Clinical Cancer Research: 20 (4)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res February 15 2014 20 (4) 777-777;

CCR Translations

CCR Translations

Are Short Telomeres Hallmarks of Cancer Recurrence?

Jerry W. Shay

Clin Cancer Res February 15 2014 20 (4) 779-781; DOI:10.1158/1078-0432.CCR-13-3198

CCR New Strategies

CCR New Strategies

New Strategies for Triple-Negative Breast Cancer—Deciphering the Heterogeneity

Ingrid A. Mayer, Vandana G. Abramson, Brian D. Lehmann and Jennifer A. Pietenpol

Clin Cancer Res February 15 2014 20 (4) 782-790; DOI:10.1158/1078-0432.CCR-13-0583

Molecular Pathways

Molecular Pathways

Molecular Pathways: Targeting Resistance in the Androgen Receptor for Therapeutic Benefit

Elahe A. Mostaghel, Stephen R. Plymate and Bruce Montgomery

Clin Cancer Res February 15 2014 20 (4) 791-798; DOI:10.1158/1078-0432.CCR-12-3601
Molecular Pathways

Molecular Pathways: Gene–Environment Interactions Regulating Dietary Fiber Induction of Proliferation and Apoptosis via Butyrate for Cancer Prevention

Scott J. Bultman

Clin Cancer Res February 15 2014 20 (4) 799-803; DOI:10.1158/1078-0432.CCR-13-2483

Review

Review

Biologic Frontiers in Multiple Myeloma: From Biomarker Identification to Clinical Practice

Ola Landgren and Gareth J. Morgan

Clin Cancer Res February 15 2014 20 (4) 804-813; DOI:10.1158/1078-0432.CCR-13-2159

Human Cancer Biology

Human Cancer Biology

DNA Methyltransferase Inhibition Reverses Epigenetically Embedded Phenotypes in Lung Cancer Preferentially Affecting Polycomb Target Genes

Antje Hascher, Ann-Kristin Haase, Katja Hebestreit, Christian Rohde, Hans-Ulrich Klein, Maria Rius, Dominik Jungen, Anika Witten, Monika Stoll, Isabell Schulze, Seishi Ogawa, Rainer Wiewrodt, Lara Tickenbrock, Wolfgang E. Berdel, Martin Dugas, Nils H. Thoennissen and Carsten Müller-Tidow

Clin Cancer Res February 15 2014 20 (4) 814-826; DOI:10.1158/1078-0432.CCR-13-1483
Human Cancer Biology | AuthorChoice

PID1 (NYGGF4), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas

Anat Erdreich-Epstein, Nathan Robison, Xiuhai Ren, Hong Zhou, Jingying Xu, Tom B. Davidson, Mathew Schur, Floyd H. Gilles, Lingyun Ji, Jemily Malvar, Gregory M. Shackleford, Ashley S. Margol, Mark D. Krieger, Alexander R. Judkins, David T.W. Jones, Stefan M. Pfister, Marcel Kool, Richard Sposto and Shahab Asgharazadeh

Clin Cancer Res February 15 2014 20 (4) 827-836; DOI:10.1158/1078-0432.CCR-13-2053
Human Cancer Biology

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

Yasmine Touil, Wassila Igoudjil, Matthieu Corvaisier, Anne-Frédérique Dessein, Jérôme Vandomme, Didier Monté, Laurence Stechly, Nicolas Skrypek, Carole Langlois, Georges Grard, Guillaume Millet, Emmanuelle Leteurtre, Patrick Dumont, Stéphanie Truant, François-René Pruvot, Mohamed Hebbar, Fan Fan, Lee M. Ellis, Pierre Formstecher, Isabelle Van Seuningen, Christian Gespach, Renata Polakowska and Guillemette Huet

Clin Cancer Res February 15 2014 20 (4) 837-846; DOI:10.1158/1078-0432.CCR-13-1854
Human Cancer Biology

HIF-1α of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target

Roberto Ria, Ivana Catacchio, Simona Berardi, Annunziata De Luisi, Antonella Caivano, Claudia Piccoli, Vitalba Ruggieri, Maria Antonia Frassanito, Domenico Ribatti, Beatrice Nico, Tiziana Annese, Simona Ruggieri, Attilio Guarini, Carla Minoia, Paolo Ditonno, Emanuele Angelucci, Daniele Derudas, Michele Moschetta, Franco Dammacco and Angelo Vacca

Clin Cancer Res February 15 2014 20 (4) 847-858; DOI:10.1158/1078-0432.CCR-13-1950
Human Cancer Biology

Colonization of the Human Gut by E. coli and Colorectal Cancer Risk

Mathilde Bonnet, Emmanuel Buc, Pierre Sauvanet, Claude Darcha, Damien Dubois, Bruno Pereira, Pierre Déchelotte, Richard Bonnet, Denis Pezet and Arlette Darfeuille-Michaud

Clin Cancer Res February 15 2014 20 (4) 859-867; DOI:10.1158/1078-0432.CCR-13-1343
Human Cancer Biology

Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma

Wojciech Mydlarz, Mamoru Uemura, Sun Ahn, Patrick Hennessey, Steven Chang, Semra Demokan, Wenyue Sun, Chunbo Shao, Justin Bishop, Julie Krosting, Elizabeth Mambo, William Westra, Patrick Ha, David Sidransky and Joseph Califano

Clin Cancer Res February 15 2014 20 (4) 868-877; DOI:10.1158/1078-0432.CCR-13-2675
Human Cancer Biology

Integrated MicroRNA Network Analyses Identify a Poor-Prognosis Subtype of Gastric Cancer Characterized by the miR-200 Family

Fengju Song, Da Yang, Ben Liu, Yan Guo, Hong Zheng, Lian Li, Tao Wang, Jinpu Yu, Yanrui Zhao, Ruifang Niu, Han Liang, Hans Winkler, Wei Zhang, Xishan Hao and Kexin Chen

Clin Cancer Res February 15 2014 20 (4) 878-889; DOI:10.1158/1078-0432.CCR-13-1844
Human Cancer Biology

Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma

Hsueh-Li Tan, Akshay Sood, Hameed A. Rahimi, Wenle Wang, Nilesh Gupta, Jessica Hicks, Stacy Mosier, Christopher D. Gocke, Jonathan I. Epstein, George J. Netto, Wennuan Liu, William B. Isaacs, Angelo M. De Marzo and Tamara L. Lotan

Clin Cancer Res February 15 2014 20 (4) 890-903; DOI:10.1158/1078-0432.CCR-13-1982
Human Cancer Biology

Telomere Content and Risk of Second Malignant Neoplasm in Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study

Maria M. Gramatges, Qi Liu, Yutaka Yasui, M. Fatih Okcu, Joseph P. Neglia, Louise C. Strong, Gregory T. Armstrong, Leslie L. Robison and Smita Bhatia

Clin Cancer Res February 15 2014 20 (4) 904-911; DOI:10.1158/1078-0432.CCR-13-2076

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

Pratiti Bandopadhayay, Guillaume Bergthold, Brian Nguyen, Simone Schubert, Sharareh Gholamin, Yujie Tang, Sara Bolin, Steven E. Schumacher, Rhamy Zeid, Sabran Masoud, Furong Yu, Nujsaubnusi Vue, William J. Gibson, Brenton R. Paolella, Siddhartha S. Mitra, Samuel H. Cheshier, Jun Qi, Kun-Wei Liu, Robert Wechsler-Reya, William A. Weiss, Fredrik J. Swartling, Mark W. Kieran, James E. Bradner, Rameen Beroukhim and Yoon-Jae Cho

Clin Cancer Res February 15 2014 20 (4) 912-925; DOI:10.1158/1078-0432.CCR-13-2281
Cancer Therapy: Preclinical

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

Radosław Polański, Cassandra L. Hodgkinson, Alberto Fusi, Daisuke Nonaka, Lynsey Priest, Paul Kelly, Francesca Trapani, Paul W. Bishop, Anne White, Susan E. Critchlow, Paul D. Smith, Fiona Blackhall, Caroline Dive and Christopher J. Morrow

Clin Cancer Res February 15 2014 20 (4) 926-937; DOI:10.1158/1078-0432.CCR-13-2270
Cancer Therapy: Preclinical

Targeting Epithelial-to-Mesenchymal Transition with Met Inhibitors Reverts Chemoresistance in Small Cell Lung Cancer

Israel Cañadas, Federico Rojo, Álvaro Taus, Oriol Arpí, Montserrat Arumí-Uría, Lara Pijuan, Silvia Menéndez, Sandra Zazo, Manuel Dómine, Marta Salido, Sergi Mojal, Antonio García de Herreros, Ana Rovira, Joan Albanell and Edurne Arriola

Clin Cancer Res February 15 2014 20 (4) 938-950; DOI:10.1158/1078-0432.CCR-13-1330
Cancer Therapy: Preclinical

Inhibition of Protein Kinase C/Twist1 Signaling Augments Anticancer Effects of Androgen Deprivation and Enzalutamide in Prostate Cancer

Masaki Shiota, Akira Yokomizo, Ario Takeuchi, Kenjiro Imada, Eiji Kashiwagi, YooHyun Song, Junichi Inokuchi, Katsunori Tatsugami, Takeshi Uchiumi and Seiji Naito

Clin Cancer Res February 15 2014 20 (4) 951-961; DOI:10.1158/1078-0432.CCR-13-1809
Cancer Therapy: Preclinical

T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo

Claudia Geldres, Barbara Savoldo, Valentina Hoyos, Ignazio Caruana, Ming Zhang, Eric Yvon, Michele Del Vecchio, Chad J. Creighton, Michael Ittmann, Soldano Ferrone and Gianpietro Dotti

Clin Cancer Res February 15 2014 20 (4) 962-971; DOI:10.1158/1078-0432.CCR-13-2218
Cancer Therapy: Preclinical

EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss

John H. Sampson, Bryan D. Choi, Luis Sanchez-Perez, Carter M. Suryadevara, David J. Snyder, Catherine T. Flores, Robert J. Schmittling, Smita K. Nair, Elizabeth A. Reap, Pamela K. Norberg, James E. Herndon II, Chien-Tsun Kuan, Richard A. Morgan, Steven A. Rosenberg and Laura A. Johnson

Clin Cancer Res February 15 2014 20 (4) 972-984; DOI:10.1158/1078-0432.CCR-13-0709
Cancer Therapy: Preclinical

Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1)

Anne T. Nies, Elke Schaeffeler, Heiko van der Kuip, Ingolf Cascorbi, Oliver Bruhn, Michael Kneba, Christiane Pott, Ute Hofmann, Christopher Volk, Shuiying Hu, Sharyn D. Baker, Alex Sparreboom, Peter Ruth, Hermann Koepsell and Matthias Schwab

Clin Cancer Res February 15 2014 20 (4) 985-994; DOI:10.1158/1078-0432.CCR-13-1999
Cancer Therapy: Preclinical

Synergistic Antitumor Activity of Cetuximab and Namitecan in Human Squamous Cell Carcinoma Models Relies on Cooperative Inhibition of EGFR Expression and Depends on High EGFR Gene Copy Number

Michelandrea De Cesare, Calogero Lauricella, Silvio Marco Veronese, Denis Cominetti, Claudio Pisano, Franco Zunino, Nadia Zaffaroni and Valentina Zuco

Clin Cancer Res February 15 2014 20 (4) 995-1006; DOI:10.1158/1078-0432.CCR-13-1684

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

Distinction between Asymptomatic Monoclonal B-cell Lymphocytosis with Cyclin D1 Overexpression and Mantle Cell Lymphoma: From Molecular Profiling to Flow Cytometry

Blanca Espinet, Ana Ferrer, Beatriz Bellosillo, Lara Nonell, Antonio Salar, Concepción Fernández-Rodríguez, Eulàlia Puigdecanet, Javier Gimeno, Mar Garcia-Garcia, Maria Carmen Vela, Elisa Luño, Rosa Collado, José Tomás Navarro, Esmeralda de la Banda, Pau Abrisqueta, Leonor Arenillas, Cristina Serrano, Josep Lloreta, Belén Miñana, Andrea Cerutti, Lourdes Florensa, Alberto Orfao, Ferran Sanz, Francesc Solé, David Dominguez-Sola and Sergio Serrano

Clin Cancer Res February 15 2014 20 (4) 1007-1019; DOI:10.1158/1078-0432.CCR-13-1077
Imaging, Diagnosis, Prognosis | Free Article

Mesothelin Overexpression Is a Marker of Tumor Aggressiveness and Is Associated with Reduced Recurrence-Free and Overall Survival in Early-Stage Lung Adenocarcinoma

Stefan S. Kachala, Adam J. Bograd, Jonathan Villena-Vargas, Kei Suzuki, Elliot L. Servais, Kyuichi Kadota, Joanne Chou, Camelia S. Sima, Eva Vertes, Valerie W. Rusch, William D. Travis, Michel Sadelain and Prasad S. Adusumilli

Clin Cancer Res February 15 2014 20 (4) 1020-1028; DOI:10.1158/1078-0432.CCR-13-1862

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma

Cigall Kadoch, Jing Li, Valerie S. Wong, Lingjing Chen, Soonmee Cha, Pamela Munster, Clifford A. Lowell, Marc A. Shuman and James L. Rubenstein

Clin Cancer Res February 15 2014 20 (4) 1029-1041; DOI:10.1158/1078-0432.CCR-13-0474

Predictive Biomarkers and Personalized Medicine

Predictive Biomarkers and Personalized Medicine

Overexpression of the Circadian Clock Gene Bmal1 Increases Sensitivity to Oxaliplatin in Colorectal Cancer

Zhao-lei Zeng, Hui-yan Luo, Jing Yang, Wen-jing Wu, Dong-liang Chen, Peng Huang and Rui-hua Xu

Clin Cancer Res February 15 2014 20 (4) 1042-1052; DOI:10.1158/1078-0432.CCR-13-0171

Letters to the Editor

Letters to the Editor

GA201: A Novel Humanized and Glycoengineered Anti-EGFR Antibody—Letter

Helmout Modjtahedi and Suzanne Eccles

Clin Cancer Res February 15 2014 20 (4) 1053-1054; DOI:10.1158/1078-0432.CCR-13-2124
Letters to the Editor

GA201: A Novel Humanized and Glycoengineered Anti-EGFR Antibody—Response

Christian A. Gerdes and Pablo Umaña

Clin Cancer Res February 15 2014 20 (4) 1055-1055; DOI:10.1158/1078-0432.CCR-13-2699
Letters to the Editor

Biomarkers and Response to Bevacizumab—Letter

Chiara Cremolini, Fotios Loupakis, Guido Bocci and Alfredo Falcone

Clin Cancer Res February 15 2014 20 (4) 1056-1057; DOI:10.1158/1078-0432.CCR-13-2763
Letters to the Editor

Biomarkers and Response to Bevacizumab—Response

Fiona Collinson, Michelle Hutchinson, Rachel A. Craven, David A. Cairns, Zougman Alexandre, Tobias C. Wind, Narinder Gahir, Michael P. Messenger, Sharon Jackson, Douglas Thompson, Cybil Adusei, Jonathan Ledermann, Geoffrey Hall, Gordon C. Jayson, Peter J. Selby and Rosamonde E. Banks

Clin Cancer Res February 15 2014 20 (4) 1058-1058; DOI:10.1158/1078-0432.CCR-13-3269

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Highlights

CCR Translations

CCR New Strategies

Molecular Pathways

Review

Human Cancer Biology

Cancer Therapy: Preclinical

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Predictive Biomarkers and Personalized Medicine

Letters to the Editor

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