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Biology of Human Tumors

TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome

Tiantian Sun, Wan Du, Hua Xiong, Yanan Yu, Yurong Weng, Linlin Ren, Huijun Zhao, Yingchao Wang, Yingxuan Chen, Jie Xu, Yongbing Xiang, Wenxin Qin, Weibiao Cao, Weiping Zou, Haoyan Chen, Jie Hong and Jing-Yuan Fang
Tiantian Sun
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Wan Du
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Hua Xiong
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Yanan Yu
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Yurong Weng
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Linlin Ren
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Huijun Zhao
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Yingchao Wang
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Yingxuan Chen
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Jie Xu
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Yongbing Xiang
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Wenxin Qin
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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Weibiao Cao
Department of Pathology and Medicine, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island.
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Weiping Zou
Department of Surgery, University of Michigan, Ann Arbor, Michigan.
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Haoyan Chen
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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  • For correspondence: jiehong97@gmail.com chenhaoyan@gmail.com jingyuanfang@yahoo.com
Jie Hong
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.Department of Pathology and Medicine, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island.
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  • For correspondence: jiehong97@gmail.com chenhaoyan@gmail.com jingyuanfang@yahoo.com
Jing-Yuan Fang
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
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  • For correspondence: jiehong97@gmail.com chenhaoyan@gmail.com jingyuanfang@yahoo.com
DOI: 10.1158/1078-0432.CCR-14-0315 Published September 2014
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ARTICLE USAGE: July 2014 to December 2019

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Total385728332541

Cited By

Article Information

Volume 20, Issue 17, pp. 4689-4704

DOI 
https://doi.org/10.1158/1078-0432.CCR-14-0315
PubMed 
24987055

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received February 5, 2014
  • Revision received May 1, 2014
  • Accepted May 20, 2014
  • Published first July 1, 2014.

Article Versions

  • Previous version (July 1, 2014 - 07:38).
  • Previous version (August 12, 2014 - 09:21).
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Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Tiantian Sun1,
  2. Wan Du1,
  3. Hua Xiong1,
  4. Yanan Yu1,
  5. Yurong Weng1,
  6. Linlin Ren1,
  7. Huijun Zhao1,
  8. Yingchao Wang1,
  9. Yingxuan Chen1,
  10. Jie Xu1,
  11. Yongbing Xiang1,
  12. Wenxin Qin1,
  13. Weibiao Cao2,
  14. Weiping Zou3,
  15. Haoyan Chen1,*,
  16. Jie Hong1,2,*, and
  17. Jing-Yuan Fang1,*
  1. 1State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
  2. 2Department of Pathology and Medicine, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island.
  3. 3Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  1. ↵*Corresponding Authors:
    Jie Hong, Shanghai Jiao-Tong University School of Medicine Renji Hospital, 145 Middle Shandong Road, Shanghai 200001, China. Phone: 86-2153882450; Fax: 86-2163266027; E-mail: jiehong97{at}gmail.com; Haoyan Chen, chenhaoyan{at}gmail.com; and Jing-Yuan Fang, jingyuanfang{at}yahoo.com
  1. T. Sun, W. Du, and H. Xiong contributed equally to this article.

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Clinical Cancer Research: 20 (17)
September 2014
Volume 20, Issue 17
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TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome
Tiantian Sun, Wan Du, Hua Xiong, Yanan Yu, Yurong Weng, Linlin Ren, Huijun Zhao, Yingchao Wang, Yingxuan Chen, Jie Xu, Yongbing Xiang, Wenxin Qin, Weibiao Cao, Weiping Zou, Haoyan Chen, Jie Hong and Jing-Yuan Fang
Clin Cancer Res September 1 2014 (20) (17) 4689-4704; DOI: 10.1158/1078-0432.CCR-14-0315

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TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome
Tiantian Sun, Wan Du, Hua Xiong, Yanan Yu, Yurong Weng, Linlin Ren, Huijun Zhao, Yingchao Wang, Yingxuan Chen, Jie Xu, Yongbing Xiang, Wenxin Qin, Weibiao Cao, Weiping Zou, Haoyan Chen, Jie Hong and Jing-Yuan Fang
Clin Cancer Res September 1 2014 (20) (17) 4689-4704; DOI: 10.1158/1078-0432.CCR-14-0315
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