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Cancer Therapy: Clinical

Phase I Study of Oral Rigosertib (ON 01910.Na), a Dual Inhibitor of the PI3K and Plk1 Pathways, in Adult Patients with Advanced Solid Malignancies

Daniel W. Bowles, Jennifer R. Diamond, Elaine T. Lam, Colin D. Weekes, David P. Astling, Ryan T. Anderson, Stephen Leong, Lia Gore, Marileila Varella-Garcia, Brian W. Vogler, Stephen B. Keysar, Elizabeth Freas, Dara L. Aisner, Chen Ren, Aik-Chook Tan, Francois Wilhelm, Manoj Maniar, S. Gail Eckhardt, Wells A. Messersmith and Antonio Jimeno
Daniel W. Bowles
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Jennifer R. Diamond
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Elaine T. Lam
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Colin D. Weekes
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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David P. Astling
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Ryan T. Anderson
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Stephen Leong
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Lia Gore
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Marileila Varella-Garcia
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Brian W. Vogler
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Stephen B. Keysar
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Elizabeth Freas
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Dara L. Aisner
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Chen Ren
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Aik-Chook Tan
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Francois Wilhelm
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Manoj Maniar
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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S. Gail Eckhardt
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Wells A. Messersmith
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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Antonio Jimeno
1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
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DOI: 10.1158/1078-0432.CCR-13-2506 Published March 2014
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Cited By

Article Information

Volume 20, Issue 6, pp. 1656-1665

DOI 
https://doi.org/10.1158/1078-0432.CCR-13-2506
PubMed 
24493827

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received September 14, 2013
  • Revision received December 5, 2013
  • Accepted December 21, 2013
  • Published first February 3, 2014.

Article Versions

  • Previous version (February 3, 2014 - 07:26).
  • Previous version (March 5, 2014 - 06:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Daniel W. Bowles1,
  2. Jennifer R. Diamond1,
  3. Elaine T. Lam1,
  4. Colin D. Weekes1,
  5. David P. Astling1,
  6. Ryan T. Anderson1,
  7. Stephen Leong1,
  8. Lia Gore1,
  9. Marileila Varella-Garcia1,
  10. Brian W. Vogler1,
  11. Stephen B. Keysar1,
  12. Elizabeth Freas1,
  13. Dara L. Aisner2,
  14. Chen Ren3,
  15. Aik-Chook Tan1,
  16. Francois Wilhelm3,
  17. Manoj Maniar3,
  18. S. Gail Eckhardt1,
  19. Wells A. Messersmith1, and
  20. Antonio Jimeno1
  1. Authors' Affiliations: 1Department of Medicine, Division of Medical Oncology; 2Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado; and 3Onconova Therapeutics Inc, Newtown, Pennsylvania
  1. Corresponding Author:
    Antonio Jimeno, University of Colorado School of Medicine, MS8117, 12801 East 17th Avenue, Room L18-8101B, Aurora, CO 80045. Phone: 303-724-2478; Fax: 303-724-3892; E-mail: antonio.jimeno{at}ucdenver.edu
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Clinical Cancer Research: 20 (6)
March 2014
Volume 20, Issue 6
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Phase I Study of Oral Rigosertib (ON 01910.Na), a Dual Inhibitor of the PI3K and Plk1 Pathways, in Adult Patients with Advanced Solid Malignancies
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Phase I Study of Oral Rigosertib (ON 01910.Na), a Dual Inhibitor of the PI3K and Plk1 Pathways, in Adult Patients with Advanced Solid Malignancies
Daniel W. Bowles, Jennifer R. Diamond, Elaine T. Lam, Colin D. Weekes, David P. Astling, Ryan T. Anderson, Stephen Leong, Lia Gore, Marileila Varella-Garcia, Brian W. Vogler, Stephen B. Keysar, Elizabeth Freas, Dara L. Aisner, Chen Ren, Aik-Chook Tan, Francois Wilhelm, Manoj Maniar, S. Gail Eckhardt, Wells A. Messersmith and Antonio Jimeno
Clin Cancer Res March 15 2014 (20) (6) 1656-1665; DOI: 10.1158/1078-0432.CCR-13-2506

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Phase I Study of Oral Rigosertib (ON 01910.Na), a Dual Inhibitor of the PI3K and Plk1 Pathways, in Adult Patients with Advanced Solid Malignancies
Daniel W. Bowles, Jennifer R. Diamond, Elaine T. Lam, Colin D. Weekes, David P. Astling, Ryan T. Anderson, Stephen Leong, Lia Gore, Marileila Varella-Garcia, Brian W. Vogler, Stephen B. Keysar, Elizabeth Freas, Dara L. Aisner, Chen Ren, Aik-Chook Tan, Francois Wilhelm, Manoj Maniar, S. Gail Eckhardt, Wells A. Messersmith and Antonio Jimeno
Clin Cancer Res March 15 2014 (20) (6) 1656-1665; DOI: 10.1158/1078-0432.CCR-13-2506
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