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Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res June 15 2014 20 (12) 3045-3045;

CCR Translations

  • CCR Translations
    Manipulating the Epigenome in Germinal Center Lymphomas: Is It Getting Easier and EZier?
    Jennifer E. Amengual and Owen A. O'Connor
    Clin Cancer Res June 15 2014 20 (12) 3047-3049; DOI:10.1158/1078-0432.CCR-14-0629

CCR New Strategies

  • CCR New Strategies | AuthorChoice
    New Strategies in Ewing Sarcoma: Lost in Translation?
    Fernanda I. Arnaldez and Lee J. Helman
    Clin Cancer Res June 15 2014 20 (12) 3050-3056; DOI:10.1158/1078-0432.CCR-13-0633

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: PI3K Pathway Phosphatases as Biomarkers for Cancer Prognosis and Therapy
    Muhan Chen, Dawid G. Nowak and Lloyd C. Trotman
    Clin Cancer Res June 15 2014 20 (12) 3057-3063; DOI:10.1158/1078-0432.CCR-12-3680

  • Molecular Pathways
    Molecular Pathways: Turning Proteasomal Protein Degradation into a Unique Treatment Approach
    Sebastian Stintzing and Heinz-Josef Lenz
    Clin Cancer Res June 15 2014 20 (12) 3064-3070; DOI:10.1158/1078-0432.CCR-13-3175

Review

  • Review
    Molecular Mechanisms of Bone Metastasis and Associated Muscle Weakness
    David L. Waning and Theresa A. Guise
    Clin Cancer Res June 15 2014 20 (12) 3071-3077; DOI:10.1158/1078-0432.CCR-13-1590

Human Cancer Biology

  • Human Cancer Biology
    EZH2 Mutations in Follicular Lymphoma from Different Ethnic Groups and Associated Gene Expression Alterations
    Shuangping Guo, John K.C. Chan, Javeed Iqbal, Timothy McKeithan, Kai Fu, Bin Meng, Yi Pan, Wah Cheuk, Donglan Luo, Ruian Wang, Weiwei Zhang, Timothy C. Greiner and Wing C. Chan
    Clin Cancer Res June 15 2014 20 (12) 3078-3086; DOI:10.1158/1078-0432.CCR-13-1597

  • Human Cancer Biology
    Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma
    Takashi Nakaoku, Koji Tsuta, Hitoshi Ichikawa, Kouya Shiraishi, Hiromi Sakamoto, Masato Enari, Koh Furuta, Yoko Shimada, Hideaki Ogiwara, Shun-ichi Watanabe, Hiroshi Nokihara, Kazuki Yasuda, Masaki Hiramoto, Takao Nammo, Teruhide Ishigame, Aaron J. Schetter, Hirokazu Okayama, Curtis C. Harris, Young Hak Kim, Michiaki Mishima, Jun Yokota, Teruhiko Yoshida and Takashi Kohno
    Clin Cancer Res June 15 2014 20 (12) 3087-3093; DOI:10.1158/1078-0432.CCR-14-0107

  • Human Cancer Biology
    GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer
    Christian A. Nebiker, Junyi Han, Serenella Eppenberger-Castori, Giandomenica Iezzi, Christian Hirt, Francesca Amicarella, Eleonora Cremonesi, Xaver Huber, Elisabetta Padovan, Basilio Angrisani, Raoul A. Droeser, Raffaele Rosso, Martin Bolli, Daniel Oertli, Urs von Holzen, Michel Adamina, Manuele G. Muraro, Chantal Mengus, Paul Zajac, Giuseppe Sconocchia, Markus Zuber, Luigi Tornillo, Luigi Terracciano and Giulio C. Spagnoli
    Clin Cancer Res June 15 2014 20 (12) 3094-3106; DOI:10.1158/1078-0432.CCR-13-2774

  • Human Cancer Biology
    A MicroRNA Cluster at 14q32 Drives Aggressive Lung Adenocarcinoma
    Ernest Nadal, Jinjie Zhong, Jules Lin, Rishindra M. Reddy, Nithya Ramnath, Mark B. Orringer, Andrew C. Chang, David G. Beer and Guoan Chen
    Clin Cancer Res June 15 2014 20 (12) 3107-3117; DOI:10.1158/1078-0432.CCR-13-3348

  • Human Cancer Biology
    Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
    Barbara Stefanska, David Cheishvili, Matthew Suderman, Ani Arakelian, Jian Huang, Michael Hallett, Ze-Guang Han, Mamun Al-Mahtab, Sheikh Mohammad Fazle Akbar, Wasif Ali Khan, Rubhana Raqib, Imrana Tanvir, Haseeb Ahmed Khan, Shafaat A. Rabbani and Moshe Szyf
    Clin Cancer Res June 15 2014 20 (12) 3118-3132; DOI:10.1158/1078-0432.CCR-13-0283

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    P-Glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain and Blood Disposition of the mTOR Inhibitor Everolimus (Afinitor) in Mice
    Seng Chuan Tang, Rolf W. Sparidans, Ka Lei Cheung, Tatsuki Fukami, Selvi Durmus, Els Wagenaar, Tsuyoshi Yokoi, Bart J.M. van Vlijmen, Jos H. Beijnen and Alfred H. Schinkel
    Clin Cancer Res June 15 2014 20 (12) 3133-3145; DOI:10.1158/1078-0432.CCR-13-1759

  • Cancer Therapy: Preclinical
    Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs
    Parag P. Patwardhan, Oliver Surriga, Michael J. Beckman, Elisa de Stanchina, Ronald P. Dematteo, William D. Tap and Gary K. Schwartz
    Clin Cancer Res June 15 2014 20 (12) 3146-3158; DOI:10.1158/1078-0432.CCR-13-2576

  • Cancer Therapy: Preclinical | AuthorChoice
    Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer
    Suganthi Chittaranjan, Svetlana Bortnik, Wieslawa H. Dragowska, Jing Xu, Namal Abeysundara, Amy Leung, Nancy E. Go, Lindsay DeVorkin, Sherry A. Weppler, Karen Gelmon, Donald T. Yapp, Marcel B. Bally and Sharon M. Gorski
    Clin Cancer Res June 15 2014 20 (12) 3159-3173; DOI:10.1158/1078-0432.CCR-13-2060

  • Cancer Therapy: Preclinical
    Small-Molecule RA-9 Inhibits Proteasome-Associated DUBs and Ovarian Cancer In Vitro and In Vivo via Exacerbating Unfolded Protein Responses
    Kathleen Coughlin, Ravi Anchoori, Yoshie Iizuka, Joyce Meints, Lauren MacNeill, Rachel Isaksson Vogel, Robert Z. Orlowski, Michael K. Lee, Richard B.S. Roden and Martina Bazzaro
    Clin Cancer Res June 15 2014 20 (12) 3174-3186; DOI:10.1158/1078-0432.CCR-13-2658

  • Cancer Therapy: Preclinical
    Gemcitabine and CHK1 Inhibition Potentiate EGFR-Directed Radioimmunotherapy against Pancreatic Ductal Adenocarcinoma
    Fares Al-Ejeh, Marina Pajic, Wei Shi, Murugan Kalimutho, Mariska Miranda, Adnan M. Nagrial, Angela Chou, Andrew V. Biankin, Sean M. Grimmond, for the Australian Pancreatic Cancer Genome Initiative, Michael P. Brown and Kum Kum Khanna
    Clin Cancer Res June 15 2014 20 (12) 3187-3197; DOI:10.1158/1078-0432.CCR-14-0048

  • Cancer Therapy: Preclinical
    Niclosamide Inhibits Androgen Receptor Variants Expression and Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer
    Chengfei Liu, Wei Lou, Yezi Zhu, Nagalakshmi Nadiminty, Chad T. Schwartz, Christopher P. Evans and Allen C. Gao
    Clin Cancer Res June 15 2014 20 (12) 3198-3210; DOI:10.1158/1078-0432.CCR-13-3296

  • Cancer Therapy: Preclinical
    RNAi Screen Identifies a Synthetic Lethal Interaction between PIM1 Overexpression and PLK1 Inhibition
    Riet van der Meer, Ha Yong Song, Seong-Hoon Park, Sarki A. Abdulkadir and Meejeon Roh
    Clin Cancer Res June 15 2014 20 (12) 3211-3221; DOI:10.1158/1078-0432.CCR-13-3116

  • Cancer Therapy: Preclinical
    Chloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer
    Katherine L. Cook, Anni Wärri, David R. Soto-Pantoja, Pamela AG. Clarke, M. Idalia Cruz, Alan Zwart and Robert Clarke
    Clin Cancer Res June 15 2014 20 (12) 3222-3232; DOI:10.1158/1078-0432.CCR-13-3227

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Expression Signature Defined by FOXM1–CCNB1 Activation Predicts Disease Recurrence in Non–Muscle-Invasive Bladder Cancer
    Seon-Kyu Kim, Yun-Gil Roh, Kiejung Park, Tae-Hong Kang, Wun-Jae Kim, Ju-Seog Lee, Sun-Hee Leem and In-Sun Chu
    Clin Cancer Res June 15 2014 20 (12) 3233-3243; DOI:10.1158/1078-0432.CCR-13-2761

  • Imaging, Diagnosis, Prognosis
    Combined PET/MRI Improves Diagnostic Accuracy in Patients with Prostate Cancer: A Prospective Diagnostic Trial
    Markus Hartenbach, Sabrina Hartenbach, Winfried Bechtloff, Burkhardt Danz, Klaus Kraft, Burkhard Klemenz, Christoph Sparwasser and Marcus Hacker
    Clin Cancer Res June 15 2014 20 (12) 3244-3253; DOI:10.1158/1078-0432.CCR-13-2653

  • Imaging, Diagnosis, Prognosis
    Impact of Initial FDG-PET/CT and Serum-Free Light Chain on Transformation of Conventionally Defined Solitary Plasmacytoma to Multiple Myeloma
    Guillemette Fouquet, Stéphanie Guidez, Charles Herbaux, Zoé Van de Wyngaert, Sarah Bonnet, David Beauvais, Hélène Demarquette, Salim Adib, Bénédicte Hivert, Mathieu Wemeau, Céline Berthon, Louis Terriou, Valérie Coiteux, Margaret Macro, Olivier Decaux, Thierry Facon, Damien Huglo and Xavier Leleu
    Clin Cancer Res June 15 2014 20 (12) 3254-3260; DOI:10.1158/1078-0432.CCR-13-2910

  • Imaging, Diagnosis, Prognosis
    CHFR Promoter Methylation Indicates Poor Prognosis in Stage II Microsatellite Stable Colorectal Cancer
    Arjen H.G. Cleven, Sarah Derks, Muriel X.G. Draht, Kim M. Smits, Veerle Melotte, Leander Van Neste, Benjamin Tournier, Valerie Jooste, Caroline Chapusot, Matty P. Weijenberg, James G. Herman, Adriaan P. de Bruïne and Manon van Engeland
    Clin Cancer Res June 15 2014 20 (12) 3261-3271; DOI:10.1158/1078-0432.CCR-12-3734

  • Imaging, Diagnosis, Prognosis
    Genetic Variations Associated with Postoperative Recurrence in Stage I Non–Small Cell Lung Cancer
    Kyong-Ah Yoon, Mee Kyung Jung, Donghoon Lee, Kieun Bae, Jung Nam Joo, Geon Kook Lee, Hyun-Sung Lee and Jin Soo Lee
    Clin Cancer Res June 15 2014 20 (12) 3272-3279; DOI:10.1158/1078-0432.CCR-13-2835

  • Imaging, Diagnosis, Prognosis
    Molecular Biomarkers of Residual Disease after Surgical Debulking of High-Grade Serous Ovarian Cancer
    Susan L. Tucker, Kshipra Gharpure, Shelley M. Herbrich, Anna K. Unruh, Alpa M. Nick, Erin K. Crane, Robert L. Coleman, Jamie Guenthoer, Heather J. Dalton, Sherry Y. Wu, Rajesha Rupaimoole, Gabriel Lopez-Berestein, Bulent Ozpolat, Cristina Ivan, Wei Hu, Keith A. Baggerly and Anil K. Sood
    Clin Cancer Res June 15 2014 20 (12) 3280-3288; DOI:10.1158/1078-0432.CCR-14-0445

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Erlotinib, Erlotinib–Sulindac versus Placebo: A Randomized, Double-Blind, Placebo-Controlled Window Trial in Operable Head and Neck Cancer
    Neil D. Gross, Julie E. Bauman, William E. Gooding, William Denq, Sufi M. Thomas, Lin Wang, Simion Chiosea, Brian L. Hood, Melanie S. Flint, Mai Sun, Thomas P. Conrads, Robert L. Ferris, Jonas T. Johnson, Seungwon Kim, Athanassios Argiris, Lori Wirth, Marina N. Nikiforova, Jill M. Siegfried and Jennifer R. Grandis
    Clin Cancer Res June 15 2014 20 (12) 3289-3298; DOI:10.1158/1078-0432.CCR-13-3360

Predictive Biomarkers and Personalized Medicine

  • Predictive Biomarkers and Personalized Medicine | AuthorChoice
    FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
    Murry W. Wynes, Trista K. Hinz, Dexiang Gao, Michael Martini, Lindsay A. Marek, Kathryn E. Ware, Michael G. Edwards, Diana Böhm, Sven Perner, Barbara A. Helfrich, Rafal Dziadziuszko, Jacek Jassem, Szymon Wojtylak, Aleksandra Sejda, Joseph M. Gozgit, Paul A. Bunn Jr, D. Ross Camidge, Aik-Choon Tan, Fred R. Hirsch and Lynn E. Heasley
    Clin Cancer Res June 15 2014 20 (12) 3299-3309; DOI:10.1158/1078-0432.CCR-13-3060

  • Predictive Biomarkers and Personalized Medicine
    Blood mRNA Expression Profiling Predicts Survival in Patients Treated with Tremelimumab
    Yvonne Saenger, Jay Magidson, Bobby Liaw, Ellen de Moll, Sara Harcharik, Yichun Fu, Karl Wassmann, David Fisher, John Kirkwood, William K. Oh and Philip Friedlander
    Clin Cancer Res June 15 2014 20 (12) 3310-3318; DOI:10.1158/1078-0432.CCR-13-2906

  • Predictive Biomarkers and Personalized Medicine
    Association Study of the let-7 miRNA-Complementary Site Variant in the 3′ Untranslated Region of the KRAS Gene in Stage III Colon Cancer (NCCTG N0147 Clinical Trial)
    Dan Sha, Adam M. Lee, Qian Shi, Steven R. Alberts, Daniel J. Sargent, Frank A. Sinicrope and Robert B. Diasio
    Clin Cancer Res June 15 2014 20 (12) 3319-3327; DOI:10.1158/1078-0432.CCR-14-0069

  • Predictive Biomarkers and Personalized Medicine
    Correlation of Somatic Mutations and Clinical Outcome in Melanoma Patients Treated with Carboplatin, Paclitaxel, and Sorafenib
    Melissa A. Wilson, Fengmin Zhao, Richard Letrero, Kurt D'Andrea, David L. Rimm, John M. Kirkwood, Harriet M. Kluger, Sandra J. Lee, Lynn M. Schuchter, Keith T. Flaherty and Katherine L. Nathanson
    Clin Cancer Res June 15 2014 20 (12) 3328-3337; DOI:10.1158/1078-0432.CCR-14-0093

  • Predictive Biomarkers and Personalized Medicine | AuthorChoice
    Hsa-miR-31-3p Expression Is Linked to Progression-free Survival in Patients with KRAS Wild-type Metastatic Colorectal Cancer Treated with Anti-EGFR Therapy
    Gilles Manceau, Sandrine Imbeaud, Raphaële Thiébaut, François Liébaert, Karine Fontaine, Francis Rousseau, Bérengère Génin, Delphine Le Corre, Audrey Didelot, Marc Vincent, Jean-Baptiste Bachet, Benoist Chibaudel, Olivier Bouché, Bruno Landi, Frédéric Bibeau, Karen Leroy, Frédérique Penault-Llorca, Jean-Luc Van Laethem, Pieter Demetter, Sabine Tejpar, Simona Rossi, Neda Mosakhani, Pia Österlund, Raija Ristamäki, Virinder Sarhadi, Sakari Knuutila, Valérie Boige, Thierry André and Pierre Laurent-Puig
    Clin Cancer Res June 15 2014 20 (12) 3338-3347; DOI:10.1158/1078-0432.CCR-13-2750

  • Predictive Biomarkers and Personalized Medicine
    The Role of Relative Lymphocyte Count as a Biomarker for the Effect of Catumaxomab on Survival in Malignant Ascites Patients: Results from a Phase II/III Study
    Markus M. Heiss, Michael A. Ströhlein, Carsten Bokemeyer, Dirk Arnold, Simon L. Parsons, Diane Seimetz, Horst Lindhofer, Elisabeth Schulze and Michael Hennig
    Clin Cancer Res June 15 2014 20 (12) 3348-3357; DOI:10.1158/1078-0432.CCR-13-2351

Retraction

  • Retraction
    Retraction: Molecular Analysis of Non–Small Cell Lung Cancer Identifies Subsets with Different Sensitivity to Insulin-like Growth Factor I Receptor Inhibition
    Clin Cancer Res June 15 2014 20 (12) 3358-3358; DOI:10.1158/1078-0432.CCR-14-1118

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Clinical Cancer Research: 20 (12)
June 2014
Volume 20, Issue 12
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Issue Highlights

  • RNAi Screen Identifies a Synthetic Lethal Interaction between PIM1 Overexpression and PLK1 Inhibition
  • Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma
  • Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs
  • Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer
  • Combined PET/MRI Improves Diagnostic Accuracy in Patients with Prostate Cancer: A Prospective Diagnostic Trial

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Clinical Cancer Research
eISSN: 1557-3265
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