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Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res February 15 2014 20 (4) 777-777;

CCR Translations

  • CCR Translations
    Are Short Telomeres Hallmarks of Cancer Recurrence?
    Jerry W. Shay
    Clin Cancer Res February 15 2014 20 (4) 779-781; DOI:10.1158/1078-0432.CCR-13-3198

CCR New Strategies

  • CCR New Strategies
    New Strategies for Triple-Negative Breast Cancer—Deciphering the Heterogeneity
    Ingrid A. Mayer, Vandana G. Abramson, Brian D. Lehmann and Jennifer A. Pietenpol
    Clin Cancer Res February 15 2014 20 (4) 782-790; DOI:10.1158/1078-0432.CCR-13-0583

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: Targeting Resistance in the Androgen Receptor for Therapeutic Benefit
    Elahe A. Mostaghel, Stephen R. Plymate and Bruce Montgomery
    Clin Cancer Res February 15 2014 20 (4) 791-798; DOI:10.1158/1078-0432.CCR-12-3601

  • Molecular Pathways
    Molecular Pathways: Gene–Environment Interactions Regulating Dietary Fiber Induction of Proliferation and Apoptosis via Butyrate for Cancer Prevention
    Scott J. Bultman
    Clin Cancer Res February 15 2014 20 (4) 799-803; DOI:10.1158/1078-0432.CCR-13-2483

Review

  • Review
    Biologic Frontiers in Multiple Myeloma: From Biomarker Identification to Clinical Practice
    Ola Landgren and Gareth J. Morgan
    Clin Cancer Res February 15 2014 20 (4) 804-813; DOI:10.1158/1078-0432.CCR-13-2159

Human Cancer Biology

  • Human Cancer Biology
    DNA Methyltransferase Inhibition Reverses Epigenetically Embedded Phenotypes in Lung Cancer Preferentially Affecting Polycomb Target Genes
    Antje Hascher, Ann-Kristin Haase, Katja Hebestreit, Christian Rohde, Hans-Ulrich Klein, Maria Rius, Dominik Jungen, Anika Witten, Monika Stoll, Isabell Schulze, Seishi Ogawa, Rainer Wiewrodt, Lara Tickenbrock, Wolfgang E. Berdel, Martin Dugas, Nils H. Thoennissen and Carsten Müller-Tidow
    Clin Cancer Res February 15 2014 20 (4) 814-826; DOI:10.1158/1078-0432.CCR-13-1483

  • Human Cancer Biology | AuthorChoice
    PID1 (NYGGF4), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
    Anat Erdreich-Epstein, Nathan Robison, Xiuhai Ren, Hong Zhou, Jingying Xu, Tom B. Davidson, Mathew Schur, Floyd H. Gilles, Lingyun Ji, Jemily Malvar, Gregory M. Shackleford, Ashley S. Margol, Mark D. Krieger, Alexander R. Judkins, David T.W. Jones, Stefan M. Pfister, Marcel Kool, Richard Sposto and Shahab Asgharazadeh
    Clin Cancer Res February 15 2014 20 (4) 827-836; DOI:10.1158/1078-0432.CCR-13-2053

  • Human Cancer Biology
    Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
    Yasmine Touil, Wassila Igoudjil, Matthieu Corvaisier, Anne-Frédérique Dessein, Jérôme Vandomme, Didier Monté, Laurence Stechly, Nicolas Skrypek, Carole Langlois, Georges Grard, Guillaume Millet, Emmanuelle Leteurtre, Patrick Dumont, Stéphanie Truant, François-René Pruvot, Mohamed Hebbar, Fan Fan, Lee M. Ellis, Pierre Formstecher, Isabelle Van Seuningen, Christian Gespach, Renata Polakowska and Guillemette Huet
    Clin Cancer Res February 15 2014 20 (4) 837-846; DOI:10.1158/1078-0432.CCR-13-1854

  • Human Cancer Biology
    HIF-1α of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target
    Roberto Ria, Ivana Catacchio, Simona Berardi, Annunziata De Luisi, Antonella Caivano, Claudia Piccoli, Vitalba Ruggieri, Maria Antonia Frassanito, Domenico Ribatti, Beatrice Nico, Tiziana Annese, Simona Ruggieri, Attilio Guarini, Carla Minoia, Paolo Ditonno, Emanuele Angelucci, Daniele Derudas, Michele Moschetta, Franco Dammacco and Angelo Vacca
    Clin Cancer Res February 15 2014 20 (4) 847-858; DOI:10.1158/1078-0432.CCR-13-1950

  • Human Cancer Biology
    Colonization of the Human Gut by E. coli and Colorectal Cancer Risk
    Mathilde Bonnet, Emmanuel Buc, Pierre Sauvanet, Claude Darcha, Damien Dubois, Bruno Pereira, Pierre Déchelotte, Richard Bonnet, Denis Pezet and Arlette Darfeuille-Michaud
    Clin Cancer Res February 15 2014 20 (4) 859-867; DOI:10.1158/1078-0432.CCR-13-1343

  • Human Cancer Biology
    Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma
    Wojciech Mydlarz, Mamoru Uemura, Sun Ahn, Patrick Hennessey, Steven Chang, Semra Demokan, Wenyue Sun, Chunbo Shao, Justin Bishop, Julie Krosting, Elizabeth Mambo, William Westra, Patrick Ha, David Sidransky and Joseph Califano
    Clin Cancer Res February 15 2014 20 (4) 868-877; DOI:10.1158/1078-0432.CCR-13-2675

  • Human Cancer Biology
    Integrated MicroRNA Network Analyses Identify a Poor-Prognosis Subtype of Gastric Cancer Characterized by the miR-200 Family
    Fengju Song, Da Yang, Ben Liu, Yan Guo, Hong Zheng, Lian Li, Tao Wang, Jinpu Yu, Yanrui Zhao, Ruifang Niu, Han Liang, Hans Winkler, Wei Zhang, Xishan Hao and Kexin Chen
    Clin Cancer Res February 15 2014 20 (4) 878-889; DOI:10.1158/1078-0432.CCR-13-1844

  • Human Cancer Biology
    Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma
    Hsueh-Li Tan, Akshay Sood, Hameed A. Rahimi, Wenle Wang, Nilesh Gupta, Jessica Hicks, Stacy Mosier, Christopher D. Gocke, Jonathan I. Epstein, George J. Netto, Wennuan Liu, William B. Isaacs, Angelo M. De Marzo and Tamara L. Lotan
    Clin Cancer Res February 15 2014 20 (4) 890-903; DOI:10.1158/1078-0432.CCR-13-1982

  • Human Cancer Biology
    Telomere Content and Risk of Second Malignant Neoplasm in Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study
    Maria M. Gramatges, Qi Liu, Yutaka Yasui, M. Fatih Okcu, Joseph P. Neglia, Louise C. Strong, Gregory T. Armstrong, Leslie L. Robison and Smita Bhatia
    Clin Cancer Res February 15 2014 20 (4) 904-911; DOI:10.1158/1078-0432.CCR-13-2076

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma
    Pratiti Bandopadhayay, Guillaume Bergthold, Brian Nguyen, Simone Schubert, Sharareh Gholamin, Yujie Tang, Sara Bolin, Steven E. Schumacher, Rhamy Zeid, Sabran Masoud, Furong Yu, Nujsaubnusi Vue, William J. Gibson, Brenton R. Paolella, Siddhartha S. Mitra, Samuel H. Cheshier, Jun Qi, Kun-Wei Liu, Robert Wechsler-Reya, William A. Weiss, Fredrik J. Swartling, Mark W. Kieran, James E. Bradner, Rameen Beroukhim and Yoon-Jae Cho
    Clin Cancer Res February 15 2014 20 (4) 912-925; DOI:10.1158/1078-0432.CCR-13-2281

  • Cancer Therapy: Preclinical
    Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
    Radosław Polański, Cassandra L. Hodgkinson, Alberto Fusi, Daisuke Nonaka, Lynsey Priest, Paul Kelly, Francesca Trapani, Paul W. Bishop, Anne White, Susan E. Critchlow, Paul D. Smith, Fiona Blackhall, Caroline Dive and Christopher J. Morrow
    Clin Cancer Res February 15 2014 20 (4) 926-937; DOI:10.1158/1078-0432.CCR-13-2270

  • Cancer Therapy: Preclinical
    Targeting Epithelial-to-Mesenchymal Transition with Met Inhibitors Reverts Chemoresistance in Small Cell Lung Cancer
    Israel Cañadas, Federico Rojo, Álvaro Taus, Oriol Arpí, Montserrat Arumí-Uría, Lara Pijuan, Silvia Menéndez, Sandra Zazo, Manuel Dómine, Marta Salido, Sergi Mojal, Antonio García de Herreros, Ana Rovira, Joan Albanell and Edurne Arriola
    Clin Cancer Res February 15 2014 20 (4) 938-950; DOI:10.1158/1078-0432.CCR-13-1330

  • Cancer Therapy: Preclinical
    Inhibition of Protein Kinase C/Twist1 Signaling Augments Anticancer Effects of Androgen Deprivation and Enzalutamide in Prostate Cancer
    Masaki Shiota, Akira Yokomizo, Ario Takeuchi, Kenjiro Imada, Eiji Kashiwagi, YooHyun Song, Junichi Inokuchi, Katsunori Tatsugami, Takeshi Uchiumi and Seiji Naito
    Clin Cancer Res February 15 2014 20 (4) 951-961; DOI:10.1158/1078-0432.CCR-13-1809

  • Cancer Therapy: Preclinical
    T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo
    Claudia Geldres, Barbara Savoldo, Valentina Hoyos, Ignazio Caruana, Ming Zhang, Eric Yvon, Michele Del Vecchio, Chad J. Creighton, Michael Ittmann, Soldano Ferrone and Gianpietro Dotti
    Clin Cancer Res February 15 2014 20 (4) 962-971; DOI:10.1158/1078-0432.CCR-13-2218

  • Cancer Therapy: Preclinical
    EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss
    John H. Sampson, Bryan D. Choi, Luis Sanchez-Perez, Carter M. Suryadevara, David J. Snyder, Catherine T. Flores, Robert J. Schmittling, Smita K. Nair, Elizabeth A. Reap, Pamela K. Norberg, James E. Herndon II, Chien-Tsun Kuan, Richard A. Morgan, Steven A. Rosenberg and Laura A. Johnson
    Clin Cancer Res February 15 2014 20 (4) 972-984; DOI:10.1158/1078-0432.CCR-13-0709

  • Cancer Therapy: Preclinical
    Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1)
    Anne T. Nies, Elke Schaeffeler, Heiko van der Kuip, Ingolf Cascorbi, Oliver Bruhn, Michael Kneba, Christiane Pott, Ute Hofmann, Christopher Volk, Shuiying Hu, Sharyn D. Baker, Alex Sparreboom, Peter Ruth, Hermann Koepsell and Matthias Schwab
    Clin Cancer Res February 15 2014 20 (4) 985-994; DOI:10.1158/1078-0432.CCR-13-1999

  • Cancer Therapy: Preclinical
    Synergistic Antitumor Activity of Cetuximab and Namitecan in Human Squamous Cell Carcinoma Models Relies on Cooperative Inhibition of EGFR Expression and Depends on High EGFR Gene Copy Number
    Michelandrea De Cesare, Calogero Lauricella, Silvio Marco Veronese, Denis Cominetti, Claudio Pisano, Franco Zunino, Nadia Zaffaroni and Valentina Zuco
    Clin Cancer Res February 15 2014 20 (4) 995-1006; DOI:10.1158/1078-0432.CCR-13-1684

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Distinction between Asymptomatic Monoclonal B-cell Lymphocytosis with Cyclin D1 Overexpression and Mantle Cell Lymphoma: From Molecular Profiling to Flow Cytometry
    Blanca Espinet, Ana Ferrer, Beatriz Bellosillo, Lara Nonell, Antonio Salar, Concepción Fernández-Rodríguez, Eulàlia Puigdecanet, Javier Gimeno, Mar Garcia-Garcia, Maria Carmen Vela, Elisa Luño, Rosa Collado, José Tomás Navarro, Esmeralda de la Banda, Pau Abrisqueta, Leonor Arenillas, Cristina Serrano, Josep Lloreta, Belén Miñana, Andrea Cerutti, Lourdes Florensa, Alberto Orfao, Ferran Sanz, Francesc Solé, David Dominguez-Sola and Sergio Serrano
    Clin Cancer Res February 15 2014 20 (4) 1007-1019; DOI:10.1158/1078-0432.CCR-13-1077

  • Imaging, Diagnosis, Prognosis | Free Article
    Mesothelin Overexpression Is a Marker of Tumor Aggressiveness and Is Associated with Reduced Recurrence-Free and Overall Survival in Early-Stage Lung Adenocarcinoma
    Stefan S. Kachala, Adam J. Bograd, Jonathan Villena-Vargas, Kei Suzuki, Elliot L. Servais, Kyuichi Kadota, Joanne Chou, Camelia S. Sima, Eva Vertes, Valerie W. Rusch, William D. Travis, Michel Sadelain and Prasad S. Adusumilli
    Clin Cancer Res February 15 2014 20 (4) 1020-1028; DOI:10.1158/1078-0432.CCR-13-1862

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma
    Cigall Kadoch, Jing Li, Valerie S. Wong, Lingjing Chen, Soonmee Cha, Pamela Munster, Clifford A. Lowell, Marc A. Shuman and James L. Rubenstein
    Clin Cancer Res February 15 2014 20 (4) 1029-1041; DOI:10.1158/1078-0432.CCR-13-0474

Predictive Biomarkers and Personalized Medicine

  • Predictive Biomarkers and Personalized Medicine
    Overexpression of the Circadian Clock Gene Bmal1 Increases Sensitivity to Oxaliplatin in Colorectal Cancer
    Zhao-lei Zeng, Hui-yan Luo, Jing Yang, Wen-jing Wu, Dong-liang Chen, Peng Huang and Rui-hua Xu
    Clin Cancer Res February 15 2014 20 (4) 1042-1052; DOI:10.1158/1078-0432.CCR-13-0171

Letters to the Editor

  • Letters to the Editor
    GA201: A Novel Humanized and Glycoengineered Anti-EGFR Antibody—Letter
    Helmout Modjtahedi and Suzanne Eccles
    Clin Cancer Res February 15 2014 20 (4) 1053-1054; DOI:10.1158/1078-0432.CCR-13-2124

  • Letters to the Editor
    GA201: A Novel Humanized and Glycoengineered Anti-EGFR Antibody—Response
    Christian A. Gerdes and Pablo Umaña
    Clin Cancer Res February 15 2014 20 (4) 1055-1055; DOI:10.1158/1078-0432.CCR-13-2699

  • Letters to the Editor
    Biomarkers and Response to Bevacizumab—Letter
    Chiara Cremolini, Fotios Loupakis, Guido Bocci and Alfredo Falcone
    Clin Cancer Res February 15 2014 20 (4) 1056-1057; DOI:10.1158/1078-0432.CCR-13-2763

  • Letters to the Editor
    Biomarkers and Response to Bevacizumab—Response
    Fiona Collinson, Michelle Hutchinson, Rachel A. Craven, David A. Cairns, Zougman Alexandre, Tobias C. Wind, Narinder Gahir, Michael P. Messenger, Sharon Jackson, Douglas Thompson, Cybil Adusei, Jonathan Ledermann, Geoffrey Hall, Gordon C. Jayson, Peter J. Selby and Rosamonde E. Banks
    Clin Cancer Res February 15 2014 20 (4) 1058-1058; DOI:10.1158/1078-0432.CCR-13-3269

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Clinical Cancer Research: 20 (4)
February 2014
Volume 20, Issue 4
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Issue Highlights

  • BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma
  • Synergistic Antitumor Activity of Cetuximab and Namitecan in Human Squamous Cell Carcinoma Models Relies on Cooperative Inhibition of EGFR Expression and Depends on High EGFR Gene Copy Number
  • Telomere Content and Risk of Second Malignant Neoplasm in Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study
  • Inhibition of Protein Kinase C/Twist1 Signaling Augments Anticancer Effects of Androgen Deprivation and Enzalutamide in Prostate Cancer
  • Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1)

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Clinical Cancer Research
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