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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res September 1 2014 20 (17) 4417-4417;

CCR Translations

  • CCR Translations
    TP53 Mutations and Lung Cancer: Not All Mutations Are Created Equal
    Ramaswamy Govindan and Jason Weber
    Clin Cancer Res September 1 2014 20 (17) 4419-4421; DOI:10.1158/1078-0432.CCR-14-0899

  • CCR Translations | AuthorChoice
    “Companion Diagnostics”: Has Their Time Come and Gone?
    Fred R. Hirsch, Paul A. Bunn Jr and Roy S. Herbst
    Clin Cancer Res September 1 2014 20 (17) 4422-4424; DOI:10.1158/1078-0432.CCR-14-0932

CCR New Strategies

  • CCR New Strategies
    New Strategies in Personalized Medicine for Solid Tumors: Molecular Markers and Clinical Trial Designs
    Juliane M. Jürgensmeier, Joseph P. Eder and Roy S. Herbst
    Clin Cancer Res September 1 2014 20 (17) 4425-4435; DOI:10.1158/1078-0432.CCR-13-0753

CCR Perspectives in Drug Approval

  • CCR Perspectives in Drug Approval
    FDA Approval: Ado-Trastuzumab Emtansine for the Treatment of Patients with HER2-Positive Metastatic Breast Cancer
    Laleh Amiri-Kordestani, Gideon M. Blumenthal, Qiang Casey Xu, Lijun Zhang, Shenghui W. Tang, Linan Ha, Wendy C. Weinberg, Bo Chi, Reyes Candau-Chacon, Patricia Hughes, Anne M. Russell, Sarah Pope Miksinski, Xiao Hong Chen, W. David McGuinn, Todd Palmby, Sarah J. Schrieber, Qi Liu, Jian Wang, Pengfei Song, Nitin Mehrotra, Lisa Skarupa, Kathleen Clouse, Ali Al-Hakim, Rajeshwari Sridhara, Amna Ibrahim, Robert Justice, Richard Pazdur and Patricia Cortazar
    Clin Cancer Res September 1 2014 20 (17) 4436-4441; DOI:10.1158/1078-0432.CCR-14-0012

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: Targeting ETS Gene Fusions in Cancer
    Felix Y. Feng, J. Chad Brenner, Maha Hussain and Arul M. Chinnaiyan
    Clin Cancer Res September 1 2014 20 (17) 4442-4448; DOI:10.1158/1078-0432.CCR-13-0275

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Dose Selection, Pharmacokinetics, and Pharmacodynamics of BRAF Inhibitor Dabrafenib (GSK2118436)
    Gerald S. Falchook, Georgina V. Long, Razelle Kurzrock, Kevin B. Kim, H.-Tobias Arkenau, Michael P. Brown, Omid Hamid, Jeffrey R. Infante, Michael Millward, Anna Pavlick, Melvin T. Chin, Steven J. O'Day, Samuel C. Blackman, C. Martin Curtis, Peter Lebowitz, Bo Ma, Daniele Ouellet and Richard F. Kefford
    Clin Cancer Res September 1 2014 20 (17) 4449-4458; DOI:10.1158/1078-0432.CCR-14-0887

  • Cancer Therapy: Clinical
    p53MVA Therapy in Patients with Refractory Gastrointestinal Malignancies Elevates p53-Specific CD8+ T-cell Responses
    Nicola R. Hardwick, Mary Carroll, Teodora Kaltcheva, Dajun Qian, Dean Lim, Lucille Leong, Peiguo Chu, Joseph Kim, Joseph Chao, Marwan Fakih, Yun Yen, Jonathan Espenschied, Joshua D. I. Ellenhorn, Don J. Diamond and Vincent Chung
    Clin Cancer Res September 1 2014 20 (17) 4459-4470; DOI:10.1158/1078-0432.CCR-13-3361

  • Cancer Therapy: Clinical
    Phase I Safety and Pharmacodynamic of Inecalcitol, a Novel VDR Agonist with Docetaxel in Metastatic Castration-Resistant Prostate Cancer Patients
    Jacques Medioni, Gael Deplanque, Jean-Marc Ferrero, Tristan Maurina, Jean-Michel P. Rodier, Eric Raymond, Jorge Allyon, Gerard Maruani, Pascal Houillier, Sarah Mackenzie, Stephanie Renaux, Jean-Francois Dufour-Lamartinie, Reza Elaidi, Celine Lerest and Stephane Oudard
    Clin Cancer Res September 1 2014 20 (17) 4471-4477; DOI:10.1158/1078-0432.CCR-13-3247

Personalized Medicine and Imaging

  • Personalized Medicine and Imaging
    Association of EGFR Expression Level and Cetuximab Activity in Patient-Derived Xenograft Models of Human Non–Small Cell Lung Cancer
    Christiane Amendt, Eike Staub, Manja Friese-Hamim, Stephan Störkel and Christopher Stroh
    Clin Cancer Res September 1 2014 20 (17) 4478-4487; DOI:10.1158/1078-0432.CCR-13-3385

  • Personalized Medicine and Imaging
    Biomarker Analyses from a Placebo-Controlled Phase II Study Evaluating Erlotinib ± Onartuzumab in Advanced Non–Small Cell Lung Cancer: MET Expression Levels Are Predictive of Patient Benefit
    Hartmut Koeppen, Wei Yu, Jiping Zha, Ajay Pandita, Elicia Penuel, Linda Rangell, Rajiv Raja, Sankar Mohan, Rajesh Patel, Rupal Desai, Ling Fu, An Do, Vaishali Parab, Xiaoling Xia, Tom Januario, Sharianne G. Louie, Ellen Filvaroff, David S. Shames, Ignacio Wistuba, Marina Lipkind, Jenny Huang, Mirella Lazarov, Vanitha Ramakrishnan, Lukas Amler, See-Chun Phan, Premal Patel, Amy Peterson and Robert L. Yauch
    Clin Cancer Res September 1 2014 20 (17) 4488-4498; DOI:10.1158/1078-0432.CCR-13-1836

  • Personalized Medicine and Imaging
    A let-7 microRNA-Binding Site Polymorphism in KRAS Predicts Improved Outcome in Patients with Metastatic Colorectal Cancer Treated with Salvage Cetuximab/Panitumumab Monotherapy
    Zenia Saridaki, Joanne B. Weidhaas, Heinz-Josef Lenz, Pierre Laurent-Puig, Bart Jacobs, Jef De Schutter, Wendy De Roock, David W. Salzman, Wu Zhang, Dongyun Yang, Camilla Pilati, Olivier Bouché, Hubert Piessevaux and Sabine Tejpar
    Clin Cancer Res September 1 2014 20 (17) 4499-4510; DOI:10.1158/1078-0432.CCR-14-0348

  • Personalized Medicine and Imaging
    FcγRIIa and FcγRIIIa Polymorphisms and Cetuximab Benefit in the Microscopic Disease
    Francesco Sclafani, David Gonzalez de Castro, David Cunningham, Sanna Hulkki Wilson, Clare Peckitt, Jaume Capdevila, Bengt Glimelius, Susana Roselló Keränen, Andrew Wotherspoon, Gina Brown, Diana Tait, Ruwaida Begum, Janet Thomas, Jacqueline Oates and Ian Chau
    Clin Cancer Res September 1 2014 20 (17) 4511-4519; DOI:10.1158/1078-0432.CCR-14-0674

  • Personalized Medicine and Imaging
    Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
    Santi Suryani, Hernan Carol, Triona Ni Chonghaile, Viktoras Frismantas, Chintanu Sarmah, Laura High, Beat Bornhauser, Mark J. Cowley, Barbara Szymanska, Kathryn Evans, Ingrid Boehm, Elise Tonna, Luke Jones, Donya Moradi Manesh, Raushan T. Kurmasheva, Catherine Billups, Warren Kaplan, Anthony Letai, Jean-Pierre Bourquin, Peter J. Houghton, Malcolm A. Smith and Richard B. Lock
    Clin Cancer Res September 1 2014 20 (17) 4520-4531; DOI:10.1158/1078-0432.CCR-14-0259

  • Personalized Medicine and Imaging
    Noninvasive Detection of Glutamate Predicts Survival in Pediatric Medulloblastoma
    Martin Wilson, Simrandip K. Gill, Lesley MacPherson, Martin English, Theodoros N. Arvanitis and Andrew C. Peet
    Clin Cancer Res September 1 2014 20 (17) 4532-4539; DOI:10.1158/1078-0432.CCR-13-2320

  • Personalized Medicine and Imaging
    Detection of Minimal Residual Disease in B Lymphoblastic Leukemia by High-Throughput Sequencing of IGH
    David Wu, Ryan O. Emerson, Anna Sherwood, Mignon L. Loh, Anne Angiolillo, Bryan Howie, Jennifer Vogt, Mark Rieder, Ilan Kirsch, Christopher Carlson, David Williamson, Brent L. Wood and Harlan Robins
    Clin Cancer Res September 1 2014 20 (17) 4540-4548; DOI:10.1158/1078-0432.CCR-13-3231

  • Personalized Medicine and Imaging | AuthorChoice
    The Combination of Circulating Ang1 and Tie2 Levels Predicts Progression-Free Survival Advantage in Bevacizumab-Treated Patients with Ovarian Cancer
    Alison Backen, Andrew G. Renehan, Andrew R. Clamp, Carlo Berzuini, Cong Zhou, Amit Oza, Selina Bannoo, Stefan J. Scherer, Rosamonde E. Banks, Caroline Dive and Gordon C. Jayson
    Clin Cancer Res September 1 2014 20 (17) 4549-4558; DOI:10.1158/1078-0432.CCR-13-3248

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical | AuthorChoice
    Functional Genetic Approach Identifies MET, HER3, IGF1R, INSR Pathways as Determinants of Lapatinib Unresponsiveness in HER2-Positive Gastric Cancer
    Zhe Zhang, Jiping Wang, Dongmei Ji, Chenchen Wang, Rujiao Liu, Zheng Wu, Lian Liu, Dan Zhu, Jinjia Chang, Ruixuan Geng, Lei Xiong, Qiangyi Fang and Jin Li
    Clin Cancer Res September 1 2014 20 (17) 4559-4573; DOI:10.1158/1078-0432.CCR-13-3396

  • Cancer Therapy: Preclinical
    SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies
    Jutta Deckert, Marie-Cécile Wetzel, Laura M. Bartle, Anna Skaletskaya, Victor S. Goldmacher, François Vallée, Qing Zhou-Liu, Paul Ferrari, Stéphanie Pouzieux, Charlotte Lahoute, Charles Dumontet, Adriana Plesa, Marielle Chiron, Pascale Lejeune, Thomas Chittenden, Peter U. Park and Véronique Blanc
    Clin Cancer Res September 1 2014 20 (17) 4574-4583; DOI:10.1158/1078-0432.CCR-14-0695

  • Cancer Therapy: Preclinical
    Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth
    Savita Sankar, Emily R. Theisen, Jared Bearss, Timothy Mulvihill, Laura M. Hoffman, Venkataswamy Sorna, Mary C. Beckerle, Sunil Sharma and Stephen L. Lessnick
    Clin Cancer Res September 1 2014 20 (17) 4584-4597; DOI:10.1158/1078-0432.CCR-14-0072

Biology of Human Tumors

  • Biology of Human Tumors
    Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
    Zhaojun Liu, Jun Zhang, Yanhong Gao, Lirong Pei, Jing Zhou, Liankun Gu, Lianhai Zhang, Budong Zhu, Naoko Hattori, Jiafu Ji, Yasuhito Yuasa, Wooho Kim, Toshikazu Ushijima, Huidong Shi and Dajun Deng
    Clin Cancer Res September 1 2014 20 (17) 4598-4612; DOI:10.1158/1078-0432.CCR-13-3380

  • Biology of Human Tumors
    Noninvasive Diagnosis of Actionable Mutations by Deep Sequencing of Circulating Free DNA in Lung Cancer from Never-Smokers: A Proof-of-Concept Study from BioCAST/IFCT-1002
    Sébastien Couraud, Felipe Vaca-Paniagua, Stéphanie Villar, Javier Oliver, Tibor Schuster, Hélène Blanché, Nicolas Girard, Jean Trédaniel, Laurent Guilleminault, Radj Gervais, Nathalie Prim, Michel Vincent, Jacques Margery, Sébastien Larivé, Pascal Foucher, Bernard Duvert, Maxime Vallee, Florence Le Calvez-Kelm, James McKay, Pascale Missy, Franck Morin, Gérard Zalcman, Magali Olivier and Pierre-Jean Souquet; for the BioCAST/IFCT-1002 investigators
    Clin Cancer Res September 1 2014 20 (17) 4613-4624; DOI:10.1158/1078-0432.CCR-13-3063

  • Biology of Human Tumors
    Expression of Androgen and Estrogen Signaling Components and Stem Cell Markers to Predict Cancer Progression and Cancer-Specific Survival in Patients with Metastatic Prostate Cancer
    Tetsuya Fujimura, Satoru Takahashi, Tomohiko Urano, Kenichi Takayama, Toru Sugihara, Daisuke Obinata, Yuta Yamada, Jimpei Kumagai, Haruki Kume, Yasuyoshi Ouchi, Satoshi Inoue and Yukio Homma
    Clin Cancer Res September 1 2014 20 (17) 4625-4635; DOI:10.1158/1078-0432.CCR-13-1105

  • Biology of Human Tumors
    miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
    Sajni Josson, Murali Gururajan, Peizhen Hu, Chen Shao, Gina Chia-Yi Chu, Haiyen E. Zhau, Chunyan Liu, Kaiqin Lao, Chia-Lun Lu, Yi-Tsung Lu, Jake Lichterman, Srinivas Nandana, Quanlin Li, Andre Rogatko, Dror Berel, Edwin M. Posadas, Ladan Fazli, Dhruv Sareen and Leland W.K. Chung
    Clin Cancer Res September 1 2014 20 (17) 4636-4646; DOI:10.1158/1078-0432.CCR-14-0305

  • Biology of Human Tumors
    Nondisruptive p53 Mutations Are Associated with Shorter Survival in Patients with Advanced Non–Small Cell Lung Cancer
    Miguel A. Molina-Vila, Jordi Bertran-Alamillo, Amaya Gascó, Clara Mayo-de-las-Casas, María Sánchez-Ronco, Laia Pujantell-Pastor, Laura Bonanno, Adolfo G. Favaretto, Andrés F. Cardona, Alain Vergnenègre, Margarita Majem, Bartomeu Massuti, Teresa Morán, Enric Carcereny, Santiago Viteri and Rafael Rosell
    Clin Cancer Res September 1 2014 20 (17) 4647-4659; DOI:10.1158/1078-0432.CCR-13-2391

  • Biology of Human Tumors
    An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non–Small Cell Lung Cancer
    Satoshi Noguchi, Akira Saito, Masafumi Horie, Yu Mikami, Hiroshi I. Suzuki, Yasuyuki Morishita, Mitsuhiro Ohshima, Yoshimitsu Abiko, Johanna Sofia Margareta Mattsson, Helena König, Miriam Lohr, Karolina Edlund, Johan Botling, Patrick Micke and Takahide Nagase
    Clin Cancer Res September 1 2014 20 (17) 4660-4672; DOI:10.1158/1078-0432.CCR-13-3328

  • Biology of Human Tumors
    To “Grow” or “Go”: TMEM16A Expression as a Switch between Tumor Growth and Metastasis in SCCHN
    Daniel J. Shiwarski, Chunbo Shao, Anke Bill, Jean Kim, Dong Xiao, Carol A. Bertrand, Raja S. Seethala, Daisuke Sano, Jeffery N. Myers, Patrick Ha, Jennifer Grandis, L. Alex Gaither, Manojkumar A. Puthenveedu and Umamaheswar Duvvuri
    Clin Cancer Res September 1 2014 20 (17) 4673-4688; DOI:10.1158/1078-0432.CCR-14-0363

  • Biology of Human Tumors | AuthorChoice
    TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome
    Tiantian Sun, Wan Du, Hua Xiong, Yanan Yu, Yurong Weng, Linlin Ren, Huijun Zhao, Yingchao Wang, Yingxuan Chen, Jie Xu, Yongbing Xiang, Wenxin Qin, Weibiao Cao, Weiping Zou, Haoyan Chen, Jie Hong and Jing-Yuan Fang
    Clin Cancer Res September 1 2014 20 (17) 4689-4704; DOI:10.1158/1078-0432.CCR-14-0315

  • Biology of Human Tumors
    Decreased Expression of miR216a Contributes to Non–Small-Cell Lung Cancer Progression
    Ren-Tao Wang, Meng Xu, Cheng-Xiong Xu, Zhi-Gang Song and Hua Jin
    Clin Cancer Res September 1 2014 20 (17) 4705-4716; DOI:10.1158/1078-0432.CCR-14-0517

  • Biology of Human Tumors
    GSK-3β–Regulated N-Acetyltransferase 10 Is Involved in Colorectal Cancer Invasion
    Hong Zhang, Wei Hou, Hua-Li Wang, Hai-Jing Liu, Xin-Ying Jia, Xing-Zheng Zheng, Yong-Xin Zou, Xin Li, Lin Hou, Michael A. McNutt and Bo Zhang
    Clin Cancer Res September 1 2014 20 (17) 4717-4729; DOI:10.1158/1078-0432.CCR-13-3477

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Clinical Cancer Research: 20 (17)
September 2014
Volume 20, Issue 17
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Issue Highlights

  • SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies
  • Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
  • Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
  • An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non–Small Cell Lung Cancer

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Clinical Cancer Research
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