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Clinical Cancer Research
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Cancer Therapy: Clinical

Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

Edward J. Kim, Vaibhav Sahai, Ethan V. Abel, Kent A. Griffith, Joel K. Greenson, Naoko Takebe, Gazala N. Khan, John L. Blau, Ronald Craig, Ulysses G. Balis, Mark M. Zalupski and Diane M. Simeone
Edward J. Kim
1Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
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Vaibhav Sahai
1Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
2Translational Oncology Program, University of Michigan, Ann Arbor, Michigan.
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Ethan V. Abel
2Translational Oncology Program, University of Michigan, Ann Arbor, Michigan.
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Kent A. Griffith
3Center for Cancer Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
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Joel K. Greenson
4Department of Pathology, University of Michigan, Ann Arbor, Michigan.
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Naoko Takebe
5Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland.
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Gazala N. Khan
1Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
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John L. Blau
4Department of Pathology, University of Michigan, Ann Arbor, Michigan.
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Ronald Craig
4Department of Pathology, University of Michigan, Ann Arbor, Michigan.
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Ulysses G. Balis
4Department of Pathology, University of Michigan, Ann Arbor, Michigan.
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Mark M. Zalupski
1Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
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Diane M. Simeone
2Translational Oncology Program, University of Michigan, Ann Arbor, Michigan.
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  • For correspondence: simeone@med.umich.edu
DOI: 10.1158/1078-0432.CCR-14-1269 Published December 2014
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Article Information

Volume 20, Issue 23, pp. 5937-5945

DOI 
https://doi.org/10.1158/1078-0432.CCR-14-1269
PubMed 
25278454

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received May 16, 2014
  • Revision received September 11, 2014
  • Accepted September 21, 2014
  • Published first October 2, 2014.

Article Versions

  • Previous version (October 2, 2014 - 10:53).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Edward J. Kim1,
  2. Vaibhav Sahai1,2,
  3. Ethan V. Abel2,
  4. Kent A. Griffith3,
  5. Joel K. Greenson4,
  6. Naoko Takebe5,
  7. Gazala N. Khan1,
  8. John L. Blau4,
  9. Ronald Craig4,
  10. Ulysses G. Balis4,
  11. Mark M. Zalupski1, and
  12. Diane M. Simeone2,*
  1. 1Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
  2. 2Translational Oncology Program, University of Michigan, Ann Arbor, Michigan.
  3. 3Center for Cancer Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
  4. 4Department of Pathology, University of Michigan, Ann Arbor, Michigan.
  5. 5Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland.
  1. ↵*Corresponding Author:
    Diane M. Simeone, Translational Oncology Program, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109. Phone: 734-615-1600; Fax: 734-647-6977; E-mail: simeone{at}med.umich.edu
  1. E.J. Kim and V. Sahai contributed equally to this article.

  • Current address for E.J. Kim: University of California at Davis, Sacramento, CA; current address for G.N. Khan, Henry Ford Hospital, Detroit, MI.

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Clinical Cancer Research: 20 (23)
December 2014
Volume 20, Issue 23
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Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
Edward J. Kim, Vaibhav Sahai, Ethan V. Abel, Kent A. Griffith, Joel K. Greenson, Naoko Takebe, Gazala N. Khan, John L. Blau, Ronald Craig, Ulysses G. Balis, Mark M. Zalupski and Diane M. Simeone
Clin Cancer Res December 1 2014 (20) (23) 5937-5945; DOI: 10.1158/1078-0432.CCR-14-1269

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Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
Edward J. Kim, Vaibhav Sahai, Ethan V. Abel, Kent A. Griffith, Joel K. Greenson, Naoko Takebe, Gazala N. Khan, John L. Blau, Ronald Craig, Ulysses G. Balis, Mark M. Zalupski and Diane M. Simeone
Clin Cancer Res December 1 2014 (20) (23) 5937-5945; DOI: 10.1158/1078-0432.CCR-14-1269
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