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Clinical Cancer Research
Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res February 1 2014 20 (3) 523-523;

CCR Translations

  • CCR Translations
    Cabozantinib and Prostate Cancer: Inhibiting Seed and Disrupting Soil?
    Richard J. Lee and Matthew R. Smith
    Clin Cancer Res February 1 2014 20 (3) 525-527; DOI:10.1158/1078-0432.CCR-13-2636

  • CCR Translations
    Managing Breast Cancers with Low Estrogen Receptor and HER2 by Drugging Both
    Todd W. Miller
    Clin Cancer Res February 1 2014 20 (3) 528-530; DOI:10.1158/1078-0432.CCR-13-2994

Statistics in Clinical Cancer Research

  • Statistics in Clinical Cancer Research
    Adaptive Prediction Model in Prospective Molecular Signature–Based Clinical Studies
    Guanghua Xiao, Shuangge Ma, John Minna and Yang Xie
    Clin Cancer Res February 1 2014 20 (3) 531-539; DOI:10.1158/1078-0432.CCR-13-2127

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: How Can BRCA-Mutated Tumors Become Resistant to PARP Inhibitors?
    Peter Bouwman and Jos Jonkers
    Clin Cancer Res February 1 2014 20 (3) 540-547; DOI:10.1158/1078-0432.CCR-13-0225

  • Molecular Pathways
    Molecular Pathways: Targeting the Microenvironment in Chronic Lymphocytic Leukemia—Focus on the B-Cell Receptor
    Elisa ten Hacken and Jan A. Burger
    Clin Cancer Res February 1 2014 20 (3) 548-556; DOI:10.1158/1078-0432.CCR-13-0226

Review

  • Review
    Oxford and the Savannah: Can the Hippo Provide an Explanation for Peto's Paradox?
    Fergal C. Kelleher and Hazel O'Sullivan
    Clin Cancer Res February 1 2014 20 (3) 557-564; DOI:10.1158/1078-0432.CCR-13-2010

Human Cancer Biology

  • Human Cancer Biology
    Tumor Suppressive Effects of Bromodomain-Containing Protein 7 (BRD7) in Epithelial Ovarian Carcinoma
    Young-Ae Park, Jeong-Won Lee, Hye-Sun Kim, Yoo-Young Lee, Tae-Joong Kim, Chel Hun Choi, Jung-Joo Choi, Hye-Kyung Jeon, Young Jae Cho, Ji Yoon Ryu, Byoung-Gie Kim and Duk-Soo Bae
    Clin Cancer Res February 1 2014 20 (3) 565-575; DOI:10.1158/1078-0432.CCR-13-1271

  • Human Cancer Biology
    Importance of 5α-Reductase Gene Polymorphisms on Circulating and Intraprostatic Androgens in Prostate Cancer
    Éric Lévesque, Isabelle Laverdière, Louis Lacombe, Patrick Caron, Mélanie Rouleau, Véronique Turcotte, Bernard Têtu, Yves Fradet and Chantal Guillemette
    Clin Cancer Res February 1 2014 20 (3) 576-584; DOI:10.1158/1078-0432.CCR-13-1100

  • Human Cancer Biology
    Interleukin-30 Expression in Prostate Cancer and Its Draining Lymph Nodes Correlates with Advanced Grade and Stage
    Serena Di Meo, Irma Airoldi, Carlo Sorrentino, Alessia Zorzoli, Silvia Esposito and Emma Di Carlo
    Clin Cancer Res February 1 2014 20 (3) 585-594; DOI:10.1158/1078-0432.CCR-13-2240

  • Human Cancer Biology
    Identification of a Subset of Human Non–Small Cell Lung Cancer Patients with High PI3Kβ and Low PTEN Expression, More Prevalent in Squamous Cell Carcinoma
    Marie Cumberbatch, Ximing Tang, Garry Beran, Sonia Eckersley, Xin Wang, Rebecca P.A. Ellston, Simon Dearden, Sabina Cosulich, Paul D. Smith, Carmen Behrens, Edward S. Kim, Xinying Su, Shuqiong Fan, Neil Gray, David P. Blowers, Ignacio I. Wistuba and Chris Womack
    Clin Cancer Res February 1 2014 20 (3) 595-603; DOI:10.1158/1078-0432.CCR-13-1638

  • Human Cancer Biology
    The Disparate Twins: A Comparative Study of CXCR4 and CXCR7 in SDF-1α–Induced Gene Expression, Invasion and Chemosensitivity of Colon Cancer
    Doreen Heckmann, Patrick Maier, Stephanie Laufs, Li Li, Jonathan P. Sleeman, Marcus J. Trunk, Jörg H. Leupold, Frederik Wenz, W. Jens Zeller, Stefan Fruehauf and Heike Allgayer
    Clin Cancer Res February 1 2014 20 (3) 604-616; DOI:10.1158/1078-0432.CCR-13-0582

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Cabozantinib Inhibits Prostate Cancer Growth and Prevents Tumor-Induced Bone Lesions
    Jinlu Dai, Honglai Zhang, Andreas Karatsinides, Jill M. Keller, Kenneth M. Kozloff, Dana T. Aftab, Frauke Schimmoller and Evan T. Keller
    Clin Cancer Res February 1 2014 20 (3) 617-630; DOI:10.1158/1078-0432.CCR-13-0839

  • Cancer Therapy: Preclinical | AuthorChoice
    Targeting Small Cell Lung Cancer Harboring PIK3CA Mutation with a Selective Oral PI3K Inhibitor PF-4989216
    Marlena Walls, Sangita M. Baxi, Pramod P. Mehta, Kevin K.-C. Liu, JinJiang Zhu, Heather Estrella, Chunze Li, Michael Zientek, Qing Zong, Tod Smeal and Min-Jean Yin
    Clin Cancer Res February 1 2014 20 (3) 631-643; DOI:10.1158/1078-0432.CCR-13-1663

  • Cancer Therapy: Preclinical
    Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors
    Chao-Yi Wu, Li-Hua Yang, Huang-Yu Yang, Jayne Knoff, Shiwen Peng, Yi-Hsin Lin, Chenguang Wang, Ronald D. Alvarez, Sara I. Pai, Richard B.S. Roden, Chien-Fu Hung and T-C Wu
    Clin Cancer Res February 1 2014 20 (3) 644-657; DOI:10.1158/1078-0432.CCR-13-1334

  • Cancer Therapy: Preclinical
    The PDGFRβ–AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors
    M. Juliachs, C. Muñoz, C.A. Moutinho, A. Vidal, E. Condom, M. Esteller, M. Graupera, O. Casanovas, J.R. Germà, A. Villanueva and F. Viñals
    Clin Cancer Res February 1 2014 20 (3) 658-667; DOI:10.1158/1078-0432.CCR-13-1131

  • Cancer Therapy: Preclinical
    Randomized, Placebo-Controlled, Double-Blinded Chemoimmunotherapy Clinical Trial in a Pet Dog Model of Diffuse Large B-cell Lymphoma
    Laura Marconato, Patrick Frayssinet, Nicole Rouquet, Stefano Comazzi, Vito Ferdinando Leone, Paola Laganga, Federica Rossi, Massimo Vignoli, Lorenzo Pezzoli and Luca Aresu
    Clin Cancer Res February 1 2014 20 (3) 668-677; DOI:10.1158/1078-0432.CCR-13-2283

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Targeted Imaging of Ewing Sarcoma in Preclinical Models Using a 64Cu-Labeled Anti-CD99 Antibody
    Allison F. O'Neill, Jason L.J. Dearling, Yuchuan Wang, Tanya Tupper, Yanping Sun, Jon C. Aster, Monica L. Calicchio, Antonio R. Perez-Atayde, Alan B. Packard and Andrew L. Kung
    Clin Cancer Res February 1 2014 20 (3) 678-687; DOI:10.1158/1078-0432.CCR-13-1660

  • Imaging, Diagnosis, Prognosis
    MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer
    Sukhwinder Kaur, Neil Sharma, Shiv Ram Krishn, Imay Lakshmanan, Satyanarayana Rachagani, Michael J. Baine, Lynette M. Smith, Subodh M. Lele, Aaron R. Sasson, Sushovan Guha, Kavita Mallya, Judy M. Anderson, Michael A. Hollingsworth and Surinder K. Batra
    Clin Cancer Res February 1 2014 20 (3) 688-700; DOI:10.1158/1078-0432.CCR-13-2174

  • Imaging, Diagnosis, Prognosis
    Common and Complex Notch1 Mutations in Chinese Oral Squamous Cell Carcinoma
    Xiaomeng Song, Ronghui Xia, Jiang Li, Zhifeng Long, Hening Ren, Wantao Chen and Li Mao
    Clin Cancer Res February 1 2014 20 (3) 701-710; DOI:10.1158/1078-0432.CCR-13-1050

  • Imaging, Diagnosis, Prognosis
    A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer
    Dong-Joo Cheon, Yunguang Tong, Myung-Shin Sim, Judy Dering, Dror Berel, Xiaojiang Cui, Jenny Lester, Jessica A. Beach, Mourad Tighiouart, Ann E. Walts, Beth Y. Karlan and Sandra Orsulic
    Clin Cancer Res February 1 2014 20 (3) 711-723; DOI:10.1158/1078-0432.CCR-13-1256

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Reducing TNF Receptor 2+ Regulatory T Cells via the Combined Action of Azacitidine and the HDAC Inhibitor, Panobinostat for Clinical Benefit in Acute Myeloid Leukemia Patients
    Chindu Govindaraj, Peter Tan, Patricia Walker, Andrew Wei, Andrew Spencer and Magdalena Plebanski
    Clin Cancer Res February 1 2014 20 (3) 724-735; DOI:10.1158/1078-0432.CCR-13-1576

Predictive Biomarkers and Personalized Medicine

  • Predictive Biomarkers and Personalized Medicine
    Quantitative ER and PgR Assessment as Predictors of Benefit from Lapatinib in Postmenopausal Women with Hormone Receptor–Positive, HER2-Negative Metastatic Breast Cancer
    Richard S. Finn, Michael F. Press, Judy Dering, Lisa O'Rourke, Allison Florance, Catherine Ellis, Anne-Marie Martin and Stephen Johnston
    Clin Cancer Res February 1 2014 20 (3) 736-743; DOI:10.1158/1078-0432.CCR-13-1260

  • Predictive Biomarkers and Personalized Medicine
    PIK3CA, BRAF, and PTEN Status and Benefit from Cetuximab in the Treatment of Advanced Colorectal Cancer—Results from NCIC CTG/AGITG CO.17
    Christos S. Karapetis, Derek Jonker, Manijeh Daneshmand, Jennifer E. Hanson, Christopher J. O'Callaghan, Celia Marginean, John R. Zalcberg, John Simes, Malcolm J. Moore, Niall C. Tebbutt, Timothy J. Price, Jeremy D. Shapiro, Nick Pavlakis, Peter Gibbs, Guy A. Van Hazel, Ursula Lee, Rashida Haq, Shakeel Virk, Dongsheng Tu, Ian A.J. Lorimer and for the NCIC Clinical Trials Group and the Australasian Gastro-Intestinal Trials Group
    Clin Cancer Res February 1 2014 20 (3) 744-753; DOI:10.1158/1078-0432.CCR-13-0606

  • Predictive Biomarkers and Personalized Medicine
    Busulfan in Infant to Adult Hematopoietic Cell Transplant Recipients: A Population Pharmacokinetic Model for Initial and Bayesian Dose Personalization
    Jeannine S. McCune, Meagan J. Bemer, Jeffrey S. Barrett, K. Scott Baker, Alan S. Gamis and Nicholas H.G. Holford
    Clin Cancer Res February 1 2014 20 (3) 754-763; DOI:10.1158/1078-0432.CCR-13-1960

  • Predictive Biomarkers and Personalized Medicine
    Germline and Somatic Mutations in Homologous Recombination Genes Predict Platinum Response and Survival in Ovarian, Fallopian Tube, and Peritoneal Carcinomas
    Kathryn P. Pennington, Tom Walsh, Maria I. Harrell, Ming K. Lee, Christopher C. Pennil, Mara H. Rendi, Anne Thornton, Barbara M. Norquist, Silvia Casadei, Alexander S. Nord, Kathy J. Agnew, Colin C. Pritchard, Sheena Scroggins, Rochelle L. Garcia, Mary-Claire King and Elizabeth M. Swisher
    Clin Cancer Res February 1 2014 20 (3) 764-775; DOI:10.1158/1078-0432.CCR-13-2287

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Clinical Cancer Research: 20 (3)
February 2014
Volume 20, Issue 3
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Issue Highlights

  • Interleukin-30 Expression in Prostate Cancer and Its Draining Lymph Nodes Correlates with Advanced Grade and Stage
  • Cabozantinib Inhibits Prostate Cancer Growth and Prevents Tumor-Induced Bone Lesions
  • The Disparate Twins: A Comparative Study of CXCR4 and CXCR7 in SDF-1α–Induced Gene Expression, Invasion and Chemosensitivity of Colon Cancer
  • Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors

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  • Highlights
  • CCR Translations
  • Statistics in Clinical Cancer Research
  • Molecular Pathways
  • Review
  • Human Cancer Biology
  • Cancer Therapy: Preclinical
  • Imaging, Diagnosis, Prognosis
  • Cancer Therapy: Clinical
  • Predictive Biomarkers and Personalized Medicine
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  • Characterization of Glioblastoma Patient-Derived Xenografts
  • FLASH-RT Spares Lung Progenitor Cells
  • AR Gene Rearrangements in Prostate Cancer
  • PDAC and GATA6 Expression
  • Guadecitabine and Carboplatin in Ovarian Cancer
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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