Clinical Cancer Research: 20 (12)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res June 15 2014 20 (12) 3045-3045;

CCR Translations

CCR Translations

Manipulating the Epigenome in Germinal Center Lymphomas: Is It Getting Easier and EZier?

Jennifer E. Amengual and Owen A. O'Connor

Clin Cancer Res June 15 2014 20 (12) 3047-3049; DOI:10.1158/1078-0432.CCR-14-0629

CCR New Strategies

CCR New Strategies | AuthorChoice

New Strategies in Ewing Sarcoma: Lost in Translation?

Fernanda I. Arnaldez and Lee J. Helman

Clin Cancer Res June 15 2014 20 (12) 3050-3056; DOI:10.1158/1078-0432.CCR-13-0633

Molecular Pathways

Molecular Pathways

Molecular Pathways: PI3K Pathway Phosphatases as Biomarkers for Cancer Prognosis and Therapy

Muhan Chen, Dawid G. Nowak and Lloyd C. Trotman

Clin Cancer Res June 15 2014 20 (12) 3057-3063; DOI:10.1158/1078-0432.CCR-12-3680
Molecular Pathways

Molecular Pathways: Turning Proteasomal Protein Degradation into a Unique Treatment Approach

Sebastian Stintzing and Heinz-Josef Lenz

Clin Cancer Res June 15 2014 20 (12) 3064-3070; DOI:10.1158/1078-0432.CCR-13-3175

Review

Review

Molecular Mechanisms of Bone Metastasis and Associated Muscle Weakness

David L. Waning and Theresa A. Guise

Clin Cancer Res June 15 2014 20 (12) 3071-3077; DOI:10.1158/1078-0432.CCR-13-1590

Human Cancer Biology

Human Cancer Biology

EZH2 Mutations in Follicular Lymphoma from Different Ethnic Groups and Associated Gene Expression Alterations

Shuangping Guo, John K.C. Chan, Javeed Iqbal, Timothy McKeithan, Kai Fu, Bin Meng, Yi Pan, Wah Cheuk, Donglan Luo, Ruian Wang, Weiwei Zhang, Timothy C. Greiner and Wing C. Chan

Clin Cancer Res June 15 2014 20 (12) 3078-3086; DOI:10.1158/1078-0432.CCR-13-1597
Human Cancer Biology

Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma

Takashi Nakaoku, Koji Tsuta, Hitoshi Ichikawa, Kouya Shiraishi, Hiromi Sakamoto, Masato Enari, Koh Furuta, Yoko Shimada, Hideaki Ogiwara, Shun-ichi Watanabe, Hiroshi Nokihara, Kazuki Yasuda, Masaki Hiramoto, Takao Nammo, Teruhide Ishigame, Aaron J. Schetter, Hirokazu Okayama, Curtis C. Harris, Young Hak Kim, Michiaki Mishima, Jun Yokota, Teruhiko Yoshida and Takashi Kohno

Clin Cancer Res June 15 2014 20 (12) 3087-3093; DOI:10.1158/1078-0432.CCR-14-0107
Human Cancer Biology

GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer

Christian A. Nebiker, Junyi Han, Serenella Eppenberger-Castori, Giandomenica Iezzi, Christian Hirt, Francesca Amicarella, Eleonora Cremonesi, Xaver Huber, Elisabetta Padovan, Basilio Angrisani, Raoul A. Droeser, Raffaele Rosso, Martin Bolli, Daniel Oertli, Urs von Holzen, Michel Adamina, Manuele G. Muraro, Chantal Mengus, Paul Zajac, Giuseppe Sconocchia, Markus Zuber, Luigi Tornillo, Luigi Terracciano and Giulio C. Spagnoli

Clin Cancer Res June 15 2014 20 (12) 3094-3106; DOI:10.1158/1078-0432.CCR-13-2774
Human Cancer Biology

A MicroRNA Cluster at 14q32 Drives Aggressive Lung Adenocarcinoma

Ernest Nadal, Jinjie Zhong, Jules Lin, Rishindra M. Reddy, Nithya Ramnath, Mark B. Orringer, Andrew C. Chang, David G. Beer and Guoan Chen

Clin Cancer Res June 15 2014 20 (12) 3107-3117; DOI:10.1158/1078-0432.CCR-13-3348
Human Cancer Biology

Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets

Barbara Stefanska, David Cheishvili, Matthew Suderman, Ani Arakelian, Jian Huang, Michael Hallett, Ze-Guang Han, Mamun Al-Mahtab, Sheikh Mohammad Fazle Akbar, Wasif Ali Khan, Rubhana Raqib, Imrana Tanvir, Haseeb Ahmed Khan, Shafaat A. Rabbani and Moshe Szyf

Clin Cancer Res June 15 2014 20 (12) 3118-3132; DOI:10.1158/1078-0432.CCR-13-0283

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

P-Glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain and Blood Disposition of the mTOR Inhibitor Everolimus (Afinitor) in Mice

Seng Chuan Tang, Rolf W. Sparidans, Ka Lei Cheung, Tatsuki Fukami, Selvi Durmus, Els Wagenaar, Tsuyoshi Yokoi, Bart J.M. van Vlijmen, Jos H. Beijnen and Alfred H. Schinkel

Clin Cancer Res June 15 2014 20 (12) 3133-3145; DOI:10.1158/1078-0432.CCR-13-1759
Cancer Therapy: Preclinical

Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs

Parag P. Patwardhan, Oliver Surriga, Michael J. Beckman, Elisa de Stanchina, Ronald P. Dematteo, William D. Tap and Gary K. Schwartz

Clin Cancer Res June 15 2014 20 (12) 3146-3158; DOI:10.1158/1078-0432.CCR-13-2576
Cancer Therapy: Preclinical | AuthorChoice

Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer

Suganthi Chittaranjan, Svetlana Bortnik, Wieslawa H. Dragowska, Jing Xu, Namal Abeysundara, Amy Leung, Nancy E. Go, Lindsay DeVorkin, Sherry A. Weppler, Karen Gelmon, Donald T. Yapp, Marcel B. Bally and Sharon M. Gorski

Clin Cancer Res June 15 2014 20 (12) 3159-3173; DOI:10.1158/1078-0432.CCR-13-2060
Cancer Therapy: Preclinical

Small-Molecule RA-9 Inhibits Proteasome-Associated DUBs and Ovarian Cancer In Vitro and In Vivo via Exacerbating Unfolded Protein Responses

Kathleen Coughlin, Ravi Anchoori, Yoshie Iizuka, Joyce Meints, Lauren MacNeill, Rachel Isaksson Vogel, Robert Z. Orlowski, Michael K. Lee, Richard B.S. Roden and Martina Bazzaro

Clin Cancer Res June 15 2014 20 (12) 3174-3186; DOI:10.1158/1078-0432.CCR-13-2658
Cancer Therapy: Preclinical

Gemcitabine and CHK1 Inhibition Potentiate EGFR-Directed Radioimmunotherapy against Pancreatic Ductal Adenocarcinoma

Fares Al-Ejeh, Marina Pajic, Wei Shi, Murugan Kalimutho, Mariska Miranda, Adnan M. Nagrial, Angela Chou, Andrew V. Biankin, Sean M. Grimmond, for the Australian Pancreatic Cancer Genome Initiative, Michael P. Brown and Kum Kum Khanna

Clin Cancer Res June 15 2014 20 (12) 3187-3197; DOI:10.1158/1078-0432.CCR-14-0048
Cancer Therapy: Preclinical

Niclosamide Inhibits Androgen Receptor Variants Expression and Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer

Chengfei Liu, Wei Lou, Yezi Zhu, Nagalakshmi Nadiminty, Chad T. Schwartz, Christopher P. Evans and Allen C. Gao

Clin Cancer Res June 15 2014 20 (12) 3198-3210; DOI:10.1158/1078-0432.CCR-13-3296
Cancer Therapy: Preclinical

RNAi Screen Identifies a Synthetic Lethal Interaction between PIM1 Overexpression and PLK1 Inhibition

Riet van der Meer, Ha Yong Song, Seong-Hoon Park, Sarki A. Abdulkadir and Meejeon Roh

Clin Cancer Res June 15 2014 20 (12) 3211-3221; DOI:10.1158/1078-0432.CCR-13-3116
Cancer Therapy: Preclinical

Chloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER⁺ Breast Cancer

Katherine L. Cook, Anni Wärri, David R. Soto-Pantoja, Pamela AG. Clarke, M. Idalia Cruz, Alan Zwart and Robert Clarke

Clin Cancer Res June 15 2014 20 (12) 3222-3232; DOI:10.1158/1078-0432.CCR-13-3227

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

Expression Signature Defined by FOXM1–CCNB1 Activation Predicts Disease Recurrence in Non–Muscle-Invasive Bladder Cancer

Seon-Kyu Kim, Yun-Gil Roh, Kiejung Park, Tae-Hong Kang, Wun-Jae Kim, Ju-Seog Lee, Sun-Hee Leem and In-Sun Chu

Clin Cancer Res June 15 2014 20 (12) 3233-3243; DOI:10.1158/1078-0432.CCR-13-2761
Imaging, Diagnosis, Prognosis

Combined PET/MRI Improves Diagnostic Accuracy in Patients with Prostate Cancer: A Prospective Diagnostic Trial

Markus Hartenbach, Sabrina Hartenbach, Winfried Bechtloff, Burkhardt Danz, Klaus Kraft, Burkhard Klemenz, Christoph Sparwasser and Marcus Hacker

Clin Cancer Res June 15 2014 20 (12) 3244-3253; DOI:10.1158/1078-0432.CCR-13-2653
Imaging, Diagnosis, Prognosis

Impact of Initial FDG-PET/CT and Serum-Free Light Chain on Transformation of Conventionally Defined Solitary Plasmacytoma to Multiple Myeloma

Guillemette Fouquet, Stéphanie Guidez, Charles Herbaux, Zoé Van de Wyngaert, Sarah Bonnet, David Beauvais, Hélène Demarquette, Salim Adib, Bénédicte Hivert, Mathieu Wemeau, Céline Berthon, Louis Terriou, Valérie Coiteux, Margaret Macro, Olivier Decaux, Thierry Facon, Damien Huglo and Xavier Leleu

Clin Cancer Res June 15 2014 20 (12) 3254-3260; DOI:10.1158/1078-0432.CCR-13-2910
Imaging, Diagnosis, Prognosis

CHFR Promoter Methylation Indicates Poor Prognosis in Stage II Microsatellite Stable Colorectal Cancer

Arjen H.G. Cleven, Sarah Derks, Muriel X.G. Draht, Kim M. Smits, Veerle Melotte, Leander Van Neste, Benjamin Tournier, Valerie Jooste, Caroline Chapusot, Matty P. Weijenberg, James G. Herman, Adriaan P. de Bruïne and Manon van Engeland

Clin Cancer Res June 15 2014 20 (12) 3261-3271; DOI:10.1158/1078-0432.CCR-12-3734
Imaging, Diagnosis, Prognosis

Genetic Variations Associated with Postoperative Recurrence in Stage I Non–Small Cell Lung Cancer

Kyong-Ah Yoon, Mee Kyung Jung, Donghoon Lee, Kieun Bae, Jung Nam Joo, Geon Kook Lee, Hyun-Sung Lee and Jin Soo Lee

Clin Cancer Res June 15 2014 20 (12) 3272-3279; DOI:10.1158/1078-0432.CCR-13-2835
Imaging, Diagnosis, Prognosis

Molecular Biomarkers of Residual Disease after Surgical Debulking of High-Grade Serous Ovarian Cancer

Susan L. Tucker, Kshipra Gharpure, Shelley M. Herbrich, Anna K. Unruh, Alpa M. Nick, Erin K. Crane, Robert L. Coleman, Jamie Guenthoer, Heather J. Dalton, Sherry Y. Wu, Rajesha Rupaimoole, Gabriel Lopez-Berestein, Bulent Ozpolat, Cristina Ivan, Wei Hu, Keith A. Baggerly and Anil K. Sood

Clin Cancer Res June 15 2014 20 (12) 3280-3288; DOI:10.1158/1078-0432.CCR-14-0445

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Erlotinib, Erlotinib–Sulindac versus Placebo: A Randomized, Double-Blind, Placebo-Controlled Window Trial in Operable Head and Neck Cancer

Neil D. Gross, Julie E. Bauman, William E. Gooding, William Denq, Sufi M. Thomas, Lin Wang, Simion Chiosea, Brian L. Hood, Melanie S. Flint, Mai Sun, Thomas P. Conrads, Robert L. Ferris, Jonas T. Johnson, Seungwon Kim, Athanassios Argiris, Lori Wirth, Marina N. Nikiforova, Jill M. Siegfried and Jennifer R. Grandis

Clin Cancer Res June 15 2014 20 (12) 3289-3298; DOI:10.1158/1078-0432.CCR-13-3360

Predictive Biomarkers and Personalized Medicine

Predictive Biomarkers and Personalized Medicine | AuthorChoice

FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies

Murry W. Wynes, Trista K. Hinz, Dexiang Gao, Michael Martini, Lindsay A. Marek, Kathryn E. Ware, Michael G. Edwards, Diana Böhm, Sven Perner, Barbara A. Helfrich, Rafal Dziadziuszko, Jacek Jassem, Szymon Wojtylak, Aleksandra Sejda, Joseph M. Gozgit, Paul A. Bunn Jr, D. Ross Camidge, Aik-Choon Tan, Fred R. Hirsch and Lynn E. Heasley

Clin Cancer Res June 15 2014 20 (12) 3299-3309; DOI:10.1158/1078-0432.CCR-13-3060
Predictive Biomarkers and Personalized Medicine

Blood mRNA Expression Profiling Predicts Survival in Patients Treated with Tremelimumab

Yvonne Saenger, Jay Magidson, Bobby Liaw, Ellen de Moll, Sara Harcharik, Yichun Fu, Karl Wassmann, David Fisher, John Kirkwood, William K. Oh and Philip Friedlander

Clin Cancer Res June 15 2014 20 (12) 3310-3318; DOI:10.1158/1078-0432.CCR-13-2906
Predictive Biomarkers and Personalized Medicine

Association Study of the let-7 miRNA-Complementary Site Variant in the 3′ Untranslated Region of the KRAS Gene in Stage III Colon Cancer (NCCTG N0147 Clinical Trial)

Dan Sha, Adam M. Lee, Qian Shi, Steven R. Alberts, Daniel J. Sargent, Frank A. Sinicrope and Robert B. Diasio

Clin Cancer Res June 15 2014 20 (12) 3319-3327; DOI:10.1158/1078-0432.CCR-14-0069
Predictive Biomarkers and Personalized Medicine

Correlation of Somatic Mutations and Clinical Outcome in Melanoma Patients Treated with Carboplatin, Paclitaxel, and Sorafenib

Melissa A. Wilson, Fengmin Zhao, Richard Letrero, Kurt D'Andrea, David L. Rimm, John M. Kirkwood, Harriet M. Kluger, Sandra J. Lee, Lynn M. Schuchter, Keith T. Flaherty and Katherine L. Nathanson

Clin Cancer Res June 15 2014 20 (12) 3328-3337; DOI:10.1158/1078-0432.CCR-14-0093
Predictive Biomarkers and Personalized Medicine | AuthorChoice

Hsa-miR-31-3p Expression Is Linked to Progression-free Survival in Patients with KRAS Wild-type Metastatic Colorectal Cancer Treated with Anti-EGFR Therapy

Gilles Manceau, Sandrine Imbeaud, Raphaële Thiébaut, François Liébaert, Karine Fontaine, Francis Rousseau, Bérengère Génin, Delphine Le Corre, Audrey Didelot, Marc Vincent, Jean-Baptiste Bachet, Benoist Chibaudel, Olivier Bouché, Bruno Landi, Frédéric Bibeau, Karen Leroy, Frédérique Penault-Llorca, Jean-Luc Van Laethem, Pieter Demetter, Sabine Tejpar, Simona Rossi, Neda Mosakhani, Pia Österlund, Raija Ristamäki, Virinder Sarhadi, Sakari Knuutila, Valérie Boige, Thierry André and Pierre Laurent-Puig

Clin Cancer Res June 15 2014 20 (12) 3338-3347; DOI:10.1158/1078-0432.CCR-13-2750
Predictive Biomarkers and Personalized Medicine

The Role of Relative Lymphocyte Count as a Biomarker for the Effect of Catumaxomab on Survival in Malignant Ascites Patients: Results from a Phase II/III Study

Markus M. Heiss, Michael A. Ströhlein, Carsten Bokemeyer, Dirk Arnold, Simon L. Parsons, Diane Seimetz, Horst Lindhofer, Elisabeth Schulze and Michael Hennig

Clin Cancer Res June 15 2014 20 (12) 3348-3357; DOI:10.1158/1078-0432.CCR-13-2351

Retraction

Retraction

Retraction: Molecular Analysis of Non–Small Cell Lung Cancer Identifies Subsets with Different Sensitivity to Insulin-like Growth Factor I Receptor Inhibition

Clin Cancer Res June 15 2014 20 (12) 3358-3358; DOI:10.1158/1078-0432.CCR-14-1118

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Table of Contents

Highlights

CCR Translations

CCR New Strategies

Molecular Pathways

Review

Human Cancer Biology

Cancer Therapy: Preclinical

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Predictive Biomarkers and Personalized Medicine

Retraction

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