Clinical Cancer Research: 20 (17)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res September 1 2014 20 (17) 4417-4417;

CCR Translations

CCR Translations

TP53 Mutations and Lung Cancer: Not All Mutations Are Created Equal

Ramaswamy Govindan and Jason Weber

Clin Cancer Res September 1 2014 20 (17) 4419-4421; DOI:10.1158/1078-0432.CCR-14-0899
CCR Translations | AuthorChoice

“Companion Diagnostics”: Has Their Time Come and Gone?

Fred R. Hirsch, Paul A. Bunn Jr and Roy S. Herbst

Clin Cancer Res September 1 2014 20 (17) 4422-4424; DOI:10.1158/1078-0432.CCR-14-0932

CCR New Strategies

CCR New Strategies

New Strategies in Personalized Medicine for Solid Tumors: Molecular Markers and Clinical Trial Designs

Juliane M. Jürgensmeier, Joseph P. Eder and Roy S. Herbst

Clin Cancer Res September 1 2014 20 (17) 4425-4435; DOI:10.1158/1078-0432.CCR-13-0753

CCR Perspectives in Drug Approval

CCR Perspectives in Drug Approval

FDA Approval: Ado-Trastuzumab Emtansine for the Treatment of Patients with HER2-Positive Metastatic Breast Cancer

Laleh Amiri-Kordestani, Gideon M. Blumenthal, Qiang Casey Xu, Lijun Zhang, Shenghui W. Tang, Linan Ha, Wendy C. Weinberg, Bo Chi, Reyes Candau-Chacon, Patricia Hughes, Anne M. Russell, Sarah Pope Miksinski, Xiao Hong Chen, W. David McGuinn, Todd Palmby, Sarah J. Schrieber, Qi Liu, Jian Wang, Pengfei Song, Nitin Mehrotra, Lisa Skarupa, Kathleen Clouse, Ali Al-Hakim, Rajeshwari Sridhara, Amna Ibrahim, Robert Justice, Richard Pazdur and Patricia Cortazar

Clin Cancer Res September 1 2014 20 (17) 4436-4441; DOI:10.1158/1078-0432.CCR-14-0012

Molecular Pathways

Molecular Pathways

Molecular Pathways: Targeting ETS Gene Fusions in Cancer

Felix Y. Feng, J. Chad Brenner, Maha Hussain and Arul M. Chinnaiyan

Clin Cancer Res September 1 2014 20 (17) 4442-4448; DOI:10.1158/1078-0432.CCR-13-0275

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Dose Selection, Pharmacokinetics, and Pharmacodynamics of BRAF Inhibitor Dabrafenib (GSK2118436)

Gerald S. Falchook, Georgina V. Long, Razelle Kurzrock, Kevin B. Kim, H.-Tobias Arkenau, Michael P. Brown, Omid Hamid, Jeffrey R. Infante, Michael Millward, Anna Pavlick, Melvin T. Chin, Steven J. O'Day, Samuel C. Blackman, C. Martin Curtis, Peter Lebowitz, Bo Ma, Daniele Ouellet and Richard F. Kefford

Clin Cancer Res September 1 2014 20 (17) 4449-4458; DOI:10.1158/1078-0432.CCR-14-0887
Cancer Therapy: Clinical

p53MVA Therapy in Patients with Refractory Gastrointestinal Malignancies Elevates p53-Specific CD8⁺ T-cell Responses

Nicola R. Hardwick, Mary Carroll, Teodora Kaltcheva, Dajun Qian, Dean Lim, Lucille Leong, Peiguo Chu, Joseph Kim, Joseph Chao, Marwan Fakih, Yun Yen, Jonathan Espenschied, Joshua D. I. Ellenhorn, Don J. Diamond and Vincent Chung

Clin Cancer Res September 1 2014 20 (17) 4459-4470; DOI:10.1158/1078-0432.CCR-13-3361
Cancer Therapy: Clinical

Phase I Safety and Pharmacodynamic of Inecalcitol, a Novel VDR Agonist with Docetaxel in Metastatic Castration-Resistant Prostate Cancer Patients

Jacques Medioni, Gael Deplanque, Jean-Marc Ferrero, Tristan Maurina, Jean-Michel P. Rodier, Eric Raymond, Jorge Allyon, Gerard Maruani, Pascal Houillier, Sarah Mackenzie, Stephanie Renaux, Jean-Francois Dufour-Lamartinie, Reza Elaidi, Celine Lerest and Stephane Oudard

Clin Cancer Res September 1 2014 20 (17) 4471-4477; DOI:10.1158/1078-0432.CCR-13-3247

Personalized Medicine and Imaging

Personalized Medicine and Imaging

Association of EGFR Expression Level and Cetuximab Activity in Patient-Derived Xenograft Models of Human Non–Small Cell Lung Cancer

Christiane Amendt, Eike Staub, Manja Friese-Hamim, Stephan Störkel and Christopher Stroh

Clin Cancer Res September 1 2014 20 (17) 4478-4487; DOI:10.1158/1078-0432.CCR-13-3385
Personalized Medicine and Imaging

Biomarker Analyses from a Placebo-Controlled Phase II Study Evaluating Erlotinib ± Onartuzumab in Advanced Non–Small Cell Lung Cancer: MET Expression Levels Are Predictive of Patient Benefit

Hartmut Koeppen, Wei Yu, Jiping Zha, Ajay Pandita, Elicia Penuel, Linda Rangell, Rajiv Raja, Sankar Mohan, Rajesh Patel, Rupal Desai, Ling Fu, An Do, Vaishali Parab, Xiaoling Xia, Tom Januario, Sharianne G. Louie, Ellen Filvaroff, David S. Shames, Ignacio Wistuba, Marina Lipkind, Jenny Huang, Mirella Lazarov, Vanitha Ramakrishnan, Lukas Amler, See-Chun Phan, Premal Patel, Amy Peterson and Robert L. Yauch

Clin Cancer Res September 1 2014 20 (17) 4488-4498; DOI:10.1158/1078-0432.CCR-13-1836
Personalized Medicine and Imaging

A let-7 microRNA-Binding Site Polymorphism in KRAS Predicts Improved Outcome in Patients with Metastatic Colorectal Cancer Treated with Salvage Cetuximab/Panitumumab Monotherapy

Zenia Saridaki, Joanne B. Weidhaas, Heinz-Josef Lenz, Pierre Laurent-Puig, Bart Jacobs, Jef De Schutter, Wendy De Roock, David W. Salzman, Wu Zhang, Dongyun Yang, Camilla Pilati, Olivier Bouché, Hubert Piessevaux and Sabine Tejpar

Clin Cancer Res September 1 2014 20 (17) 4499-4510; DOI:10.1158/1078-0432.CCR-14-0348
Personalized Medicine and Imaging

FcγRIIa and FcγRIIIa Polymorphisms and Cetuximab Benefit in the Microscopic Disease

Francesco Sclafani, David Gonzalez de Castro, David Cunningham, Sanna Hulkki Wilson, Clare Peckitt, Jaume Capdevila, Bengt Glimelius, Susana Roselló Keränen, Andrew Wotherspoon, Gina Brown, Diana Tait, Ruwaida Begum, Janet Thomas, Jacqueline Oates and Ian Chau

Clin Cancer Res September 1 2014 20 (17) 4511-4519; DOI:10.1158/1078-0432.CCR-14-0674
Personalized Medicine and Imaging

Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts

Santi Suryani, Hernan Carol, Triona Ni Chonghaile, Viktoras Frismantas, Chintanu Sarmah, Laura High, Beat Bornhauser, Mark J. Cowley, Barbara Szymanska, Kathryn Evans, Ingrid Boehm, Elise Tonna, Luke Jones, Donya Moradi Manesh, Raushan T. Kurmasheva, Catherine Billups, Warren Kaplan, Anthony Letai, Jean-Pierre Bourquin, Peter J. Houghton, Malcolm A. Smith and Richard B. Lock

Clin Cancer Res September 1 2014 20 (17) 4520-4531; DOI:10.1158/1078-0432.CCR-14-0259
Personalized Medicine and Imaging

Noninvasive Detection of Glutamate Predicts Survival in Pediatric Medulloblastoma

Martin Wilson, Simrandip K. Gill, Lesley MacPherson, Martin English, Theodoros N. Arvanitis and Andrew C. Peet

Clin Cancer Res September 1 2014 20 (17) 4532-4539; DOI:10.1158/1078-0432.CCR-13-2320
Personalized Medicine and Imaging

Detection of Minimal Residual Disease in B Lymphoblastic Leukemia by High-Throughput Sequencing of IGH

David Wu, Ryan O. Emerson, Anna Sherwood, Mignon L. Loh, Anne Angiolillo, Bryan Howie, Jennifer Vogt, Mark Rieder, Ilan Kirsch, Christopher Carlson, David Williamson, Brent L. Wood and Harlan Robins

Clin Cancer Res September 1 2014 20 (17) 4540-4548; DOI:10.1158/1078-0432.CCR-13-3231
Personalized Medicine and Imaging | AuthorChoice

The Combination of Circulating Ang1 and Tie2 Levels Predicts Progression-Free Survival Advantage in Bevacizumab-Treated Patients with Ovarian Cancer

Alison Backen, Andrew G. Renehan, Andrew R. Clamp, Carlo Berzuini, Cong Zhou, Amit Oza, Selina Bannoo, Stefan J. Scherer, Rosamonde E. Banks, Caroline Dive and Gordon C. Jayson

Clin Cancer Res September 1 2014 20 (17) 4549-4558; DOI:10.1158/1078-0432.CCR-13-3248

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical | AuthorChoice

Functional Genetic Approach Identifies MET, HER3, IGF1R, INSR Pathways as Determinants of Lapatinib Unresponsiveness in HER2-Positive Gastric Cancer

Zhe Zhang, Jiping Wang, Dongmei Ji, Chenchen Wang, Rujiao Liu, Zheng Wu, Lian Liu, Dan Zhu, Jinjia Chang, Ruixuan Geng, Lei Xiong, Qiangyi Fang and Jin Li

Clin Cancer Res September 1 2014 20 (17) 4559-4573; DOI:10.1158/1078-0432.CCR-13-3396
Cancer Therapy: Preclinical

SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38⁺ Hematologic Malignancies

Jutta Deckert, Marie-Cécile Wetzel, Laura M. Bartle, Anna Skaletskaya, Victor S. Goldmacher, François Vallée, Qing Zhou-Liu, Paul Ferrari, Stéphanie Pouzieux, Charlotte Lahoute, Charles Dumontet, Adriana Plesa, Marielle Chiron, Pascale Lejeune, Thomas Chittenden, Peter U. Park and Véronique Blanc

Clin Cancer Res September 1 2014 20 (17) 4574-4583; DOI:10.1158/1078-0432.CCR-14-0695
Cancer Therapy: Preclinical

Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth

Savita Sankar, Emily R. Theisen, Jared Bearss, Timothy Mulvihill, Laura M. Hoffman, Venkataswamy Sorna, Mary C. Beckerle, Sunil Sharma and Stephen L. Lessnick

Clin Cancer Res September 1 2014 20 (17) 4584-4597; DOI:10.1158/1078-0432.CCR-14-0072

Biology of Human Tumors

Biology of Human Tumors

Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis

Zhaojun Liu, Jun Zhang, Yanhong Gao, Lirong Pei, Jing Zhou, Liankun Gu, Lianhai Zhang, Budong Zhu, Naoko Hattori, Jiafu Ji, Yasuhito Yuasa, Wooho Kim, Toshikazu Ushijima, Huidong Shi and Dajun Deng

Clin Cancer Res September 1 2014 20 (17) 4598-4612; DOI:10.1158/1078-0432.CCR-13-3380
Biology of Human Tumors

Noninvasive Diagnosis of Actionable Mutations by Deep Sequencing of Circulating Free DNA in Lung Cancer from Never-Smokers: A Proof-of-Concept Study from BioCAST/IFCT-1002

Sébastien Couraud, Felipe Vaca-Paniagua, Stéphanie Villar, Javier Oliver, Tibor Schuster, Hélène Blanché, Nicolas Girard, Jean Trédaniel, Laurent Guilleminault, Radj Gervais, Nathalie Prim, Michel Vincent, Jacques Margery, Sébastien Larivé, Pascal Foucher, Bernard Duvert, Maxime Vallee, Florence Le Calvez-Kelm, James McKay, Pascale Missy, Franck Morin, Gérard Zalcman, Magali Olivier and Pierre-Jean Souquet; for the BioCAST/IFCT-1002 investigators

Clin Cancer Res September 1 2014 20 (17) 4613-4624; DOI:10.1158/1078-0432.CCR-13-3063
Biology of Human Tumors

Expression of Androgen and Estrogen Signaling Components and Stem Cell Markers to Predict Cancer Progression and Cancer-Specific Survival in Patients with Metastatic Prostate Cancer

Tetsuya Fujimura, Satoru Takahashi, Tomohiko Urano, Kenichi Takayama, Toru Sugihara, Daisuke Obinata, Yuta Yamada, Jimpei Kumagai, Haruki Kume, Yasuyoshi Ouchi, Satoshi Inoue and Yukio Homma

Clin Cancer Res September 1 2014 20 (17) 4625-4635; DOI:10.1158/1078-0432.CCR-13-1105
Biology of Human Tumors

miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer

Sajni Josson, Murali Gururajan, Peizhen Hu, Chen Shao, Gina Chia-Yi Chu, Haiyen E. Zhau, Chunyan Liu, Kaiqin Lao, Chia-Lun Lu, Yi-Tsung Lu, Jake Lichterman, Srinivas Nandana, Quanlin Li, Andre Rogatko, Dror Berel, Edwin M. Posadas, Ladan Fazli, Dhruv Sareen and Leland W.K. Chung

Clin Cancer Res September 1 2014 20 (17) 4636-4646; DOI:10.1158/1078-0432.CCR-14-0305
Biology of Human Tumors

Nondisruptive p53 Mutations Are Associated with Shorter Survival in Patients with Advanced Non–Small Cell Lung Cancer

Miguel A. Molina-Vila, Jordi Bertran-Alamillo, Amaya Gascó, Clara Mayo-de-las-Casas, María Sánchez-Ronco, Laia Pujantell-Pastor, Laura Bonanno, Adolfo G. Favaretto, Andrés F. Cardona, Alain Vergnenègre, Margarita Majem, Bartomeu Massuti, Teresa Morán, Enric Carcereny, Santiago Viteri and Rafael Rosell

Clin Cancer Res September 1 2014 20 (17) 4647-4659; DOI:10.1158/1078-0432.CCR-13-2391
Biology of Human Tumors

An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non–Small Cell Lung Cancer

Satoshi Noguchi, Akira Saito, Masafumi Horie, Yu Mikami, Hiroshi I. Suzuki, Yasuyuki Morishita, Mitsuhiro Ohshima, Yoshimitsu Abiko, Johanna Sofia Margareta Mattsson, Helena König, Miriam Lohr, Karolina Edlund, Johan Botling, Patrick Micke and Takahide Nagase

Clin Cancer Res September 1 2014 20 (17) 4660-4672; DOI:10.1158/1078-0432.CCR-13-3328
Biology of Human Tumors

To “Grow” or “Go”: TMEM16A Expression as a Switch between Tumor Growth and Metastasis in SCCHN

Daniel J. Shiwarski, Chunbo Shao, Anke Bill, Jean Kim, Dong Xiao, Carol A. Bertrand, Raja S. Seethala, Daisuke Sano, Jeffery N. Myers, Patrick Ha, Jennifer Grandis, L. Alex Gaither, Manojkumar A. Puthenveedu and Umamaheswar Duvvuri

Clin Cancer Res September 1 2014 20 (17) 4673-4688; DOI:10.1158/1078-0432.CCR-14-0363
Biology of Human Tumors | AuthorChoice

TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome

Tiantian Sun, Wan Du, Hua Xiong, Yanan Yu, Yurong Weng, Linlin Ren, Huijun Zhao, Yingchao Wang, Yingxuan Chen, Jie Xu, Yongbing Xiang, Wenxin Qin, Weibiao Cao, Weiping Zou, Haoyan Chen, Jie Hong and Jing-Yuan Fang

Clin Cancer Res September 1 2014 20 (17) 4689-4704; DOI:10.1158/1078-0432.CCR-14-0315
Biology of Human Tumors

Decreased Expression of miR216a Contributes to Non–Small-Cell Lung Cancer Progression

Ren-Tao Wang, Meng Xu, Cheng-Xiong Xu, Zhi-Gang Song and Hua Jin

Clin Cancer Res September 1 2014 20 (17) 4705-4716; DOI:10.1158/1078-0432.CCR-14-0517
Biology of Human Tumors

GSK-3β–Regulated N-Acetyltransferase 10 Is Involved in Colorectal Cancer Invasion

Hong Zhang, Wei Hou, Hua-Li Wang, Hai-Jing Liu, Xin-Ying Jia, Xing-Zheng Zheng, Yong-Xin Zou, Xin Li, Lin Hou, Michael A. McNutt and Bo Zhang

Clin Cancer Res September 1 2014 20 (17) 4717-4729; DOI:10.1158/1078-0432.CCR-13-3477

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Table of Contents

Highlights

CCR Translations

CCR New Strategies

CCR Perspectives in Drug Approval

Molecular Pathways

Cancer Therapy: Clinical

Personalized Medicine and Imaging

Cancer Therapy: Preclinical

Biology of Human Tumors

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