P. Angus, Jon S. Zawistowski and Lee M. Graves
    Clin Cancer Res May 15 2014 20 (10) 2516-2522; DOI:10.1158/1078-0432.CCR-13-1081

CCR Focus

  • CCR Focus
    The Language of Pharmacodynamics
    Susan E. Bates
    Clin Cancer Res May 15 2014 20 (10) 2524-2524; DOI:10.1158/1078-0432.CCR-14-0739

  • CCR Focus
    Pharmacologic Biomarkers in the Development of Stratified Cancer Medicine
    William Douglas Figg and David R. Newell
    Clin Cancer Res May 15 2014 20 (10) 2525-2529; DOI:10.1158/1078-0432.CCR-14-0511

  • CCR Focus
    Using Pharmacogene Polymorphism Panels to Detect Germline Pharmacodynamic Markers in Oncology
    Daniel L. Hertz and Howard L. McLeod
    Clin Cancer Res May 15 2014 20 (10) 2530-2540; DOI:10.1158/1078-0432.CCR-13-2780

  • CCR Focus
    Genome-Wide Association Study: A Useful Tool to Identify Common Genetic Variants Associated with Drug Toxicity and Efficacy in Cancer Pharmacogenomics
    Siew-Kee Low, Atsushi Takahashi, Taisei Mushiroda and Michiaki Kubo
    Clin Cancer Res May 15 2014 20 (10) 2541-2552; DOI:10.1158/1078-0432.CCR-13-2755

  • CCR Focus
    Circulating Tumor Cells: A Multifunctional Biomarker
    Timothy A. Yap, David Lorente, Aurelius Omlin, David Olmos and Johann S. de Bono
    Clin Cancer Res May 15 2014 20 (10) 2553-2568; DOI:10.1158/1078-0432.CCR-13-2664

  • CCR Focus
    In Vivo Imaging as a Pharmacodynamic Marker
    Astrid A.M. van der Veldt and Adriaan A. Lammertsma
    Clin Cancer Res May 15 2014 20 (10) 2569-2577; DOI:10.1158/1078-0432.CCR-13-2666

  • CCR Focus
    Implementation of Validated Pharmacodynamic Assays in Multiple Laboratories: Challenges, Successes, and Limitations
    Robert Kinders, Kate Ferry-Galow, Lihua Wang, Apurva K. Srivastava, Jiuping (Jay) Ji and Ralph E. Parchment
    Clin Cancer Res May 15 2014 20 (10) 2578-2586; DOI:10.1158/1078-0432.CCR-14-0476

  • CCR Focus
    Pharmacodynamic Biomarkers: Falling Short of the Mark?
    Justin F. Gainor, Dan L. Longo and Bruce A. Chabner
    Clin Cancer Res May 15 2014 20 (10) 2587-2594; DOI:10.1158/1078-0432.CCR-13-3132

Human Cancer Biology

  • Human Cancer Biology
    FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression
    Jiujie Cui, Min Shi, Dacheng Xie, Daoyan Wei, Zhiliang Jia, Shaojiang Zheng, Yong Gao, Suyun Huang and Keping Xie
    Clin Cancer Res May 15 2014 20 (10) 2595-2606; DOI:10.1158/1078-0432.CCR-13-2407

  • Human Cancer Biology
    Human Melanoma Metastases Demonstrate Nonstochastic Site-Specific Antigen Heterogeneity That Correlates with T-cell Infiltration
    Edmund K. Bartlett, Patricia A. Fetsch, Armando C. Filie, Andrea Abati, Seth M. Steinberg, John R. Wunderlich, Donald E. White, Daniel J. Stephens, Francesco M. Marincola, Steven A. Rosenberg and Udai S. Kammula
    Clin Cancer Res May 15 2014 20 (10) 2607-2616; DOI:10.1158/1078-0432.CCR-13-2690

  • Human Cancer Biology
    miR-141 Is a Key Regulator of Renal Cell Carcinoma Proliferation and Metastasis by Controlling EphA2 Expression
    Xuanyu Chen, Xuegang Wang, Anming Ruan, Weiwei Han, Yan Zhao, Xing Lu, Pei Xiao, Hangchuan Shi, Rong Wang, Li Chen, Shaoyong Chen, Quansheng Du, Hongmei Yang and Xiaoping Zhang
    Clin Cancer Res May 15 2014 20 (10) 2617-2630; DOI:10.1158/1078-0432.CCR-13-3224

  • Human Cancer Biology | AuthorChoice
    Regulation of Colorectal Carcinoma Stemness, Growth, and Metastasis by an miR-200c-Sox2–Negative Feedback Loop Mechanism
    Yan-Xia Lu, Li Yuan, Xiao-Lei Xue, Min Zhou, Yan Liu, Chao Zhang, Jing-Ping Li, Lin Zheng, Min Hong and Xue-Nong Li
    Clin Cancer Res May 15 2014 20 (10) 2631-2642; DOI:10.1158/1078-0432.CCR-13-2348

  • Human Cancer Biology
    Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer
    Julia A. Beaver, Danijela Jelovac, Sasidharan Balukrishna, Rory L. Cochran, Sarah Croessmann, Daniel J. Zabransky, Hong Yuen Wong, Patricia Valda Toro, Justin Cidado, Brian G. Blair, David Chu, Timothy Burns, Michaela J. Higgins, Vered Stearns, Lisa Jacobs, Mehran Habibi, Julie Lange, Paula J. Hurley, Josh Lauring, Dustin A. VanDenBerg, Jill Kessler, Stacie Jeter, Michael L. Samuels, Dianna Maar, Leslie Cope, Ashley Cimino-Mathews, Pedram Argani, Antonio C. Wolff and Ben Ho Park
    Clin Cancer Res May 15 2014 20 (10) 2643-2650; DOI:10.1158/1078-0432.CCR-13-2933

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance—Implications for IGF-II and IGF-IR–Targeted Therapy
    Bin Li, Sai Wah Tsao, Kwok Wah Chan, Dale L. Ludwig, Ruslan Novosyadlyy, Yuk Yin Li, Qing Yu He and Annie L.M. Cheung
    Clin Cancer Res May 15 2014 20 (10) 2651-2662; DOI:10.1158/1078-0432.CCR-13-2735

  • Cancer Therapy: Preclinical
    COX-2–Independent Effects of Celecoxib Sensitize Lymphoma B Cells to TRAIL-Mediated Apoptosis
    Anne-Sophie Gallouet, Marion Travert, Laurence Bresson-Bepoldin, Fabien Guilloton, Céline Pangault, Sylvie Caulet-Maugendre, Thierry Lamy, Karin Tarte and Thierry Guillaudeux
    Clin Cancer Res May 15 2014 20 (10) 2663-2673; DOI:10.1158/1078-0432.CCR-13-2305

  • Cancer Therapy: Preclinical | AuthorChoice
    Selective JAK2 Inhibition Specifically Decreases Hodgkin Lymphoma and Mediastinal Large B-cell Lymphoma Growth In Vitro and In Vivo
    Yansheng Hao, Bjoern Chapuy, Stefano Monti, Heather H. Sun, Scott J. Rodig and Margaret A. Shipp
    Clin Cancer Res May 15 2014 20 (10) 2674-2683; DOI:10.1158/1078-0432.CCR-13-3007

  • Cancer Therapy: Preclinical
    Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells
    Smita K. Nair, Gabriel De Leon, David Boczkowski, Robert Schmittling, Weihua Xie, Janet Staats, Rebecca Liu, Laura A. Johnson, Kent Weinhold, Gary E. Archer, John H. Sampson and Duane A. Mitchell
    Clin Cancer Res May 15 2014 20 (10) 2684-2694; DOI:10.1158/1078-0432.CCR-13-3268

  • Cancer Therapy: Preclinical
    Anti-VEGF Antibodies Mitigate the Development of Radiation Necrosis in Mouse Brain
    Xiaoyu Jiang, John A. Engelbach, Liya Yuan, Jeremy Cates, Feng Gao, Robert E. Drzymala, Dennis E. Hallahan, Keith M. Rich, Robert E. Schmidt, Joseph J.H. Ackerman and Joel R. Garbow
    Clin Cancer Res May 15 2014 20 (10) 2695-2702; DOI:10.1158/1078-0432.CCR-13-1941

  • Cancer Therapy: Preclinical
    ABCB1, ABCG2, and PTEN Determine the Response of Glioblastoma to Temozolomide and ABT-888 Therapy
    Fan Lin, Mark C. de Gooijer, Eloy Moreno Roig, Levi C.M. Buil, Susan M. Christner, Jan H. Beumer, Thomas Würdinger, Jos H. Beijnen and Olaf van Tellingen
    Clin Cancer Res May 15 2014 20 (10) 2703-2713; DOI:10.1158/1078-0432.CCR-14-0084

  • Cancer Therapy: Preclinical
    Metformin Sensitizes EGFR-TKI–Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal
    Li Li, Rui Han, Hualiang Xiao, Caiyu Lin, Yubo Wang, Hao Liu, Kunlin Li, Hengyi Chen, Fenfen Sun, Zhenzhou Yang, Jianxin Jiang and Yong He
    Clin Cancer Res May 15 2014 20 (10) 2714-2726; DOI:10.1158/1078-0432.CCR-13-2613

  • Cancer Therapy: Preclinical
    Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner
    Diane Palmieri, Renata Duchnowska, Stephan Woditschka, Emily Hua, Yongzhen Qian, Wojciech Biernat, Katarzyna Sosińska-Mielcarek, Brunilde Gril, Andreas M. Stark, Stephen M. Hewitt, David J. Liewehr, Seth M. Steinberg, Jacek Jassem and Patricia S. Steeg
    Clin Cancer Res May 15 2014 20 (10) 2727-2739; DOI:10.1158/1078-0432.CCR-13-2588

  • Cancer Therapy: Preclinical
    Biologic Effects of Platelet-Derived Growth Factor Receptor α Blockade in Uterine Cancer
    Ju-Won Roh, Jie Huang, Wei Hu, XiaoYun Yang, Nicholas B. Jennings, Vasudha Sehgal, Bo Hwa Sohn, Hee Dong Han, Sun Joo Lee, Duangmani Thanapprapasr, Justin Bottsford-Miller, Behrouz Zand, Heather J. Dalton, Rebecca A. Previs, Ashley N. Davis, Koji Matsuo, Ju-Seog Lee, Prahlad Ram, Robert L. Coleman and Anil K. Sood
    Clin Cancer Res May 15 2014 20 (10) 2740-2750; DOI:10.1158/1078-0432.CCR-13-2507

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Repeatability of Quantitative FDG-PET/CT and Contrast-Enhanced CT in Recurrent Ovarian Carcinoma: Test–Retest Measurements for Tumor FDG Uptake, Diameter, and Volume
    Andrea G. Rockall, Norbert Avril, Raymond Lam, Robert Iannone, P. David Mozley, Christine Parkinson, Donald Bergstrom, Evis Sala, Shah-Jalal Sarker, Iain A. McNeish and James D. Brenton
    Clin Cancer Res May 15 2014 20 (10) 2751-2760; DOI:10.1158/1078-0432.CCR-13-2634

  • Imaging, Diagnosis, Prognosis
    A Signature Predicting Poor Prognosis in Gastric and Ovarian Cancer Represents a Coordinated Macrophage and Stromal Response
    Rita A. Busuttil, Joshy George, Richard W. Tothill, Kylie Ioculano, Adam Kowalczyk, Catherine Mitchell, Stephen Lade, Patrick Tan, Izhak Haviv and Alex Boussioutas
    Clin Cancer Res May 15 2014 20 (10) 2761-2772; DOI:10.1158/1078-0432.CCR-13-3049

  • Imaging, Diagnosis, Prognosis
    In Situ Tumor PD-L1 mRNA Expression Is Associated with Increased TILs and Better Outcome in Breast Carcinomas
    Kurt A. Schalper, Vamsidhar Velcheti, Daniel Carvajal, Hallie Wimberly, Jason Brown, Lajos Pusztai and David L. Rimm
    Clin Cancer Res May 15 2014 20 (10) 2773-2782; DOI:10.1158/1078-0432.CCR-13-2702

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Population Pharmacokinetics of Bevacizumab in Children with Osteosarcoma: Implications for Dosing
    David C. Turner, Fariba Navid, Najat C. Daw, Shenghua Mao, Jianrong Wu, Victor M. Santana, Michael Neel, Bhaskar Rao, Jennifer Reikes Willert, David M. Loeb, K. Elaine Harstead, Stacy L. Throm, Burgess B. Freeman III and Clinton F. Stewart
    Clin Cancer Res May 15 2014 20 (10) 2783-2792; DOI:10.1158/1078-0432.CCR-13-2364

  • Cancer Therapy: Clinical
    A Pharmacodynamic/Pharmacokinetic Study of Ficlatuzumab in Patients with Advanced Solid Tumors and Liver Metastases
    Josep Tabernero, Maria Elena Elez, Maria Herranz, Isabel Rico, Ludmila Prudkin, Jordi Andreu, Jose Mateos, Maria Josep Carreras, May Han, James Gifford, Marc Credi, Wei Yin, Shefali Agarwal, Philip Komarnitsky and Jose Baselga
    Clin Cancer Res May 15 2014 20 (10) 2793-2804; DOI:10.1158/1078-0432.CCR-13-1837

Predictive Biomarkers and Personalized Medicine

  • Predictive Biomarkers and Personalized Medicine | AuthorChoice
    Quantitative Measurements of Tumoral p95HER2 Protein Expression in Metastatic Breast Cancer Patients Treated with Trastuzumab: Independent Validation of the p95HER2 Clinical Cutoff
    Renata Duchnowska, Jeff Sperinde, Ahmed Chenna, Mojgan Haddad, Agnes Paquet, Yolanda Lie, Jodi M. Weidler, Weidong Huang, John Winslow, Tomasz Jankowski, Bogumiła Czartoryska-Arłukowicz, Piotr J. Wysocki, Małgorzata Foszczyńska-Kłoda, Barbara Radecka, Maria M. Litwiniuk, Jolanta Żok, Michał Wiśniewski, Dorota Zuziak, Wojciech Biernat and Jacek Jassem
    Clin Cancer Res May 15 2014 20 (10) 2805-2813; DOI:10.1158/1078-0432.CCR-13-2782

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Clinical Cancer Research: 20 (10)
May 2014
Volume 20, Issue 10
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  • Table of Contents (PDF)
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Issue Highlights

  • Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner
  • Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance—Implications for IGF-II and IGF-IR–Targeted Therapy
  • Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer
  • COX-2–Independent Effects of Celecoxib Sensitize Lymphoma B Cells to TRAIL-Mediated Apoptosis
  • Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells

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  • Characterization of Glioblastoma Patient-Derived Xenografts
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  • AR Gene Rearrangements in Prostate Cancer
  • PDAC and GATA6 Expression
  • Guadecitabine and Carboplatin in Ovarian Cancer
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Clinical Cancer Research
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