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Cancer Therapy: Clinical

Neoadjuvant Imatinib in Advanced Primary or Locally Recurrent Dermatofibrosarcoma Protuberans: A Multicenter Phase II DeCOG Trial with Long-term Follow-up

Selma Ugurel, Thomas Mentzel, Jochen Utikal, Peter Helmbold, Peter Mohr, Claudia Pföhler, Meinhard Schiller, Axel Hauschild, Rüdiger Hein, Eckhardt Kämpgen, Ivonne Kellner, Martin Leverkus, Jürgen C. Becker, Philip Ströbel and Dirk Schadendorf
Selma Ugurel
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Thomas Mentzel
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Jochen Utikal
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Peter Helmbold
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Peter Mohr
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Claudia Pföhler
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Meinhard Schiller
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Axel Hauschild
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Rüdiger Hein
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Eckhardt Kämpgen
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Ivonne Kellner
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Martin Leverkus
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Jürgen C. Becker
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Philip Ströbel
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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Dirk Schadendorf
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
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DOI: 10.1158/1078-0432.CCR-13-1411 Published January 2014
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Cited By

Article Information

Volume 20, Issue 2, pp. 499-510

DOI 
https://doi.org/10.1158/1078-0432.CCR-13-1411
PubMed 
24173542

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received May 22, 2013
  • Revision received October 16, 2013
  • Accepted October 21, 2013
  • Published first October 30, 2013.

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  • Previous version (October 30, 2013 - 07:21).
  • Previous version (January 9, 2014 - 07:00).
  • You are viewing the most recent version of this article.
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©2013 American Association for Cancer Research.

Author Information

  1. Selma Ugurel1,
  2. Thomas Mentzel2,
  3. Jochen Utikal3,5,
  4. Peter Helmbold4,6,
  5. Peter Mohr7,
  6. Claudia Pföhler8,
  7. Meinhard Schiller9,
  8. Axel Hauschild10,
  9. Rüdiger Hein11,
  10. Eckhardt Kämpgen12,
  11. Ivonne Kellner13,
  12. Martin Leverkus5,
  13. Jürgen C. Becker16,
  14. Philip Ströbel14, and
  15. Dirk Schadendorf15
  1. Authors' Affiliations: 1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
  1. Corresponding Author:
    Selma Ugurel, Department of Dermatology, Julius-Maximilians University, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany. Phone: 00-49-931-201-26351; Fax: 00-49-931-201-26700; E-mail: ugurel_s{at}klinik.uni-wuerzburg.de
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Clinical Cancer Research: 20 (2)
January 2014
Volume 20, Issue 2
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Neoadjuvant Imatinib in Advanced Primary or Locally Recurrent Dermatofibrosarcoma Protuberans: A Multicenter Phase II DeCOG Trial with Long-term Follow-up
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Neoadjuvant Imatinib in Advanced Primary or Locally Recurrent Dermatofibrosarcoma Protuberans: A Multicenter Phase II DeCOG Trial with Long-term Follow-up
Selma Ugurel, Thomas Mentzel, Jochen Utikal, Peter Helmbold, Peter Mohr, Claudia Pföhler, Meinhard Schiller, Axel Hauschild, Rüdiger Hein, Eckhardt Kämpgen, Ivonne Kellner, Martin Leverkus, Jürgen C. Becker, Philip Ströbel and Dirk Schadendorf
Clin Cancer Res January 15 2014 (20) (2) 499-510; DOI: 10.1158/1078-0432.CCR-13-1411

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Neoadjuvant Imatinib in Advanced Primary or Locally Recurrent Dermatofibrosarcoma Protuberans: A Multicenter Phase II DeCOG Trial with Long-term Follow-up
Selma Ugurel, Thomas Mentzel, Jochen Utikal, Peter Helmbold, Peter Mohr, Claudia Pföhler, Meinhard Schiller, Axel Hauschild, Rüdiger Hein, Eckhardt Kämpgen, Ivonne Kellner, Martin Leverkus, Jürgen C. Becker, Philip Ströbel and Dirk Schadendorf
Clin Cancer Res January 15 2014 (20) (2) 499-510; DOI: 10.1158/1078-0432.CCR-13-1411
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    • Authors' Contributions
    • Grant Support
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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