Cancer Therapy: Clinical
Neoadjuvant Imatinib in Advanced Primary or Locally Recurrent Dermatofibrosarcoma Protuberans: A Multicenter Phase II DeCOG Trial with Long-term Follow-up
Selma Ugurel, Thomas Mentzel, Jochen Utikal, Peter Helmbold, Peter Mohr, Claudia Pföhler, Meinhard Schiller, Axel Hauschild, Rüdiger Hein, Eckhardt Kämpgen, Ivonne Kellner, Martin Leverkus, Jürgen C. Becker, Philip Ströbel and Dirk Schadendorf
Selma Ugurel
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Thomas Mentzel
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Jochen Utikal
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Peter Helmbold
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Peter Mohr
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Claudia Pföhler
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Meinhard Schiller
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Axel Hauschild
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Rüdiger Hein
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Eckhardt Kämpgen
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Ivonne Kellner
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Martin Leverkus
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Jürgen C. Becker
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Philip Ströbel
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
Dirk Schadendorf
1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
DOI: 10.1158/1078-0432.CCR-13-1411 Published January 2014

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Volume 20, Issue 2, pp. 499-510
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History
- Received May 22, 2013
- Revision received October 16, 2013
- Accepted October 21, 2013
- Published first October 30, 2013.
Article Versions
- Previous version (October 30, 2013 - 07:21).
- Previous version (January 9, 2014 - 07:00).
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©2013 American Association for Cancer Research.
Author Information
- Selma Ugurel1,
- Thomas Mentzel2,
- Jochen Utikal3,5,
- Peter Helmbold4,6,
- Peter Mohr7,
- Claudia Pföhler8,
- Meinhard Schiller9,
- Axel Hauschild10,
- Rüdiger Hein11,
- Eckhardt Kämpgen12,
- Ivonne Kellner13,
- Martin Leverkus5,
- Jürgen C. Becker16,
- Philip Ströbel14, and
- Dirk Schadendorf15
- Authors' Affiliations: 1Department of Dermatology, University of Würzburg, Würzburg; 2Dermatopathology Bodensee, Friedrichshafen; 3Skin Cancer Unit, German Cancer Research Center, Heidelberg; 4Department of Dermatology, University Hospital Heidelberg, Heidelberg; 5Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim; 6Department of Dermatology, Martin Luther University, Halle/Saale; 7Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude; 8Department of Dermatology, Saarland University Hospital, Homburg, Saarland; 9Department of Dermatology, University Hospital of Münster, Münster; 10Department of Dermatology, University of Kiel, Kiel; 11Department of Dermatology, Technical University Munich, Munich; 12Department of Dermatology, University Hospital Erlangen, Erlangen; 13Department of Dermatology, Helios Klinikum Erfurt, Erfurt; 14Department of Pathology, University of Göttingen, Göttingen; 15Department of Dermatology, University of Essen, Essen, Germany; and 16Department of Dermatology, Medical University Graz, Graz, Austria
- Corresponding Author:
Selma Ugurel, Department of Dermatology, Julius-Maximilians University, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany. Phone: 00-49-931-201-26351; Fax: 00-49-931-201-26700; E-mail: ugurel_s{at}klinik.uni-wuerzburg.de
January 2014
Volume 20, Issue 2
Volume 20, Issue 2
Neoadjuvant Imatinib in Advanced Primary or Locally Recurrent Dermatofibrosarcoma Protuberans: A Multicenter Phase II DeCOG Trial with Long-term Follow-up
Selma Ugurel, Thomas Mentzel, Jochen Utikal, Peter Helmbold, Peter Mohr, Claudia Pföhler, Meinhard Schiller, Axel Hauschild, Rüdiger Hein, Eckhardt Kämpgen, Ivonne Kellner, Martin Leverkus, Jürgen C. Becker, Philip Ströbel and Dirk Schadendorf
Clin Cancer Res January 15 2014 (20) (2) 499-510; DOI: 10.1158/1078-0432.CCR-13-1411
Neoadjuvant Imatinib in Advanced Primary or Locally Recurrent Dermatofibrosarcoma Protuberans: A Multicenter Phase II DeCOG Trial with Long-term Follow-up
Selma Ugurel, Thomas Mentzel, Jochen Utikal, Peter Helmbold, Peter Mohr, Claudia Pföhler, Meinhard Schiller, Axel Hauschild, Rüdiger Hein, Eckhardt Kämpgen, Ivonne Kellner, Martin Leverkus, Jürgen C. Becker, Philip Ströbel and Dirk Schadendorf
Clin Cancer Res January 15 2014 (20) (2) 499-510; DOI: 10.1158/1078-0432.CCR-13-1411
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