Clinical Cancer Research: 20 (3)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res February 1 2014 20 (3) 523-523;

CCR Translations

CCR Translations

Cabozantinib and Prostate Cancer: Inhibiting Seed and Disrupting Soil?

Richard J. Lee and Matthew R. Smith

Clin Cancer Res February 1 2014 20 (3) 525-527; DOI:10.1158/1078-0432.CCR-13-2636
CCR Translations

Managing Breast Cancers with Low Estrogen Receptor and HER2 by Drugging Both

Todd W. Miller

Clin Cancer Res February 1 2014 20 (3) 528-530; DOI:10.1158/1078-0432.CCR-13-2994

Statistics in Clinical Cancer Research

Statistics in Clinical Cancer Research

Adaptive Prediction Model in Prospective Molecular Signature–Based Clinical Studies

Guanghua Xiao, Shuangge Ma, John Minna and Yang Xie

Clin Cancer Res February 1 2014 20 (3) 531-539; DOI:10.1158/1078-0432.CCR-13-2127

Molecular Pathways

Molecular Pathways

Molecular Pathways: How Can BRCA-Mutated Tumors Become Resistant to PARP Inhibitors?

Peter Bouwman and Jos Jonkers

Clin Cancer Res February 1 2014 20 (3) 540-547; DOI:10.1158/1078-0432.CCR-13-0225
Molecular Pathways

Molecular Pathways: Targeting the Microenvironment in Chronic Lymphocytic Leukemia—Focus on the B-Cell Receptor

Elisa ten Hacken and Jan A. Burger

Clin Cancer Res February 1 2014 20 (3) 548-556; DOI:10.1158/1078-0432.CCR-13-0226

Review

Review

Oxford and the Savannah: Can the Hippo Provide an Explanation for Peto's Paradox?

Fergal C. Kelleher and Hazel O'Sullivan

Clin Cancer Res February 1 2014 20 (3) 557-564; DOI:10.1158/1078-0432.CCR-13-2010

Human Cancer Biology

Human Cancer Biology

Tumor Suppressive Effects of Bromodomain-Containing Protein 7 (BRD7) in Epithelial Ovarian Carcinoma

Young-Ae Park, Jeong-Won Lee, Hye-Sun Kim, Yoo-Young Lee, Tae-Joong Kim, Chel Hun Choi, Jung-Joo Choi, Hye-Kyung Jeon, Young Jae Cho, Ji Yoon Ryu, Byoung-Gie Kim and Duk-Soo Bae

Clin Cancer Res February 1 2014 20 (3) 565-575; DOI:10.1158/1078-0432.CCR-13-1271
Human Cancer Biology

Importance of 5α-Reductase Gene Polymorphisms on Circulating and Intraprostatic Androgens in Prostate Cancer

Éric Lévesque, Isabelle Laverdière, Louis Lacombe, Patrick Caron, Mélanie Rouleau, Véronique Turcotte, Bernard Têtu, Yves Fradet and Chantal Guillemette

Clin Cancer Res February 1 2014 20 (3) 576-584; DOI:10.1158/1078-0432.CCR-13-1100
Human Cancer Biology

Interleukin-30 Expression in Prostate Cancer and Its Draining Lymph Nodes Correlates with Advanced Grade and Stage

Serena Di Meo, Irma Airoldi, Carlo Sorrentino, Alessia Zorzoli, Silvia Esposito and Emma Di Carlo

Clin Cancer Res February 1 2014 20 (3) 585-594; DOI:10.1158/1078-0432.CCR-13-2240
Human Cancer Biology

Identification of a Subset of Human Non–Small Cell Lung Cancer Patients with High PI3Kβ and Low PTEN Expression, More Prevalent in Squamous Cell Carcinoma

Marie Cumberbatch, Ximing Tang, Garry Beran, Sonia Eckersley, Xin Wang, Rebecca P.A. Ellston, Simon Dearden, Sabina Cosulich, Paul D. Smith, Carmen Behrens, Edward S. Kim, Xinying Su, Shuqiong Fan, Neil Gray, David P. Blowers, Ignacio I. Wistuba and Chris Womack

Clin Cancer Res February 1 2014 20 (3) 595-603; DOI:10.1158/1078-0432.CCR-13-1638
Human Cancer Biology

The Disparate Twins: A Comparative Study of CXCR4 and CXCR7 in SDF-1α–Induced Gene Expression, Invasion and Chemosensitivity of Colon Cancer

Doreen Heckmann, Patrick Maier, Stephanie Laufs, Li Li, Jonathan P. Sleeman, Marcus J. Trunk, Jörg H. Leupold, Frederik Wenz, W. Jens Zeller, Stefan Fruehauf and Heike Allgayer

Clin Cancer Res February 1 2014 20 (3) 604-616; DOI:10.1158/1078-0432.CCR-13-0582

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Cabozantinib Inhibits Prostate Cancer Growth and Prevents Tumor-Induced Bone Lesions

Jinlu Dai, Honglai Zhang, Andreas Karatsinides, Jill M. Keller, Kenneth M. Kozloff, Dana T. Aftab, Frauke Schimmoller and Evan T. Keller

Clin Cancer Res February 1 2014 20 (3) 617-630; DOI:10.1158/1078-0432.CCR-13-0839
Cancer Therapy: Preclinical | AuthorChoice

Targeting Small Cell Lung Cancer Harboring PIK3CA Mutation with a Selective Oral PI3K Inhibitor PF-4989216

Marlena Walls, Sangita M. Baxi, Pramod P. Mehta, Kevin K.-C. Liu, JinJiang Zhu, Heather Estrella, Chunze Li, Michael Zientek, Qing Zong, Tod Smeal and Min-Jean Yin

Clin Cancer Res February 1 2014 20 (3) 631-643; DOI:10.1158/1078-0432.CCR-13-1663
Cancer Therapy: Preclinical

Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors

Chao-Yi Wu, Li-Hua Yang, Huang-Yu Yang, Jayne Knoff, Shiwen Peng, Yi-Hsin Lin, Chenguang Wang, Ronald D. Alvarez, Sara I. Pai, Richard B.S. Roden, Chien-Fu Hung and T-C Wu

Clin Cancer Res February 1 2014 20 (3) 644-657; DOI:10.1158/1078-0432.CCR-13-1334
Cancer Therapy: Preclinical

The PDGFRβ–AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors

M. Juliachs, C. Muñoz, C.A. Moutinho, A. Vidal, E. Condom, M. Esteller, M. Graupera, O. Casanovas, J.R. Germà, A. Villanueva and F. Viñals

Clin Cancer Res February 1 2014 20 (3) 658-667; DOI:10.1158/1078-0432.CCR-13-1131
Cancer Therapy: Preclinical

Randomized, Placebo-Controlled, Double-Blinded Chemoimmunotherapy Clinical Trial in a Pet Dog Model of Diffuse Large B-cell Lymphoma

Laura Marconato, Patrick Frayssinet, Nicole Rouquet, Stefano Comazzi, Vito Ferdinando Leone, Paola Laganga, Federica Rossi, Massimo Vignoli, Lorenzo Pezzoli and Luca Aresu

Clin Cancer Res February 1 2014 20 (3) 668-677; DOI:10.1158/1078-0432.CCR-13-2283

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

Targeted Imaging of Ewing Sarcoma in Preclinical Models Using a ⁶⁴Cu-Labeled Anti-CD99 Antibody

Allison F. O'Neill, Jason L.J. Dearling, Yuchuan Wang, Tanya Tupper, Yanping Sun, Jon C. Aster, Monica L. Calicchio, Antonio R. Perez-Atayde, Alan B. Packard and Andrew L. Kung

Clin Cancer Res February 1 2014 20 (3) 678-687; DOI:10.1158/1078-0432.CCR-13-1660
Imaging, Diagnosis, Prognosis

MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer

Sukhwinder Kaur, Neil Sharma, Shiv Ram Krishn, Imay Lakshmanan, Satyanarayana Rachagani, Michael J. Baine, Lynette M. Smith, Subodh M. Lele, Aaron R. Sasson, Sushovan Guha, Kavita Mallya, Judy M. Anderson, Michael A. Hollingsworth and Surinder K. Batra

Clin Cancer Res February 1 2014 20 (3) 688-700; DOI:10.1158/1078-0432.CCR-13-2174
Imaging, Diagnosis, Prognosis

Common and Complex Notch1 Mutations in Chinese Oral Squamous Cell Carcinoma

Xiaomeng Song, Ronghui Xia, Jiang Li, Zhifeng Long, Hening Ren, Wantao Chen and Li Mao

Clin Cancer Res February 1 2014 20 (3) 701-710; DOI:10.1158/1078-0432.CCR-13-1050
Imaging, Diagnosis, Prognosis

A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer

Dong-Joo Cheon, Yunguang Tong, Myung-Shin Sim, Judy Dering, Dror Berel, Xiaojiang Cui, Jenny Lester, Jessica A. Beach, Mourad Tighiouart, Ann E. Walts, Beth Y. Karlan and Sandra Orsulic

Clin Cancer Res February 1 2014 20 (3) 711-723; DOI:10.1158/1078-0432.CCR-13-1256

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Reducing TNF Receptor 2⁺ Regulatory T Cells via the Combined Action of Azacitidine and the HDAC Inhibitor, Panobinostat for Clinical Benefit in Acute Myeloid Leukemia Patients

Chindu Govindaraj, Peter Tan, Patricia Walker, Andrew Wei, Andrew Spencer and Magdalena Plebanski

Clin Cancer Res February 1 2014 20 (3) 724-735; DOI:10.1158/1078-0432.CCR-13-1576

Predictive Biomarkers and Personalized Medicine

Predictive Biomarkers and Personalized Medicine

Quantitative ER and PgR Assessment as Predictors of Benefit from Lapatinib in Postmenopausal Women with Hormone Receptor–Positive, HER2-Negative Metastatic Breast Cancer

Richard S. Finn, Michael F. Press, Judy Dering, Lisa O'Rourke, Allison Florance, Catherine Ellis, Anne-Marie Martin and Stephen Johnston

Clin Cancer Res February 1 2014 20 (3) 736-743; DOI:10.1158/1078-0432.CCR-13-1260
Predictive Biomarkers and Personalized Medicine

PIK3CA, BRAF, and PTEN Status and Benefit from Cetuximab in the Treatment of Advanced Colorectal Cancer—Results from NCIC CTG/AGITG CO.17

Christos S. Karapetis, Derek Jonker, Manijeh Daneshmand, Jennifer E. Hanson, Christopher J. O'Callaghan, Celia Marginean, John R. Zalcberg, John Simes, Malcolm J. Moore, Niall C. Tebbutt, Timothy J. Price, Jeremy D. Shapiro, Nick Pavlakis, Peter Gibbs, Guy A. Van Hazel, Ursula Lee, Rashida Haq, Shakeel Virk, Dongsheng Tu, Ian A.J. Lorimer and for the NCIC Clinical Trials Group and the Australasian Gastro-Intestinal Trials Group

Clin Cancer Res February 1 2014 20 (3) 744-753; DOI:10.1158/1078-0432.CCR-13-0606
Predictive Biomarkers and Personalized Medicine

Busulfan in Infant to Adult Hematopoietic Cell Transplant Recipients: A Population Pharmacokinetic Model for Initial and Bayesian Dose Personalization

Jeannine S. McCune, Meagan J. Bemer, Jeffrey S. Barrett, K. Scott Baker, Alan S. Gamis and Nicholas H.G. Holford

Clin Cancer Res February 1 2014 20 (3) 754-763; DOI:10.1158/1078-0432.CCR-13-1960
Predictive Biomarkers and Personalized Medicine

Germline and Somatic Mutations in Homologous Recombination Genes Predict Platinum Response and Survival in Ovarian, Fallopian Tube, and Peritoneal Carcinomas

Kathryn P. Pennington, Tom Walsh, Maria I. Harrell, Ming K. Lee, Christopher C. Pennil, Mara H. Rendi, Anne Thornton, Barbara M. Norquist, Silvia Casadei, Alexander S. Nord, Kathy J. Agnew, Colin C. Pritchard, Sheena Scroggins, Rochelle L. Garcia, Mary-Claire King and Elizabeth M. Swisher

Clin Cancer Res February 1 2014 20 (3) 764-775; DOI:10.1158/1078-0432.CCR-13-2287

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Table of Contents

Highlights

CCR Translations

Statistics in Clinical Cancer Research

Molecular Pathways

Review

Human Cancer Biology

Cancer Therapy: Preclinical

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Predictive Biomarkers and Personalized Medicine

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